1992 年度実績報告書

熱産生器官・褐色脂肪組織の生理と病態に関する総合的研究

研究課題

研究課題/領域番号	03304027
研究機関	旭川医科大学
研究代表者	黒島晨汎旭川医科大学, 医学部, 教授 (90002774)
研究分担者	村上悳山口大学, 医学部, 教授 (90040518) 永坂鉄夫金沢大学, 医学部, 教授 (80023646) 金村秦輔関西医科大学, 医学部, 教授 (50027091) 嶋津孝愛媛大学, 医学部, 教授 (30090400) 入來正躬山梨医科大学, 医学部, 教授 (90072967)
キーワード	褐色脂肪組織 / 非ふるえ熱産生 / 寒冷馴化 / 視床下部 / 肥満 / 脂質代謝 / インスリン / ノルアドレナリン
研究概要	褐色脂肪組織の分化・発生、機能調節の生理・生化学的機構、病態特に肥満との関係について、又褐色脂肪組織と関連する幾つかの問題について平成3年度に引き続き、今後の研究を推進する上で有益な示唆を与える多くの知見が得られた。1.褐色脂肪組織の中枢性調節:視床下部腹内側核刺激は交感神経を介して褐色脂肪組織を刺激するが、また中脳、橋、延髄などの関与も示唆された(堀)。褐色脂肪組織の脂肪合成に関与する中枢性因子の存在が示唆された(嶋津)。ストレス性熱産生には褐色脂肪組織の関与が示されているが、その際Interleukinl-CRF-ACTH系の関与が示唆された(村上)。暑熱馴化により非ふるえ熱産生発現の環境温度は高くなり、抑制がみられ、褐色脂肪組織の熱産生抑制が推測される(永坂、小坂)。2.褐色脂肪組織の病態機能:高β_3特異性アドレナリン受容体作動物質の抗肥満、抗糖尿病作用は褐色脂肪組織機能の亢進による(吉田)。褐色脂肪組織機能の低下を介する肥満の発現にInterleukinlの関与する胃機能の変化が示唆された(高杉)。3.褐色脂肪組織の構造:褐色脂肪細胞の分化・増殖の機能を知るための新しい三次元培養法の有効なことが明らかにされた(杉原)。褐色脂肪細胞は明暗を環境温度の変化によって影響を受け、松果体機能との関係が示唆された(松嶋)。褐色脂肪組織にはアドレナリン作動性線維以外に、NP-Y、S-P線維が血管、実質細胞に分布していることが示された(金村)。4.褐色脂肪組織の末梢性調節:褐色脂肪細胞のCa^<2+>の動態の解析が行われ、細胞内Ca^<2+>結合タンパク質の存在が示唆された(入來)。低圧、低酸素下の高地に生息するげっし類の褐色脂肪組織の特性の検討が行われた(柳平)。G_<M3>が褐色脂肪組織の主要ガングリオシドであり、組織増殖、機能亢進の調節要素の一つであることが示唆された(黒島)。

研究成果

(29件)

すべてその他

すべて文献書誌 (29件)

[文献書誌] Ogawa,K.: "Effects of cold acclimation on cold-induced changes in lipid metabolism of rat brown adipose tissue." Jpn.J.Physiol.42. 63-73 (1992)
[文献書誌] Kikuchi,K.: "Effects of chronic administration of noradrenaline and glucagon on in vitro brown adipose tissue thermogenesis." Jpn.J.Physiol.42. 165-170 (1992)
[文献書誌] Nozu,T.: "Effect of immobilization stress on in vitro and in vivo thermogenesis of brown adipose tiossue." Jpn.J.Physiol.42. 299-308 (1992)
[文献書誌] Okano,S.: "In vitro thermogenesis of brown adipose tissue in fasted rats." Jpn.J.Biometeor.29. 35-41 (1992)
[文献書誌] Ohno,T.: "Postnatal changes in fatty acids composition of brown adipose tissue." Int.J.Biometeorol.36. 30-35 (1992)
[文献書誌] Nozu,T.: "Effects of running training on in vitro brown adipose tissue thermogenesis in rats." Int.J.Biometeorol.36. 88-92 (1992)
[文献書誌] Ohno,T.: "Non-thermal stress-induced modifications of fatty acids profiles in rat brown adipose tissue." J.therm.Biol.17. 251-256 (1992)
[文献書誌] Uehara,A.: "Evidence that the gastric antisecretory and action of lipopolysaccharide is not due to a toxic effect on gastric parietal cells." Dig.Dis.Sci.37. 1039-1044 (1992)
[文献書誌] Uehara,A.: "Gastric antisecretory and anti-ulcer actions of interleukin-1:evidence for the presence of an ¨immune-brain-gut¨ axis." J.Clin.Gastroenterol.14. S149-S155 (1992)
[文献書誌] Okumura,T.: "Prevention by interleukin-1 of thyrotropin-relesing hormone(TRH)-induced gastric mucosal lesions in rats." Neurosci.Lett.125. 31-33 (1991)
[文献書誌] 平義樹: "チャイニーズハムスターにおける松果体と褐色脂肪組織の関連性" 解剖学雑志. 67. 492 (1992)
[文献書誌] Nagai,M.: "The role of serotonergic system in body temperature regulation." Physiol.Res.41. 65-69 (1992)
[文献書誌] Nagai,M.: "Hypothermia enhances contractile responses of of the guinea pig taenia caeci to acetylcholine,5-hydroxytryptamine,caffeine and calcium." Ital.J.Gastroenterol.24. 13-18 (1992)
[文献書誌] Nagai,M.: "Enhanced contraction of the guinea-pig taenia caeci at low temperature." Autonom.Nerv.Syst.29. 365-369 (1992)
[文献書誌] Minokoshi,Y.: "Sympathetic activation of lipid synthesis in brown adipose tissue in the rat." J.Physiol.398. 361-370 (1988)
[文献書誌] Sudo,M.: "Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats." Am.J.Physiol.261. E298-E303 (1991)
[文献書誌] Hori,T.: "Effects of temperature and neuroactive substances on hypothalamic neurones in vitro:possible implications for the induction of fever." Physiol.Res.41. 77-81 (1992)
[文献書誌] Shimizu,N.: "In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis:significant enhancement by immobilization stress in rats." Brain Res.Bull.28. 727-734 (1992)
[文献書誌] Matsuda,T.: "Thermal and PGE_2 sensitivity of the organum lamina terminalis region and proptic area in rat brain slices." J.Physiol.(Lond.). 454. 213-230 (1992)
[文献書誌] Fijimoto,S.: "Distribution of cathecholaminergic and peptidergic nerves in interscapular brown adipose tissues of mice." Acta Histochem.Cytochem.26. (1993)
[文献書誌] Mishiro,K.: "Absence of cross-innervation and paravascular projections of noradrenergic nerves in mouse interscapular brown adipose tissue." Acta Histochem.Cytochem.26. (1993)
[文献書誌] Shido,O.: "Effect of heat acclimation on diurnal chahges in body temperature and locomotor activity in rats." J.Physiol.(Lond.). 433. 59-71 (1991)
[文献書誌] Tan,N.: "Effect of running training on the blood glucose and lactate in rats during rest and swimming." Physiol.&Behav.51. 927-931 (1992)
[文献書誌] Morimoto,A.: "Does an increase in prostaglandin E_2 in the blood circulation contribute to a febrile response in rabbits?" Brain Res.Bull.29. 189-192 (1992)
[文献書誌] Yahata,T.: "High Altitude Medicine "Functional changes in brown adipose tissue under various conditions."" Shinsyu Univ., 492-496 (1992)
[文献書誌] Ohinata,H.: "High altitude Medicine "Some compositional changes in brown adipose tissue." Shinsyu Univ., 497-501 (1992)
[文献書誌] 永井正則: "『生気象学の事典』、日本生気象学会編温熱による直接的生理作用" 朝倉書店, 174-175 (1992)
[文献書誌] Niijima,A.: "New Trends in Autonomic Nervous System Research"The effects of interleukin 1β and 2 on efferent activity of splenic,adrenal and renal branches of the splanchinic nerve in the rat."" Elsevier Sci.Pub.,589 (1991)
[文献書誌] 海塚安郎: "『生気象学の事典』、日本生気象学会編体温調節と免疫機能" 朝倉書店, 198-199 (1992)

1992 年度 実績報告書

熱産生器官・褐色脂肪組織の生理と病態に関する総合的研究

研究代表者

黒島 晨汎 旭川医科大学, 医学部, 教授 (90002774)

研究成果

[文献書誌] Ogawa,K.: "Effects of cold acclimation on cold-induced changes in lipid metabolism of rat brown adipose tissue." Jpn.J.Physiol.42. 63-73 (1992)

[文献書誌] Kikuchi,K.: "Effects of chronic administration of noradrenaline and glucagon on in vitro brown adipose tissue thermogenesis." Jpn.J.Physiol.42. 165-170 (1992)

[文献書誌] Nozu,T.: "Effect of immobilization stress on in vitro and in vivo thermogenesis of brown adipose tiossue." Jpn.J.Physiol.42. 299-308 (1992)

[文献書誌] Okano,S.: "In vitro thermogenesis of brown adipose tissue in fasted rats." Jpn.J.Biometeor.29. 35-41 (1992)

[文献書誌] Ohno,T.: "Postnatal changes in fatty acids composition of brown adipose tissue." Int.J.Biometeorol.36. 30-35 (1992)

[文献書誌] Nozu,T.: "Effects of running training on in vitro brown adipose tissue thermogenesis in rats." Int.J.Biometeorol.36. 88-92 (1992)

[文献書誌] Ohno,T.: "Non-thermal stress-induced modifications of fatty acids profiles in rat brown adipose tissue." J.therm.Biol.17. 251-256 (1992)

[文献書誌] Uehara,A.: "Evidence that the gastric antisecretory and action of lipopolysaccharide is not due to a toxic effect on gastric parietal cells." Dig.Dis.Sci.37. 1039-1044 (1992)

[文献書誌] Uehara,A.: "Gastric antisecretory and anti-ulcer actions of interleukin-1:evidence for the presence of an ¨immune-brain-gut¨ axis." J.Clin.Gastroenterol.14. S149-S155 (1992)

[文献書誌] Okumura,T.: "Prevention by interleukin-1 of thyrotropin-relesing hormone(TRH)-induced gastric mucosal lesions in rats." Neurosci.Lett.125. 31-33 (1991)

[文献書誌] 平 義樹: "チャイニーズハムスターにおける松果体と褐色脂肪組織の関連性" 解剖学雑志. 67. 492 (1992)

[文献書誌] Nagai,M.: "The role of serotonergic system in body temperature regulation." Physiol.Res.41. 65-69 (1992)

[文献書誌] Nagai,M.: "Hypothermia enhances contractile responses of of the guinea pig taenia caeci to acetylcholine,5-hydroxytryptamine,caffeine and calcium." Ital.J.Gastroenterol.24. 13-18 (1992)

[文献書誌] Nagai,M.: "Enhanced contraction of the guinea-pig taenia caeci at low temperature." Autonom.Nerv.Syst.29. 365-369 (1992)

[文献書誌] Minokoshi,Y.: "Sympathetic activation of lipid synthesis in brown adipose tissue in the rat." J.Physiol.398. 361-370 (1988)

[文献書誌] Sudo,M.: "Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats." Am.J.Physiol.261. E298-E303 (1991)

[文献書誌] Hori,T.: "Effects of temperature and neuroactive substances on hypothalamic neurones in vitro:possible implications for the induction of fever." Physiol.Res.41. 77-81 (1992)

[文献書誌] Shimizu,N.: "In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis:significant enhancement by immobilization stress in rats." Brain Res.Bull.28. 727-734 (1992)

[文献書誌] Matsuda,T.: "Thermal and PGE_2 sensitivity of the organum lamina terminalis region and proptic area in rat brain slices." J.Physiol.(Lond.). 454. 213-230 (1992)

[文献書誌] Fijimoto,S.: "Distribution of cathecholaminergic and peptidergic nerves in interscapular brown adipose tissues of mice." Acta Histochem.Cytochem.26. (1993)

[文献書誌] Mishiro,K.: "Absence of cross-innervation and paravascular projections of noradrenergic nerves in mouse interscapular brown adipose tissue." Acta Histochem.Cytochem.26. (1993)

[文献書誌] Shido,O.: "Effect of heat acclimation on diurnal chahges in body temperature and locomotor activity in rats." J.Physiol.(Lond.). 433. 59-71 (1991)

[文献書誌] Tan,N.: "Effect of running training on the blood glucose and lactate in rats during rest and swimming." Physiol.&Behav.51. 927-931 (1992)

[文献書誌] Morimoto,A.: "Does an increase in prostaglandin E_2 in the blood circulation contribute to a febrile response in rabbits?" Brain Res.Bull.29. 189-192 (1992)

[文献書誌] Yahata,T.: "High Altitude Medicine "Functional changes in brown adipose tissue under various conditions."" Shinsyu Univ., 492-496 (1992)

[文献書誌] Ohinata,H.: "High altitude Medicine "Some compositional changes in brown adipose tissue." Shinsyu Univ., 497-501 (1992)

[文献書誌] 永井 正則: "『生気象学の事典』、日本生気象学会編温熱による直接的生理作用" 朝倉書店, 174-175 (1992)

[文献書誌] Niijima,A.: "New Trends in Autonomic Nervous System Research"The effects of interleukin 1β and 2 on efferent activity of splenic,adrenal and renal branches of the splanchinic nerve in the rat."" Elsevier Sci.Pub.,589 (1991)

[文献書誌] 海塚 安郎: "『生気象学の事典』、日本生気象学会編体温調節と免疫機能" 朝倉書店, 198-199 (1992)

1992 年度実績報告書

黒島晨汎旭川医科大学, 医学部, 教授 (90002774)

[文献書誌] 平義樹: "チャイニーズハムスターにおける松果体と褐色脂肪組織の関連性" 解剖学雑志. 67. 492 (1992)

[文献書誌] 永井正則: "『生気象学の事典』、日本生気象学会編温熱による直接的生理作用" 朝倉書店, 174-175 (1992)

[文献書誌] 海塚安郎: "『生気象学の事典』、日本生気象学会編体温調節と免疫機能" 朝倉書店, 198-199 (1992)