公募研究
新学術領域研究(研究領域提案型)
We have made continued progress in Heisei 26 on delineating a circuit mechanism for setting fear learning levels. Following up on our previous work from Heisei, we have discovered that central nucleus of the amygdala (CeA) inputs to the periaqueductal gray (PAG) regulates prediction error neural coding and memory strength through differential modulation of distinct subregions of the PAG.Specifically we found that optogenetic inhibition of CE inputs to ventrolateral PAG (vlPAG) inhibited auditory conditioned stimulus (CS) processing in vlPAG without affecting shock unconditioned stimulus (US) processing.In contrast, the same optogenetic manipulation disinhibited shock US processing, but had no effect on CS processing in dorsolateral PAG neurons.
26年度が最終年度であるため、記入しない。
すべて 2015 2014 2013 その他
すべて 雑誌論文 (4件) (うち査読あり 4件、 オープンアクセス 3件、 謝辞記載あり 3件) 学会発表 (21件) (うち招待講演 21件) 備考 (1件)
Proceedings of the National Academy of Sciences
巻: 111(51)
Nature Neuroscience
巻: 17(12) ページ: 1644-54
Current Biology
巻: 24 (15)
Nature
巻: 496 号: 7444 ページ: 174-175
10.1038/nature12087
http://jlab.brain.riken.jp/
