1992 年度実績報告書

がん特別調査に関する総括研究

研究課題

研究課題/領域番号	04042019
研究機関	愛知県がんセンター
研究代表者	富永祐民愛知県がんセンター, 研究所, 所長 (30124530)
研究分担者	佐々木隆一郎愛知医科大学, 公衆衛生学教室, 教授 (80131241) 清水弘之岐阜大学, 医学部・公衆衛生学教室, 教授 (90073139) 吉村健清産業医科大学, 生態科学研究所, 所長 (20037435) 山口宣生東京大学医科学研究所, 癌ウイルス研究部, 教授 (90012723) 藤木博太国立がんセンター, 研究所・がん予防研究部, 部長 (60124426) 豊島久真男大阪大学, 微生物病研究所, 所長 (90029760) 高山昭三昭和大学, 医学部, 客員教授 (00085630) 黒木登志夫東京大学, 医科学研究所, 教授 (90006073) 北川知行癌研究会癌研究所, 副所長 (50085619)
キーワード	がん / 疫学 / 中国 / ガテマラ / コスタリカ / コロンビア
研究概要	がん特別調査に関する総括研究としては次の5項目についての研究活動を行った。 1)総括班会議の開催:平成4年度中に3回の総括班会議を開催し、がん特別調査を円滑に、かつ効果的に行うために種々の点について討議し、予備調査の企画、実施、計画調査の企画、選定、推薦を行った。また、今後の予備調査および計画調査の企画、選定方法についても検討した。 2)国際がんニュースレターの発刊:国際学術研究がん特別調査の研究者相互間の情報交換を促進するために、国際がん特別調査に関するニュースレターを平成4年度中に3回発刊した。 3)国際がん予備調査の実施:将来の計画研究を企画、選定するために、がんの特別調査に関する予備調査を3件実施した。この予備調査の目的は本格的な計画研究実施の可能性の探索、ならびに本格調査を実施するために具体的な打ち合わせ、準備を行うことである。本年度は4か国を対象として3件の予備調査を実施し、いずれも多大の成果をおさめた。平成5年度にも引き続き予備調査を行う予定である。 4)国際がん班長会議の開催:国際学術研究がん特別調査に関する22班の班長および予備調査を実施した3人の研究者が各研究の進捗置況、主要成果を報告し、合わせて意見、情報の交換を行った。この班長会議でいくつかの問題点が明らかにされた。 5)国際がんシンポジウムの開催:平成5年3月17日に東京都内(NSビルSRLセミナールーム)において、第8回シンポジウムを開催し、5人の研究者が平成4年度までに得た主要研究成果を報告し、討議を行った。

研究成果
(28件)

すべてその他

すべて文献書誌 (28件)

[文献書誌] 富永祐民: "A prospective study of stomach cancer among a rural Japanese population:A 6 year survey" Jpn.J.Cancer Res.83. 568-575 (1992)
[文献書誌] 富永祐民: "Atrophic gastritis and stomach cancer risk:cross-sectional analyses" Jpn.J.Cancer Res.83. 1041-1046 (1992)
[文献書誌] 富永祐民: "A prospective study of atrophic gastritis and stomach cancer risk" Jpn.J.Cancer Res.83. 1137-1142 (1992)
[文献書誌] 富永祐民: "The role of socioeconomic factors in the survival of patients with gastrointestinal cancers" Jpn.J.Clin.Oncol.22. 270-277 (1992)
[文献書誌] 富永祐民: "The risk and predictive factors for developing liver cancer among patients with decompensated liver cirrhosis" Jpn.J.Clin.Oncol.22. 278-285 (1992)
[文献書誌] 北川知行: "Clonal growth of hepatitis B virus-induced hepatocytes in cirrhotic liver nodules" Cancer Res.52. 6810-6814 (1992)
[文献書誌] 北川知行: "Frequent spontaneous sister chromatid exchange in hepatocytes of transgenic mice harboringthe SV40-T antigen" J.Cancer Res.Clin.Oncol.118. 601-605 (1992)
[文献書誌] 北川知行: "Alletotype of non-small cell lung carcinoma" Cancer Res.52. 2478-2481 (1992)
[文献書誌] 黒木登志夫: "Predominant expression of nPKC a Ca^<2+>-independent isoform of protein kinase C in association with epithelial differentiation" Cell Growth and Differentiation. 4. IN PRESS (1993)
[文献書誌] 黒木登志夫: "Rapid phosphorylation of 28-kDa heat shock protein by treatment with okadaic acid and phorbol ester of BALB/MK-2 mouse keratinocytes" Eur.J.Biochem.IN PRESS (1993)
[文献書誌] 豊島久真男: "Phosphorylation of the retinoblastoma protein by cdk2" Proc.Natl Acad.Sci.U.S.A.89. 7900-7904 (1992)
[文献書誌] 豊島久真男: "Purification and characterization of a possible protooncogene fyn product,p59fyn,from a rat brain particulate fraction" J.Biochem.112. 729-732 (1992)
[文献書誌] 豊島久真男: "Oncogenic activation of murine mos protein kinase by DNA rearrengement of its N-terminal coding region" Oncogene. 7. 331-338 (1992)
[文献書誌] 藤木博太: "An alternative computer model of the 3-dimensional structures of microcystin-LR and nodularin rationalisting their interactions with protein phosphateses 1 and 2A" BioMed.Chem Lett.2. 299-302 (1992)
[文献書誌] 藤木博太: "The role of arginine in interactions of microcystins with protein phosphatases 1 and 2A" BioMed.Chem Lett.4. IN PRESS (1993)
[文献書誌] 山口宣生: "Negative regulation of Rb expression by the p53 gene product" Proc.Natl.Acad.Sci.U.S.A.89. 5206-5210 (1993)
[文献書誌] 山口宣生: "Delection analysis of a replication origin of human cytomegarovirus by a novel assay system with a combination of microinjection and polymorase chain reaction" Virology. 192. 332-335 (1993)
[文献書誌] 吉村健清: "A method for the estimation of completeness of cancer registration-Application to the Fukuoka cancer registry-" Journal of Epidemiology. 2. 7-12 (1992)
[文献書誌] 吉村健清: "Human T cell leukemia virus type 1 antibody in patients on chronic hemodialysis in Fukuoka,Japan" Journal of Epidemiology. 2. 21-25 (1992)
[文献書誌] 清水弘之: "5-alpha-reductase activity and risk of prostate cancer among Japanese and US wthie and black males" Lancet. 339. 887-889 (1992)
[文献書誌] 佐々木隆一郎: "Cohort study on association of malignant neoplasms among the pulmonary tuberculosis patients in Nagoya TB registry" BioMed.Chem Lett.2. 89-95 (1992)
[文献書誌] 佐々木隆一郎: "βカロチンと成人病" Proc.Natl.Acad.Sci.U.S.A.3567. 130-131 (1992)
[文献書誌] 森永謙二: "アスベストの健康障害" 日本医師会雑誌. 108. 1869-1874 (1992)
[文献書誌] 原田健一: "Separation and identification of microcystins in cyanobacteria by frit-fast atom bombardment liquid chromatography/mass spoetromctry" Toxicon. 30. 227-237 (1992)
[文献書誌] 原田健一: "Relase of heptapeptide toxin(microcystin)during the decomposition process of microcystis aerusinosa" Toxicon. 1. 48-53 (1992)
[文献書誌] 原田健一: "Characerization and toxicity of the glutathione and cysteine conjugates of toxic heptapeptide microcystins" Chem.Res.Toxicol.5. 591-596 (1992)
[文献書誌] 佐々木隆一郎: "最新内科学大系19号白血病の疫学" 中山書店, 27-37 (1992)
[文献書誌] 森永謙二: "環境百科-アスベスト" 駿河台出版, 152-153 (1992)

1992 年度 実績報告書

がん特別調査に関する総括研究

研究代表者

富永 祐民 愛知県がんセンター, 研究所, 所長 (30124530)

研究成果

[文献書誌] 富永 祐民: "A prospective study of stomach cancer among a rural Japanese population:A 6 year survey" Jpn.J.Cancer Res.83. 568-575 (1992)

[文献書誌] 富永 祐民: "Atrophic gastritis and stomach cancer risk:cross-sectional analyses" Jpn.J.Cancer Res.83. 1041-1046 (1992)

[文献書誌] 富永 祐民: "A prospective study of atrophic gastritis and stomach cancer risk" Jpn.J.Cancer Res.83. 1137-1142 (1992)

[文献書誌] 富永 祐民: "The role of socioeconomic factors in the survival of patients with gastrointestinal cancers" Jpn.J.Clin.Oncol.22. 270-277 (1992)

[文献書誌] 富永 祐民: "The risk and predictive factors for developing liver cancer among patients with decompensated liver cirrhosis" Jpn.J.Clin.Oncol.22. 278-285 (1992)

[文献書誌] 北川 知行: "Clonal growth of hepatitis B virus-induced hepatocytes in cirrhotic liver nodules" Cancer Res.52. 6810-6814 (1992)

[文献書誌] 北川 知行: "Frequent spontaneous sister chromatid exchange in hepatocytes of transgenic mice harboringthe SV40-T antigen" J.Cancer Res.Clin.Oncol.118. 601-605 (1992)

[文献書誌] 北川 知行: "Alletotype of non-small cell lung carcinoma" Cancer Res.52. 2478-2481 (1992)

[文献書誌] 黒木 登志夫: "Predominant expression of nPKC a Ca^<2+>-independent isoform of protein kinase C in association with epithelial differentiation" Cell Growth and Differentiation. 4. IN PRESS (1993)

[文献書誌] 黒木 登志夫: "Rapid phosphorylation of 28-kDa heat shock protein by treatment with okadaic acid and phorbol ester of BALB/MK-2 mouse keratinocytes" Eur.J.Biochem.IN PRESS (1993)

[文献書誌] 豊島 久真男: "Phosphorylation of the retinoblastoma protein by cdk2" Proc.Natl Acad.Sci.U.S.A.89. 7900-7904 (1992)

[文献書誌] 豊島 久真男: "Purification and characterization of a possible protooncogene fyn product,p59fyn,from a rat brain particulate fraction" J.Biochem.112. 729-732 (1992)

[文献書誌] 豊島 久真男: "Oncogenic activation of murine mos protein kinase by DNA rearrengement of its N-terminal coding region" Oncogene. 7. 331-338 (1992)

[文献書誌] 藤木 博太: "An alternative computer model of the 3-dimensional structures of microcystin-LR and nodularin rationalisting their interactions with protein phosphateses 1 and 2A" BioMed.Chem Lett.2. 299-302 (1992)

[文献書誌] 藤木 博太: "The role of arginine in interactions of microcystins with protein phosphatases 1 and 2A" BioMed.Chem Lett.4. IN PRESS (1993)

[文献書誌] 山口 宣生: "Negative regulation of Rb expression by the p53 gene product" Proc.Natl.Acad.Sci.U.S.A.89. 5206-5210 (1993)

[文献書誌] 山口 宣生: "Delection analysis of a replication origin of human cytomegarovirus by a novel assay system with a combination of microinjection and polymorase chain reaction" Virology. 192. 332-335 (1993)

[文献書誌] 吉村 健清: "A method for the estimation of completeness of cancer registration-Application to the Fukuoka cancer registry-" Journal of Epidemiology. 2. 7-12 (1992)

[文献書誌] 吉村 健清: "Human T cell leukemia virus type 1 antibody in patients on chronic hemodialysis in Fukuoka,Japan" Journal of Epidemiology. 2. 21-25 (1992)

[文献書誌] 清水 弘之: "5-alpha-reductase activity and risk of prostate cancer among Japanese and US wthie and black males" Lancet. 339. 887-889 (1992)

[文献書誌] 佐々木 隆一郎: "Cohort study on association of malignant neoplasms among the pulmonary tuberculosis patients in Nagoya TB registry" BioMed.Chem Lett.2. 89-95 (1992)

[文献書誌] 佐々木 隆一郎: "βカロチンと成人病" Proc.Natl.Acad.Sci.U.S.A.3567. 130-131 (1992)

[文献書誌] 森永 謙二: "アスベストの健康障害" 日本医師会雑誌. 108. 1869-1874 (1992)

[文献書誌] 原田 健一: "Separation and identification of microcystins in cyanobacteria by frit-fast atom bombardment liquid chromatography/mass spoetromctry" Toxicon. 30. 227-237 (1992)

[文献書誌] 原田 健一: "Relase of heptapeptide toxin(microcystin)during the decomposition process of microcystis aerusinosa" Toxicon. 1. 48-53 (1992)

[文献書誌] 原田 健一: "Characerization and toxicity of the glutathione and cysteine conjugates of toxic heptapeptide microcystins" Chem.Res.Toxicol.5. 591-596 (1992)

[文献書誌] 佐々木 隆一郎: "最新内科学大系19号白血病の疫学" 中山書店, 27-37 (1992)

[文献書誌] 森永 謙二: "環境百科-アスベスト" 駿河台出版, 152-153 (1992)

1992 年度実績報告書

富永祐民愛知県がんセンター, 研究所, 所長 (30124530)

[文献書誌] 富永祐民: "A prospective study of stomach cancer among a rural Japanese population:A 6 year survey" Jpn.J.Cancer Res.83. 568-575 (1992)

[文献書誌] 富永祐民: "Atrophic gastritis and stomach cancer risk:cross-sectional analyses" Jpn.J.Cancer Res.83. 1041-1046 (1992)

[文献書誌] 富永祐民: "A prospective study of atrophic gastritis and stomach cancer risk" Jpn.J.Cancer Res.83. 1137-1142 (1992)

[文献書誌] 富永祐民: "The role of socioeconomic factors in the survival of patients with gastrointestinal cancers" Jpn.J.Clin.Oncol.22. 270-277 (1992)

[文献書誌] 富永祐民: "The risk and predictive factors for developing liver cancer among patients with decompensated liver cirrhosis" Jpn.J.Clin.Oncol.22. 278-285 (1992)

[文献書誌] 北川知行: "Clonal growth of hepatitis B virus-induced hepatocytes in cirrhotic liver nodules" Cancer Res.52. 6810-6814 (1992)

[文献書誌] 北川知行: "Frequent spontaneous sister chromatid exchange in hepatocytes of transgenic mice harboringthe SV40-T antigen" J.Cancer Res.Clin.Oncol.118. 601-605 (1992)

[文献書誌] 北川知行: "Alletotype of non-small cell lung carcinoma" Cancer Res.52. 2478-2481 (1992)

[文献書誌] 黒木登志夫: "Predominant expression of nPKC a Ca^<2+>-independent isoform of protein kinase C in association with epithelial differentiation" Cell Growth and Differentiation. 4. IN PRESS (1993)

[文献書誌] 黒木登志夫: "Rapid phosphorylation of 28-kDa heat shock protein by treatment with okadaic acid and phorbol ester of BALB/MK-2 mouse keratinocytes" Eur.J.Biochem.IN PRESS (1993)

[文献書誌] 豊島久真男: "Phosphorylation of the retinoblastoma protein by cdk2" Proc.Natl Acad.Sci.U.S.A.89. 7900-7904 (1992)

[文献書誌] 豊島久真男: "Purification and characterization of a possible protooncogene fyn product,p59fyn,from a rat brain particulate fraction" J.Biochem.112. 729-732 (1992)

[文献書誌] 豊島久真男: "Oncogenic activation of murine mos protein kinase by DNA rearrengement of its N-terminal coding region" Oncogene. 7. 331-338 (1992)

[文献書誌] 藤木博太: "An alternative computer model of the 3-dimensional structures of microcystin-LR and nodularin rationalisting their interactions with protein phosphateses 1 and 2A" BioMed.Chem Lett.2. 299-302 (1992)

[文献書誌] 藤木博太: "The role of arginine in interactions of microcystins with protein phosphatases 1 and 2A" BioMed.Chem Lett.4. IN PRESS (1993)

[文献書誌] 山口宣生: "Negative regulation of Rb expression by the p53 gene product" Proc.Natl.Acad.Sci.U.S.A.89. 5206-5210 (1993)

[文献書誌] 山口宣生: "Delection analysis of a replication origin of human cytomegarovirus by a novel assay system with a combination of microinjection and polymorase chain reaction" Virology. 192. 332-335 (1993)

[文献書誌] 吉村健清: "A method for the estimation of completeness of cancer registration-Application to the Fukuoka cancer registry-" Journal of Epidemiology. 2. 7-12 (1992)

[文献書誌] 吉村健清: "Human T cell leukemia virus type 1 antibody in patients on chronic hemodialysis in Fukuoka,Japan" Journal of Epidemiology. 2. 21-25 (1992)

[文献書誌] 清水弘之: "5-alpha-reductase activity and risk of prostate cancer among Japanese and US wthie and black males" Lancet. 339. 887-889 (1992)

[文献書誌] 佐々木隆一郎: "Cohort study on association of malignant neoplasms among the pulmonary tuberculosis patients in Nagoya TB registry" BioMed.Chem Lett.2. 89-95 (1992)

[文献書誌] 佐々木隆一郎: "βカロチンと成人病" Proc.Natl.Acad.Sci.U.S.A.3567. 130-131 (1992)

[文献書誌] 森永謙二: "アスベストの健康障害" 日本医師会雑誌. 108. 1869-1874 (1992)

[文献書誌] 原田健一: "Separation and identification of microcystins in cyanobacteria by frit-fast atom bombardment liquid chromatography/mass spoetromctry" Toxicon. 30. 227-237 (1992)

[文献書誌] 原田健一: "Relase of heptapeptide toxin(microcystin)during the decomposition process of microcystis aerusinosa" Toxicon. 1. 48-53 (1992)

[文献書誌] 原田健一: "Characerization and toxicity of the glutathione and cysteine conjugates of toxic heptapeptide microcystins" Chem.Res.Toxicol.5. 591-596 (1992)

[文献書誌] 佐々木隆一郎: "最新内科学大系19号白血病の疫学" 中山書店, 27-37 (1992)

[文献書誌] 森永謙二: "環境百科-アスベスト" 駿河台出版, 152-153 (1992)