1992 年度実績報告書

細胞エネルギー共役系の構築と調節

研究課題

研究課題/領域番号	04266102
研究機関	東京大学
研究代表者	安楽泰宏東京大学, 理学部, 教授 (20012643)
研究分担者	向畑泰男名古屋大学, 理学部, 教授 (10028110) 川喜田正夫東京都臨床医学総合研究所, 医化学研究部, 部長 (00012740) 松原央大阪大学, 理学部, 教授 (00028242) 吉田賢右東京工業大学, 資源化学研究所, 教授 (90049073) 二井将光大阪大学, 産業科学研究所, 教授 (50012646)
キーワード	細胞エネルギー / ATP合成酵素 / 液胞型ATP分解酵素 / 呼吸酵素 / 電子伝達複合体 / 輸送蛋白 / オスモエンザイム / 化学浸透学説
研究概要	1.研究開始報告書および研究組織・班員班友名簿の作製:標記の資料を作製し、文部省および総括班員に提出配布した。2.ニュースレターの刊行:第1号(6月),第2号(9月),第3号(12月)を刊行し、重点領域研究の目的,計画,実施方法,国際交流の成果等を全班員に周知伝達した。3.運営委員会班長会審議の開催:10月に標記会議を開催し,平成5年度の研究組織計画を審議した。平成5年10月に「ATPase」,同12月に「呼繰酵素」に関するシンポジウムを開催することを決定した。4.平成5年度重点領域研究組織計画表の作製:標記の計画表を作製し(10月),文部省に提出した。5.総括班後援のシンポジウム「呼吸鎖電子伝達系膜複合体酸素:その立体構造と反応機構の最先端」の開催:標記シンポジウム(演者6名)を10月に開催し(福岡),計画班員,公募班員の最新成果を公開討議した。6.総括班主催のシンポジウム「生体膜のポンプと輸送」の開催:標記の公開シンポジウム(演者9名)を12月(東京)に開催し,計画班員,公募班員の最新成果を討議した。民間研究者も多数参会し盛況であった。7.総括班会議の開催:12月(東京)に開催し,平成4年度の経過報告,平成5年度の研究計画等を審議した。8.合同班会議の開催と研究成果の評価:合同班会議(12月17〜19日)を開催し、全班員の研究発表,成果の評価,平成5年度の実施計画,共同研究の推進,国際交流の活性化について討議した。

研究成果

(79件)

すべてその他

すべて文献書誌 (79件)

[文献書誌] Y.Anraku: "Genetic and cell biological aspects of the yeast vacuolar H^+-ATPase." J.Bioenerg.Biomembr.24. 395-405 (1992)
[文献書誌] Y.Anraku: "Molecular genetics of the yeast vacuolar H^+-ATPase." J.Exp.Biol.172. 67-81 (1992)
[文献書誌] Y.Wada: "Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae.1.Isolation anmd characterzation of two classes of vam mutants." J.Biol.Chem.267. 18665-18670 (1992)
[文献書誌] Y.Wada: "Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae.2.VAM7,a gene for regulating morphogenic assembly of the vacuoes." J.Biol.Chem.267. 18671-18675 (1992)
[文献書誌] Y.Wada: "Chloride transport of yeast vacuolar membrane vesicles: A study of in vacuolar acidification." Biochim.Biophys.Acta. 1101. 296-302 (1992)
[文献書誌] R.Hirata: "Mutations at the putative junction sites of the yeast VMA1 protein,the catalytic subunit of the vacuoal membrane H^+-ATPase,inhibit its processing by protein splicing." Biochem.Biophys.Res.Commun.188. 40-47 (1992)
[文献書誌] T.Hisabori: "Single site hydrolysis of TNP-ATP by F_1-ATPase from the thermophilic bacterium PS3 is accelerated by chase-addition of excess ATP." J.Biol.Chem.267. 4551-4556 (1992)
[文献書誌] D.Bar-Zvi: "Covalent binding of 3'-0-(4-Benzoyl)benzoyl adenosine 5'-triphosphate (BzATP)to the isolated α and β subunits and α_3β_3 core complex of TF_1." J.Biol.Chem.267. 11029-11033 (1992)
[文献書誌] K.Tozawa: "Molecular dissection of the β subunit of F_1-ATPase into peptide fragments." J.Biol.Chem.267. 16484-16490 (1992)
[文献書誌] M.Sumi: "A DNA fragment homologous to F^1-ATPase β subunit was amplified from genomic DNA of Methanosarsina barkeri: Indication of an archaebacterial F-type ATPase." FEBS Lett.314. 207-210 (1992)
[文献書誌] N.Ishii.: "Three dimentional structure of F^1-ATPase of thermophilic bacterium PS3 obtained from electron crystallography." J.Biochem.113. 245-250 (1993)
[文献書誌] M,Jounouchi: "Catalytic site in the β subunit of H^+-ATPase from Escherichia coli:Glycine-rich sequence and its interaction weth Ser-174." Arch.Biochem.Biophys.292. 376-381 (1992)
[文献書誌] M,Jounouchi: "Role of the amino terminal region of the ε subunit of Escherichia coli H^+-ATPase(F_0F_1)." Arch.Biochem.Biophys.292. 87-94 (1992)
[文献書誌] M.Futai: "Catalytic site the β subunit of H^+-ATPase from Escherichia coli: Glycine-rich sequence and its interaction with Ser-174." Acta Physiol.Scan.146. 125-130 (1992)
[文献書誌] J.Miki: "Mapping of antigenic sites to monoclonal antibodies on the primary structure of the F_1-ATPase β subunit from Escherichia coli: Conserved amino-terminal region of the subunit in the F_1." Arch.Biochem.Biophys.294. 373-381 (1992)
[文献書誌] S.Noguchi: "Assembly of a hybrid from the α subunit Na^+/K^+-ATPase and β subunit of H^+/K^+-ATPase and β subunit of H^+/K^+-ATPase." Biochem.Biophys.Res.Commun.182. 659-666 (1992)
[文献書誌] M.Hasebe: "Vacuolar type H^+-ATPase genes:Presence of four genes including pseudogenes for the 16 kDa proteolipid subunit in the human genome." Biochem.Biophys.Res.Commyn.183. 659-666 (1992)
[文献書誌] S.Tamura: "Sequence motif in control region of the H^+/K^+-ATPase a and β subunit genes recognized by gastric specific nuclear protein." FEBS Lett.298. 137-141 (1992)
[文献書誌] Y.Moriyama: "Involvement of a non-proton pump factor (possibly Donnan-type equilibrium)in maintenance of an acidic pH in lysosomes." FEBS Lett.302. 18-20 (1992)
[文献書誌] M.Futai: "A glycine-rich sequence in the catalytic site of F-type ATPase." J.Biomembr.and Bioenerg.24. 463-467 (1992)
[文献書誌] Y.Moriyqma: "Role of vacuolar-type H^+-ATPase in neuronal and endocrine systems." J.Exp.Biol.172. 171-178 (1992)
[文献書誌] M.Futai: "Escherichia coli ATP synthase (F-type ATPase):Catalytic site and regulation of H^+ translocation." J.Exp.Biol.172. 443-449 (1992)
[文献書誌] H.Omote: "Effects mutations of conserved Lys-155 and Thr-156 residues in the phosphate binding glycine-rich sequence of the F_1-ATPase β subunit of Escherichia coli." J.Biol.Chem.267. 20571-20576 (1992)
[文献書誌] K.Shin: "F_0F_1-ATPase γ subunit mutations perturb the coupling between catalysis and transport" J.Biol.Chem.267. 20835-20839 (1992)
[文献書誌] R.K.Nakamoto: "Escherichia coli F_0F_1-ATPase:Residues involved in catalysis and coupling." Anal.N.Y.Acad.Sci.(1992)
[文献書誌] R.K.Nakamoto: "The γ subunit of the Escherichia coli ATP synthase:Mutations in the carboxyl-terminal region restore energy coupling to the amino-terminal mutant γ Met-23->Lys." Anal.N.Y.Acad.Sci.268. (1993)
[文献書誌] A.Iwamoto: "Domains near ATP γ phosphate in the catalytic site of H^+-ATPase:Model proposed from mutagenesis and inhibitor studies" J.Bl.N.Y.Acad.Sci.268. (1993)
[文献書誌] X.Wang: "Characterization of human autoantibodies reactibe to gastric parietal cells" Biochem.Biophys.Res.Commun.190. (1993)
[文献書誌] S.Yoshikawa: "Stategies for ctystallization of large membrane protein complexes." J.Crystal Growth. 122. 298-302 (1992)
[文献書誌] T.Yamashita: "Reconstitution of Na^+/H^+-antiporter of bovine renal brush-border membrane into proterliposomes and detection of a 110kDa protein cross- reactive with antibodies against a human Na^+/H^+-antiporter partial peptide in antiporter-active fractions after partial fractionation." J.Biochem.111. 162-167 (1992)
[文献書誌] M.Kuroda: "Immunohistochemical assessement of sarcoplasmic reticulum Ca^<2+>-ATPase distribution in various human tissues using novel monoclonal antibodies." Virchows Archiv A:Pathol. Anat.Histophthol.421. 527-532 (1992)
[文献書誌] T.Yamashita: "Characterization of Na^+/H^+-antipoter of bovine renal cortex and its immunoaffinity purification in reconstitutively actibe form." J.Biochem.113(2). (1993)
[文献書誌] Y.Kagawa: "The α_3β_3 and α_1β_1 complexes of ATP synthase." Ann.New York Acad.Sci.671. 366-376 (1992)
[文献書誌] H.Kamata: "Primary structure of the alanine carrier protein of thermophilic bacterium PS3." J.Biol.Chem.267. 21650-21655 (1992)
[文献書誌] Y.Kagawa: "The αβ complexes of ATP synthase:The αα_3β_3oligomer and α_1β_1 protomer." J.Bioenerg.Biomembr.24. 441-445 (1992)
[文献書誌] Y.Kobayashi: "The mutant mitochondrial genes in mitochondrial myopathy,encephalopathy,lactic acidosis and stroke-ike episodes (MELAS)were selectibely amplified through generations." J.Inher.Metab.Dis.15. 803-808 (1992)
[文献書誌] K.Tominaga: "Upstream region of a genomic gene for human mitochondrial transcription factor l." Biochim.Biophys.Acta. 1131. 217-219 (1992)
[文献書誌] H.Kamata: "Partial purification and reconstitution of inisitol 1,4,5-triphosphate receptor/Ca^2channel of bovine liver microsomes." J.Biochem.111. 546-552 (1992)
[文献書誌] C.Matsuda: "Immunohistochemical investigation of intracellular calcium pools in gerbil hippocampus following transient ischemia." Neuroscience Res.S17. S331 (1992)
[文献書誌] J.Masai: "Immaging of subunit complexes of thermophilic bacterium H^+-ATPase with scanning tunneling microscopy." UItramicroscopy. 42-44. 1194-1199 (1992)
[文献書誌] A.Ando: "Primary structure of chitosanase produced by Bacillus circulans MH-K." J.Gen.Appl.Microbiol.38. 135-144 (1992)
[文献書誌] Y.Kagawa: "Mitochondrial myopathy and transcriptional control." Med.Sports Sci.(Integration of Medical and Sports Science,Karger). 37. 324-328 (1992)
[文献書誌] S.Kawano: "Effect of proton pump inhibitor on gastric mucosa hemodynamics and tissue oxygenation in anesthetized rats." Eur.J.Pharmacol.211. 55-60 (1992)
[文献書誌] K.Shimazaki: "Involvement of calmodulin and calmodulin-dependent myosin light chain kinase in blue light-dependent H^+ pumping by guard cell protoplast from Vicia faba L" Plant Physiol.99(4). 1416-1421 (1992)
[文献書誌] K.Kusumi: "Accumulation of chloroplast tRNAGlu is temperature sensitive in virescent seedlings of rice." Plant Physiol.99(1). 142 (1992)
[文献書誌] H.Yamasaki: "Inhibition of the light-induced H^+ release from uncoupled thylakoid membrones by N-ethylmaleimide." Biochem.Biophys.Res.Commun.182. 1277-1281 (1992)
[文献書誌] I.Iwasaki: "Two types of channels involved in the malate ion transport across the tonoplast of a Crassulacean acid metabolism plant." Plant Physiol.98. 1494-1497 (1992)
[文献書誌] H.Arata: "Thermodynamics of malate transport across the tonoplast of leaf cells of CAM plants." Plant Cell Physiol.33. 873-880 (1992)
[文献書誌] K.Kusumi: "Temperature-sensitive expression of chloroplast tRNAGlu in virescent mutants of rice." Research in Photosynthesis(ed.N.Murata)Kluwer,Dordrecht. (1992)
[文献書誌] K.Kusumi: "Circadian rhythms in the regulation of phosphoenolpyruvate carbxylase from a CAM plant." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)
[文献書誌] I.Iwasaki: "Circadian rhythms in the regulation of phosphoenolpyruvate carbxylase from a CAM plant." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)
[文献書誌] T.Fuse: "Effects of light and high temperature on the leaves of a rice mutant sensitive to solar radiation." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)
[文献書誌] T.Kinoshita: "Dephosphorylation of the LHCII protein by light in guardcell protoplasts from Vicia faba L." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)
[文献書誌] H.Yamasaki: "Effect of catechols on the light-induced H^+ release from uncoupled membranes." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)
[文献書誌] K.Iba: "Chromosome walking in the region of Arabidopsis fadD locus using yeast artificial chromosomes." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)
[文献書誌] T.Matsuyama: "Leucine dehydrogenase from Bacillus stearothermophilus:Identification of active-site lysine by modification with pyridoxal phosphate." J.Biochem.112. 258-265 (1992)
[文献書誌] Y.Kazuta: "Probing the pyrophosphate-binding site in potato tuber UDP-glucose pyrophosphorylase with pyridoxal diphosphate." Protein Science. 2. (1993)
[文献書誌] H.Mori: "A chimeric α-glucan phosphorylase of plant type L and H isozymes.Functional role of 78-residue insertion in type L isozyme." J.Biol.Chem.268. (1993)
[文献書誌] T.Takada: "Quantitative immunogold localization of Na,K-ATPase along rat nephron." Histochemistry. 98. 183-197 (1992)
[文献書誌] K.Kawasaki: "Quantitative immunoelectron microscopic localization of Na,K-ATPase α-subunit in the epitherial cells of rat vestibular apparatus." Hear.Res.60. 64-72 (1992)
[文献書誌] T.Okami: "UItrastructural localization of Na^+,K^+-ATPase in the exorbital lacrimal gland of rat." Invest.Ophthamol.Vis,Sci.33. 196-204 (1992)
[文献書誌] H.Hayashi: "Properties of Active magnesium flux across the small intestine of guinea pig." Jpn.J.physiol.42. 561-575 (1992)
[文献書誌] T.Hoshi: "Proton secretion by the enterocytes and its role in intestinal absorptive functions." Adv.Physiol.Sci.(S.K.Manchanda,W.Selvamurthy,V.M.Kumar eds.)McMillan India,Delli,. 64-70 (1992)
[文献書誌] M.Nagasawa: "Purification of brush border membrane vesicles from rat renal cortex by size-exclusion chromatography." Anal.Biochem.201. 301-305 (1992)
[文献書誌] T.Goda: "Carbohydrate digestive capacity in jejunum of rats subjected to simulated weightlessness." J.Nutr.Biochem.3. 172-175 (1992)
[文献書誌] K.Ueda: "Human P-glycoprotein transports cortisol,aldosterone,and dexamethasone,but not progesterone." J.Biol.Chem.267. 24248-24252 (1992)
[文献書誌] H.Saito: "Transcellular transport of organic cation across monolayers of kidney epithelial cell line LLC-PK_1." Am.J.Physiol.262. C59-C66 (1992)
[文献書誌] R.Hori: "Expression of renal organic cation transporter in Xenopus leavis oocytes." Blochem.J.283(3. 409 (1992)
[文献書誌] R.Hori: "Surface binding and intracellular uptake of gentamicin in the cultured kidney epithelial cell line(LLC-PK_1)." J.Pharmacol.Exp.Ther.261(3. 1200-1205 (1992)
[文献書誌] M.Takano: "Transport of procainamide in a kidney epithelial cell line LLC-PK_1." Biochim.Biophys.Acta. 1108. 133-139 (1992)
[文献書誌] Y.Tanigawa: "Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1)." J.Pharmacol.Exp.Ther.263(2. 840-845 (1992)
[文献書誌] K.Ohoka: "P-Aminohippurate transport in rat renal brush-border membranes:a potential-sensitive transport system and an anion exchanger." Biol.Pharm.Bull.
[文献書誌] T.Katsura: "Characteristics of organic cation transporter in rat renal basolateral membrane." Blochim.Biophys.Acta.
[文献書誌] Y.Mukuhata: "Photophosphorylation elements in Halobacteriaan A-type ATP synthase and bacterial rhodopsins." J.Bioenerg.Biomembr.24(6). 547-553 (1992)
[文献書誌] K.Ihara: "Halobacterial A-ATP synthase in relation to V-ATPase." J.Exp.Biol.172. 475-485 (1992)
[文献書誌] Y.Mukohata: "Comparative studies on bacteriorhodopsin-type pumps:Basic physicochemical data for proton pumps." Structures and Functions of Retinal Proteins (ed.J.L.Rigaud)Colloque INSERM,John Libbey Eurotext Ltd.,Montrouge,France. 221. PP101-104 (1992)
[文献書誌] J.Minagawa: "Identification of geme and copper ligands in subunit I of the cytochrome bo complex in Escherichia coli." J.Biol.Chem.267. 2096-2104 (1992)
[文献書誌] K.Saiki: "Hemo O biosynthesis in Escherichia coli:The cyoE gene in the cytocgrome bo operon encodes a protoheme IX farnesyltransferase." Biochim.Biophys.Res.Commun.189. 1491-1497 (1992)
[文献書誌] M.Tsubaki: "Structure of heme-copper binuclear center of the cytochrome bo complex in Escherichia coli:EPR and Fourier-transform infrared spectroscopic studies." Biochemistry. 32. (1993)

1992 年度 実績報告書

細胞エネルギー共役系の構築と調節

研究代表者

安楽 泰宏 東京大学, 理学部, 教授 (20012643)

研究成果

[文献書誌] Y.Anraku: "Genetic and cell biological aspects of the yeast vacuolar H^+-ATPase." J.Bioenerg.Biomembr.24. 395-405 (1992)

[文献書誌] Y.Anraku: "Molecular genetics of the yeast vacuolar H^+-ATPase." J.Exp.Biol.172. 67-81 (1992)

[文献書誌] Y.Wada: "Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae.1.Isolation anmd characterzation of two classes of vam mutants." J.Biol.Chem.267. 18665-18670 (1992)

[文献書誌] Y.Wada: "Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae.2.VAM7,a gene for regulating morphogenic assembly of the vacuoes." J.Biol.Chem.267. 18671-18675 (1992)

[文献書誌] Y.Wada: "Chloride transport of yeast vacuolar membrane vesicles: A study of in vacuolar acidification." Biochim.Biophys.Acta. 1101. 296-302 (1992)

[文献書誌] R.Hirata: "Mutations at the putative junction sites of the yeast VMA1 protein,the catalytic subunit of the vacuoal membrane H^+-ATPase,inhibit its processing by protein splicing." Biochem.Biophys.Res.Commun.188. 40-47 (1992)

[文献書誌] T.Hisabori: "Single site hydrolysis of TNP-ATP by F_1-ATPase from the thermophilic bacterium PS3 is accelerated by chase-addition of excess ATP." J.Biol.Chem.267. 4551-4556 (1992)

[文献書誌] D.Bar-Zvi: "Covalent binding of 3'-0-(4-Benzoyl)benzoyl adenosine 5'-triphosphate (BzATP)to the isolated α and β subunits and α_3β_3 core complex of TF_1." J.Biol.Chem.267. 11029-11033 (1992)

[文献書誌] K.Tozawa: "Molecular dissection of the β subunit of F_1-ATPase into peptide fragments." J.Biol.Chem.267. 16484-16490 (1992)

[文献書誌] M.Sumi: "A DNA fragment homologous to F^1-ATPase β subunit was amplified from genomic DNA of Methanosarsina barkeri: Indication of an archaebacterial F-type ATPase." FEBS Lett.314. 207-210 (1992)

[文献書誌] N.Ishii.: "Three dimentional structure of F^1-ATPase of thermophilic bacterium PS3 obtained from electron crystallography." J.Biochem.113. 245-250 (1993)

[文献書誌] M,Jounouchi: "Catalytic site in the β subunit of H^+-ATPase from Escherichia coli:Glycine-rich sequence and its interaction weth Ser-174." Arch.Biochem.Biophys.292. 376-381 (1992)

[文献書誌] M,Jounouchi: "Role of the amino terminal region of the ε subunit of Escherichia coli H^+-ATPase(F_0F_1)." Arch.Biochem.Biophys.292. 87-94 (1992)

[文献書誌] M.Futai: "Catalytic site the β subunit of H^+-ATPase from Escherichia coli: Glycine-rich sequence and its interaction with Ser-174." Acta Physiol.Scan.146. 125-130 (1992)

[文献書誌] J.Miki: "Mapping of antigenic sites to monoclonal antibodies on the primary structure of the F_1-ATPase β subunit from Escherichia coli: Conserved amino-terminal region of the subunit in the F_1." Arch.Biochem.Biophys.294. 373-381 (1992)

[文献書誌] S.Noguchi: "Assembly of a hybrid from the α subunit Na^+/K^+-ATPase and β subunit of H^+/K^+-ATPase and β subunit of H^+/K^+-ATPase." Biochem.Biophys.Res.Commun.182. 659-666 (1992)

[文献書誌] M.Hasebe: "Vacuolar type H^+-ATPase genes:Presence of four genes including pseudogenes for the 16 kDa proteolipid subunit in the human genome." Biochem.Biophys.Res.Commyn.183. 659-666 (1992)

[文献書誌] S.Tamura: "Sequence motif in control region of the H^+/K^+-ATPase a and β subunit genes recognized by gastric specific nuclear protein." FEBS Lett.298. 137-141 (1992)

[文献書誌] Y.Moriyama: "Involvement of a non-proton pump factor (possibly Donnan-type equilibrium)in maintenance of an acidic pH in lysosomes." FEBS Lett.302. 18-20 (1992)

[文献書誌] M.Futai: "A glycine-rich sequence in the catalytic site of F-type ATPase." J.Biomembr.and Bioenerg.24. 463-467 (1992)

[文献書誌] Y.Moriyqma: "Role of vacuolar-type H^+-ATPase in neuronal and endocrine systems." J.Exp.Biol.172. 171-178 (1992)

[文献書誌] M.Futai: "Escherichia coli ATP synthase (F-type ATPase):Catalytic site and regulation of H^+ translocation." J.Exp.Biol.172. 443-449 (1992)

[文献書誌] H.Omote: "Effects mutations of conserved Lys-155 and Thr-156 residues in the phosphate binding glycine-rich sequence of the F_1-ATPase β subunit of Escherichia coli." J.Biol.Chem.267. 20571-20576 (1992)

[文献書誌] K.Shin: "F_0F_1-ATPase γ subunit mutations perturb the coupling between catalysis and transport" J.Biol.Chem.267. 20835-20839 (1992)

[文献書誌] R.K.Nakamoto: "Escherichia coli F_0F_1-ATPase:Residues involved in catalysis and coupling." Anal.N.Y.Acad.Sci.(1992)

[文献書誌] R.K.Nakamoto: "The γ subunit of the Escherichia coli ATP synthase:Mutations in the carboxyl-terminal region restore energy coupling to the amino-terminal mutant γ Met-23->Lys." Anal.N.Y.Acad.Sci.268. (1993)

[文献書誌] A.Iwamoto: "Domains near ATP γ phosphate in the catalytic site of H^+-ATPase:Model proposed from mutagenesis and inhibitor studies" J.Bl.N.Y.Acad.Sci.268. (1993)

[文献書誌] X.Wang: "Characterization of human autoantibodies reactibe to gastric parietal cells" Biochem.Biophys.Res.Commun.190. (1993)

[文献書誌] S.Yoshikawa: "Stategies for ctystallization of large membrane protein complexes." J.Crystal Growth. 122. 298-302 (1992)

[文献書誌] M.Kuroda: "Immunohistochemical assessement of sarcoplasmic reticulum Ca^<2+>-ATPase distribution in various human tissues using novel monoclonal antibodies." Virchows Archiv A:Pathol. Anat.Histophthol.421. 527-532 (1992)

[文献書誌] T.Yamashita: "Characterization of Na^+/H^+-antipoter of bovine renal cortex and its immunoaffinity purification in reconstitutively actibe form." J.Biochem.113(2). (1993)

[文献書誌] Y.Kagawa: "The α_3β_3 and α_1β_1 complexes of ATP synthase." Ann.New York Acad.Sci.671. 366-376 (1992)

[文献書誌] H.Kamata: "Primary structure of the alanine carrier protein of thermophilic bacterium PS3." J.Biol.Chem.267. 21650-21655 (1992)

[文献書誌] Y.Kagawa: "The αβ complexes of ATP synthase:The αα_3β_3oligomer and α_1β_1 protomer." J.Bioenerg.Biomembr.24. 441-445 (1992)

[文献書誌] Y.Kobayashi: "The mutant mitochondrial genes in mitochondrial myopathy,encephalopathy,lactic acidosis and stroke-ike episodes (MELAS)were selectibely amplified through generations." J.Inher.Metab.Dis.15. 803-808 (1992)

[文献書誌] K.Tominaga: "Upstream region of a genomic gene for human mitochondrial transcription factor l." Biochim.Biophys.Acta. 1131. 217-219 (1992)

[文献書誌] H.Kamata: "Partial purification and reconstitution of inisitol 1,4,5-triphosphate receptor/Ca^2channel of bovine liver microsomes." J.Biochem.111. 546-552 (1992)

[文献書誌] C.Matsuda: "Immunohistochemical investigation of intracellular calcium pools in gerbil hippocampus following transient ischemia." Neuroscience Res.S17. S331 (1992)

[文献書誌] J.Masai: "Immaging of subunit complexes of thermophilic bacterium H^+-ATPase with scanning tunneling microscopy." UItramicroscopy. 42-44. 1194-1199 (1992)

[文献書誌] A.Ando: "Primary structure of chitosanase produced by Bacillus circulans MH-K." J.Gen.Appl.Microbiol.38. 135-144 (1992)

[文献書誌] Y.Kagawa: "Mitochondrial myopathy and transcriptional control." Med.Sports Sci.(Integration of Medical and Sports Science,Karger). 37. 324-328 (1992)

[文献書誌] S.Kawano: "Effect of proton pump inhibitor on gastric mucosa hemodynamics and tissue oxygenation in anesthetized rats." Eur.J.Pharmacol.211. 55-60 (1992)

[文献書誌] K.Shimazaki: "Involvement of calmodulin and calmodulin-dependent myosin light chain kinase in blue light-dependent H^+ pumping by guard cell protoplast from Vicia faba L" Plant Physiol.99(4). 1416-1421 (1992)

[文献書誌] K.Kusumi: "Accumulation of chloroplast tRNAGlu is temperature sensitive in virescent seedlings of rice." Plant Physiol.99(1). 142 (1992)

[文献書誌] H.Yamasaki: "Inhibition of the light-induced H^+ release from uncoupled thylakoid membrones by N-ethylmaleimide." Biochem.Biophys.Res.Commun.182. 1277-1281 (1992)

[文献書誌] I.Iwasaki: "Two types of channels involved in the malate ion transport across the tonoplast of a Crassulacean acid metabolism plant." Plant Physiol.98. 1494-1497 (1992)

[文献書誌] H.Arata: "Thermodynamics of malate transport across the tonoplast of leaf cells of CAM plants." Plant Cell Physiol.33. 873-880 (1992)

[文献書誌] K.Kusumi: "Temperature-sensitive expression of chloroplast tRNAGlu in virescent mutants of rice." Research in Photosynthesis(ed.N.Murata)Kluwer,Dordrecht. (1992)

[文献書誌] K.Kusumi: "Circadian rhythms in the regulation of phosphoenolpyruvate carbxylase from a CAM plant." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)

[文献書誌] I.Iwasaki: "Circadian rhythms in the regulation of phosphoenolpyruvate carbxylase from a CAM plant." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)

[文献書誌] T.Fuse: "Effects of light and high temperature on the leaves of a rice mutant sensitive to solar radiation." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)

[文献書誌] T.Kinoshita: "Dephosphorylation of the LHCII protein by light in guardcell protoplasts from Vicia faba L." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)

[文献書誌] H.Yamasaki: "Effect of catechols on the light-induced H^+ release from uncoupled membranes." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)

[文献書誌] K.Iba: "Chromosome walking in the region of Arabidopsis fadD locus using yeast artificial chromosomes." Research in Photosynthesis (ed.N.Murata)Kluwer,Dodrecht. (1992)

[文献書誌] T.Matsuyama: "Leucine dehydrogenase from Bacillus stearothermophilus:Identification of active-site lysine by modification with pyridoxal phosphate." J.Biochem.112. 258-265 (1992)

[文献書誌] Y.Kazuta: "Probing the pyrophosphate-binding site in potato tuber UDP-glucose pyrophosphorylase with pyridoxal diphosphate." Protein Science. 2. (1993)

[文献書誌] H.Mori: "A chimeric α-glucan phosphorylase of plant type L and H isozymes.Functional role of 78-residue insertion in type L isozyme." J.Biol.Chem.268. (1993)

[文献書誌] T.Takada: "Quantitative immunogold localization of Na,K-ATPase along rat nephron." Histochemistry. 98. 183-197 (1992)

[文献書誌] K.Kawasaki: "Quantitative immunoelectron microscopic localization of Na,K-ATPase α-subunit in the epitherial cells of rat vestibular apparatus." Hear.Res.60. 64-72 (1992)

[文献書誌] T.Okami: "UItrastructural localization of Na^+,K^+-ATPase in the exorbital lacrimal gland of rat." Invest.Ophthamol.Vis,Sci.33. 196-204 (1992)

[文献書誌] H.Hayashi: "Properties of Active magnesium flux across the small intestine of guinea pig." Jpn.J.physiol.42. 561-575 (1992)

[文献書誌] T.Hoshi: "Proton secretion by the enterocytes and its role in intestinal absorptive functions." Adv.Physiol.Sci.(S.K.Manchanda,W.Selvamurthy,V.M.Kumar eds.)McMillan India,Delli,. 64-70 (1992)

[文献書誌] M.Nagasawa: "Purification of brush border membrane vesicles from rat renal cortex by size-exclusion chromatography." Anal.Biochem.201. 301-305 (1992)

[文献書誌] T.Goda: "Carbohydrate digestive capacity in jejunum of rats subjected to simulated weightlessness." J.Nutr.Biochem.3. 172-175 (1992)

[文献書誌] K.Ueda: "Human P-glycoprotein transports cortisol,aldosterone,and dexamethasone,but not progesterone." J.Biol.Chem.267. 24248-24252 (1992)

[文献書誌] H.Saito: "Transcellular transport of organic cation across monolayers of kidney epithelial cell line LLC-PK_1." Am.J.Physiol.262. C59-C66 (1992)

[文献書誌] R.Hori: "Expression of renal organic cation transporter in Xenopus leavis oocytes." Blochem.J.283(3. 409 (1992)

[文献書誌] R.Hori: "Surface binding and intracellular uptake of gentamicin in the cultured kidney epithelial cell line(LLC-PK_1)." J.Pharmacol.Exp.Ther.261(3. 1200-1205 (1992)

[文献書誌] M.Takano: "Transport of procainamide in a kidney epithelial cell line LLC-PK_1." Biochim.Biophys.Acta. 1108. 133-139 (1992)

[文献書誌] Y.Tanigawa: "Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1)." J.Pharmacol.Exp.Ther.263(2. 840-845 (1992)

[文献書誌] K.Ohoka: "P-Aminohippurate transport in rat renal brush-border membranes:a potential-sensitive transport system and an anion exchanger." Biol.Pharm.Bull.

[文献書誌] T.Katsura: "Characteristics of organic cation transporter in rat renal basolateral membrane." Blochim.Biophys.Acta.

[文献書誌] Y.Mukuhata: "Photophosphorylation elements in Halobacteriaan A-type ATP synthase and bacterial rhodopsins." J.Bioenerg.Biomembr.24(6). 547-553 (1992)

[文献書誌] K.Ihara: "Halobacterial A-ATP synthase in relation to V-ATPase." J.Exp.Biol.172. 475-485 (1992)

[文献書誌] Y.Mukohata: "Comparative studies on bacteriorhodopsin-type pumps:Basic physicochemical data for proton pumps." Structures and Functions of Retinal Proteins (ed.J.L.Rigaud)Colloque INSERM,John Libbey Eurotext Ltd.,Montrouge,France. 221. PP101-104 (1992)

1992 年度実績報告書

安楽泰宏東京大学, 理学部, 教授 (20012643)