1991 年度実績報告書

発生の制御における細胞成長因子の役割

研究課題

研究課題/領域番号	03304009
研究機関	麻布大学
研究代表者	黒田行昭麻布大学, 生物科学総合研究所, 所長 (40000228)
研究分担者	井出宏之東北大学, 理学部, 助教授 (70022704) 西川克三金沢医科大学, 医学部, 教授 (10029960) 中村敏一九州大学, 理学部, 教授 (00049397) 能村哲郎埼玉大学, 理学部, 教授 (40072970) 浅島誠横浜市立大学, 文理学部, 教授 (00090564)
キーワード	発生の制御 / 細胞成長因子 / 細胞分化 / 培養細胞 / 繊維芽細胞成長因子 / 上皮成長因子 / 腫瘍成長因子 / レセプタ-
研究概要	1.ヒドラを用いた細胞成長因子の作用とその遺伝子の研究。ヒドラの幹細胞の移植導入実験によって、幹細胞が分化した神経細胞から幹細胞の維持増殖因子が産生されることが分った(藤沢)。 2.ウニ、ホヤ、両生類の胚を用いた細胞成長因子の研究。ウニの外腸胚形成ペプチドを精製し、6KDaのペプチドを分離した(末光)。出芽期のホヤより内在性レチナ-ルを検出し、抗体を用いてそれが表皮に局在し、形態形成に関与することが分った(川村)。ツメガエルの未受精卵にTGFβの1つアクチビンが存在し、フォリスタチンにより分化誘導能が抑制された(浅島)。 3.ニワトリ胚の培養細胞を用いた細胞成長因子の研究。ニワトリ胚の肢芽の細胞が未分化のままで増殖するのに、外胚葉性頂堤からのbFGFが有効であった(井出)。また、眼球の強膜繊維芽細胞でレチノイン酸がDNA合成の調節を行っていた(渡辺)。胚の精巣培養液上清より、ウズラ胚のミュラ-管抑制物質を分離した(能村)。 4.哺乳動物を用いた細胞成長因子の研究。ラットの肝、肺、腎臓で肝細胞増殖因子を検出し、これら器官の成長成熟に関与していた(中村)。bFGFに対する中和単クロ-ン抗体を用いて、血液や各臓器で抗体の分布がみられた(西川)。 5.高等動物の培養細胞を用いた細胞成長因子の研究。ヒト胎児の肺繊維芽細胞のクロ-ン培養で、FGFは非分裂細胞の分裂を促進し、分裂細胞の分裂周期を早めた(黒田)。ヒト皮膚細胞の遊走促進物質としてPDGFとIコラ-ゲンの共存が有効であった(近藤)。また、無血清培養では、PDGF、FGF、EGTは増殖促進因子として、TGFβは阻害因として作用した(加治)。 ^<125>I標識TGFβ1を用いてTGF受容体の検索を行いタンパクを同定した(平井)。

研究成果
(48件)

すべてその他

すべて文献書誌 (48件)

[文献書誌] Kuroda,Y.,Jain,A.K.,Tezuka,H.& Kada,T.: "Antimutagenicity in cultured mammalian cells." Mutation Res.(1992)
[文献書誌] Kojima,H.,Konishi,H.& Kuroda,Y.: "Effects of Lーascorbic acid on mutagenicity of ethyl methaneーsulfonate in cultured mammalian cells." Mutation Res.(1992)
[文献書誌] Kojima,H.,Konishi,H.& Kuroda,Y.: "Combined mutagenicity of methyl methanesulfonate and ethyl methaneーsulfonate in Chinese hamster V79 cells." Mutation Res.(1992)
[文献書誌] Tamai,K.,Tezuka,H.& Kuroda,Y.: "Different modifications by vanillin in cytotoxicity and genetic changes induced by EMS and H_2O_2 in cultured Chinese hamster cells." Mutation Res.(1992)
[文献書誌] Yokoiyama,A.,Kada,T.& Kuroda,Y.: "Inhibitor of potentially lethal damage(PLD)repair,reduces the frequency of γーrayーinduced mutations in cultured Chltured Chinese hamster V79 cells." Mutation Res.(1992)
[文献書誌] Kuroda,Y.,Shimada,Y.,Sakaguchi,B.& Oishi,K.: "Effects of sexーRatio(SR)ーspiroplasma infection of Drosophila primary embryonic cultured cells and on embryogenesis." Zool.Sci.9. (1992)
[文献書誌] Kawamura,K.and Nakauchi,M.: "Homeostatic integration of stem cell dynamics during plalleal budding of ascidians." Zool.Sci.8. 11-22 (1991)
[文献書誌] Kawamura,K.,Nomura,M.,Kameda,T.,Shimamoto,H.and Nakauchi.: "Selfーnonself recognition activity extracted from selfーsterile eggs of the ascidian,Ciona intestinalis." Develop.Growth Differ.33. 139-148 (1991)
[文献書誌] Kawamura,K.and Nakauchi,M.: "The effect of aphidicolin on morphogenesis of epithelial stem cells during budding in ascidians." Mem.Fac.Sci.Kochi Univ.Ser.D. 12. 61-65 (1992)
[文献書誌] Kawamura,K.,Fujiwara,S.and Sugino,Y.M.: "Buddingーspecific lectin induced in epithelial cells is and extracellular matrix component for stem cell aggregation in tunicates." Development. 113. 995-1005 (1991)
[文献書誌] Kawamura,K.,Ymamoto,t.,Sugino,Y.M.and Fujiwara,S.: "Alkaline phosphatase and peroxydase activities of blood cells in the polystyelid ascidian,Polyandrocarpa misakiensis." Merm Fac.Sci.Kochi Univ.Ser.D. 13. 19-27 (1992)
[文献書誌] Fujiwara,S.,Xu,J.and Kawamura,K.: "One step separation of mesenchymal cells of the ascidian Polyandrocarpa misakiensis." Mem.Fac.Sci.Kochi Univ.Ser.D. 13. 29-36 (1992)
[文献書誌] David,C.N.,Fujisawa,T.,& Bosch,T.C.G.: "Interstitial stem cell proliferation in Hydra;Evidence for strainーspecific regulatory sighal." Develop.Biol.148. 501-507 (1991)
[文献書誌] Fujisawa,T.: "Homeostatic recovery of interstitial cell population in Hydra." Develop,Biol.(1992)
[文献書誌] Sakaguchi,M.,Hanai,K.Ohta,K.,Kitajima,M.,Matsuhashi,S.,Hori,K.& Morita,H.: "Monoclonal antibodies that depress a specific subset of multiple components of the glutathinoneーinduced response of Hydra." J.Comp.Physiol.168. 409-416 (1991)
[文献書誌] Tooyama,I.,Hara,Y.Yasuhara,O.,Oomura,Y.Hanai,K.et al.: "Production of antisera to acidic fibroblast growth factor and their application to immunohistochemical study in rat brain." Nouroscience. 40. 769-779 (1991)
[文献書誌] Nakayasu,H.,Mizutani,H.,Hanai,K.,Kimura,H.& Kuriyama,K.: "Monoclonal antibody to GABA binding protein,a possible GABA receptor" Biochem.Biophys.Res.Commun.182. 722-726 (1992)
[文献書誌] Suyemitsu,T.,Fujii,Y.,Kinosita,K.,Yamasu,K.& Ishihara,K.: "Changes of exogastrulaーinducing activities in eggs or embryos of the sea urchin,Anthocidaris crassispina,during development." Zool.Sci.8. 1085 (1991)
[文献書誌] Sugino,Y.M.,Koguchi,S.and Kawamura,K.: "Ultrastructure of cellーtoーcell contact in epidermai stolon of the ascidian Perophora japonica." Mem.Fac.Sci.Kochi Univ.Ser.D. 13. 37-43 (1992)
[文献書誌] M.Asashima,H.,Nakano,H.,Uchiyama,H.,Sugino T.,Nakamura,Y.,Eto,D.Ejima,M.Davids,S.Plossow,I.Cichoka and K.Kinoshita: "Follistatin inhibits the mesoderm inducing activity of activin A and the vegetalizing factor from chicken embryo." Rouxs Archives Develop.Biol.,200(1). 4-7 (1991)
[文献書誌] M.Asashima,H.Nakano,H.Uchiyama,H.Sugino,T.Nakamura,Y.Eto,D.Ejima,S.I.Nishimatsu N.Ueno and K.Kinoshita: "The presence of activin(Erythroid Differentiation Factor)in unfertilized eggs and blastulae of Xenopus lacvis." Proc.N.A.S.88(15). 6511-6514 (1991)
[文献書誌] Asashima,M.,Uchiyama,H.,Nakano,H.et al.: "The vegetalizing factor from chicken embryos; Its EDF(activin)ーlike activity." Mechanism of Cell Development. 34. 135-141 (1991)
[文献書誌] Asashima,M.,Shimada,K.& Pfeiffer,C.J.: "Magnetic shieldding induces early developmental abnormalities in the newt,Cynops pyrrhogaster." Bioelectromagnetics. 12. 215-224 (1991)
[文献書誌] Fukui,A.Tashiro,A.,Koyama,H.,Iwamura,Y.& Asashima,M.: "A new cell line(XTY)from a tumor of Xenopus laevis." Experientia. 48. 87-91 (1992)
[文献書誌] Arizumi,T.Moriya,N.Uchiyama,H.& Asashima,M.: "Concentration dependent inducing activity of activin A." Roux's Archives Develop.Biol.200. 230-233 (1991)
[文献書誌] Noji,S.,Nohno,T.,Kyoama E.,Muto K.,Ohyama K.,Aoki Y.,Tamura K.,Ohsugi K.,Ide H.,Taniguchi S.,Saito T.: "Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud." Nature. 350. 83-86 (1991)
[文献書誌] Yokouchi Y.,Ohsugi K.,Uchiyama K.and Ide H.: "Control of the expression of AVー1 protin,a positionーspecific antigen,by ZPA factor in the chick limb bud." Develop.Growth & Differ.33. 173-180 (1991)
[文献書誌] T.Kobayashi,T.Suzuki and T.Noumura: "Purification of chicken testicular Mullerian inhibiting substance." Zoological Science. 8. 1167 (1991)
[文献書誌] Toshikazu Nakamura: "Structure and function of hepatocyte growth factor." Progress in Growth Factor Research. 3. 67-85 (1991)
[文献書誌] Matsumoto,K.,Hashimoto,K.,Yoshikawa,K.& Nakamura,T.: "Marked stimulation of growth and motility of human keratinocyte by hepatocyte growth factor." Exp.Cell Res.196. 114-120 (1991)
[文献書誌] Mantesano,R.,Matsumoto,K.,Nakamura,T.& Orei L.: "I dentification of a fibroblastーderived epithelial epithelial morphogen as hepotocyte growth factor." Cell. 67. 901-908 (1991)
[文献書誌] Mine,T.,Kojima,I.,Ogata,E.& Nakamura,T.: "Comparison of effects of HGF and EGF on cellular calcium in rat hepatocytes" Biochem.Biophys.Res.Commun.181. 1173-1180 (1991)
[文献書誌] N.Yamamoto,S.Matsutani,Y.Yoshitake and K.Nishikawa: "Immunohistochemical locallization of basic fibroblast growth factor in A431 human epidermoid carcinoma cells." Histochemistry. 96. 479-485 (1991)
[文献書誌] K.Yamada,Y.Yoshitake,H.Norimatsu and K.Nishikawa: "Roles of various growth factors in growth of human osteosarcoma cells which can grow in proteinーfree medium." Cell Struct.Funct.17. (1992)
[文献書誌] Y.Yoshitake and N.Nishikawa: "Distribution of fibroblast growth factors in cultured tumor cells and their transplants." In Vitro Cell.Dev.Biol.28. (1992)
[文献書誌] K.Matsumoto and T.Nakamura: "Hepatocyte growth factor : molecular structure,roles in liver regeneration,and other biological functions." Critical Reviews in Oncogenesis. 3. 27-54 (1992)
[文献書誌] Shimizu,I.Ichihara,A.,& Nakamura,T.: "Hepatocyte growth factor in ascites from patients with cirrhosis." J.Biochem.109. 14-18 (1991)
[文献書誌] Seki,T.,Hagiya,M.Shimonishi,M.,Nakamura,T.& Shimizu,S.: "Organization of the human hepatocyte growth factorーencoding gene." Gene. 102. 213-217 (1991)
[文献書誌] Higuchi,O.& Nakamura,T.: "Identification and characterization of receptor for hepatocyte growth factor and change in the receptor in rat liver after partial hepatectomy and hepatitis." Biochem.Biophys.Res.Commun.176. 599-607 (1991)
[文献書誌] Matsumoto,K.,Tajima,H.& Nakamura,T.: "Hepatocyte growth factor is a potent stimulator for human melanocytes DNA synthesis and growth." Biochem.Biophys.Res.Commun.176. 45-51 (1991)
[文献書誌] Kinoshita,T.,Hirao,S.Matsumoto,K.& Nakamura,T.: "Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy." Biochem.Biophys.Res.Commun.177. 330-335 (1991)
[文献書誌] H.Kondo,R.Matsuda and Y.Yonezawa: "Plateletーderived growth factor in combination with collagen promotes the migration of human skin fibroblasts into a denuded area of a cell monolayer." Experimental Cell Research.
[文献書誌] K.Kaji,R.Hirai,K.Yamaoka,M.Matsuo: "Growth inhibition and cell shape alteration of human diploid fibroblasts due to transforming growth factorーβ1 in serumーfree media." Zoological Science. 8. 491-497 (1991)
[文献書誌] Kuroda,Y.: "Plants and Health for All." Elsevier(The Netherlands), (1992)
[文献書誌] 黒田行昭: "新生理科学大系(第7巻)「発生・分化の生理学」" 医学書院(東京), 213-220 (1992)
[文献書誌] Ide H.,Ohkubo Y.,Noji,S.,Taniguchi S.: "Retinoic acid and limb pattern formation in cell culture.in Developmental Patterning of the Vertebrate Limb(eds.Hinchliffe et al.)" Plenum, 105-113 (1991)
[文献書誌] Y.Yoshitake,K.Matsuzaki and K.Nishikawa: "Derivation of monoclonal antibody to basic fibroblast growth factor and its application.Methods Enzymol.198" Academic Press(D.Barnes,J.P.Mather and G.H.Sato eds.), 148-157 (1991)
[文献書誌] "3ーー〔(3・Chloamidopropyl)dimethylamnonio〕ー1ーpropane sulfonate as noncytotoxic atabilizing agent for growth factors.Methods Enzymol.198" Academic Press(D.Barnes,J.P.Mather and G.H.Sato eds.), 511-518 (1991)

1991 年度 実績報告書

発生の制御における細胞成長因子の役割

研究代表者

黒田 行昭 麻布大学, 生物科学総合研究所, 所長 (40000228)

研究成果

[文献書誌] Kuroda,Y.,Jain,A.K.,Tezuka,H.& Kada,T.: "Antimutagenicity in cultured mammalian cells." Mutation Res.(1992)

[文献書誌] Kojima,H.,Konishi,H.& Kuroda,Y.: "Effects of Lーascorbic acid on mutagenicity of ethyl methaneーsulfonate in cultured mammalian cells." Mutation Res.(1992)

[文献書誌] Kojima,H.,Konishi,H.& Kuroda,Y.: "Combined mutagenicity of methyl methanesulfonate and ethyl methaneーsulfonate in Chinese hamster V79 cells." Mutation Res.(1992)

[文献書誌] Tamai,K.,Tezuka,H.& Kuroda,Y.: "Different modifications by vanillin in cytotoxicity and genetic changes induced by EMS and H_2O_2 in cultured Chinese hamster cells." Mutation Res.(1992)

[文献書誌] Yokoiyama,A.,Kada,T.& Kuroda,Y.: "Inhibitor of potentially lethal damage(PLD)repair,reduces the frequency of γーrayーinduced mutations in cultured Chltured Chinese hamster V79 cells." Mutation Res.(1992)

[文献書誌] Kuroda,Y.,Shimada,Y.,Sakaguchi,B.& Oishi,K.: "Effects of sexーRatio(SR)ーspiroplasma infection of Drosophila primary embryonic cultured cells and on embryogenesis." Zool.Sci.9. (1992)

[文献書誌] Kawamura,K.and Nakauchi,M.: "Homeostatic integration of stem cell dynamics during plalleal budding of ascidians." Zool.Sci.8. 11-22 (1991)

[文献書誌] Kawamura,K.,Nomura,M.,Kameda,T.,Shimamoto,H.and Nakauchi.: "Selfーnonself recognition activity extracted from selfーsterile eggs of the ascidian,Ciona intestinalis." Develop.Growth Differ.33. 139-148 (1991)

[文献書誌] Kawamura,K.and Nakauchi,M.: "The effect of aphidicolin on morphogenesis of epithelial stem cells during budding in ascidians." Mem.Fac.Sci.Kochi Univ.Ser.D. 12. 61-65 (1992)

[文献書誌] Kawamura,K.,Fujiwara,S.and Sugino,Y.M.: "Buddingーspecific lectin induced in epithelial cells is and extracellular matrix component for stem cell aggregation in tunicates." Development. 113. 995-1005 (1991)

[文献書誌] Kawamura,K.,Ymamoto,t.,Sugino,Y.M.and Fujiwara,S.: "Alkaline phosphatase and peroxydase activities of blood cells in the polystyelid ascidian,Polyandrocarpa misakiensis." Merm Fac.Sci.Kochi Univ.Ser.D. 13. 19-27 (1992)

[文献書誌] Fujiwara,S.,Xu,J.and Kawamura,K.: "One step separation of mesenchymal cells of the ascidian Polyandrocarpa misakiensis." Mem.Fac.Sci.Kochi Univ.Ser.D. 13. 29-36 (1992)

[文献書誌] David,C.N.,Fujisawa,T.,& Bosch,T.C.G.: "Interstitial stem cell proliferation in Hydra;Evidence for strainーspecific regulatory sighal." Develop.Biol.148. 501-507 (1991)

[文献書誌] Fujisawa,T.: "Homeostatic recovery of interstitial cell population in Hydra." Develop,Biol.(1992)

[文献書誌] Sakaguchi,M.,Hanai,K.Ohta,K.,Kitajima,M.,Matsuhashi,S.,Hori,K.& Morita,H.: "Monoclonal antibodies that depress a specific subset of multiple components of the glutathinoneーinduced response of Hydra." J.Comp.Physiol.168. 409-416 (1991)

[文献書誌] Tooyama,I.,Hara,Y.Yasuhara,O.,Oomura,Y.Hanai,K.et al.: "Production of antisera to acidic fibroblast growth factor and their application to immunohistochemical study in rat brain." Nouroscience. 40. 769-779 (1991)

[文献書誌] Nakayasu,H.,Mizutani,H.,Hanai,K.,Kimura,H.& Kuriyama,K.: "Monoclonal antibody to GABA binding protein,a possible GABA receptor" Biochem.Biophys.Res.Commun.182. 722-726 (1992)

[文献書誌] Suyemitsu,T.,Fujii,Y.,Kinosita,K.,Yamasu,K.& Ishihara,K.: "Changes of exogastrulaーinducing activities in eggs or embryos of the sea urchin,Anthocidaris crassispina,during development." Zool.Sci.8. 1085 (1991)

[文献書誌] Sugino,Y.M.,Koguchi,S.and Kawamura,K.: "Ultrastructure of cellーtoーcell contact in epidermai stolon of the ascidian Perophora japonica." Mem.Fac.Sci.Kochi Univ.Ser.D. 13. 37-43 (1992)

[文献書誌] M.Asashima,H.,Nakano,H.,Uchiyama,H.,Sugino T.,Nakamura,Y.,Eto,D.Ejima,M.Davids,S.Plossow,I.Cichoka and K.Kinoshita: "Follistatin inhibits the mesoderm inducing activity of activin A and the vegetalizing factor from chicken embryo." Rouxs Archives Develop.Biol.,200(1). 4-7 (1991)

[文献書誌] M.Asashima,H.Nakano,H.Uchiyama,H.Sugino,T.Nakamura,Y.Eto,D.Ejima,S.I.Nishimatsu N.Ueno and K.Kinoshita: "The presence of activin(Erythroid Differentiation Factor)in unfertilized eggs and blastulae of Xenopus lacvis." Proc.N.A.S.88(15). 6511-6514 (1991)

[文献書誌] Asashima,M.,Uchiyama,H.,Nakano,H.et al.: "The vegetalizing factor from chicken embryos; Its EDF(activin)ーlike activity." Mechanism of Cell Development. 34. 135-141 (1991)

[文献書誌] Asashima,M.,Shimada,K.& Pfeiffer,C.J.: "Magnetic shieldding induces early developmental abnormalities in the newt,Cynops pyrrhogaster." Bioelectromagnetics. 12. 215-224 (1991)

[文献書誌] Fukui,A.Tashiro,A.,Koyama,H.,Iwamura,Y.& Asashima,M.: "A new cell line(XTY)from a tumor of Xenopus laevis." Experientia. 48. 87-91 (1992)

[文献書誌] Arizumi,T.Moriya,N.Uchiyama,H.& Asashima,M.: "Concentration dependent inducing activity of activin A." Roux's Archives Develop.Biol.200. 230-233 (1991)

[文献書誌] Noji,S.,Nohno,T.,Kyoama E.,Muto K.,Ohyama K.,Aoki Y.,Tamura K.,Ohsugi K.,Ide H.,Taniguchi S.,Saito T.: "Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud." Nature. 350. 83-86 (1991)

[文献書誌] Yokouchi Y.,Ohsugi K.,Uchiyama K.and Ide H.: "Control of the expression of AVー1 protin,a positionーspecific antigen,by ZPA factor in the chick limb bud." Develop.Growth & Differ.33. 173-180 (1991)

[文献書誌] T.Kobayashi,T.Suzuki and T.Noumura: "Purification of chicken testicular Mullerian inhibiting substance." Zoological Science. 8. 1167 (1991)

[文献書誌] Toshikazu Nakamura: "Structure and function of hepatocyte growth factor." Progress in Growth Factor Research. 3. 67-85 (1991)

[文献書誌] Matsumoto,K.,Hashimoto,K.,Yoshikawa,K.& Nakamura,T.: "Marked stimulation of growth and motility of human keratinocyte by hepatocyte growth factor." Exp.Cell Res.196. 114-120 (1991)

[文献書誌] Mantesano,R.,Matsumoto,K.,Nakamura,T.& Orei L.: "I dentification of a fibroblastーderived epithelial epithelial morphogen as hepotocyte growth factor." Cell. 67. 901-908 (1991)

[文献書誌] Mine,T.,Kojima,I.,Ogata,E.& Nakamura,T.: "Comparison of effects of HGF and EGF on cellular calcium in rat hepatocytes" Biochem.Biophys.Res.Commun.181. 1173-1180 (1991)

[文献書誌] N.Yamamoto,S.Matsutani,Y.Yoshitake and K.Nishikawa: "Immunohistochemical locallization of basic fibroblast growth factor in A431 human epidermoid carcinoma cells." Histochemistry. 96. 479-485 (1991)

[文献書誌] K.Yamada,Y.Yoshitake,H.Norimatsu and K.Nishikawa: "Roles of various growth factors in growth of human osteosarcoma cells which can grow in proteinーfree medium." Cell Struct.Funct.17. (1992)

[文献書誌] Y.Yoshitake and N.Nishikawa: "Distribution of fibroblast growth factors in cultured tumor cells and their transplants." In Vitro Cell.Dev.Biol.28. (1992)

[文献書誌] K.Matsumoto and T.Nakamura: "Hepatocyte growth factor : molecular structure,roles in liver regeneration,and other biological functions." Critical Reviews in Oncogenesis. 3. 27-54 (1992)

[文献書誌] Shimizu,I.Ichihara,A.,& Nakamura,T.: "Hepatocyte growth factor in ascites from patients with cirrhosis." J.Biochem.109. 14-18 (1991)

[文献書誌] Seki,T.,Hagiya,M.Shimonishi,M.,Nakamura,T.& Shimizu,S.: "Organization of the human hepatocyte growth factorーencoding gene." Gene. 102. 213-217 (1991)

[文献書誌] Higuchi,O.& Nakamura,T.: "Identification and characterization of receptor for hepatocyte growth factor and change in the receptor in rat liver after partial hepatectomy and hepatitis." Biochem.Biophys.Res.Commun.176. 599-607 (1991)

[文献書誌] Matsumoto,K.,Tajima,H.& Nakamura,T.: "Hepatocyte growth factor is a potent stimulator for human melanocytes DNA synthesis and growth." Biochem.Biophys.Res.Commun.176. 45-51 (1991)

[文献書誌] Kinoshita,T.,Hirao,S.Matsumoto,K.& Nakamura,T.: "Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy." Biochem.Biophys.Res.Commun.177. 330-335 (1991)

[文献書誌] H.Kondo,R.Matsuda and Y.Yonezawa: "Plateletーderived growth factor in combination with collagen promotes the migration of human skin fibroblasts into a denuded area of a cell monolayer." Experimental Cell Research.

[文献書誌] K.Kaji,R.Hirai,K.Yamaoka,M.Matsuo: "Growth inhibition and cell shape alteration of human diploid fibroblasts due to transforming growth factorーβ1 in serumーfree media." Zoological Science. 8. 491-497 (1991)

[文献書誌] Kuroda,Y.: "Plants and Health for All." Elsevier(The Netherlands), (1992)

[文献書誌] 黒田 行昭: "新生理科学大系(第7巻)「発生・分化の生理学」" 医学書院(東京), 213-220 (1992)

[文献書誌] Ide H.,Ohkubo Y.,Noji,S.,Taniguchi S.: "Retinoic acid and limb pattern formation in cell culture.in Developmental Patterning of the Vertebrate Limb(eds.Hinchliffe et al.)" Plenum, 105-113 (1991)

[文献書誌] Y.Yoshitake,K.Matsuzaki and K.Nishikawa: "Derivation of monoclonal antibody to basic fibroblast growth factor and its application.Methods Enzymol.198" Academic Press(D.Barnes,J.P.Mather and G.H.Sato eds.), 148-157 (1991)

[文献書誌] "3ーー〔(3・Chloamidopropyl)dimethylamnonio〕ー1ーpropane sulfonate as noncytotoxic atabilizing agent for growth factors.Methods Enzymol.198" Academic Press(D.Barnes,J.P.Mather and G.H.Sato eds.), 511-518 (1991)

1991 年度実績報告書

黒田行昭麻布大学, 生物科学総合研究所, 所長 (40000228)

[文献書誌] 黒田行昭: "新生理科学大系(第7巻)「発生・分化の生理学」" 医学書院(東京), 213-220 (1992)