1997 年度実績報告書

無機有機複合体による生物機能の高次制御

研究課題

研究課題/領域番号	09594003
研究機関	奈良女子大学
研究代表者	矢野重信奈良女子大学, 理学部, 教授 (60011186)
研究分担者	藤井有起茨城大学, 理学部, 教授 (50007564) 大倉一郎東京工業大学, 生命理工学部, 教授 (90089821) 長野哲雄東京大学, 大学院・薬学研究科, 教授 (20111552) 柴原隆志岡山理科大学, 理学部, 教授 (10252826) 大川尚士九州大学, 大学院・理学研究科, 教授 (00037219)
キーワード	dブロック元素 / エネルギー変換 / 水素発生 / 錯体触媒 / 分子変換 / 金属クラスター / 多核錯体 / 酸素類似機能
研究概要	1.無機化学者、有機化学者、物理化学者と薬学者の強力な連携のもとにdブロック元素化学のハイパーイノベーション(超新機軸)を拓くことを目的として研究を行った。 2.新規大環状ヘテロ二核錯体の構造、物性、機能を調べた(大川)。光エネルギー変換用ポルフィリン類を開発した(大倉)。銅イオン中心における分子状酸素の活性化とアルカンの水酸化反応機構を解明した(伊東、福住)。電極被覆有機高分子膜に分散した亜鉛ポルフィリンが光電気化学的にプロトンを還元して水素を発生することを見いだした(金子)。錯体の集合化により生体との類似性を見いだした(木下)。新規オキソ架橋Ru,Os,Re複核錯体によるルイス酸付加と共役した酸化還元挙動を明かにした(佐々木)。硫黄架橋錯体のアミン配位子からの水素イオン解離を見いだした(柴原)。遷移金属スルフィド錯体およびその複合体を構築した(巽)。プロトン濃度変化によるエネルギー変換を行った(田中)。細胞内のZn^<2+>をバイオイメージングとして捉える蛍光プローブ試薬を開発した(長野)。Mn(III)ポルフィリン二重体の過酸酸化による四価二核錯体への定量的変換と酸素発生錯体との関連を解明した(成田)。高度好塩菌フェレドキシンの遺伝子クローニングに成功した(中村)。選択的二量化反応触媒として二核Co錯体を開発した(久枝)。銅(II)-TACH錯体によるDNAの高速・高選択的な加水分解を行った(藤井)。非ヘム鉄錯体を用いた酸素化酸素類似機能発現を行った(船引)。白金(III)の二核錯体を触媒としてオレフィンをジオールに酸化する方法を開発した(松本)。遷移金属-超分子レドックスシステムを設計合成した(平尾)。糖質を変換する三核Mn錯体を開発した(矢野、棚瀬)。加水分解酵素のZn中心と同じ配列を持つペプチドとZnイオンの相互作用を検討した。(山村)。人工ペルオキシゲナーゼの合成に成功した(渡辺)。

研究成果
(20件)

すべてその他

すべて文献書誌 (20件)

[文献書誌] S.Yano: "Trimanganese complexes with a linear MnIIMnIIIMnII assemblage bridged by carbohydarates" Chem.Commun.997-998 (1997)
[文献書誌] T.Tanase: "Peroxo-Bridged Dinuclear Cobalt (III) Complex Containing N-Glycoside Ligands from Tris (2-aminoethyl) amine and D-Glucose and its Reversible Dioxygen Binding Property" Chem.Commun.2115-2116 (1997)
[文献書誌] H.Okawa: "(μ-Phenoxo) 2CO (II) M (II) (M=Mn,Fe,Co) Core Complexes Having a ′Co (salen)′ Entity Embedded in a Macrocyclic Framework : Synthesis,Structure and Properties" Inorg.Chem.36・18. 3911-3918 (1997)
[文献書誌] S.Itoh: "Mechanistic Studies of Aliphatic Ligand Hydroxylation of a Copper Complex by Dioxygen : A Model Reaction for Copper Monooxygenases" J.Am.Chem.Soc.(in press). (1998)
[文献書誌] M.Kaneko: "Photoelectrochemical proton reduction with coated zinc-tetraphenylporphyrin dispersed into poly (4-vinylpyridine)" J.Porphyrins and Phthalocyanines. 1. 215-220 (1997)
[文献書誌] T.Tanase: "Seven-coordinate Manganese (II) Complexes with a Cage-type N-Glycoside Ligand. Configurational Switch Depending on Counter Anions" Inorg.Chim.Acta.266. 5-7 (1997)
[文献書誌] V.Y.Kukushkin: "Hydrogen-Bonding Patterns i Oxime/Oximato Platinum (II) Species Providing the Formation of One-Dimensional Chains,Two-Dimensional Networks,and Cages" Inorg.Chem.36・27. 6157-6165 (1997)
[文献書誌] C.Koshi: "Oxo-Carboxylate Bridged Diruthenium (III) Complexes of Tris (2-pyridylmethyl) amine" Chem.Lett.1155-1156 (1997)
[文献書誌] T.Shibahara: "Sulfur-Bridged Cubane-Type Molybdenum-Gallium Clusters with Mo _3GaS_4^<n+> (n=5,6) cores." Inorg.Chem.36・8. 1702-1706 (1997)
[文献書誌] H.Kawaguchi: "A New Entry into Molybdenum/Tungsten Sulfur Chemistry : Synthesis and Reactions of Mononuclear Sulfido Complexes of Pentamethylcyclopentadienyl-Molybdenum (VI) and-Tungsten (VI)" J.Am.Chem.Soc.119・43. 12008-12009 (1997)
[文献書誌] Y.Urano: "Pronounced Axial Thiolate Ligand Effect on the Reactivity of High-valent Oxo-iron Porphyrin Intermediate" J.Am.Chem.Soc.119・46. 12008-12009 (1997)
[文献書誌] Y.Naruta: "Functional Modeling of Manganese-containing O2 Evolution Enzymes with Manganese Porphyrin dimers" Inorg.Mol.Catl.chemical. 117. 115-121 (1997)
[文献書誌] A.Ikeda: "Molecular cloning of the gene encoding a 2Fe-2S ferredoxin from extremely halophilic archaeon Haloarcula japonica strain TR-1." Nucleic Acids Symp.Ser.37. 109-110 (1997)
[文献書誌] Y.Hisaeda: "Hydrophobic Vitamin B12.Part 14. Ring-expansion Reactions Catalyzed by Hydrophobic Viamin B12 under Electrochemical Conditions in Nonaqueous Medium" Electrochim.Acta.42. 2165-2172 (1997)
[文献書誌] T.Itoh: "Hydrolytic cleavage of DNA by a novel copper (II) complexwith cis," Chem.Commun.677-678 (1997)
[文献書誌] T.Funabiki: "Oxygenative Cleavage of Chlorocatechols with Moelcular Oxygen Catalyzed by Non-heme Iron (III) Complexes and its Relevance to Chlorocatechol Dioxygenases" Angew.Chem.Intern.Eng.Ed.in press (1998)
[文献書誌] J.Yuan: "Highly Sensitive Time-Resolved Fluoroimmunoassay of Human Immunoglobulin E by Usin a New Europium Fluorescent Chelate as a Label" Anal.Biochem.254. 283-287 (1997)
[文献書誌] M.Higuchi: "A Novel Synthetic Metal Catalytic System" J.Org.Chem.62・4. 1072-1078 (1997)
[文献書誌] T.Yamamura: "Conformation Control of Peptidesby Metal Ions. Coordination Conformation Correlation Observed in a Modelfor Cys-X-Y-Cys/M^<2+> in Proteins" Inorg.Chem.36. 4849-4859 (1997)
[文献書誌] T.Matsui: "On the Formation and Reactivity of Compound I of the His-64 Myoglobin Mutants" J.Bio.Chem.272・52. 32735-32738 (1997)

1997 年度 実績報告書

無機有機複合体による生物機能の高次制御

研究代表者

矢野 重信 奈良女子大学, 理学部, 教授 (60011186)

研究成果

[文献書誌] S.Yano: "Trimanganese complexes with a linear MnIIMnIIIMnII assemblage bridged by carbohydarates" Chem.Commun.997-998 (1997)

[文献書誌] T.Tanase: "Peroxo-Bridged Dinuclear Cobalt (III) Complex Containing N-Glycoside Ligands from Tris (2-aminoethyl) amine and D-Glucose and its Reversible Dioxygen Binding Property" Chem.Commun.2115-2116 (1997)

[文献書誌] H.Okawa: "(μ-Phenoxo) 2CO (II) M (II) (M=Mn,Fe,Co) Core Complexes Having a ′Co (salen)′ Entity Embedded in a Macrocyclic Framework : Synthesis,Structure and Properties" Inorg.Chem.36・18. 3911-3918 (1997)

[文献書誌] S.Itoh: "Mechanistic Studies of Aliphatic Ligand Hydroxylation of a Copper Complex by Dioxygen : A Model Reaction for Copper Monooxygenases" J.Am.Chem.Soc.(in press). (1998)

[文献書誌] M.Kaneko: "Photoelectrochemical proton reduction with coated zinc-tetraphenylporphyrin dispersed into poly (4-vinylpyridine)" J.Porphyrins and Phthalocyanines. 1. 215-220 (1997)

[文献書誌] T.Tanase: "Seven-coordinate Manganese (II) Complexes with a Cage-type N-Glycoside Ligand. Configurational Switch Depending on Counter Anions" Inorg.Chim.Acta.266. 5-7 (1997)

[文献書誌] V.Y.Kukushkin: "Hydrogen-Bonding Patterns i Oxime/Oximato Platinum (II) Species Providing the Formation of One-Dimensional Chains,Two-Dimensional Networks,and Cages" Inorg.Chem.36・27. 6157-6165 (1997)

[文献書誌] C.Koshi: "Oxo-Carboxylate Bridged Diruthenium (III) Complexes of Tris (2-pyridylmethyl) amine" Chem.Lett.1155-1156 (1997)

[文献書誌] T.Shibahara: "Sulfur-Bridged Cubane-Type Molybdenum-Gallium Clusters with Mo _3GaS_4^<n+> (n=5,6) cores." Inorg.Chem.36・8. 1702-1706 (1997)

[文献書誌] H.Kawaguchi: "A New Entry into Molybdenum/Tungsten Sulfur Chemistry : Synthesis and Reactions of Mononuclear Sulfido Complexes of Pentamethylcyclopentadienyl-Molybdenum (VI) and-Tungsten (VI)" J.Am.Chem.Soc.119・43. 12008-12009 (1997)

[文献書誌] Y.Urano: "Pronounced Axial Thiolate Ligand Effect on the Reactivity of High-valent Oxo-iron Porphyrin Intermediate" J.Am.Chem.Soc.119・46. 12008-12009 (1997)

[文献書誌] Y.Naruta: "Functional Modeling of Manganese-containing O2 Evolution Enzymes with Manganese Porphyrin dimers" Inorg.Mol.Catl.chemical. 117. 115-121 (1997)

[文献書誌] A.Ikeda: "Molecular cloning of the gene encoding a 2Fe-2S ferredoxin from extremely halophilic archaeon Haloarcula japonica strain TR-1." Nucleic Acids Symp.Ser.37. 109-110 (1997)

[文献書誌] Y.Hisaeda: "Hydrophobic Vitamin B12.Part 14. Ring-expansion Reactions Catalyzed by Hydrophobic Viamin B12 under Electrochemical Conditions in Nonaqueous Medium" Electrochim.Acta.42. 2165-2172 (1997)

[文献書誌] T.Itoh: "Hydrolytic cleavage of DNA by a novel copper (II) complexwith cis," Chem.Commun.677-678 (1997)

[文献書誌] T.Funabiki: "Oxygenative Cleavage of Chlorocatechols with Moelcular Oxygen Catalyzed by Non-heme Iron (III) Complexes and its Relevance to Chlorocatechol Dioxygenases" Angew.Chem.Intern.Eng.Ed.in press (1998)

[文献書誌] J.Yuan: "Highly Sensitive Time-Resolved Fluoroimmunoassay of Human Immunoglobulin E by Usin a New Europium Fluorescent Chelate as a Label" Anal.Biochem.254. 283-287 (1997)

[文献書誌] M.Higuchi: "A Novel Synthetic Metal Catalytic System" J.Org.Chem.62・4. 1072-1078 (1997)

[文献書誌] T.Yamamura: "Conformation Control of Peptidesby Metal Ions. Coordination Conformation Correlation Observed in a Modelfor Cys-X-Y-Cys/M^<2+> in Proteins" Inorg.Chem.36. 4849-4859 (1997)

[文献書誌] T.Matsui: "On the Formation and Reactivity of Compound I of the His-64 Myoglobin Mutants" J.Bio.Chem.272・52. 32735-32738 (1997)

1997 年度実績報告書

矢野重信奈良女子大学, 理学部, 教授 (60011186)