1999 年度実績報告書

内在性レクチンの存在様式と意義

研究課題

研究課題/領域番号	09470004
研究機関	杏林大学
研究代表者	平野寛杏林大学, 医学部, 教授 (10086481)
キーワード	内在性レクチン / 外来性レクチン / 糖鎖 / 糖転移酵素 / 組織細胞化学 / 画像処理 / 転移 / 分化
研究概要	ガレクチン-1とガレクチン-3とは、その局在性が異なっていた。即ち,ガレクチン-1は主に糸球体および尿細管間質に存在し、一方、ガレクチン-3は主に遠位尿細管と集合管に局在することが確認された。また、ガレクチンの局在は、同じ種類の細胞においても発現している場合と、そうでない場合があり、cell cycleによっても発現が変化すると推測された。

研究成果

(32件)

すべてその他

すべて文献書誌 (32件)

[文献書誌] Takata K,Fujikura K,Suzuki M,Suzuki T,Hirano H: "GLUT1 glucose transporter in the lactating mammary gland in the rat"Acta Histochem Cytochem. 30. 623-628 (1997)
[文献書誌] Takata K,Hirano H: "Mechanism of glucose transport across the human and rat placental barrier:A review"Microsc Res Tech. 38. 145-152 (1997)
[文献書誌] Mizuochi S,Akimoto Y,Imai Y,Hirano H,Irimura T: "Unique tissue distribution of a mouse macrophage C-type lectin"Glycobiology. 7. 137-146 (1997)
[文献書誌] Okada T,Hirano H,Takahashi K,Okamura Y: "Distinct neuronal lineages of the ascidian embryo revealed by expression of a sodium channel gene"Dev Biol. 190. 257-272 (1997)
[文献書誌] Yamaguchi H,Osaki T,Taguchi H,Yamamoto T,Hanawa T,Fukuda M,Kawakami H,Hirano H,Kamiya S: "Growth inhibition of Helicobacter pylori by monoclonal antibody to heat-shock protein 60"Microbiol Immunol. 41. 909-916 (1997)
[文献書誌] 松田実,福島久喜,田中良太,山東生弥,花岡健夫,呉屋朝幸,宮東昭彦,川上速人,平野寛: "乳癌組織におけるHSP90・pS2とホルモンレセプターの免疫組織化学的検討"乳癌基礎研究. 6. 24-28 (1997)
[文献書誌] 平野寛企画・構成,宮東昭彦,柴田知子,平野寛: "精巣生殖細胞におけるアンドロゲンレセプター-螢光標識法,共焦点レーザー走査顕微鏡法の適用"Mebio. 14(6). 129-131 (1997)
[文献書誌] Mitsunaga-Nakatsubo K,Akasaka K,Akimoto Y,Akiba E,Kitajima T,Tomita M,Hirano H,Shimada H: "Arylsulfatase exists as non-enzymatic cell surface protein in sea urchin embryos"J Exp Zool. 280. 220-230 (1998)
[文献書誌] Mizuochi S,Akimoto Y,Imai Y,Hirano H,Irimura T: "Immunohistochemical study on a macrophage calcium-type lectin in mouse embryos:transient expression in chondroblasts during endochondral ossification"Glycoconjugate J. 15. 397-404 (1998)
[文献書誌] Osaki T,Yamaguchi H,Tagushi H,Fukuda M,Kawakami H,Hirano H,Watanabe S,Takagi A,Kamiya S: "Establishment and characterisation of a monoclonal antibody to inhibit adhesion of Helicobacter pylori to gastric epithelial cells"J Med Microbiol. 47. 505-512 (1998)
[文献書誌] Kurosaki M,Watanabe T,Hori T,Hirai K,Kawakami H,Hirano H: "Co-localization of human growth hormone and human prolactin in hormonally pure human growth hormone-producing pituitary adenomas"Neurol Med-Chir. 38. 335-341 (1998)
[文献書誌] Kobayashi Y,Kawakami H,Yoshino Y,Hirano H: "Binding of Griffonia simplicifolia I-B4 lectin in the substantia gelatinosa of the rat spinal cord"Acta Histochem Cytochem. 31. 509-515 (1998)
[文献書誌] 川上速人,平野寛: "血小板の電子顕微鏡像活性化と突起形成"MEDICO. 29. 12870-12871 (1998)
[文献書誌] 秋元義弘,Hart GW,Kreppel LK,平野寛: "O-GlcNAcと細胞機能"蛋白質核酸酵素. 43(16). 2574-2581 (1998)
[文献書誌] 松田実,須田一晴,喜多秀文,田中良太,山東生弥,福島久喜,花岡健夫,呉屋朝幸,宮東昭彦,川上速人,平野寛: "乳癌組織におけるHSP90・pS2とホルモンレセプターの免疫組織化学的検討"乳癌基礎研究. 7(Proceeding). 24-28 (1998)
[文献書誌] 平野寛企画・構成,秋元義弘、Hart GW, Kreppel LK,平野寛: "大動脈ならびに大動脈由来平滑筋細胞におけO-GlcNAc移転酵素"Mebio. 15(4). 111-113 (1998)
[文献書誌] 平野寛企画・構成,秋元義弘,Hart GW, Kreppel LK,平野寛: "膵臓における糖転移酵素"Mebio. 15(9). 115-117 (1998)
[文献書誌] Hirano H: "Factors promoting research and development in electron microscopy in Japan"JEOL news. 34. 8-9 (1999)
[文献書誌] Fukawa W,Kawakami H,Hirano H: "Changes in lectin binding pattern in rat esophageal epithelium during development"Okajimas Folia Anat Jpn. 75. 335-344 (1999)
[文献書誌] Kawakami H,Hirano H: "Importance of carbohydrates and platelets in the early events of cancer metastasis"Acta Histochem Cytochem. 32. 203-208 (1999)
[文献書誌] Kubo A,Hirano H: "The practical side of image processing with the use of a personal computer:Automation of the analyzing processes employing NIH image and Adobe Photoshop with Power Macintosh Computers"Acta Histochem Cytochem. 32. 229-233 (1999)
[文献書誌] Akimoto Y,Kreppel LK,Hirano H,Hart GW: "Localization of the O-linked N-acetylglucosamine transferase in rat pancreas"Diabetes. 48. 2407-2413 (1999)
[文献書誌] Hanawa T,Fukuda M,Kawakami H,Hirano H,Shigeru Kamiya,Yamamoto T: "The Listeria monocytogenes DnaK chaperone is required for stress tolerance and efficient phagocytosis with macrophages"Cell Stress Chaperones. 4. 118-128 (1999)
[文献書誌] Yan K,Kudo A,Hirano H,Watanabe T,Tasaka T,Kataoka S,Nakajima N,Nishibori Y,Shibata T,Kohsaka T,Higashihara E,Tanaka H,Watanabe H,Nagasawa T,Awa S: "Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus"Kidney Int. 56. 65-73 (1999)
[文献書誌] Yamamoto K,Kawakami H,Sugiyama M,Atomi Y,Hirano H: "Immunohistochemical localization of β-1,4-galactosyltransferase in human pancreatic tissues"Pancreas. 19. 137-142 (1999)
[文献書誌] Kamiya S,Yamaguchi H,Osaki T,Fukuda M,Kawakami H,Hirano H: "Effect of an aluminum hydroxide-magnesium hydroxide combination drug on adhesion,IL-8 inducibility,and expression of HSP60 by Helicobacter pylori"Scand J Gastroenterol. 34. 663-670 (1999)
[文献書誌] Negishi Y,Kubo A,Obinata A,Kawashima K,Hirano H,Yanai N,Obinata M,Endo H: "Multipotency of a bone marrow stromal cell line,TBR31-2,established from ts-SV40 T antigen gene transgenic mice"Biochem Biophys Res Commun. 268. 450-455 (2000)
[文献書誌] Kosaka Y,Akimoto Y,Obinata A,Hirano H: "Expression of the HB9 homeobox gene concomitant with proliferation accompanying epidermal stratification during development of chick embryonic tarsometatarsal skin"Histochemical J. (in press). (2000)
[文献書誌] Takata K,Hirano H,Kasahara M: "Transport of glucose across the blood-tissue barriers"Int Rev Cytol 172. 53 (1997)
[文献書誌] Akimoto Y,Imai Y,Hirabayashi J,Kasai K,Hirano H: "Histochemistry and cytochemistry of endogenousanimal lectins"Progress in Histochemistry and Cytochemistry 33(1). 92 (1998)
[文献書誌] 川上速人,平野寛: "グライドバイオロジーへの電子顕微鏡の応用.電子顕微鏡基礎技術と応用 1999-電子顕微鏡で見るために-(第10回電顕サマースクール実行委員会編)"学際企画,東京. 10 (1999)
[文献書誌] 川上速人,平野寛: "糖蛋白質および糖脂質糖鎖の組織化学的検出.組織細胞化学 1999(日本組織細胞化学会編)"学際企画,東京. 6 (1999)

1999 年度 実績報告書

内在性レクチンの存在様式と意義

研究代表者

平野 寛 杏林大学, 医学部, 教授 (10086481)

研究成果

[文献書誌] Takata K,Fujikura K,Suzuki M,Suzuki T,Hirano H: "GLUT1 glucose transporter in the lactating mammary gland in the rat"Acta Histochem Cytochem. 30. 623-628 (1997)

[文献書誌] Takata K,Hirano H: "Mechanism of glucose transport across the human and rat placental barrier:A review"Microsc Res Tech. 38. 145-152 (1997)

[文献書誌] Mizuochi S,Akimoto Y,Imai Y,Hirano H,Irimura T: "Unique tissue distribution of a mouse macrophage C-type lectin"Glycobiology. 7. 137-146 (1997)

[文献書誌] Okada T,Hirano H,Takahashi K,Okamura Y: "Distinct neuronal lineages of the ascidian embryo revealed by expression of a sodium channel gene"Dev Biol. 190. 257-272 (1997)

[文献書誌] Yamaguchi H,Osaki T,Taguchi H,Yamamoto T,Hanawa T,Fukuda M,Kawakami H,Hirano H,Kamiya S: "Growth inhibition of Helicobacter pylori by monoclonal antibody to heat-shock protein 60"Microbiol Immunol. 41. 909-916 (1997)

[文献書誌] 松田 実,福島久喜,田中良太,山東生弥,花岡健夫,呉屋朝幸,宮東昭彦,川上速人,平野 寛: "乳癌組織におけるHSP90・pS2とホルモンレセプターの免疫組織化学的検討"乳癌基礎研究. 6. 24-28 (1997)

[文献書誌] 平野 寛 企画・構成,宮東昭彦,柴田知子,平野 寛: "精巣生殖細胞におけるアンドロゲンレセプター-螢光標識法,共焦点レーザー走査顕微鏡法の適用"Mebio. 14(6). 129-131 (1997)

[文献書誌] Mitsunaga-Nakatsubo K,Akasaka K,Akimoto Y,Akiba E,Kitajima T,Tomita M,Hirano H,Shimada H: "Arylsulfatase exists as non-enzymatic cell surface protein in sea urchin embryos"J Exp Zool. 280. 220-230 (1998)

[文献書誌] Mizuochi S,Akimoto Y,Imai Y,Hirano H,Irimura T: "Immunohistochemical study on a macrophage calcium-type lectin in mouse embryos:transient expression in chondroblasts during endochondral ossification"Glycoconjugate J. 15. 397-404 (1998)

[文献書誌] Osaki T,Yamaguchi H,Tagushi H,Fukuda M,Kawakami H,Hirano H,Watanabe S,Takagi A,Kamiya S: "Establishment and characterisation of a monoclonal antibody to inhibit adhesion of Helicobacter pylori to gastric epithelial cells"J Med Microbiol. 47. 505-512 (1998)

[文献書誌] Kurosaki M,Watanabe T,Hori T,Hirai K,Kawakami H,Hirano H: "Co-localization of human growth hormone and human prolactin in hormonally pure human growth hormone-producing pituitary adenomas"Neurol Med-Chir. 38. 335-341 (1998)

[文献書誌] Kobayashi Y,Kawakami H,Yoshino Y,Hirano H: "Binding of Griffonia simplicifolia I-B4 lectin in the substantia gelatinosa of the rat spinal cord"Acta Histochem Cytochem. 31. 509-515 (1998)

[文献書誌] 川上速人,平野 寛: "血小板の電子顕微鏡像 活性化と突起形成"MEDICO. 29. 12870-12871 (1998)

[文献書誌] 秋元義弘,Hart GW,Kreppel LK,平野 寛: "O-GlcNAcと細胞機能"蛋白質核酸酵素. 43(16). 2574-2581 (1998)

[文献書誌] 松田 実,須田一晴,喜多秀文,田中良太,山東生弥,福島久喜,花岡健夫,呉屋朝幸,宮東昭彦,川上速人,平野 寛: "乳癌組織におけるHSP90・pS2とホルモンレセプターの免疫組織化学的検討"乳癌基礎研究. 7(Proceeding). 24-28 (1998)

[文献書誌] 平野 寛 企画・構成,秋元義弘、Hart GW, Kreppel LK,平野 寛: "大動脈ならびに大動脈由来平滑筋細胞におけO-GlcNAc移転酵素"Mebio. 15(4). 111-113 (1998)

[文献書誌] 平野 寛 企画・構成,秋元義弘,Hart GW, Kreppel LK,平野 寛: "膵臓における糖転移酵素"Mebio. 15(9). 115-117 (1998)

[文献書誌] Hirano H: "Factors promoting research and development in electron microscopy in Japan"JEOL news. 34. 8-9 (1999)

[文献書誌] Fukawa W,Kawakami H,Hirano H: "Changes in lectin binding pattern in rat esophageal epithelium during development"Okajimas Folia Anat Jpn. 75. 335-344 (1999)

[文献書誌] Kawakami H,Hirano H: "Importance of carbohydrates and platelets in the early events of cancer metastasis"Acta Histochem Cytochem. 32. 203-208 (1999)

[文献書誌] Kubo A,Hirano H: "The practical side of image processing with the use of a personal computer:Automation of the analyzing processes employing NIH image and Adobe Photoshop with Power Macintosh Computers"Acta Histochem Cytochem. 32. 229-233 (1999)

[文献書誌] Akimoto Y,Kreppel LK,Hirano H,Hart GW: "Localization of the O-linked N-acetylglucosamine transferase in rat pancreas"Diabetes. 48. 2407-2413 (1999)

[文献書誌] Hanawa T,Fukuda M,Kawakami H,Hirano H,Shigeru Kamiya,Yamamoto T: "The Listeria monocytogenes DnaK chaperone is required for stress tolerance and efficient phagocytosis with macrophages"Cell Stress Chaperones. 4. 118-128 (1999)

[文献書誌] Yan K,Kudo A,Hirano H,Watanabe T,Tasaka T,Kataoka S,Nakajima N,Nishibori Y,Shibata T,Kohsaka T,Higashihara E,Tanaka H,Watanabe H,Nagasawa T,Awa S: "Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus"Kidney Int. 56. 65-73 (1999)

[文献書誌] Yamamoto K,Kawakami H,Sugiyama M,Atomi Y,Hirano H: "Immunohistochemical localization of β-1,4-galactosyltransferase in human pancreatic tissues"Pancreas. 19. 137-142 (1999)

[文献書誌] Kamiya S,Yamaguchi H,Osaki T,Fukuda M,Kawakami H,Hirano H: "Effect of an aluminum hydroxide-magnesium hydroxide combination drug on adhesion,IL-8 inducibility,and expression of HSP60 by Helicobacter pylori"Scand J Gastroenterol. 34. 663-670 (1999)

[文献書誌] Negishi Y,Kubo A,Obinata A,Kawashima K,Hirano H,Yanai N,Obinata M,Endo H: "Multipotency of a bone marrow stromal cell line,TBR31-2,established from ts-SV40 T antigen gene transgenic mice"Biochem Biophys Res Commun. 268. 450-455 (2000)

[文献書誌] Kosaka Y,Akimoto Y,Obinata A,Hirano H: "Expression of the HB9 homeobox gene concomitant with proliferation accompanying epidermal stratification during development of chick embryonic tarsometatarsal skin"Histochemical J. (in press). (2000)

[文献書誌] Takata K,Hirano H,Kasahara M: "Transport of glucose across the blood-tissue barriers"Int Rev Cytol 172. 53 (1997)

[文献書誌] Akimoto Y,Imai Y,Hirabayashi J,Kasai K,Hirano H: "Histochemistry and cytochemistry of endogenousanimal lectins"Progress in Histochemistry and Cytochemistry 33(1). 92 (1998)

[文献書誌] 川上速人,平野 寛: "グライドバイオロジーへの電子顕微鏡の応用.電子顕微鏡 基礎技術と応用 1999-電子顕微鏡で見るために-(第10回電顕サマースクール実行委員会 編)"学際企画,東京. 10 (1999)

[文献書誌] 川上速人,平野 寛: "糖蛋白質および糖脂質糖鎖の組織化学的検出.組織細胞化学 1999(日本組織細胞化学会 編)"学際企画,東京. 6 (1999)

1999 年度実績報告書

平野寛杏林大学, 医学部, 教授 (10086481)

[文献書誌] 松田実,福島久喜,田中良太,山東生弥,花岡健夫,呉屋朝幸,宮東昭彦,川上速人,平野寛: "乳癌組織におけるHSP90・pS2とホルモンレセプターの免疫組織化学的検討"乳癌基礎研究. 6. 24-28 (1997)

[文献書誌] 平野寛企画・構成,宮東昭彦,柴田知子,平野寛: "精巣生殖細胞におけるアンドロゲンレセプター-螢光標識法,共焦点レーザー走査顕微鏡法の適用"Mebio. 14(6). 129-131 (1997)

[文献書誌] 川上速人,平野寛: "血小板の電子顕微鏡像活性化と突起形成"MEDICO. 29. 12870-12871 (1998)

[文献書誌] 秋元義弘,Hart GW,Kreppel LK,平野寛: "O-GlcNAcと細胞機能"蛋白質核酸酵素. 43(16). 2574-2581 (1998)

[文献書誌] 松田実,須田一晴,喜多秀文,田中良太,山東生弥,福島久喜,花岡健夫,呉屋朝幸,宮東昭彦,川上速人,平野寛: "乳癌組織におけるHSP90・pS2とホルモンレセプターの免疫組織化学的検討"乳癌基礎研究. 7(Proceeding). 24-28 (1998)

[文献書誌] 平野寛企画・構成,秋元義弘、Hart GW, Kreppel LK,平野寛: "大動脈ならびに大動脈由来平滑筋細胞におけO-GlcNAc移転酵素"Mebio. 15(4). 111-113 (1998)

[文献書誌] 平野寛企画・構成,秋元義弘,Hart GW, Kreppel LK,平野寛: "膵臓における糖転移酵素"Mebio. 15(9). 115-117 (1998)

[文献書誌] 川上速人,平野寛: "グライドバイオロジーへの電子顕微鏡の応用.電子顕微鏡基礎技術と応用 1999-電子顕微鏡で見るために-(第10回電顕サマースクール実行委員会編)"学際企画,東京. 10 (1999)

[文献書誌] 川上速人,平野寛: "糖蛋白質および糖脂質糖鎖の組織化学的検出.組織細胞化学 1999(日本組織細胞化学会編)"学際企画,東京. 6 (1999)