1992 年度実績報告書

中枢シナプスの分子生物学

研究課題

研究課題/領域番号	04267102
研究機関	新潟大学
研究代表者	三品昌美新潟大学, 脳研究所, 教授 (80144351)
研究分担者	伊藤正男理化学研究所, チームリーダー (90009887) 津本忠治大阪大学, 医学部, 教授 (50028619) 山本長三郎金沢大学, 医学部, 教授 (50008231) 吉岡亨早稲田大学, 人間科学部, 教授 (70046027) 清水孝雄東京大学, 医学部, 教授 (80127092)
キーワード	中枢シナプス / 可塑性 / グルタミン酸受容体 / 逆行性伝達物質 / 神経伝達物質放出 / 長期増強 / 長期抑圧 / 総合的研究
研究概要	本重点領域研究の推進、総合的研究体制の促進および研究成果の評価と助言を行うために以下の会議等を開催した。1.研究代表者および研究班長を中心に4名のワーキンググループを作り、本重点領域研究の推進および共同研究の促進のための方策について検討した。2.我が国の第一線の脳・神経研究者を含む総括班会議を開催し、本重点領域研究の推進と総合的研究への取り組みについて討議した。同時に、研究成果に対する評価と貴重な助言を頂いた。3.班全員が参加する班会議を開催し、計画班員と公募班員の全員が現在までの研究成果と今後の研究計画について発表し、すべての班員がこの発表を聞く機会を設けた。この班会議により班員すべてが互いによく知り合い、共同研究や研究協力を推進させることができた。4.公開シンポジウムを開催するとともにニュースレターを発行することにより、本重点領域研究の目的、進展状況と成果、今後の中枢シナプス研究の展望ならびに中枢シナプス研究の重要性を広く知らせた。班会議でも明らかになったようにグルタミン酸受容体の分子的実体の解明、大脳皮質における長期増強と長期抑圧とカルシウム動態との関係、逆行性伝達物質の候補のシナプス可塑性に及ぼす影響の解析、シナプス前部の機能分子の単離などすでに本重点領域研究の成果が着実に出始めている。特筆すべきことはシナプス長期増強に中心的役割を果たすNMDA型グルタミン酸受容体チャネルの分子的多様性が本重点領域研究で世界に先駆けて解明されたことである。この成果をさらに発展させてシナプス可塑性、脳の高次機能解明に結び付けるためには分子生物学、電気生理学、解剖学、発生工学などの研究分野の結集が必要不可欠である。そのような総合的研究は本重点領域研究においてはじめて可能であり、本重点領域研究の発足は時宜を得たものである。

研究成果

(81件)

すべてその他

すべて文献書誌 (81件)

[文献書誌] Sakimura,K.,et al.: "Primary structure and expression of the γ2 subunit of the glutamate receptor channel selective for kainate." Neuron. 8. 267-274 (1992)
[文献書誌] Morita,T.,et al.: "Cloning and functional expression of cDNA encoding the mouse β2 subunit of the kainate-selective glutamate receptor channel." Mol.Brain Res.14. 143-146 (1992)
[文献書誌] Yamazaki,M.,et al.: "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family." Biochem.Biophys.Res.Commun.183. 886-892 (1992)
[文献書誌] Yamazaki,M.,et al.: "Cloning,expression and modulation of a mouse NMDA receptor subunit." FEBS Lett.300. 39-45 (1992)
[文献書誌] Meguro,H.,et al.: "Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs." Nature. 357. 70-74 (1992)
[文献書誌] Kutsuwada,T.,et al.: "Molecular diversity of the NMDA receptor channel." Nature. 358. 36-41 (1992)
[文献書誌] Mori,H.,et al.: "Identification by mutagenesis of a Mg^<2+> block site of the NMDA receptor channel." Nature. 358. 673-675 (1992)
[文献書誌] Uchino,S.,et al.: "Mutations in a putative agonist binding region of the AMPA-selective glutamate receptor channel." FEBS Lett.308. 253-257 (1992)
[文献書誌] Morita,T.,et al.: "Synaptocanalin I,a protein associated with brain ω-conotoxin-sensitive calcium channels." Biomed.Res.13. 357-364 (1992)
[文献書誌] Ikeda,K.,et al.: "Cloning and expression of the ε4 subunit of the NMDA receptor channel." FEBS Lett.313. 34-38 (1992)
[文献書誌] Watanabe,M.,et al.: "Developmental changes in distribution of the NMDA receptor channel subunit mRNAs in the brain." NeuroReport. 3. 1138-1140 (1992)
[文献書誌] Alkon D.L.,et al.: "Long-term transformation of an inhibitory into an exicitatory GABAergic synaptic response." Proc.Natl.Acad.Sci.U.S.A.89. 11862-11866 (1992)
[文献書誌] Voorhout W.F.,et al.: "Subcellular localization of glycolipids as revealed by immunoelectronmicroscopy." TIGG. 4. 533-546 (1992)
[文献書誌] Takagi H.,et al.: "Delayed appearance of G-protein coupled signal transduction system in developing cerebellar Purkinje cell dendrites." Neurosci.Res.15. 206-212 (1992)
[文献書誌] Suzuki N.,et al.: "Augmantation of transient low-threshold Ca^<2+> current induced by GTP-binding protein signal transduction system in GH_3 pituitary cells." Biochem.Biophys.Res.Commun.187. 529-536 (1992)
[文献書誌] Miyazawa A.,et al.: "Monoclonal antibody analysis of phosphatidylserine and protein kinase C localizations in developing rat cerebellum." J.Neurochem.59. 1547-1554 (1992)
[文献書誌] Inoue H.,et al.: "Partial purification and characterization of membrane-associated diacylglycerol kinase of Drosophila heads." Biochim.Biophys.Acta.1122. 219-224 (1992)
[文献書誌] Bito,H.,et al.: "Platelet-activating factor(PAF)receptor in ret brain:PAF mobilizes intracellular Ca2+ in hippocampal neurons." Neuron. 9. 285-294 (1992)
[文献書誌] Sakanaka,C.,et al.: "Three typer of Gi protein of the quinea pig lung;cDNA cloning and analysis of their tissue distribution." Biochim.Biophys.Acta. 1175. 61-66 (1992)
[文献書誌] Nakamura,M.,et al.: "Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor." FEBS Lett.314. 125-129 (1992)
[文献書誌] Shimizu,T.: "Platelet-activating factor receptor and signal transduction." Biochem.Pharmacol.44. 1001-1008 (1992)
[文献書誌] Yamamoto,C.,Sawada,S.and Kamiya,H.: "Enhancement of postsynaptic responsiveness during long-term potentiation of mossy fiber synapses in guinea pig hippocampus." Neurosci.Lett.138. 111-114 (1992)
[文献書誌] Kamiya,H.,Sawada,S.and Yamamoto,C.: "An empirical test for the reliability of quantal analysis based on Pascal statistics." J.Neurosci.Methods. 42. 19-26 (1992)
[文献書誌] Hirata,K.,Sawada,S.and Yamamoto,C.,: "Quantal analysis of supperssing action of baclofen on mossy fiber synapses in guinea pig hippocampus." Brain Res.578. 33-40 (1992)
[文献書誌] Ohno-Shosaku,T.and Yamamoto,C.: "Identification of an ATP-sensitive K^+ channel in rat cultured cortical neurons." Pflugers Arch.422. 260-266 (1992)
[文献書誌] Tamura,H.et al.: "Activity-dependent potentiation and depression of visual cortical responses to optic nerve stimulation in kittens." Journal of Neurophysiology. 68. 1603-1612 (1992)
[文献書誌] Funauchi,M.et al.: "Long-term depression is induced in Ca2+/ calmodulin kinase-inhibited neurons in visual cortex." NeuroReport. 3. 173-176 (1992)
[文献書誌] Tsumoto,T.: "Long-term potentiation and long-term depression in the neocortex." Progress in Neurobiology. 39. 209-228 (1992)
[文献書誌] Hata,Y.et al.: "Development of local horizontal interactions in cat visual cortex studied by cross-correlation analysis." Journal of Neurophysiology. 69. 40-56 (1993)
[文献書誌] Ito,M.,et al.: "Protein kinases and protein phosphatase inhibitors mediating long-term desensitigation in cerebellar Purkinje cells." Neurosci.Res.14. 27-38 (1992)
[文献書誌] Nakaoka,T.,et al.: "Bimodal regulation of protein phosphorylation by a ganglioside in rat brain membrane." J.Neurosci.31. 724-730 (1992)
[文献書誌] Tsuji,S.,et al.: "A novel glycosignaling system:GQ1b-dependent neuritogenesis of human reuroblastoma cell line,goto is closely associated with GQ1b-dependent ecto-type protein phosphorylation." Neurochem.Int.Vol.21No.4. 549-554 (1992)
[文献書誌] Kusunoki,S.,et al.: "Developmental changes of fucosylated glycoconjugates in rabbit dorsal root ganglia." Neurosci.Res.15. 74-80 (1992)
[文献書誌] Yanagisawa M.et al.: "The isolated spinal cord-skin preparation of the newborn rat and effects of some algogenic and analgesic substances." Eur.J.Pharmacol.220. 111-117 (1992)
[文献書誌] Yanagisawa M.et al.: "Enzymatic inactivation of tachykinin neurotransmitters in the isolated spinal cord of the newborn rat." Neurosci.Res.15. 289-292 (1992)
[文献書誌] Sakuma M.et al.: "Substance P-evoked release of GABA from isolated spinal cord of the newborn rat." Neuroscience. 45. 323-330 (1991)
[文献書誌] Kobayashi N.et al.: "Substance P-evoked release of acetylcholine from isolated spinal cord of the newborn rat." Neuroscience. 45. 331-337 (1991)
[文献書誌] Yoshioka K.et al.: "Curaneous nerve-evoked cholinergic inhibition of monosynaptic reflex in the neonatal rat spinal cord." Neuroscience. 38. 195-203 (1990)
[文献書誌] Yanagisawa M.et al.: "Pharmacological profile of a tachykinin antagonist,spantide,as examined on rat spinal motoneurones." Br.J.Pharmacol.100. 711-716 (1990)
[文献書誌] Shigeko Araki,et al.: "Characterization of two novel pyruvylated glycosphingo-lipids containing 2′-aminoethylphosphoryl(→6)-galactose from the nervous system of Aplysia kurodai." Journal of Biochemistry. 112. 461-469 (1992)
[文献書誌] Yamazawa,T.,Iino,M.and Endo,M.: "Presence of functionally different compartment of the Ca^<2+> store in single intestinal smooth muscle cells." FEBS Lett.301. 181-184 (1992)
[文献書誌] Iino,M.,Takano Ohmuro,H.,Kawana,Y.and Endo,M.: "Enhancement of Ca^<2+> -induced Ca^<2+> release in calpain treated rabbit skinned muscle fibers." Biochem.Biophys.Res.Coomun.185. 713-718 (1992)
[文献書誌] Kawana,Y.,Iino,M.,Horiuti,K.,Matsumura,N.,Ohta,T.,Matsui,: "Acceleration in calcium-induced calcium release in the biopsied mucle fibers from patients with malignant hyperthermia." K.and Endo,M.Biomed.Res.13. 287-297 (1992)
[文献書誌] Iino,M.,and Endo,M.: "Calcium-dependent immedicate feedback control of inositol 1,4,5,-trisphosphate-induced Ca^<2+> release." Nature. 360. 76-78 (1992)
[文献書誌] Endo,M.: "Calcium-induced calcium release mechanism in skeletal muscle and its modification by drugs." Muscular Contraction(Simmons,R.M.ed.)Cambridge University Press. 67-82 (1992)
[文献書誌] Shigetada Nakanishi: "Molecular diversity of glutamate receptors and implications for brain function." Science. 258. 597-603 (1992)
[文献書誌] Yasuto Tanabe,et al.: "A family of metabotropic glutamate receptors." Neuron. 8. 169-179 (1992)
[文献書誌] Ichiro Aramori,et al.: "Signal transduciton and pharmacological characteristics of a metabotropic glutamate receptor mGlurl in transfected Chinese hamster ovary cells." Neuron. 8. 757-765 (1992)
[文献書誌] Yasunori Hayashi,et al.: "Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells." British Journal of Pharmacology. 107. 539-543 (1992)
[文献書誌] Takaaki Abe,et al.: "Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca^<2+> signal transduction." Journal of Biological Chemistry. 267. 13361-13368 (1992)
[文献書誌] Kazuhiro Sakurada,et al.: "Alterlation of Ca^<2+> permeability and sensitivity to Mg^<2+> and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor." Journal of Biological Chemistry. 268. 410-415 (1993)
[文献書誌] M.Kasai他: "K^+ channel involvement in induction of synaptic enhancement by mast cell degranulating(MCD)peptide" Neurosci.Res.13. 207-216 (1992)
[文献書誌] M.Kasai他: "Permeation of neutral molecules through calcium channel in sarcoplasmic reticulum vesicles" J.Biochem.112. 197-203 (1992)
[文献書誌] M.Kasai他: "Ion channels on synaptic vesicle membranes studied by planar lipid bilayer mothod" Biophys.J.63. 1500-1505 (1992)
[文献書誌] M.Kasai他: "Immunological identification of a Cl^- channel protein in electric organs of Narke japonica" Biochem.Biophys.Res.Commun.188. 1228-1234 (1992)
[文献書誌] Takeuchi,M.,et al.: "The 72KD microtuble associated protein from porcine brain." J.Neurochem.58. 1510-1516 (1992)
[文献書誌] Ikabe,S.,et al.: "Differential behavior of photoactivated microtubules in growing axon of mouse and frog neurons." J.Cell Biol.117. 105-120 (1992)
[文献書誌] Hirokawa,N.,et al.: "Microtubules on the move?" Curr.Biol.2. 193-195 (1992)
[文献書誌] Nakata,T.,et al.: "Organization of cortical cytoskeleton of cultured chromaff in cells and involvement in secretion as revealed by quick-freeze,deep-etching,and double-label immunoelectron microscopy" J.Neurosci.12. 2186-2197 (1992)
[文献書誌] Oshima,T.,et al.: "Immunocytochemical localization of 205 kDa microtubule-associated protein(205kDa MAP)in the guinea pig organ of corti." Brain Res.590. 53-65 (1992)
[文献書誌] Maeda,K.,et al.: "Dynamin:its enzymatic activity and interaction with microtubules." Mol.Biol.Cell. 3. 1181-1194 (1992)
[文献書誌] Kanai,Y.,et al.: "Microtubule bundling by tau proteins in vivo:analysis of the functional domains." EMBO J.11. 3953-3961 (1992)
[文献書誌] Aizawa,H.,et al.: "Kinesin family in murine central nervous system." J.Cell Biol.119. 1287-1296 (1992)
[文献書誌] Tanaka,Y.,et al.: "Chronological expression of microtubule-associated proteins(MAPs)in EC cell p 19 after neuronal induction by retinoic acid." Brain Res.596. 269-278 (1992)
[文献書誌] Sato-Yoshitake,R.,et al.: "Phosphorylation of kinesin regulates its binding to synaptic vesicles." J.Biol.Chem.267. 23930-23926 (1992)
[文献書誌] Chin,J.,et al.: "Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons." Nature. 360. 674-677 (1992)
[文献書誌] Takemura,R.,et al.: "Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B,MAP2 or tau." J.Cell Sci.103. 952-964 (1992)
[文献書誌] Takemura,R.,et al.: "Reorganization of brain spectrin(fodrin)during differentiation of PC12 cells." Neurosci.52. 381-391 (1993)
[文献書誌] Umeyama,T.et al.: "Dynamics of microtubules bundled by microtubule associated protein 2 C(MAP2)." J.Cell Biol.120. 451-465 (1993)
[文献書誌] Okabe,S.,et al.: "Do photobleached fluorescent microtubules move?:Re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon." J.Cell Biol.(1993)
[文献書誌] Noda,Y.,et al: "Localization of dynamin:Widespread distribution in neurons and association with membraneous organelles transported anterogradely." Neurosci.(1993)
[文献書誌] Okabe,S.,et al.: "Dynamic of the neuronal intermediate filaments." J.Cell Biol.(1993)
[文献書誌] Nakata,T.,et al.: "T-dynamin,a novel member of dynamin-family protein is expressed specific to testis." J.Cell Sci.(1993)
[文献書誌] Muyazaki,S.,et al.: "Block of Ca^<2+> wave and Ca^<2+> oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs." Science. 257. 251-255 (1992)
[文献書誌] Yoshikawa,S.,et al.: "Molecular cloning and characterization of inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster." J.Biol.Chem.267. 16613-16619 (1992)
[文献書誌] Fujimoto,T.,et al.: "Localization o Inositol 1,4,5-trisphosphate receptor-like protein in plasmealemmal caveolae." J.Cell Biol.119. 1507-1513 (1992)
[文献書誌] Wojcikiewicz,R,J,H.,et al.: "Inositol 1,4,5-trisphosphate receptor immunoreactivity in SH-SY5Y human neuroblastoma cells is reduced by chronic muscarinic receptor activation." J.Neurochem.59. 383-386 (1992)
[文献書誌] A.Kuniyasu et al.: "Structural characterization of the dihydropyridine receptor-linke calcium channel from porcine heart." J.Biochem.112. 235-242 (1992)
[文献書誌] H.Tokumaru,K.Anzai,T.Abe,Y.Kirino: "Purification of the cardiac 1,4-dihydropyridine receptor using immunoaffinity chromatography with a monoclonal antibody against the α_2s subunit of the skeletal muscle dihyaropyridune receptor." Eur.J.Pharmacol.227. 363-370 (1992)
[文献書誌] Ito,M.: "Neurosciences,Paths of Discovery II" Birkhauser,Boston., 622 (1992)
[文献書誌] Mei Satake: "The Molecular Basis of Neuronal Connectivity" KOHKO-DO Niigata, 208 (1992)

1992 年度 実績報告書

中枢シナプスの分子生物学

研究代表者

三品 昌美 新潟大学, 脳研究所, 教授 (80144351)

研究成果

[文献書誌] Sakimura,K.,et al.: "Primary structure and expression of the γ2 subunit of the glutamate receptor channel selective for kainate." Neuron. 8. 267-274 (1992)

[文献書誌] Morita,T.,et al.: "Cloning and functional expression of cDNA encoding the mouse β2 subunit of the kainate-selective glutamate receptor channel." Mol.Brain Res.14. 143-146 (1992)

[文献書誌] Yamazaki,M.,et al.: "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family." Biochem.Biophys.Res.Commun.183. 886-892 (1992)

[文献書誌] Yamazaki,M.,et al.: "Cloning,expression and modulation of a mouse NMDA receptor subunit." FEBS Lett.300. 39-45 (1992)

[文献書誌] Meguro,H.,et al.: "Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs." Nature. 357. 70-74 (1992)

[文献書誌] Kutsuwada,T.,et al.: "Molecular diversity of the NMDA receptor channel." Nature. 358. 36-41 (1992)

[文献書誌] Mori,H.,et al.: "Identification by mutagenesis of a Mg^<2+> block site of the NMDA receptor channel." Nature. 358. 673-675 (1992)

[文献書誌] Uchino,S.,et al.: "Mutations in a putative agonist binding region of the AMPA-selective glutamate receptor channel." FEBS Lett.308. 253-257 (1992)

[文献書誌] Morita,T.,et al.: "Synaptocanalin I,a protein associated with brain ω-conotoxin-sensitive calcium channels." Biomed.Res.13. 357-364 (1992)

[文献書誌] Ikeda,K.,et al.: "Cloning and expression of the ε4 subunit of the NMDA receptor channel." FEBS Lett.313. 34-38 (1992)

[文献書誌] Watanabe,M.,et al.: "Developmental changes in distribution of the NMDA receptor channel subunit mRNAs in the brain." NeuroReport. 3. 1138-1140 (1992)

[文献書誌] Alkon D.L.,et al.: "Long-term transformation of an inhibitory into an exicitatory GABAergic synaptic response." Proc.Natl.Acad.Sci.U.S.A.89. 11862-11866 (1992)

[文献書誌] Voorhout W.F.,et al.: "Subcellular localization of glycolipids as revealed by immunoelectronmicroscopy." TIGG. 4. 533-546 (1992)

[文献書誌] Takagi H.,et al.: "Delayed appearance of G-protein coupled signal transduction system in developing cerebellar Purkinje cell dendrites." Neurosci.Res.15. 206-212 (1992)

[文献書誌] Suzuki N.,et al.: "Augmantation of transient low-threshold Ca^<2+> current induced by GTP-binding protein signal transduction system in GH_3 pituitary cells." Biochem.Biophys.Res.Commun.187. 529-536 (1992)

[文献書誌] Miyazawa A.,et al.: "Monoclonal antibody analysis of phosphatidylserine and protein kinase C localizations in developing rat cerebellum." J.Neurochem.59. 1547-1554 (1992)

[文献書誌] Inoue H.,et al.: "Partial purification and characterization of membrane-associated diacylglycerol kinase of Drosophila heads." Biochim.Biophys.Acta.1122. 219-224 (1992)

[文献書誌] Bito,H.,et al.: "Platelet-activating factor(PAF)receptor in ret brain:PAF mobilizes intracellular Ca2+ in hippocampal neurons." Neuron. 9. 285-294 (1992)

[文献書誌] Sakanaka,C.,et al.: "Three typer of Gi protein of the quinea pig lung;cDNA cloning and analysis of their tissue distribution." Biochim.Biophys.Acta. 1175. 61-66 (1992)

[文献書誌] Nakamura,M.,et al.: "Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor." FEBS Lett.314. 125-129 (1992)

[文献書誌] Shimizu,T.: "Platelet-activating factor receptor and signal transduction." Biochem.Pharmacol.44. 1001-1008 (1992)

[文献書誌] Yamamoto,C.,Sawada,S.and Kamiya,H.: "Enhancement of postsynaptic responsiveness during long-term potentiation of mossy fiber synapses in guinea pig hippocampus." Neurosci.Lett.138. 111-114 (1992)

[文献書誌] Kamiya,H.,Sawada,S.and Yamamoto,C.: "An empirical test for the reliability of quantal analysis based on Pascal statistics." J.Neurosci.Methods. 42. 19-26 (1992)

[文献書誌] Hirata,K.,Sawada,S.and Yamamoto,C.,: "Quantal analysis of supperssing action of baclofen on mossy fiber synapses in guinea pig hippocampus." Brain Res.578. 33-40 (1992)

[文献書誌] Ohno-Shosaku,T.and Yamamoto,C.: "Identification of an ATP-sensitive K^+ channel in rat cultured cortical neurons." Pflugers Arch.422. 260-266 (1992)

[文献書誌] Tamura,H.et al.: "Activity-dependent potentiation and depression of visual cortical responses to optic nerve stimulation in kittens." Journal of Neurophysiology. 68. 1603-1612 (1992)

[文献書誌] Funauchi,M.et al.: "Long-term depression is induced in Ca2+/ calmodulin kinase-inhibited neurons in visual cortex." NeuroReport. 3. 173-176 (1992)

[文献書誌] Tsumoto,T.: "Long-term potentiation and long-term depression in the neocortex." Progress in Neurobiology. 39. 209-228 (1992)

[文献書誌] Hata,Y.et al.: "Development of local horizontal interactions in cat visual cortex studied by cross-correlation analysis." Journal of Neurophysiology. 69. 40-56 (1993)

[文献書誌] Ito,M.,et al.: "Protein kinases and protein phosphatase inhibitors mediating long-term desensitigation in cerebellar Purkinje cells." Neurosci.Res.14. 27-38 (1992)

[文献書誌] Nakaoka,T.,et al.: "Bimodal regulation of protein phosphorylation by a ganglioside in rat brain membrane." J.Neurosci.31. 724-730 (1992)

[文献書誌] Tsuji,S.,et al.: "A novel glycosignaling system:GQ1b-dependent neuritogenesis of human reuroblastoma cell line,goto is closely associated with GQ1b-dependent ecto-type protein phosphorylation." Neurochem.Int.Vol.21No.4. 549-554 (1992)

[文献書誌] Kusunoki,S.,et al.: "Developmental changes of fucosylated glycoconjugates in rabbit dorsal root ganglia." Neurosci.Res.15. 74-80 (1992)

[文献書誌] Yanagisawa M.et al.: "The isolated spinal cord-skin preparation of the newborn rat and effects of some algogenic and analgesic substances." Eur.J.Pharmacol.220. 111-117 (1992)

[文献書誌] Yanagisawa M.et al.: "Enzymatic inactivation of tachykinin neurotransmitters in the isolated spinal cord of the newborn rat." Neurosci.Res.15. 289-292 (1992)

[文献書誌] Sakuma M.et al.: "Substance P-evoked release of GABA from isolated spinal cord of the newborn rat." Neuroscience. 45. 323-330 (1991)

[文献書誌] Kobayashi N.et al.: "Substance P-evoked release of acetylcholine from isolated spinal cord of the newborn rat." Neuroscience. 45. 331-337 (1991)

[文献書誌] Yoshioka K.et al.: "Curaneous nerve-evoked cholinergic inhibition of monosynaptic reflex in the neonatal rat spinal cord." Neuroscience. 38. 195-203 (1990)

[文献書誌] Yanagisawa M.et al.: "Pharmacological profile of a tachykinin antagonist,spantide,as examined on rat spinal motoneurones." Br.J.Pharmacol.100. 711-716 (1990)

[文献書誌] Shigeko Araki,et al.: "Characterization of two novel pyruvylated glycosphingo-lipids containing 2′-aminoethylphosphoryl(→6)-galactose from the nervous system of Aplysia kurodai." Journal of Biochemistry. 112. 461-469 (1992)

[文献書誌] Yamazawa,T.,Iino,M.and Endo,M.: "Presence of functionally different compartment of the Ca^<2+> store in single intestinal smooth muscle cells." FEBS Lett.301. 181-184 (1992)

[文献書誌] Iino,M.,Takano Ohmuro,H.,Kawana,Y.and Endo,M.: "Enhancement of Ca^<2+> -induced Ca^<2+> release in calpain treated rabbit skinned muscle fibers." Biochem.Biophys.Res.Coomun.185. 713-718 (1992)

[文献書誌] Kawana,Y.,Iino,M.,Horiuti,K.,Matsumura,N.,Ohta,T.,Matsui,: "Acceleration in calcium-induced calcium release in the biopsied mucle fibers from patients with malignant hyperthermia." K.and Endo,M.Biomed.Res.13. 287-297 (1992)

[文献書誌] Iino,M.,and Endo,M.: "Calcium-dependent immedicate feedback control of inositol 1,4,5,-trisphosphate-induced Ca^<2+> release." Nature. 360. 76-78 (1992)

[文献書誌] Endo,M.: "Calcium-induced calcium release mechanism in skeletal muscle and its modification by drugs." Muscular Contraction(Simmons,R.M.ed.)Cambridge University Press. 67-82 (1992)

[文献書誌] Shigetada Nakanishi: "Molecular diversity of glutamate receptors and implications for brain function." Science. 258. 597-603 (1992)

[文献書誌] Yasuto Tanabe,et al.: "A family of metabotropic glutamate receptors." Neuron. 8. 169-179 (1992)

[文献書誌] Ichiro Aramori,et al.: "Signal transduciton and pharmacological characteristics of a metabotropic glutamate receptor mGlurl in transfected Chinese hamster ovary cells." Neuron. 8. 757-765 (1992)

[文献書誌] Yasunori Hayashi,et al.: "Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells." British Journal of Pharmacology. 107. 539-543 (1992)

[文献書誌] Takaaki Abe,et al.: "Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca^<2+> signal transduction." Journal of Biological Chemistry. 267. 13361-13368 (1992)

[文献書誌] Kazuhiro Sakurada,et al.: "Alterlation of Ca^<2+> permeability and sensitivity to Mg^<2+> and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor." Journal of Biological Chemistry. 268. 410-415 (1993)

[文献書誌] M.Kasai他: "K^+ channel involvement in induction of synaptic enhancement by mast cell degranulating(MCD)peptide" Neurosci.Res.13. 207-216 (1992)

[文献書誌] M.Kasai他: "Permeation of neutral molecules through calcium channel in sarcoplasmic reticulum vesicles" J.Biochem.112. 197-203 (1992)

[文献書誌] M.Kasai他: "Ion channels on synaptic vesicle membranes studied by planar lipid bilayer mothod" Biophys.J.63. 1500-1505 (1992)

[文献書誌] M.Kasai他: "Immunological identification of a Cl^- channel protein in electric organs of Narke japonica" Biochem.Biophys.Res.Commun.188. 1228-1234 (1992)

[文献書誌] Takeuchi,M.,et al.: "The 72KD microtuble associated protein from porcine brain." J.Neurochem.58. 1510-1516 (1992)

[文献書誌] Ikabe,S.,et al.: "Differential behavior of photoactivated microtubules in growing axon of mouse and frog neurons." J.Cell Biol.117. 105-120 (1992)

[文献書誌] Hirokawa,N.,et al.: "Microtubules on the move?" Curr.Biol.2. 193-195 (1992)

[文献書誌] Nakata,T.,et al.: "Organization of cortical cytoskeleton of cultured chromaff in cells and involvement in secretion as revealed by quick-freeze,deep-etching,and double-label immunoelectron microscopy" J.Neurosci.12. 2186-2197 (1992)

[文献書誌] Oshima,T.,et al.: "Immunocytochemical localization of 205 kDa microtubule-associated protein(205kDa MAP)in the guinea pig organ of corti." Brain Res.590. 53-65 (1992)

[文献書誌] Maeda,K.,et al.: "Dynamin:its enzymatic activity and interaction with microtubules." Mol.Biol.Cell. 3. 1181-1194 (1992)

[文献書誌] Kanai,Y.,et al.: "Microtubule bundling by tau proteins in vivo:analysis of the functional domains." EMBO J.11. 3953-3961 (1992)

[文献書誌] Aizawa,H.,et al.: "Kinesin family in murine central nervous system." J.Cell Biol.119. 1287-1296 (1992)

[文献書誌] Tanaka,Y.,et al.: "Chronological expression of microtubule-associated proteins(MAPs)in EC cell p 19 after neuronal induction by retinoic acid." Brain Res.596. 269-278 (1992)

[文献書誌] Sato-Yoshitake,R.,et al.: "Phosphorylation of kinesin regulates its binding to synaptic vesicles." J.Biol.Chem.267. 23930-23926 (1992)

[文献書誌] Chin,J.,et al.: "Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons." Nature. 360. 674-677 (1992)

[文献書誌] Takemura,R.,et al.: "Increased microtubule stability and alpha tubulin acetylation in cells transfected with microtubule-associated proteins MAP1B,MAP2 or tau." J.Cell Sci.103. 952-964 (1992)

[文献書誌] Takemura,R.,et al.: "Reorganization of brain spectrin(fodrin)during differentiation of PC12 cells." Neurosci.52. 381-391 (1993)

[文献書誌] Umeyama,T.et al.: "Dynamics of microtubules bundled by microtubule associated protein 2 C(MAP2)." J.Cell Biol.120. 451-465 (1993)

[文献書誌] Okabe,S.,et al.: "Do photobleached fluorescent microtubules move?:Re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon." J.Cell Biol.(1993)

[文献書誌] Noda,Y.,et al: "Localization of dynamin:Widespread distribution in neurons and association with membraneous organelles transported anterogradely." Neurosci.(1993)

[文献書誌] Okabe,S.,et al.: "Dynamic of the neuronal intermediate filaments." J.Cell Biol.(1993)

[文献書誌] Nakata,T.,et al.: "T-dynamin,a novel member of dynamin-family protein is expressed specific to testis." J.Cell Sci.(1993)

[文献書誌] Muyazaki,S.,et al.: "Block of Ca^<2+> wave and Ca^<2+> oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs." Science. 257. 251-255 (1992)

[文献書誌] Yoshikawa,S.,et al.: "Molecular cloning and characterization of inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster." J.Biol.Chem.267. 16613-16619 (1992)

1992 年度実績報告書

三品昌美新潟大学, 脳研究所, 教授 (80144351)