• 研究課題をさがす
  • 研究者をさがす
  • KAKENの使い方
  1. 課題ページに戻る

1997 年度 実績報告書

C型肝炎ウイルスによる心筋炎・心筋症発症機序の解明

研究課題

研究課題/領域番号 08457207
研究機関京都大学

研究代表者

松森 明  京都大学, 医学研究科, 講師 (70135573)

キーワードC型肝炎ウイルス / 心筋症 / 拡張型心筋症 / 肥大型心筋症 / 心筋炎 / PCR法 / 肝炎 / ウイルス
研究概要

【目的】近年、われわれの研究により、心筋症の病因としてC型肝炎ウイルス(HCV)感染の重要性が明らかになった。拡張型心筋症53例中8例(15.1%)、肥大型心筋症66例中11例(16.7%)において血清HCV抗体が陽性であった。これは虚血性心疾患40例中1例(2.5%)に比し有意に高頻度であった(p<0.05)。HCV抗体陽性であった拡張型心筋症8例において、7例は心不全、1例は心室頻拍、3例は急性心筋炎が疑われる病歴を有していた。また、5例の心筋標本からHCVゲノムのプラス鎖RNAを認め、このうち3例ではマイナス鎖RNAを認めた。一方、NCV抗体陽性であった肥大型心筋症11例においては、剖検心1例および生検心筋5例の6例前列の心筋標本からウイルスRNAを認め、このうち2例では血中HCVRNAが検出されなかった。また、多施設の共同研究としてわが国における心筋症におけるHCV感染およびHCV抗体陽性者の臨床像に関するアンケート調査を行った結果、拡張型心筋症619例中37例(6.0%)、肥大型心筋症585例中61例(10.4%)において血清HCV抗体が陽性であった。一方、HCV抗体陽性者は11,210例中604例(5.4%)に見られた。このHCV抗体陽性例の臨床診断名は不整脈、高血圧症をはじめとして多くの疾患でみられ、HCV感染は心筋症意外の心疾患にも関与している可能性が示唆された。
HCV抗体陽性例における心電図異常は62.8%にみられ、不整脈、伝導障害が46.6%と最も頻度が高く、左室肥大が65.9%、非対象中隔肥大が28.9%にみられ、また駆出率の低下も34.4%にみられた。これらの結果から、HCV感染は心筋症に加え他の心異常をもきたす可能性が示唆された。

  • 研究成果

    (36件)

すべて その他

すべて 文献書誌 (36件)

  • [文献書誌] Furukawa Y.et al.: "Angiotensin II receptor antagonist TCV-116 reduces graft coronary artery disease and preserves graft status in a murine model." Circulation. 93. 333-339 (1996)

  • [文献書誌] Sasayama S, et al.: "Role of cytokines in the syndrome of heart failure." Int Med. 35. 60-63 (1996)

  • [文献書誌] Matsumori A, et al.: "Increased circulating hepatocyte growth factor in early stage of acute myocardial infarction." Biochem Biophys Res Commun. 221. 391-395 (1996)

  • [文献書誌] Furukawa Y, et al.: "Immunomodulation by an adenylate cyclase activator,NKH477,in vivo and in vitro." Clin Immunol Immunopathol. 79. 25-35 (1996)

  • [文献書誌] Hasegawa K, et al.: "Endothelin-1 and its receptor in hypertrophic cardiomyopathy." Hypertension. 27. 254-264 (1996)

  • [文献書誌] Matsumori A.et al.: "Detection of hepatitis C virus RNA from the heart of patients with hypetrophic cardiomyopathy." Biochem Biophys Res Commun. 222. 678-682 (1996)

  • [文献書誌] Matsumori A.: "Cytokines in myocarditis and cardiomyopathies." Curr Opin Cardiol. 11. 302-309 (1996)

  • [文献書誌] Matsumori A, et al.: "Antimyosin antibody imaging in clinical myocarditis and cardiomyopathy : principle and application." Int J Cardiol. 54. 183-190 (1996)

  • [文献書誌] Matsumori A, et al.: "Inotropic agents differentially inhibit the induction of nitric oxide synthase by endotoxin in cultured macrophages." Life Sci. 59. PL121-PL125 (1996)

  • [文献書誌] LiL-X, et al.: "Comparative study of 201TI-scintigraphic image and myocardial pathologic findings in patients with dilated cardiomyodathv." Nucl Med. 10. 307-314 (1996)

  • [文献書誌] Nakamura H, et al.: "A pathogenic mechanisms of chronic ongoing myocarditis." Jpn Circ J. 60. 609-617 (1996)

  • [文献書誌] Matsumori A, et al.: "Differential modulation of cytokine production by drugs : Implication for therapy in heart failure." J Mol Cell Cardiol. 28. 2491-2499 (1996)

  • [文献書誌] Sasayama S, et al.: "Vesnarinone : A Potential Cytokine Inhibitor." J Cardiac Failure. 2. 251-258 (1996)

  • [文献書誌] Shioi T, et al.: "Persistent expression of cytokine in the chronic stage of viral myocarditis in mice." Circulation. 94. 2930-2937 (1996)

  • [文献書誌] Matsumori A, et al.: "Newer aspects of pathogenesis of heart failure : Hepatitis C virus infection in myocarditis and cardiomyopathy." J Cardiac Failure. 2. S187-S194 (1996)

  • [文献書誌] Sasayama S, et al.: "Immunomodulation : A new horizon for medical treatment of heart failure." J Cardiac Failure. 2. S287-S294 (1996)

  • [文献書誌] Tadamura E, et al.: "Myocardial metabolic changes in hypertrophic cardiomyopathy." J Nucl Med. 37. 572-577 (1996)

  • [文献書誌] Nakamura H, et al.: "Autoimmune response in chronic ongoing myocarditis demonstrated by heterotopic cardiac transplantation in mice." Circulation. 94. 3348-3354 (1996)

  • [文献書誌] Sasayama S, et al.: "Immunomodulatory therapy and survival with cardiac disease." Heart Failure Reviews. 1. 221-227 (1996)

  • [文献書誌] Sato Y, et al.: "Elevated circulating levels of tumor necrosis factor in patients with mitral valve disease and ventricular septum defect." Heart Vessels. 11. 218-220 (1996)

  • [文献書誌] Wang W-Z, et al.: "Beneficial effects of amlodipine in a murine model of congestive heart failure induced by viral myocarditis : A possible mechanism through inhibition of nitric oxide production." Circulation. 95. 245-251 (1997)

  • [文献書誌] Matsumori A.: "Implications of cytokine inhibition for the drug therapy of heart failure." BioDrugs. 7. 107-118 (1997)

  • [文献書誌] Hirozane T, et al.: "Prolongation of murine cardiac allograft survival with vesnarinone." J Mol Cell Cardiol. 29. 67-76 (1997)

  • [文献書誌] Matsumori A, et al.: "Plasma levels of the monocyte chemotactic and activating factor/monocyte chemotactic protein-1 are elevated in patients with acute myocardial infarction." J Mol Cell Cardiol. 29. 419-423 (1997)

  • [文献書誌] Matsumori A.: "Molecular and immune mechanisms in the pathogenesis of cardiomyopathy." Jpn Circ J. 61. 275-291 (1997)

  • [文献書誌] Ono K, et al.: "Enhanced expression of hepatocyte growth factor/c-met by myocardial ischemia and reperfusion in a rat model." Circulation. 95. 2552-2558 (1997)

  • [文献書誌] Yamada T, et al.: "Indium-111 antimyosin antibody imaging and thallium-201 imaging : A comparative myocardial scintigraphic study using SPECT in patients with myocarditis and dilated cardiomyopathy." Jpn Circ J. 61. 827-835 (1997)

  • [文献書誌] Matsumori A, et al.: "Modulation of cytokine production and protection against lethal endotoxemia by the cardiac glycoside ouabain." Circulation. 96. 1501-1506 (1997)

  • [文献書誌] Matsumori A, et al.: "Amiodarone inhibits production of tumor necrosis factor-α by human mononuclear cells. A possible mechanism for its effect in heart failure." Circulation. 96. 1386-1389 (1997)

  • [文献書誌] Shioi T, et al.: "Increased expression of interleukin-1 β and monocyte chemotactic and activating factor (MCAF)/monocyte chemoattractant protein-1 (MCP-1) in the hypertrophied and failing heart with pressure overload." Circ Res. 81. 664-671 (1997)

  • [文献書誌] Sato Y, et al.: "Measuring serum aminoterminal type III procollagen peptide,7S domain of type IV collagen,and cardiac troponin T in patients with idiopathic dilated cardiomyopathy and secondary cardiomyopathy." HEART. 78. 505-508 (1997)

  • [文献書誌] Shioi T, et al: "Protective role of Interleukin-12 in viral myocarditis." J Mol Cell Cardiol. 29. 2327-2334 (1997)

  • [文献書誌] Matsumori A.: "Calcium channel blocker-induced protection against cardiovascular damage." Int.J.Cardiol.62. S39-S46 (1997)

  • [文献書誌] Matsumori A.: "The use of cytokine inhibitors A new therapeutic insight into heart failure." Int.J.Cardiol.62. S3-S12 (1997)

  • [文献書誌] Matsumori A, et al.: "Edited by Sasayama S,Springer-Verlag,Tokyo" Cytokines and heart failure : Immunomodulating agents for the management of heart failure. In New Horizons for Failing Heart Syndrome,14 (1996)

  • [文献書誌] Sasayama S, et al.: "Edited by Endoh M,Morad M,Scholz H,Iijima T,Springer-Verlag,Tokyo" Immunomodulating effects as new aspects of a positive inotropic agent. In Molecular and Cellular Mechanism of Cardiovascular Regulation,11 (1996)

URL: 

公開日: 1999-03-15   更新日: 2016-04-21  

サービス概要 検索マニュアル よくある質問 お知らせ 利用規程 科研費による研究の帰属

Powered by NII kakenhi