1994 年度実績報告書

免疫制御・寛容の分子機構

研究課題

研究課題/領域番号	05272103
研究機関	九州大学
研究代表者	笹月健彦九州大学, 生体防御医学研究所, 教授 (50014121)
研究分担者	谷口維紹東大, 医学部, 教授 (50133616) 渡辺武九州大学, 生体防御医学研究所, 教授 (40028684) 岸本忠三阪大, 医学部, 教授 (10093402) 本庶佑京大, 医学部, 教授 (80090504) 奥村康順天堂大, 医学部, 教授 (50009700)
キーワード	免疫制御 / 免疫寛容
研究概要	本重点領域研究は、免疫応答の制御機構と免疫寛容の分子機構を解明することにより、現代医学が解決を迫られている臓器・骨髄移植における拒絶反応やGvH病、自己免疫性難病やアレルギー性疾患、さらにはウィルス・細菌感染後の免疫学的炎症などの疾患の根元的制御法、治療法、さらには予防法確立への道を拓くことを目的としている。総括班は、1)免疫制御の分子機構、2)免疫制御の分子機構、3)免疫機構の分子機構の3つの計画班それぞれの研究評価を行い、3班が密な連携をもって研究を推進できるよう以下の活動を行った。 1)年3回のニューズレターの発行を行った。 2)合同シンポジウム、合同カンファレンスを各一回開催した。 3)総括班会議を2回開催し、計画研究班の研究進捗状況の討議および研究支援に関する討議を行った。

研究成果
(15件)

すべてその他

すべて文献書誌 (15件)

[文献書誌] Okabe T.: "cDNA cloning of a NGF1-B/nur77 related transcription factor from an apoptotic T cell line." J.Immunol.(in press).
[文献書誌] Takeda T.: "EIA respression of IL-6-induced gene activation by blocking the assembly of IL-6 response element binding complexes." J.Immunol.(in press).
[文献書誌] Hara H.: "Detection of human T lymphotropic Virus Type I(HTLV-1) proviral DNA and analysis of T cell receptor V CDR3 sequences in spinal cord lesions of HTLV-1 associated myelopathy Tropical spastic paraparesis." J.Exp.Med.(in press).
[文献書誌] Rae SM.Yeung: "Human CD4-major histocompatibility complex class II (DOW6) transgenic mice in an endogenous CD4/CD8-deficient background:Reconstitution of phenotype and human restrieted function." J.Exp.Med.180. 1911-1920 (1994)
[文献書誌] Yamamoto K.: "Functional interaction between human histocompatibility leukocyte antigen(HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DO transgenic mice." J.Exp.Med.180. 165-171 (1994)
[文献書誌] Hanabuchi S.: "Fas and its ligand in a general mechanism of T cell-mediated cytotoxity." Proc.Natl.Acad.Sci.USA. 91. 4930-4934 (1994)
[文献書誌] Koide Y.: "Molecular analysis of the pathogenesis of autoimmune insulitis in NOD mice." Tohoku J.Exp.Med.173. 157-170 (1994)
[文献書誌] Nakano T.: "Generation of lymphomatopoietic cells from embryonic stem cells in culture." Science. 265. 1098-1101 (1994)
[文献書誌] Kishimoto,T.: "Cytokine signal transduction." Cell. 76. 253-262 (1994)
[文献書誌] Akira S.: "Molecular cloning of APRF,a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp 130-mediated signaling pathway." Cell. 77. 63-71 (1994)
[文献書誌] Kaisho T.: "EST-1,a surface molecule of bone marrow stromal cell lines that facilitates pre-B cell growth." Proc.Natl.Acad.Sci.USA. 91. 5325-5329 (1994)
[文献書誌] Sawada M.: "cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells." Biochm.Biophys.Res.Commun.203. 479-484 (1994)
[文献書誌] Tanaka N.: "Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1." Cell. 77. 829-839 (1994)
[文献書誌] Kimura T.: "Involvement of the IRF-1 transcription factor in antiviral responses to interferones." Science. 264. 1921-1924 (1994)
[文献書誌] Isobe M.: "Immunosuppression to cardiac allografts and soluble antigens by anti-VCAM-1 and anti-VLA-4 monoclonal antibodies." J.Immunol.153. 5810-5818 (1994)

1994 年度 実績報告書

免疫制御・寛容の分子機構

研究代表者

笹月 健彦 九州大学, 生体防御医学研究所, 教授 (50014121)

研究成果

[文献書誌] Okabe T.: "cDNA cloning of a NGF1-B/nur77 related transcription factor from an apoptotic T cell line." J.Immunol.(in press).

[文献書誌] Takeda T.: "EIA respression of IL-6-induced gene activation by blocking the assembly of IL-6 response element binding complexes." J.Immunol.(in press).

[文献書誌] Hara H.: "Detection of human T lymphotropic Virus Type I(HTLV-1) proviral DNA and analysis of T cell receptor V CDR3 sequences in spinal cord lesions of HTLV-1 associated myelopathy Tropical spastic paraparesis." J.Exp.Med.(in press).

[文献書誌] Rae SM.Yeung: "Human CD4-major histocompatibility complex class II (DOW6) transgenic mice in an endogenous CD4/CD8-deficient background:Reconstitution of phenotype and human restrieted function." J.Exp.Med.180. 1911-1920 (1994)

[文献書誌] Yamamoto K.: "Functional interaction between human histocompatibility leukocyte antigen(HLA) class II and mouse CD4 molecule in antigen recognition by T cells in HLA-DR and DO transgenic mice." J.Exp.Med.180. 165-171 (1994)

[文献書誌] Hanabuchi S.: "Fas and its ligand in a general mechanism of T cell-mediated cytotoxity." Proc.Natl.Acad.Sci.USA. 91. 4930-4934 (1994)

[文献書誌] Koide Y.: "Molecular analysis of the pathogenesis of autoimmune insulitis in NOD mice." Tohoku J.Exp.Med.173. 157-170 (1994)

[文献書誌] Nakano T.: "Generation of lymphomatopoietic cells from embryonic stem cells in culture." Science. 265. 1098-1101 (1994)

[文献書誌] Kishimoto,T.: "Cytokine signal transduction." Cell. 76. 253-262 (1994)

[文献書誌] Akira S.: "Molecular cloning of APRF,a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp 130-mediated signaling pathway." Cell. 77. 63-71 (1994)

[文献書誌] Kaisho T.: "EST-1,a surface molecule of bone marrow stromal cell lines that facilitates pre-B cell growth." Proc.Natl.Acad.Sci.USA. 91. 5325-5329 (1994)

[文献書誌] Sawada M.: "cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells." Biochm.Biophys.Res.Commun.203. 479-484 (1994)

[文献書誌] Tanaka N.: "Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1." Cell. 77. 829-839 (1994)

[文献書誌] Kimura T.: "Involvement of the IRF-1 transcription factor in antiviral responses to interferones." Science. 264. 1921-1924 (1994)

[文献書誌] Isobe M.: "Immunosuppression to cardiac allografts and soluble antigens by anti-VCAM-1 and anti-VLA-4 monoclonal antibodies." J.Immunol.153. 5810-5818 (1994)

1994 年度実績報告書

笹月健彦九州大学, 生体防御医学研究所, 教授 (50014121)