| 研究領域 | マルチスケール精神病態の構成的理解 |
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| 研究課題/領域番号 |
21H00218
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| 研究種目 |
新学術領域研究(研究領域提案型)
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| 配分区分 | 補助金 |
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| 審査区分 |
生物系
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| 研究機関 | 国立研究開発法人理化学研究所 |
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研究代表者 |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| 研究期間 (年度) |
2021-04-01 – 2023-03-31
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| 研究課題ステータス |
完了 (2022年度)
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| 配分額 *注記 |
7,800千円 (直接経費: 6,000千円、間接経費: 1,800千円)
2022年度: 3,900千円 (直接経費: 3,000千円、間接経費: 900千円)
2021年度: 3,900千円 (直接経費: 3,000千円、間接経費: 900千円)
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| キーワード | hippocampus / schizophrenia / CA2 / replay / Schizophrenia / social behavior / hypothalamus |
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| 研究開始時の研究の概要 |
Recent work, including studies in my lab, have revealed that the CA2 region of the hippocampus, an area impacted in patients and mouse models of schizophrenia, could be a key node in social cognition and its dysfunction in mental disease. This project will build on our recent discovery of a hypothalamic-CA2 circuit that signals social novelty by employing in vivo recording and optogenetic approaches to elucidate the dynamics of social cognition and how they are altered in a mouse model of schizophrenia.
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| 研究実績の概要 |
During FY2022 we combined in vivo physiological recordings and optogenetic manipulation of CA2 transmission during social memory behavioral paradigms. Our results found both enhancement and impairments in encoding of social identity with inhibition and stimulation of specific CA2 outputs respectively. On the level of physiology we observed changes in the power of theta band oscillations in the CA1 region of the hippocampus that corresponded to the changes in behavior that we observed. Namely, impaired encoding of social memory was correlated with a decrease in theta power during the session and enhanced encoding of social memory was correlated with an increase in the power of the theta band oscillation. Currently we are extending the analyses of these data to look at single unit activity both in CA1 and CA2 during this behavioral paradigm, as well as conducting additional experiments using in vivo imaging with sensors designed to be sensitive to the extracellular concentration of specific neuromodulators. We are excited about these results will continue these experiments in the future to test the hypothesis this is mediated through slow-time scale changes in the power of the theta oscillation.
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| 現在までの達成度 (段落) |
令和4年度が最終年度であるため、記入しない。
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| 今後の研究の推進方策 |
令和4年度が最終年度であるため、記入しない。
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