1992 年度実績報告書

産業および地域保健における神経,精神,行動障害とその評価法に関する研究

研究課題

研究課題/領域番号	03454204
研究機関	東京大学
研究代表者	荒記俊一東京大学, 医学部(医), 教授 (00111493)
研究分担者	谷川武東京大学, 医学部(医), 助手 (80227214) 佐田文宏東京大学, 医学部(医), 助手 (90187154) 川上憲人岐阜大学, 医学部(医), 助教授 (90177650) 村田勝敬東京大学, 医学部(医), 助手 (80157776) 横山和仁東京大学, 医学部(医), 助教授 (00158370)
キーワード	産業保健 / 地域保健 / 疫学的方法 / 神経中毒 / 精神障害 / 行動障害 / 神経生理学的方法 / 質問紙調査法
研究概要	今回の研究では、各種有害化学物質および物理学的環境因子に暴露する作業者集団と中毒・職業病・成人病患者で、末梢神経(神経伝導速度、「神経伝導速度分布」)、中枢および脳神経(事象関連電位、短潜時体性感覚誘発電位、聴覚誘発電位、視覚誘発電位、平衡機能検査)、自律神経(心電図R-R間隔変動)、精神・行動(神経行動テスト)、感情・ストレス(質問紙法、誘発電位誘発電位)の各種の神経・精神・行動機能の測定を行ない、以下の成果を得た。 1)鉛、混合有機溶剤、スチレン、局所振動等に暴露する明らかな神経徴候のない作業者集団で、末梢神経の伝導の障害を見出し、さらにこの障害は伝導が速い神経線維の方が遅い神経線維より強く起こることを明らかにした。同様の障害を、糖尿病およびアルコール依存症患者でも観察した。 2)同じくこれらの作業者および患者で、事象関連電位または各種誘発電位の潜時の遅延を見出した。また、自律神経機能の低下を明らかにした。 3)スチレンに暴露する作業者で神経行動テスト得点の低下を見出した。 4)混合有機溶剤等に暴露する作業者集団で、平衡機能の障害を明らかにした。 5)職場での技能労働者(男子)の精神障害の発生に影響を与える主要な社会心理的因子は、(1)仕事への不満、不適合と(2)人間関係の障害であり、仕事量の影響は少ないことを明らかにした。さらに、コンピューター技術者の労働ストレス、精神症状および性格傾向に影響を与える主要な疫学因子は年齢であり、コンピューター作業自体の影響は少ないことを観察した。 6)ストレスチェックリスト(SCL-86)、感情プロフィール検査(POMS)などの質問紙法の日本語版の標準化を行ない、正常値および信頼性・妥当性を明らかにした。 7)鉛および2.5ヘキサンジオン中毒動物で、末梢神経軸索内輸送および脊髄エネルギー代謝の障害を明らかにした。 8)脳血管障害患者の三次予防のための地域ケアシステムに関する疫学調査により、(1)地域住民の脳血管障害予防事業への参加促進、(2)効果的な事業内容、および(3)他の事業との連携等について、ガイドラインを明らかにした。

研究成果

(37件)

すべてその他

すべて文献書誌 (37件)

[文献書誌] Kawakami,N.,Araki,S.,Haratani,T.,Hemmi,T.: "Relations of work stress to alcohol use and drinking problems in male and female employees of a computer factory in Japan" Environmental Research.
[文献書誌] Ezoe,S.,Araki,S.,Ono,Y.,Kawakami,N.,Murata,K.: "Work stress in Japanese computer workers effects of computer work or bioeducational factors?" Environmental Research.
[文献書誌] Uchida,E.,Araki,S.,Murata,K.: "Socloeconomic factors affecting marriage,divorce and birth rates in Japanese population." Journal of Biosocial Science.
[文献書誌] Uchida,E.,Araki,S.,Murata,K.: "Socioeconomic factors affecting first marriage and birth rates by sex and age in the total Japanese population." Journal of Human Ergology.
[文献書誌] Imanaka,Y.,Araki,S.,Nobumoto,K.: "Effects of patient health beliefs and satisfacion on compliance with medication regimens in ambulatory care of general hospitals." Japanese Journal of Hygiene.
[文献書誌] Araki,S.,Tamigawa,T.,Ishizu,S.,Minato,N.: "Decrease of CD4 positive T lymphocytes in workers exposed to benzidine and Betanaphthy laminc." Archieves of Environmental Health(in press).
[文献書誌] Araki,S.,Murata,K.,Uchida,E.: "Radial and median nerve conduction velocities in workers exposed to lead,copper and zinc:a follow-up study for two years." Environmental Research.
[文献書誌] Murata,K.,Araki,S.,Yokoyama,K.,Uchida,E.,Fujimura,Y.: "Assessment of central,peripheral and autonomic nervous system functions in lead workers:neuroele ctrophysiological studies." Environmental Research.
[文献書誌] Sata,F.,Araki,S.,Murata,K.,Uchida,E.: "Are faster of slower learge myelinated nerve fibers more sensitive to chronic lead exposure?:a study of the distribution of conduction velocities." Environmental Research.
[文献書誌] Fujimura,Y.,Araki,S.,Murata,K.,Yokoyama,K.,Handa,S.: "Assessment of the distripution of nerve conduction velocities in alcoholics." Envirohmental Research.
[文献書誌] Araki,S.,Yokoyama,K.,Murata,K.: "Assessment of the effects of occupational and environmental factors on ail faster and slower large myelinated nerve fibers:a study of the distribution of nerve conduction velocities." Environmental Research.
[文献書誌] Araki,S.,Murata,K.,Yokoyama,K.: "Assessment of central peripheral and autonomic nervous system functions in vibrating tool operators:neuroelectrophysiological studies." Environmental Research.
[文献書誌] Kawakami,N.,Haratani,T.,Araki,S.: "Effects of perceived job stress on depressive symptoms in blue-collar workers of an electrical factory in Japan." Scandinavian Journal of Work,Environment & Health. 18. 195-200 (1992)
[文献書誌] Kawakami,N.,Haratani,T.,Hemmi,T.,Araki,S.: "Prevalence and demographic correlates of alcohol-related problems in Japanese employees." Social Psychiatry and Psychiatric Epidemiology. 27. 198-202 (1992)
[文献書誌] Uchida,E.,Araki,S.,Murata,K.: "Socioeconomic factors affecting the longevity of the Japanese population:a study for 1980 and 1985." Journal of Biosocial Science. 24. 497-504 (1992)
[文献書誌] 赤林朗,横山和仁,荒記俊一,島田恭子: "POMS(感情プロフィール検査)日本語版の臨床応用の検討" 心身医学. 31. 577-582 (1991)
[文献書誌] Yokoyama,K.,Araki,S.,Murata,K.: "Effects of low level styrene exposure on psychological performance in FRP boat laminating workers." Neurotoxicology. 13. 551-556 (1992)
[文献書誌] Murata,K.,Araki,S.,Tanigawa,T.,Uchida,E.: "Acute effects of alcohol on cognitive function and central nervous system assessed by auditory eventrelated potentials." Japanese Journal of Hygiene. 47. 958-964 (1992)
[文献書誌] Yokoyama,K.,Araki,S.: "Assessment of slow axonal Transport in lead-exposed rats." Environmental Research. 59. 440-446 (1992)
[文献書誌] Ezoe,S.,Araki,S.,Ono,Y.,Kawakami,N.,Murata,K.: "Assessment of personality traits and psychi atric symptoms in workers in a computer manufacturing in Japan." American Journal of Industrial Medicine.
[文献書誌] 森田陽子,坂井公,荒記俊一: "血中δ-アミノレブリン酸(ALA-B)とδ-アミノレブリン酸脱水酵素(ALA-D)活性" ポルフィリン誌. 1. 135-140 (1992)
[文献書誌] 加藤尚彦,赤林朗,横山和仁,荒記俊一: "鉛ニューロパチーの脊髄におけるエネルギー代謝特性" 神経化学. 31. 582-583 (1992)
[文献書誌] 鈴木研一,大山武,後藤由夫,松本雅博,豊田隆謙,横山和仁,荒記俊一: "糖尿病神経障害の神経伝導速度分布(DCV)のコンピューター測定による解析" 糖尿病. 35. 893-898 (1992)
[文献書誌] 森田陽子,坂井公,荒記俊一,高木高明,増山善明: "血中δ-アミノレブリン酸(ALA-B)の鉛曝露指標としての有効性" 産業医学.
[文献書誌] Murata,K.,Araki,S.,Maeda,K.: "Autonomic and peripheral nervous system dysfunction in workers exposed to hand-arm Vibration:a study of R-R interval variability and distribution of nerve conduction velocities." International Archives of Occupational and Environmental Health. 63. 205-211 (1991)
[文献書誌] Murata,K.,Araki,S.,Yokohama,K.Maeda,K.: "Autonomic and peripheral nervous system dysfunction in workers exposed to mixed organic solvents." International Archives of Occupational and Environmental Health. 63. 335-340 (1991)
[文献書誌] Muraoka,K.,Araki,S.: "Autonomic nervous system dysfunction in workers exposed to lead,zinc,and copper in relation to peripheral nerve conduction:a study of R-R interval variability." American Journal of Industrial Medicine. 20. 663-671 (1991)
[文献書誌] Murata,K.,Araki,S.,Yokoyama,K.: "Assessment of the peripheral,central,and autonomic nervous system function in styrene workers." American Journal of Industrial Medicine. 20. 775-784 (1991)
[文献書誌] Murata,K.,Landrigan,P.J.,Araki,S.: "Effects of age,heart rate,qender,tobacco and alcohol ingestion on R-R interval variability in human ECG." Journal of the Autonomic Nervous System. 37. 199-206 (1992)
[文献書誌] Araki,S.,Murata,K.,Yokoyama,K.,Uchida,E.: "Auditory event-related potential(p300)in relation to peripheral nerve conduction in workers exposed to lead,zinc,and copper:effects of lead on cognitive function and central nervous system." American Journal of Industrial Medicine. 21. 539-547 (1992)
[文献書誌] 川上憲人,原谷隆史: "企業従業員におけるライフスタイルと抑うつ症状:1年間の追跡調査森本兼襄(編):ライフスタイルと健康" 医学書院,東京, 188-196 (1991)
[文献書誌] Tanigawa,T.,Araki,S.,Morimoto,K.,Yokoyama,K.: "Effects of physical exercise on natural killer cell activity in healthy men in relation to life-style.Araki S.(Ed):Behavioral Medicine:An Integrated Biobehaviarol Approach to Health and Illness." Elsevier,Amsterdam,Netherlands, 79-84 (1992)
[文献書誌] Kawakami,N.,Araki,S.,Haratani,T.: "Assessment of indicators of work stree affecting psychosomatic and behavioral health.Araki,S.(Ed):behavioral Medicine:An Integrated Biobehavioral Approach to Health and Illness." Elsevier,Amsterdam,Netherlands, 165-172 (1992)
[文献書誌] Ezoe,S.,Araki,S.,Ono,Y.,Kawakami,N.,Murata,K.: "Psychiadric Symptoms,Work Stress and Pernonality traits in Japanese Computer Workers:A Comparative Study of The effects ofage,Schodl Career and Computer Work.Araki,S.(Ed):Behavioral Medicine:An Integrated Biobehavioral Approach to Health and Illness." Elsevier,Amsterdam,Netherlands, 181-188 (1992)
[文献書誌] Nomura,S.,Akabayashi,H.,Kuboki,T.,Suematsu,H.,Yokoyama,K.,Araki,S.: "Development,Validation and application of a new questiounaire (Stress Checklist:SCL-86)for Stress manage-ment in occupational heqlth.Araki,S.(Ed):Behaviorol Medlclne:An Integrated Biobehavioral Approach to Health and Illness." Elsevler,Amsterdam,Netherlands, 195-203 (1992)
[文献書誌] Araki,S.(Ed): "Behavioral Medicine:An Integrated Biobehavioral Approach to Health and Illness" Elsevier,Amsterdam,Netherland, 1-382 (1992)
[文献書誌] 荒記俊一,宋朝忠: "鉛中毒森田寛,宮本昭正(編):内科治療のポイント" 日本医事新報社,東京, 860 (1991)

1992 年度 実績報告書

産業および地域保健における神経,精神,行動障害とその評価法に関する研究

研究代表者

荒記 俊一 東京大学, 医学部(医), 教授 (00111493)

研究成果

[文献書誌] Kawakami,N.,Araki,S.,Haratani,T.,Hemmi,T.: "Relations of work stress to alcohol use and drinking problems in male and female employees of a computer factory in Japan" Environmental Research.

[文献書誌] Ezoe,S.,Araki,S.,Ono,Y.,Kawakami,N.,Murata,K.: "Work stress in Japanese computer workers effects of computer work or bioeducational factors?" Environmental Research.

[文献書誌] Uchida,E.,Araki,S.,Murata,K.: "Socloeconomic factors affecting marriage,divorce and birth rates in Japanese population." Journal of Biosocial Science.

[文献書誌] Uchida,E.,Araki,S.,Murata,K.: "Socioeconomic factors affecting first marriage and birth rates by sex and age in the total Japanese population." Journal of Human Ergology.

[文献書誌] Imanaka,Y.,Araki,S.,Nobumoto,K.: "Effects of patient health beliefs and satisfacion on compliance with medication regimens in ambulatory care of general hospitals." Japanese Journal of Hygiene.

[文献書誌] Araki,S.,Tamigawa,T.,Ishizu,S.,Minato,N.: "Decrease of CD4 positive T lymphocytes in workers exposed to benzidine and Betanaphthy laminc." Archieves of Environmental Health(in press).

[文献書誌] Araki,S.,Murata,K.,Uchida,E.: "Radial and median nerve conduction velocities in workers exposed to lead,copper and zinc:a follow-up study for two years." Environmental Research.

[文献書誌] Murata,K.,Araki,S.,Yokoyama,K.,Uchida,E.,Fujimura,Y.: "Assessment of central,peripheral and autonomic nervous system functions in lead workers:neuroele ctrophysiological studies." Environmental Research.

[文献書誌] Sata,F.,Araki,S.,Murata,K.,Uchida,E.: "Are faster of slower learge myelinated nerve fibers more sensitive to chronic lead exposure?:a study of the distribution of conduction velocities." Environmental Research.

[文献書誌] Fujimura,Y.,Araki,S.,Murata,K.,Yokoyama,K.,Handa,S.: "Assessment of the distripution of nerve conduction velocities in alcoholics." Envirohmental Research.

[文献書誌] Araki,S.,Yokoyama,K.,Murata,K.: "Assessment of the effects of occupational and environmental factors on ail faster and slower large myelinated nerve fibers:a study of the distribution of nerve conduction velocities." Environmental Research.

[文献書誌] Araki,S.,Murata,K.,Yokoyama,K.: "Assessment of central peripheral and autonomic nervous system functions in vibrating tool operators:neuroelectrophysiological studies." Environmental Research.

[文献書誌] Kawakami,N.,Haratani,T.,Araki,S.: "Effects of perceived job stress on depressive symptoms in blue-collar workers of an electrical factory in Japan." Scandinavian Journal of Work,Environment & Health. 18. 195-200 (1992)

[文献書誌] Kawakami,N.,Haratani,T.,Hemmi,T.,Araki,S.: "Prevalence and demographic correlates of alcohol-related problems in Japanese employees." Social Psychiatry and Psychiatric Epidemiology. 27. 198-202 (1992)

[文献書誌] Uchida,E.,Araki,S.,Murata,K.: "Socioeconomic factors affecting the longevity of the Japanese population:a study for 1980 and 1985." Journal of Biosocial Science. 24. 497-504 (1992)

[文献書誌] 赤林 朗,横山 和仁,荒記 俊一,島田 恭子: "POMS(感情プロフィール検査)日本語版の臨床応用の検討" 心身医学. 31. 577-582 (1991)

[文献書誌] Yokoyama,K.,Araki,S.,Murata,K.: "Effects of low level styrene exposure on psychological performance in FRP boat laminating workers." Neurotoxicology. 13. 551-556 (1992)

[文献書誌] Murata,K.,Araki,S.,Tanigawa,T.,Uchida,E.: "Acute effects of alcohol on cognitive function and central nervous system assessed by auditory eventrelated potentials." Japanese Journal of Hygiene. 47. 958-964 (1992)

[文献書誌] Yokoyama,K.,Araki,S.: "Assessment of slow axonal Transport in lead-exposed rats." Environmental Research. 59. 440-446 (1992)

[文献書誌] Ezoe,S.,Araki,S.,Ono,Y.,Kawakami,N.,Murata,K.: "Assessment of personality traits and psychi atric symptoms in workers in a computer manufacturing in Japan." American Journal of Industrial Medicine.

[文献書誌] 森田 陽子,坂井 公,荒記 俊一: "血中δ-アミノレブリン酸(ALA-B)とδ-アミノレブリン酸 脱水酵素(ALA-D)活性" ポルフィリン誌. 1. 135-140 (1992)

[文献書誌] 加藤 尚彦,赤林 朗,横山 和仁,荒記 俊一: "鉛ニューロパチーの脊髄におけるエネルギー代謝特性" 神経化学. 31. 582-583 (1992)

[文献書誌] 鈴木 研一,大山 武,後藤 由夫,松本 雅博,豊田 隆謙,横山 和仁,荒記 俊一: "糖尿病神経障害の神経伝導速度分布(DCV)のコンピューター測定による解析" 糖尿病. 35. 893-898 (1992)

[文献書誌] 森田 陽子,坂井 公,荒記 俊一,高木 高明,増山 善明: "血中δ-アミノレブリン酸(ALA-B)の鉛曝露指標としての有効性" 産業医学.

[文献書誌] Murata,K.,Araki,S.,Yokohama,K.Maeda,K.: "Autonomic and peripheral nervous system dysfunction in workers exposed to mixed organic solvents." International Archives of Occupational and Environmental Health. 63. 335-340 (1991)

[文献書誌] Muraoka,K.,Araki,S.: "Autonomic nervous system dysfunction in workers exposed to lead,zinc,and copper in relation to peripheral nerve conduction:a study of R-R interval variability." American Journal of Industrial Medicine. 20. 663-671 (1991)

[文献書誌] Murata,K.,Araki,S.,Yokoyama,K.: "Assessment of the peripheral,central,and autonomic nervous system function in styrene workers." American Journal of Industrial Medicine. 20. 775-784 (1991)

[文献書誌] Murata,K.,Landrigan,P.J.,Araki,S.: "Effects of age,heart rate,qender,tobacco and alcohol ingestion on R-R interval variability in human ECG." Journal of the Autonomic Nervous System. 37. 199-206 (1992)

[文献書誌] 川上 憲人,原谷 隆史: "企業従業員におけるライフスタイルと抑うつ症状:1年間の追跡調査 森本兼襄(編):ライフスタイルと健康" 医学書院,東京, 188-196 (1991)

[文献書誌] Kawakami,N.,Araki,S.,Haratani,T.: "Assessment of indicators of work stree affecting psychosomatic and behavioral health.Araki,S.(Ed):behavioral Medicine:An Integrated Biobehavioral Approach to Health and Illness." Elsevier,Amsterdam,Netherlands, 165-172 (1992)

[文献書誌] Araki,S.(Ed): "Behavioral Medicine:An Integrated Biobehavioral Approach to Health and Illness" Elsevier,Amsterdam,Netherland, 1-382 (1992)

[文献書誌] 荒記 俊一,宋 朝忠: "鉛中毒 森田寛,宮本昭正(編):内科治療のポイント" 日本医事新報社,東京, 860 (1991)

1992 年度実績報告書

荒記俊一東京大学, 医学部(医), 教授 (00111493)

[文献書誌] 赤林朗,横山和仁,荒記俊一,島田恭子: "POMS(感情プロフィール検査)日本語版の臨床応用の検討" 心身医学. 31. 577-582 (1991)

[文献書誌] 森田陽子,坂井公,荒記俊一: "血中δ-アミノレブリン酸(ALA-B)とδ-アミノレブリン酸脱水酵素(ALA-D)活性" ポルフィリン誌. 1. 135-140 (1992)

[文献書誌] 加藤尚彦,赤林朗,横山和仁,荒記俊一: "鉛ニューロパチーの脊髄におけるエネルギー代謝特性" 神経化学. 31. 582-583 (1992)

[文献書誌] 鈴木研一,大山武,後藤由夫,松本雅博,豊田隆謙,横山和仁,荒記俊一: "糖尿病神経障害の神経伝導速度分布(DCV)のコンピューター測定による解析" 糖尿病. 35. 893-898 (1992)

[文献書誌] 森田陽子,坂井公,荒記俊一,高木高明,増山善明: "血中δ-アミノレブリン酸(ALA-B)の鉛曝露指標としての有効性" 産業医学.

[文献書誌] 川上憲人,原谷隆史: "企業従業員におけるライフスタイルと抑うつ症状:1年間の追跡調査森本兼襄(編):ライフスタイルと健康" 医学書院,東京, 188-196 (1991)

[文献書誌] 荒記俊一,宋朝忠: "鉛中毒森田寛,宮本昭正(編):内科治療のポイント" 日本医事新報社,東京, 860 (1991)