1997 年度実績報告書

アメリカ大陸を中心としたがん研究先進グループとの研究交流

研究課題

研究課題/領域番号	09042002
研究種目	国際学術研究
研究機関	東京大学
研究代表者	山本雅東京大学, 医科大学研究所, 教授 (40134621)
研究分担者	浜口道成名古屋大学, 医学部, 教授 (90135351) 後藤典子東京大学, 医科学研究所, 助手 (10251448) 神田浩明 (財)癌研究会癌研究所, 病理部, 研究員 (90260067) 上出利光北海道大学, 免疫科学研究所, 教授 (00160185) 秋山伸一鹿児島大学, 医学部, 教授 (60117413)
キーワード	国際学術 / 海外派遣 / ウイルス発癌 / シグナル伝達 / 細胞接着 / 細胞周期 / 癌治療 / 化学発癌
研究概要	近年の発がん遺伝子やがん抑制遺伝子に関する研究の進展は、がん発症の仕組みを分子レベルで理解する上で大きく貢献した。さらにまた、発生工学的手法を用いたがんモデル動物に関する研究や、ゲノムプロジェクトに基づくがん関連遺伝子の研究の進展は、細胞の増殖制御に関する、遺伝子・蛋白質・細胞レベルの研究と相俟って、がん研究を進展される大きな力となっている。一方でこのような遺伝子レベル研究成果に基づいて、特定のがんの遺伝子診断が可能となっている。またがん遺伝子・がん抑制遺伝子とその産物の機能に関する知見に基づいて、遺伝子治療をはじめとする新しいがん治療の試みが大きく進展しようとしている。このような研究において、我が国の研究者が果たしている役割は極めて大きい。一方で、アメリカ合衆国等アメリカ大陸のいては、国際的にも極めて先進的な研究が進められている。我が国のがん研究に従事している第一線の研究者がそのような研究者と交流を深め、共同研究や情報交換を推し進めることは、我が国のがん研究、がん治療を推進する上で大変有意義である。その目的に沿って本年度は22名の研究者を米国の研究室や研究集会に派遣した。我が国のがん研究の進展を支えている文部省科学研究費「がん重点」の総括班から推薦された研究者を中心に、今年度は特にがん転移、がん遺伝子診断に重きをおきながらも、がん研究の諸領域、つまりがん治療、抗がん剤、免疫、ゲノム安定性、疫学、シグナル伝達、細胞周期、不死化、ウイルス発がんに係わる研究を推進している研究者を派遣した。このような派遣を通して、細胞増殖の制御、がん転移に関する新しい視点を得、たがん治療に関して薬品設計や遺伝子治療等の貴重な情報の交換を行った。

研究成果
(22件)

すべてその他

すべて文献書誌 (22件)

[文献書誌] Shinichi Akiyama: "A canalicular multispecific organic anion transporter(cMOAT) antisense cDNA enhances drug sensitivity in human cancer cells" Cancer Res.57. 5475-5479 (1997)
[文献書誌] Jun-ichi Nakayama: "TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats familt" Cell. 88. 875-884 (1997)
[文献書誌] Hiroyuki Yamamoto: "Association of reduced cell adhesion regulator messenger RNA expression with tumor progression in human hepatocellular carcinoma" Int.J.Cencer(pred.Oncol.). 74. 251-254 (1997)
[文献書誌] Mitsuru Hayakawa: "B7-1-transfected tumor vaccine countaracts chemotherapy-induced immunosuppression and prolongs the survival of rats bearing highly metastatic osteosarcoma cells" Int.J.Cnacer. 71. 1091-1102 (1997)
[文献書誌] Ken-ichi Takeyama: "25-hydroxyvitamin D_3 1α-hydroxylase and vitamin D synthesis" Science. 277. 1827-1830 (1997)
[文献書誌] Satomi Kuramochi: "LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes" J.Biol.Chem.272. 22679-22684 (1997)
[文献書誌] Masahiko Obata: "Loss of heterozygosity at Loci on chromosome 4,a common genetic event during the spontaneous immortalization of mouose embryonic fivroblasts" Molecular Carcinogenesis. 19. 17-24 (1997)
[文献書誌] Noriko Gotoh: "Tyrosine phosphorylation sites at amino acids 239 and 240 of She are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/Mitogen-activated proteinkinase activation" Molecular Cellular Biology. 17. 1824-1831 (1997)
[文献書誌] Keisuke Sasai: "Radiation therapy of rocular chorodial neovascularization(phase I/II study): preliminary report" Int.J.Radiation Oncology Biol.Phys.39. 173-178 (1997)
[文献書誌] Kazuo Takahashi: "Direct interaction of teh Rho GDP dissociation inhibitor with Ezrrm/Radixin/Moesin initiates the activation of the Fho small G prtorein" J.Biol.Chem.37. 23371-23376 (1997)
[文献書誌] Takashi Kojima: "Different changes in expression and function of connexin 26 and connexin 32 during DNA synthesis and redifferentiation in primary rat hepatocytes using a DMSO culture system" Hepatology. 26. 585-597 (1997)
[文献書誌] Hideo Yanai: "Epstein-BARR virus infection in non-carcinomatous gasteric epithelium" Journal of Pathology. 183. 293-298 (1997)
[文献書誌] Tatsuroh Joh: "Chimetic MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11)(q27;q23)leukemia localize in the nucleus" Oncogene. 15. 1681-1687 (1997)
[文献書誌] Yutaka Takahashi: "Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer" Archives of Surgery. 132. 541-546 (1997)
[文献書誌] Yoshitaka Tsubono: "Food consumption and gastric cnacer mortality in five regions of Japan" Nutrition and Cancer. 27. 60-64 (1997)
[文献書誌] Tokutaro Yasue: "A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5" Proc.Natl.Acad.Sci.USA. 94. 10307-10312 (1997)
[文献書誌] Aye Aye Thant: "c-RAs is required for the activation of the matrix metalloproteinases by concanavalin A in 3Y1 cells" FEBS Letter. 406. 28-30 (1997)
[文献書誌] Tetsuya Nakamoto: "Requirements for localization of p130^<cas> to focal adhesions" Molecular and Cellular Biology. 17. 3884-3897 (1997)
[文献書誌] Mariko Kashiwagi: "Specific Inhibition on hair follicle formation by epidermal growth factor in an organ culture of developing mouse skin" Developmental Biology. 189. 22-32 (1997)
[文献書誌] Susannah M.W-Murphy: "Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases" Molecular and Cellular Biology. 17. 1289-1297 (1997)
[文献書誌] Testuo Mashima: "Actin cleavage by CPP-32/apopain during the development of apoptosis" Oncogene. 14. 1007-1012 (1997)
[文献書誌] Hisashi Umemori: "Activation of the G protein Gq/11 through tyrosine phosphorylation of the α subunit" Science. 276. 1878-1881 (1997)

1997 年度 実績報告書

アメリカ大陸を中心としたがん研究先進グループとの研究交流

研究代表者

山本 雅 東京大学, 医科大学研究所, 教授 (40134621)

研究成果

[文献書誌] Shinichi Akiyama: "A canalicular multispecific organic anion transporter(cMOAT) antisense cDNA enhances drug sensitivity in human cancer cells" Cancer Res.57. 5475-5479 (1997)

[文献書誌] Jun-ichi Nakayama: "TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats familt" Cell. 88. 875-884 (1997)

[文献書誌] Hiroyuki Yamamoto: "Association of reduced cell adhesion regulator messenger RNA expression with tumor progression in human hepatocellular carcinoma" Int.J.Cencer(pred.Oncol.). 74. 251-254 (1997)

[文献書誌] Mitsuru Hayakawa: "B7-1-transfected tumor vaccine countaracts chemotherapy-induced immunosuppression and prolongs the survival of rats bearing highly metastatic osteosarcoma cells" Int.J.Cnacer. 71. 1091-1102 (1997)

[文献書誌] Ken-ichi Takeyama: "25-hydroxyvitamin D_3 1α-hydroxylase and vitamin D synthesis" Science. 277. 1827-1830 (1997)

[文献書誌] Satomi Kuramochi: "LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes" J.Biol.Chem.272. 22679-22684 (1997)

[文献書誌] Masahiko Obata: "Loss of heterozygosity at Loci on chromosome 4,a common genetic event during the spontaneous immortalization of mouose embryonic fivroblasts" Molecular Carcinogenesis. 19. 17-24 (1997)

[文献書誌] Noriko Gotoh: "Tyrosine phosphorylation sites at amino acids 239 and 240 of She are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/Mitogen-activated proteinkinase activation" Molecular Cellular Biology. 17. 1824-1831 (1997)

[文献書誌] Keisuke Sasai: "Radiation therapy of rocular chorodial neovascularization(phase I/II study): preliminary report" Int.J.Radiation Oncology Biol.Phys.39. 173-178 (1997)

[文献書誌] Kazuo Takahashi: "Direct interaction of teh Rho GDP dissociation inhibitor with Ezrrm/Radixin/Moesin initiates the activation of the Fho small G prtorein" J.Biol.Chem.37. 23371-23376 (1997)

[文献書誌] Takashi Kojima: "Different changes in expression and function of connexin 26 and connexin 32 during DNA synthesis and redifferentiation in primary rat hepatocytes using a DMSO culture system" Hepatology. 26. 585-597 (1997)

[文献書誌] Hideo Yanai: "Epstein-BARR virus infection in non-carcinomatous gasteric epithelium" Journal of Pathology. 183. 293-298 (1997)

[文献書誌] Tatsuroh Joh: "Chimetic MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11)(q27;q23)leukemia localize in the nucleus" Oncogene. 15. 1681-1687 (1997)

[文献書誌] Yutaka Takahashi: "Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer" Archives of Surgery. 132. 541-546 (1997)

[文献書誌] Yoshitaka Tsubono: "Food consumption and gastric cnacer mortality in five regions of Japan" Nutrition and Cancer. 27. 60-64 (1997)

[文献書誌] Tokutaro Yasue: "A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5" Proc.Natl.Acad.Sci.USA. 94. 10307-10312 (1997)

[文献書誌] Aye Aye Thant: "c-RAs is required for the activation of the matrix metalloproteinases by concanavalin A in 3Y1 cells" FEBS Letter. 406. 28-30 (1997)

[文献書誌] Tetsuya Nakamoto: "Requirements for localization of p130^<cas> to focal adhesions" Molecular and Cellular Biology. 17. 3884-3897 (1997)

[文献書誌] Mariko Kashiwagi: "Specific Inhibition on hair follicle formation by epidermal growth factor in an organ culture of developing mouse skin" Developmental Biology. 189. 22-32 (1997)

[文献書誌] Susannah M.W-Murphy: "Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases" Molecular and Cellular Biology. 17. 1289-1297 (1997)

[文献書誌] Testuo Mashima: "Actin cleavage by CPP-32/apopain during the development of apoptosis" Oncogene. 14. 1007-1012 (1997)

[文献書誌] Hisashi Umemori: "Activation of the G protein Gq/11 through tyrosine phosphorylation of the α subunit" Science. 276. 1878-1881 (1997)

1997 年度実績報告書

山本雅東京大学, 医科大学研究所, 教授 (40134621)