1997 年度実績報告書

感染症と免疫病の分子生物学と医学

研究課題

研究課題/領域番号	09CE2007
研究種目	COE形成基礎研究費
研究機関	大阪大学
研究代表者	岸本忠三大阪大学, 医学部, 総長 (10093402)
研究分担者	菊谷仁大阪大学, 微生物病研究所, 教授 (80161412) 清野宏大阪大学, 微生物病研究所, 教授 (10271032) 木下タロウ大阪大学, 微生物病研究所, 教授 (10153165) 山西弘一大阪大学, 医学部, 教授 (10029811)
キーワード	感染症 / 免疫病 / サイトカイン / インターロイキン6 / ヒトヘルペスウイルス6 / GPIアンカー / CD40 / 粘膜免疫
研究概要	岸本 1.IL-6のシグナルを負に制御する分子SSI-1およびSSI-1と相似性を有する複数の分子を同定し、これらの分子が種々のサイトカインのシグナルを負に調節していることを示した。 2.I型アレルギー疾患ではTh2細胞への優位な分化がその発症に中心的な役割を果すことを明らかにした。またアトピー性皮膚炎患者の単核球からは、IL-6やPGE2が過剰に分泌されており、それらがI型アレルギーで認められる過剰なTh2分化への責任分子である可能性を示した。 3.無ガンマグロブリン血症(XLA)の責任遺伝子であるBtkと相互作用する新規分子Sabを同定した。またBtkの生理的基質としてWASP(Wiskott-Aldrich症候群の責任遺伝子)を同定した。一方、フローサイトメトリー法によるXLA患者、保因者診断法を確立した。 4.マウスプレB細胞刺激因子(PBSF)の受容体としてケモカインレセプターCXCR4を同定した。ヒトCXCR4はエイズウイルスの宿主細胞への感染に必須の受容体であるが、マウスCXCR4もHIVの宿主細胞への侵入を支持することを明らかにした。山西 1.ヘルペスウイルスの潜伏感染・再活性化が免疫系に与える影響を解明することを目的として、ヒトヘルペスウイルス6(HHV-6)の潜伏感染時に特異的に発現するmRNA及び再活性化時に特異的に発現するmRNAを同定し、潜伏感染・再活性化の機序の一部を明らかにした。 2.ヘルペスウイルスには、免疫細胞の走化性、接着などに関係するケモカイン及びそのレセプターに類似の分子がコードされている。HHV-6感染の免疫系への影響を明らかにするために、HHV-6上のケモカイン様蛋白U83とレセプター様蛋白U12の性質を検討し、生理活性を明らかにした。木下 1.GPIアンカー生合成の第1ステップの酵素が、PIGA,PIG-H,PIG-C,GPI-1の4成分複合体であること、第2ステップの酵素がPIG-Lタンパク質であることを明らかにした。 2.GPIアンカーをタンパク質に結合するトランスアミダーゼが、GPI8とGAA1の2成分を含む複合体であることを示し、このうちGAA1のC末端がGPIアンカー付加シグナル配列を認識するサブユニットであることを示した。 3.GPIアンカーのドリコールリン酸マンノース合成酵素において、哺乳動物では2種類の酵素(DPM1,DPM2)が必須であることを証明た。 4.トリパノソーマのPIG-Bホモログをクローニングし第3のマンノースの転移に働くことを示した。菊谷 1.CD40のリガンド(CD40L)の遺伝子の変異が原因で発症する高IgM血症の自己免疫現象の機序を解明するために、CD40欠損マウスのリンパ球をヌードマウスへ移入した。結果、自己抗体の産生、自己免疫性の胃炎や甲状腺炎が誘導され、CD40-CD40L相互作用が自己反応性CD4T細胞の制御においても機能していることが明らかになった。 1.ヒト野生型CD40を発現するトランスジェニックマウスでは、B細胞の出現は正常であったが、抗体産生が著しく阻害されており、CD40が形質細胞分化を抑制するシグナルを伝達している可能性が示唆された。更に、この抑制シグナルはCD40の細胞質内領域の膜遠位部より伝達されていた。清野 1.炎症性腸疾患IBDの発症には、Th2系の禁止クローンの出現が発病に強く関わること、禁止T細胞クローンは腸管局所において消化管常在細菌の刺激により増殖しIL-4を自発的に産出して自己や食餌抗原に対する異常なB細胞応答を誘導することを明らかにした。 2.腸管の上皮細胞表面に腸管上皮細胞間リンパ球の機能を特異的に調節制御する分子が存在することを示した。 3.鼻粘膜関連リンパ組織(NALT)とパイエル板との類似点を見い出し、NALTが鼻粘膜関連組織における粘膜免疫誘導組織であることを示した。また、抗原を多量に経鼻投与する事により鼻粘膜での抗原特異的免疫寛容を誘導し、鼻粘膜アレルギー治療に対する治療法の可能性を示唆した。

研究成果
(55件)

すべてその他

すべて文献書誌 (55件)

[文献書誌] Murakami T.et al.: "A Small molecule CXCR4 inhibitor that blocks T cell line tropic HIV-1 infection." J.Exp.Med.186. 1389-93 (1997)
[文献書誌] Tachibana K.et al.: "CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry." J.Exp.Med.185. 1865-70 (1997)
[文献書誌] Futatani T.et al.: "Dificient expresion of Bruton's tyrosine kinase in monocytes from X-linked agammaglobulinemia as evaluated by a flow cytometric analysis and its clinical application to carrier detection." Blood. 91. 595-602 (1998)
[文献書誌] Naka T.et al.: "Structure and function of a new STAT-induced STAT inhibitor." Nature. 387. 924-929 (1997)
[文献書誌] Minamoto S.et al.: "Clonong and functional analysis of new members of STAT induced STAT inhibito(SSI)family : SSI-2 and SSI-3" Biochem.Biophys.Res.Comu.237. 79-83 (1997)
[文献書誌] Maruo S.et al.: "B cell regulate CD40 ligand-induced IL-12 production in antigen-presenting cells(APC) during T cell/APC interactions." J.Immunol.158. 120-26 (1997)
[文献書誌] Kumanogho A.et al.: "Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130." Proc.Natl.Acad.Sci.USA. 94. 2478-82 (1997)
[文献書誌] Nishimoto N.et al.: "Myeloma biology and therapy." Hematol./Oncol.Clin.NA. 11. 159-72 (1997)
[文献書誌] Komori T.et al.: "Targeted disruption of CBFA1/PEBP2aA gene results in complete lack of bone formation due to the maturational arrest of osteoblasts." Cell. 89. 755-64 (1997)
[文献書誌] Nakajima-Taniguchi,C.et al.: "Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy." J.Mol.Cell.Cardiol.29. 839-843 (10997)
[文献書誌] Takagi M.et al.: "Interleukin-6 secreting phaeochromocytoma associated with clincal markers of inflammation." Clinical Endocrinology. 46. 507-9 (1997)
[文献書誌] Takagi M.et al.: "Advanced glycation endproducts stimulate interleukin-6 production by human bonederived cells." J.Bone.Miner.Res.12. 439-46 (1997)
[文献書誌] Taga,T.and T.Kishimoto: "GP130 and the Interleukin-6 family of cytokines." Ann.Rev.Immunol.15. 797-819 (1997)
[文献書誌] Inoue M.et al.: "The amino acid residues immediately carboxy terminal to the tyrosine phosphorylation site contribute to IL-6-specific activation of Stat3." J.Biol.Chem.272. 9550-5 (1997)
[文献書誌] Stephanoou A.et al.: "Interleukin 6 activates heat-shock protein 90β gene expression." Biochem.J.321. 103-6 (1997)
[文献書誌] Inoue K.et al.: "Aberrant overexpression of the wilms tumor gene(WT1)in human leukemia." Blood. 89. 1405-12 (1997)
[文献書誌] Fujio Y.et al.: "Signals through gp130 up-regulates bcl-x gene expression via STAT1 binding cis-element in cardiac myocytes." J.Clin.Invest.99. 2898-905 (1997)
[文献書誌] Takada K.et al.: "Targeted disruption of the mouse STAT3 gene leads to early embryonic lethality." Proc.Natl.Acad.Sci.USA. 94. 3801-4 (1997)
[文献書誌] Kurebayashi S.et al.: "Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor." Steroid Biochem.Molec.Biol.60. 11-17 (1997)
[文献書誌] Tanaka F.et al.: "The anti-human tumor effect and generation of human cytotoxic T Cells in SCID mice given human peripheral blood lymphocytes by the in vivo transfer of the interleukin-6 gene using adenovirus vector." Cancer Res.57 : 1335-1343,1997.57. 1335-43 (1997)
[文献書誌] Nishimoto N.et al.: "Plasma cell dyscrasias." Adv.Immunol.64. 219-281 (1997)
[文献書誌] Takeda K.et al.: "STAT6 : its role in interleukin 4-mediated biological functions." J.Mol.Med.75. 317-26 (1997)
[文献書誌] Tsunenari T.et al.: "New xenograft model of multiple myeloma and effecacy of a humanized antibody against human interleukin-6 receptor." Blood. 90. 2437-44 (1997)
[文献書誌] Kawasaki K.et al.: "Osteoclasts are present in gp130-deficient mice." Endocrinology. 138. 4959-65 (1997)
[文献書誌] Kosuge H.et al.: "Nucleotide sequence analysis of a 30-kilobase-pair region of human herpesvirus-6B(HHV-6B) genome and strain-specific variations in major immediate-early genes." Virus Res.52. 1-14 (1997)
[文献書誌] Tajiri H.et al.: "Chronic hepatitis in an infant,in association with human herpesvirus-6 infection." J Pediatr.131. 473-75 (1997)
[文献書誌] Nishinoto S.et al.: "Prevalence of human herpesvirus-8 in skin lesions." Br J Dermatol.137. 179-84 (1997)
[文献書誌] Takeda K.et al.: "Identification of a variant B-specific neutralizing epitope on glycoprotein H of human herpesvirus-6." J.Gen Virol.78. 2171-78 (1997)
[文献書誌] Mori C.st al.: "Nucleotide sequence at position 1081 of the hemagglutinin-neuraminidase gene in the mumps virus Urabe vaccine strain." J.Infect Dis.175. 1548-49 (1997)
[文献書誌] Nakagawa N.et al.: "Antigenic analysis of human herpesvirus 7(HHV-7) and HHV-6 using immune sera and monoclonal antibodies against HHV-7." Microbiol Immunol.41. 43-50 (1997)
[文献書誌] Mori Y.et al.: "Analysis of Human Herpesvirus 6 U3 Gene (A Homolog of Human Cytomegalovirus UL 24 Gene)." Virology. (1998)
[文献書誌] Isegawa Y.et al.: "Human Herpesvirus 6(HHV-6) Open Reading Frame U12 Encodes a Functional β Chemokine Receptor." J.Virology. (1998)
[文献書誌] Nishimura J.et al.: "A patient with paroxysmal nocturnal hemoglobinuria bearing four independent PIG-A mutant clones." Blood. 89. 3470-6 (1997)
[文献書誌] Toyomura,K.et al.: "Molecular cloning of a pig homologue of membrane cofactor protein(CD46)." Int.Immunol.9. 869-76 (1997)
[文献書誌] Nakamura N.et al.: "Expression cloning of PIG-L,a candidate N-acetylglcosaminyl-phosphatidylinositol deacetylase." J.Biol.Chem.272. 15834-40 (1997)
[文献書誌] Turutani M.et al.: "Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development." Proc.Natl.Acad.Sci.USA.94. 7400-5 (1997)
[文献書誌] Hong Y. et al.: "Structure and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1." Genomics. 44. 347-9 (1997)
[文献書誌] Zarkadis I.et al.: "Defferentiation-dependent changes in human trophoblast expression of decay-accelerating factor are modulated by 3′,5′ cyclic adenosine monophosphate." J.Soc.Gynecol.Invest.4. 47-53 (1997)
[文献書誌] Watanabe R.et al.: "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A,PIG-H,PIG-c and GPI1." EMBO J.17. 877-885 (1998)
[文献書誌] Tomita S.et al.: "A homologue of Saccharomyces cerevisiae Dpmlp is not sufficient for synthesis of dolichol-phosphatemannose in mammalian cells." J.Biol.Chem.(1998)
[文献書誌] Takahashi I.et al.: "CD4+T Cell population mediates development of inflammatory bowel disease in T cell receptor a-chain deficient mice." Gastoroenterology. 112. 1876-86 (1997)
[文献書誌] Kubota M.et al.: "Oral immunization with simian immunodeficiency virus(SIV)p55 gag and cholera toxin(CT)elicits both mucosal IgA and systemic IgG immune responses in non-human primates." J.Immunol.158. 5321-29 (1997)
[文献書誌] Yamamoto S.et al.: "A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity." Proc.Natl.Acad.Sci.USA.94. 5267-72 (1997)
[文献書誌] Yamamoto S.et al.: "Mutants in the putative ADP-ribosy transferase cleft of cholera toxin lack diarrhoeagenisity but retain adjuvanticity." J.Exp.Med.185. 1203-10 (1997)
[文献書誌] Fujihashi K.et al.: "An interleukin 7 internet for intestinal intraepithelial gd T cell development : Knockoout of ligand or receptor reveal deifferences in the immunodeficient state." Eur.J.Immunol.27. 2123-32 (1997)
[文献書誌] Marinaro M.et al.: "Mucosal IL-12 switches type 2 help to an oral vaccine containing cholera toxin as adjuvant to type 1 help with secretory IgA responses." J.Exp.Med.185. 415-27 (1997)
[文献書誌] Yamamoto M.et al.: "Oral immunization of PspA elicits protective humoral immunity from Streptococcus pneumoniae infection." Infect.Immun.65. 640-44 (1997)
[文献書誌] van Ginkel F.W.et al.: "Respiratory immunity to a replication-deficient adenovirus 5(Ade 5)vector and to its transgene : segregation of T helper cell responses." J.Immunol. 59. 685-93 (1997)
[文献書誌] Higashi Y.et al.: "Impairment of T cell development in gEF1 mutant mice." J.Exp.Med.185. 1467-79 (1997)
[文献書誌] Hogan S.P.et al.: "Aeroallergen-induced eosinophilic inflammation,lung damage,and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunolobulins." J.Clin.Invest.99. 1329-39 (1997)
[文献書誌] Oshiba A.et al.: "Modulation of antigen-induced B and T cell responses by antigen-specific IgE antibodies." J.Immunol.159. 4056-63 (1997)
[文献書誌] Gonzalez A.et al.: "Genetic control of diabetes progression." Immunity. 7. 873-883 (1997)
[文献書誌] Mackey M.F.et al.: "Protective immunity induced by tumor vaccines requires interaction between CD40 ad its ligand,CD154." Cancer Res.57. 2569-74 (1997)
[文献書誌] Cosyns M.et al.: "Requirement for CD40-CD40 ligand interaction for elimination of Cryptosporidium parvum from mice." Infection and Immunity. 66. 603-7 (1998)
[文献書誌] Wang X.-J.et al.: "gp130,The cytokine common signal-tranducer of interleukin-6 cytokine family,is down-regulated in T cells in vivo by interleukin-6." Blood. (1998)

1997 年度 実績報告書

感染症と免疫病の分子生物学と医学

研究代表者

岸本 忠三 大阪大学, 医学部, 総長 (10093402)

研究成果

[文献書誌] Murakami T.et al.: "A Small molecule CXCR4 inhibitor that blocks T cell line tropic HIV-1 infection." J.Exp.Med.186. 1389-93 (1997)

[文献書誌] Tachibana K.et al.: "CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry." J.Exp.Med.185. 1865-70 (1997)

[文献書誌] Futatani T.et al.: "Dificient expresion of Bruton's tyrosine kinase in monocytes from X-linked agammaglobulinemia as evaluated by a flow cytometric analysis and its clinical application to carrier detection." Blood. 91. 595-602 (1998)

[文献書誌] Naka T.et al.: "Structure and function of a new STAT-induced STAT inhibitor." Nature. 387. 924-929 (1997)

[文献書誌] Minamoto S.et al.: "Clonong and functional analysis of new members of STAT induced STAT inhibito(SSI)family : SSI-2 and SSI-3" Biochem.Biophys.Res.Comu.237. 79-83 (1997)

[文献書誌] Maruo S.et al.: "B cell regulate CD40 ligand-induced IL-12 production in antigen-presenting cells(APC) during T cell/APC interactions." J.Immunol.158. 120-26 (1997)

[文献書誌] Kumanogho A.et al.: "Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130." Proc.Natl.Acad.Sci.USA. 94. 2478-82 (1997)

[文献書誌] Nishimoto N.et al.: "Myeloma biology and therapy." Hematol./Oncol.Clin.NA. 11. 159-72 (1997)

[文献書誌] Komori T.et al.: "Targeted disruption of CBFA1/PEBP2aA gene results in complete lack of bone formation due to the maturational arrest of osteoblasts." Cell. 89. 755-64 (1997)

[文献書誌] Nakajima-Taniguchi,C.et al.: "Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy." J.Mol.Cell.Cardiol.29. 839-843 (10997)

[文献書誌] Takagi M.et al.: "Interleukin-6 secreting phaeochromocytoma associated with clincal markers of inflammation." Clinical Endocrinology. 46. 507-9 (1997)

[文献書誌] Takagi M.et al.: "Advanced glycation endproducts stimulate interleukin-6 production by human bonederived cells." J.Bone.Miner.Res.12. 439-46 (1997)

[文献書誌] Taga,T.and T.Kishimoto: "GP130 and the Interleukin-6 family of cytokines." Ann.Rev.Immunol.15. 797-819 (1997)

[文献書誌] Inoue M.et al.: "The amino acid residues immediately carboxy terminal to the tyrosine phosphorylation site contribute to IL-6-specific activation of Stat3." J.Biol.Chem.272. 9550-5 (1997)

[文献書誌] Stephanoou A.et al.: "Interleukin 6 activates heat-shock protein 90β gene expression." Biochem.J.321. 103-6 (1997)

[文献書誌] Inoue K.et al.: "Aberrant overexpression of the wilms tumor gene(WT1)in human leukemia." Blood. 89. 1405-12 (1997)

[文献書誌] Fujio Y.et al.: "Signals through gp130 up-regulates bcl-x gene expression via STAT1 binding cis-element in cardiac myocytes." J.Clin.Invest.99. 2898-905 (1997)

[文献書誌] Takada K.et al.: "Targeted disruption of the mouse STAT3 gene leads to early embryonic lethality." Proc.Natl.Acad.Sci.USA. 94. 3801-4 (1997)

[文献書誌] Kurebayashi S.et al.: "Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor." Steroid Biochem.Molec.Biol.60. 11-17 (1997)

[文献書誌] Tanaka F.et al.: "The anti-human tumor effect and generation of human cytotoxic T Cells in SCID mice given human peripheral blood lymphocytes by the in vivo transfer of the interleukin-6 gene using adenovirus vector." Cancer Res.57 : 1335-1343,1997.57. 1335-43 (1997)

[文献書誌] Nishimoto N.et al.: "Plasma cell dyscrasias." Adv.Immunol.64. 219-281 (1997)

[文献書誌] Takeda K.et al.: "STAT6 : its role in interleukin 4-mediated biological functions." J.Mol.Med.75. 317-26 (1997)

[文献書誌] Tsunenari T.et al.: "New xenograft model of multiple myeloma and effecacy of a humanized antibody against human interleukin-6 receptor." Blood. 90. 2437-44 (1997)

[文献書誌] Kawasaki K.et al.: "Osteoclasts are present in gp130-deficient mice." Endocrinology. 138. 4959-65 (1997)

[文献書誌] Kosuge H.et al.: "Nucleotide sequence analysis of a 30-kilobase-pair region of human herpesvirus-6B(HHV-6B) genome and strain-specific variations in major immediate-early genes." Virus Res.52. 1-14 (1997)

[文献書誌] Tajiri H.et al.: "Chronic hepatitis in an infant,in association with human herpesvirus-6 infection." J Pediatr.131. 473-75 (1997)

[文献書誌] Nishinoto S.et al.: "Prevalence of human herpesvirus-8 in skin lesions." Br J Dermatol.137. 179-84 (1997)

[文献書誌] Takeda K.et al.: "Identification of a variant B-specific neutralizing epitope on glycoprotein H of human herpesvirus-6." J.Gen Virol.78. 2171-78 (1997)

[文献書誌] Mori C.st al.: "Nucleotide sequence at position 1081 of the hemagglutinin-neuraminidase gene in the mumps virus Urabe vaccine strain." J.Infect Dis.175. 1548-49 (1997)

[文献書誌] Nakagawa N.et al.: "Antigenic analysis of human herpesvirus 7(HHV-7) and HHV-6 using immune sera and monoclonal antibodies against HHV-7." Microbiol Immunol.41. 43-50 (1997)

[文献書誌] Mori Y.et al.: "Analysis of Human Herpesvirus 6 U3 Gene (A Homolog of Human Cytomegalovirus UL 24 Gene)." Virology. (1998)

[文献書誌] Isegawa Y.et al.: "Human Herpesvirus 6(HHV-6) Open Reading Frame U12 Encodes a Functional β Chemokine Receptor." J.Virology. (1998)

[文献書誌] Nishimura J.et al.: "A patient with paroxysmal nocturnal hemoglobinuria bearing four independent PIG-A mutant clones." Blood. 89. 3470-6 (1997)

[文献書誌] Toyomura,K.et al.: "Molecular cloning of a pig homologue of membrane cofactor protein(CD46)." Int.Immunol.9. 869-76 (1997)

[文献書誌] Nakamura N.et al.: "Expression cloning of PIG-L,a candidate N-acetylglcosaminyl-phosphatidylinositol deacetylase." J.Biol.Chem.272. 15834-40 (1997)

[文献書誌] Turutani M.et al.: "Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development." Proc.Natl.Acad.Sci.USA.94. 7400-5 (1997)

[文献書誌] Hong Y. et al.: "Structure and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1." Genomics. 44. 347-9 (1997)

[文献書誌] Zarkadis I.et al.: "Defferentiation-dependent changes in human trophoblast expression of decay-accelerating factor are modulated by 3′,5′ cyclic adenosine monophosphate." J.Soc.Gynecol.Invest.4. 47-53 (1997)

[文献書誌] Watanabe R.et al.: "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A,PIG-H,PIG-c and GPI1." EMBO J.17. 877-885 (1998)

[文献書誌] Tomita S.et al.: "A homologue of Saccharomyces cerevisiae Dpmlp is not sufficient for synthesis of dolichol-phosphatemannose in mammalian cells." J.Biol.Chem.(1998)

[文献書誌] Takahashi I.et al.: "CD4+T Cell population mediates development of inflammatory bowel disease in T cell receptor a-chain deficient mice." Gastoroenterology. 112. 1876-86 (1997)

[文献書誌] Kubota M.et al.: "Oral immunization with simian immunodeficiency virus(SIV)p55 gag and cholera toxin(CT)elicits both mucosal IgA and systemic IgG immune responses in non-human primates." J.Immunol.158. 5321-29 (1997)

[文献書誌] Yamamoto S.et al.: "A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity." Proc.Natl.Acad.Sci.USA.94. 5267-72 (1997)

[文献書誌] Yamamoto S.et al.: "Mutants in the putative ADP-ribosy transferase cleft of cholera toxin lack diarrhoeagenisity but retain adjuvanticity." J.Exp.Med.185. 1203-10 (1997)

[文献書誌] Fujihashi K.et al.: "An interleukin 7 internet for intestinal intraepithelial gd T cell development : Knockoout of ligand or receptor reveal deifferences in the immunodeficient state." Eur.J.Immunol.27. 2123-32 (1997)

[文献書誌] Marinaro M.et al.: "Mucosal IL-12 switches type 2 help to an oral vaccine containing cholera toxin as adjuvant to type 1 help with secretory IgA responses." J.Exp.Med.185. 415-27 (1997)

[文献書誌] Yamamoto M.et al.: "Oral immunization of PspA elicits protective humoral immunity from Streptococcus pneumoniae infection." Infect.Immun.65. 640-44 (1997)

[文献書誌] van Ginkel F.W.et al.: "Respiratory immunity to a replication-deficient adenovirus 5(Ade 5)vector and to its transgene : segregation of T helper cell responses." J.Immunol. 59. 685-93 (1997)

[文献書誌] Higashi Y.et al.: "Impairment of T cell development in gEF1 mutant mice." J.Exp.Med.185. 1467-79 (1997)

[文献書誌] Hogan S.P.et al.: "Aeroallergen-induced eosinophilic inflammation,lung damage,and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunolobulins." J.Clin.Invest.99. 1329-39 (1997)

[文献書誌] Oshiba A.et al.: "Modulation of antigen-induced B and T cell responses by antigen-specific IgE antibodies." J.Immunol.159. 4056-63 (1997)

[文献書誌] Gonzalez A.et al.: "Genetic control of diabetes progression." Immunity. 7. 873-883 (1997)

[文献書誌] Mackey M.F.et al.: "Protective immunity induced by tumor vaccines requires interaction between CD40 ad its ligand,CD154." Cancer Res.57. 2569-74 (1997)

[文献書誌] Cosyns M.et al.: "Requirement for CD40-CD40 ligand interaction for elimination of Cryptosporidium parvum from mice." Infection and Immunity. 66. 603-7 (1998)

[文献書誌] Wang X.-J.et al.: "gp130,The cytokine common signal-tranducer of interleukin-6 cytokine family,is down-regulated in T cells in vivo by interleukin-6." Blood. (1998)

1997 年度実績報告書

岸本忠三大阪大学, 医学部, 総長 (10093402)