1999 年度実績報告書

脳磁場計測とDC電位の解析によるヒトのてんかん焦点での興奮および抑制過程の研究

研究課題

研究課題/領域番号	10670583
研究機関	京都大学
研究代表者	池田昭夫京都大学, 医学研究科, 助手 (90212761)
研究分担者	長峯隆京都大学, 医学研究科, 助手 (10231490)
キーワード	発作時DC電位 / てんかん焦点 / 脳電位 / 硬膜下電極 / 脳磁図
研究概要	本年度は、2年度目として当初の研究計画を更に推進して以下の研究成果を得た。 1)ヒトのてんかん原性焦点における興奮抑制機構難治部分てんかん患者の焦点切除のために慢性に留置された硬膜下電極から増幅器の時定数を10秒に設定して多数の患者からそれぞれ多数回の発作で検討した。新皮質てんかんおよび内側側頭葉てんかん患者において同様に、発作時DC電位は記録発作中の約80%で明瞭に記録され、その最大部位は従来の脳波記録による発作時焦点と一致あるいはより狭い範囲に認められた。しかし発作開始に必ずしも先行せず、むしろ脳波が低振幅速波化した時点に一致した。これは動物実験での発作時の突発性脱分極変位(PDS)の所見によく一致した。また切除された組織所見との対比においてDC電位の出現率と組織所見の種類とには明らかな相関はなく、発作時DC電位はてんかん発作に共通した特に初期の活動であることが強く支持された。一方脳磁図によるDC発作時DC電位の検索は、生理的現象例えば随意運動に先行するDC電位の検索をまず手掛け、運動準備を反映する脳磁場変化を主に体側の一次感覚運動野にその発生源を求めることができた。しかし発作に伴う体動等の人工雑音が記録の信頼性において大きな影響をおよぼすのは否めず、今後装置の改良あるいは対象患者の選択等検討の余地を残した。 2)ヒトのてんかん原性焦点の生理学的特徴海面静脈洞内脳波記録により内側頭葉てんかんにおける発作間欠期のてんかん性放電に加えて、発作時てんかん性活動を多数例にて検討することができた。海面静脈洞内脳波としては発作時DC電位を記録することができなかったが、低振幅速波波活動は頭皮上電極よりも鋭敏に記録された。これは上記の発作時DC電位は特異的な所見であることを裏付けるが逆に鋭敏度に関する検討を更に必要とする。

研究成果
(21件)

すべてその他

すべて文献書誌 (21件)

[文献書誌] Ikeda A. et al.: "Focal ictal DC shifts in human epilepsy as studied by subdural and scalp recording"Brain. 122. 827-838 (1999)
[文献書誌] Ikeda A. et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials"Brain. 122. 915-931 (1999)
[文献書誌] Ikeda A. et al.: "Clonic convulsion caused by epileptic discharges arising from human supplementary motor area (SMA) as studied by subdural recording"Epileptic Disord. 1. 21-26 (1999)
[文献書誌] Ikeda A. et al.: "Seizure with prominent tonic initial signs followed by psychomotor features : a case report clinically manifesting an unusual ictal evolution"Epileptic Disord. 1. 127-133 (1999)
[文献書誌] Ikeda A. et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press). (2000)
[文献書誌] Ikeda A. et al.: "Role of mesial temporal lobe in voluntary movements : Bereitschaftspotential study in epileptic patients after left antero-mesial temporal resection"Electroenceph clin Neurophysiol. (in press). (2000)
[文献書誌] Nishitani N. et al.: "Role of hippocampus in auditory processing studied by event-related electric potential and magnetic fields before and after temporal lobectomy"Brain. 122. 687-707 (1999)
[文献書誌] Yazawa S.et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials"Brain. 122. 1357-1366 (1999)
[文献書誌] Terada K. et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles"Electroenceph clin Neurophysiol. 110. 397-403 (1999)
[文献書誌] Mima T.et al.: "Somesthetic function of supplementary motor area during voluntary movements"NeuroReport. 10. 1859-1862 (1999)
[文献書誌] Hamano T.et al.: "Abnormal contingent negative variation in writer's cramp"Clin.Neurophysiol... 110. 508-515 (1999)
[文献書誌] Kanda M.et al.: "Cortical mechanisms underlying point localization of pain spot as studied by event-related potentials following CO2 laser stimulation in man"Exp Brain Res. 127. 131-140 (1999)
[文献書誌] Toma K.et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation : an event-related fMRI study"J.Neurosci.. 19. 3527-3534 (1999)
[文献書誌] Kanda M.et al.: "Primary somatosensory cortex is actively involved in pain processing in human"Brain Res.. 853. 282-289 (2000)
[文献書誌] Shimazu H.et al.: "Pre-movement gating of short-latency somatosensory evoked potentials"NeuroReport. 10. 2457-2460 (1999)
[文献書誌] Ohara S et al.: "Movement-related pcsillatory change in human SMA proper"Brain. (in press). (2000)
[文献書誌] Kunieda T.et al.: "Use of cavernous sinus EEG in the detection of seizure onset and spread in mesial temporal lobe epilepsy"Epilepsia. (in press). (2000)
[文献書誌] Kunieda T.et al.: "Different activation of pre-supplementary motor area(pre-SMA),SMA proper and primary sensori-motor area depending on the movement repetition rate in humans"Exp.Brain Res.. (in press). (2000)
[文献書誌] Yazawa S.et al.: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from media frontal cortex"Exp.Brain Res.. (in press). (2000)
[文献書誌] Bai O.et al.: "Markov process amplitude EEG model for spontaneous brain activity"Medical & Biomedical Engineering & Computing. (in press). (2000)
[文献書誌] Murase N.et al.: "Abnormal premovement gating of somatosensory input in writer's cramp"Brain. (in press). (2000)

1999 年度 実績報告書

脳磁場計測とDC電位の解析によるヒトのてんかん焦点での興奮および抑制過程の研究

研究代表者

池田 昭夫 京都大学, 医学研究科, 助手 (90212761)

研究成果

[文献書誌] Ikeda A. et al.: "Focal ictal DC shifts in human epilepsy as studied by subdural and scalp recording"Brain. 122. 827-838 (1999)

[文献書誌] Ikeda A. et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials"Brain. 122. 915-931 (1999)

[文献書誌] Ikeda A. et al.: "Clonic convulsion caused by epileptic discharges arising from human supplementary motor area (SMA) as studied by subdural recording"Epileptic Disord. 1. 21-26 (1999)

[文献書誌] Ikeda A. et al.: "Seizure with prominent tonic initial signs followed by psychomotor features : a case report clinically manifesting an unusual ictal evolution"Epileptic Disord. 1. 127-133 (1999)

[文献書誌] Ikeda A. et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press). (2000)

[文献書誌] Ikeda A. et al.: "Role of mesial temporal lobe in voluntary movements : Bereitschaftspotential study in epileptic patients after left antero-mesial temporal resection"Electroenceph clin Neurophysiol. (in press). (2000)

[文献書誌] Nishitani N. et al.: "Role of hippocampus in auditory processing studied by event-related electric potential and magnetic fields before and after temporal lobectomy"Brain. 122. 687-707 (1999)

[文献書誌] Yazawa S.et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials"Brain. 122. 1357-1366 (1999)

[文献書誌] Terada K. et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles"Electroenceph clin Neurophysiol. 110. 397-403 (1999)

[文献書誌] Mima T.et al.: "Somesthetic function of supplementary motor area during voluntary movements"NeuroReport. 10. 1859-1862 (1999)

[文献書誌] Hamano T.et al.: "Abnormal contingent negative variation in writer's cramp"Clin.Neurophysiol... 110. 508-515 (1999)

[文献書誌] Kanda M.et al.: "Cortical mechanisms underlying point localization of pain spot as studied by event-related potentials following CO2 laser stimulation in man"Exp Brain Res. 127. 131-140 (1999)

[文献書誌] Toma K.et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation : an event-related fMRI study"J.Neurosci.. 19. 3527-3534 (1999)

[文献書誌] Kanda M.et al.: "Primary somatosensory cortex is actively involved in pain processing in human"Brain Res.. 853. 282-289 (2000)

[文献書誌] Shimazu H.et al.: "Pre-movement gating of short-latency somatosensory evoked potentials"NeuroReport. 10. 2457-2460 (1999)

[文献書誌] Ohara S et al.: "Movement-related pcsillatory change in human SMA proper"Brain. (in press). (2000)

[文献書誌] Kunieda T.et al.: "Use of cavernous sinus EEG in the detection of seizure onset and spread in mesial temporal lobe epilepsy"Epilepsia. (in press). (2000)

[文献書誌] Kunieda T.et al.: "Different activation of pre-supplementary motor area(pre-SMA),SMA proper and primary sensori-motor area depending on the movement repetition rate in humans"Exp.Brain Res.. (in press). (2000)

[文献書誌] Yazawa S.et al.: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from media frontal cortex"Exp.Brain Res.. (in press). (2000)

[文献書誌] Bai O.et al.: "Markov process amplitude EEG model for spontaneous brain activity"Medical & Biomedical Engineering & Computing. (in press). (2000)

[文献書誌] Murase N.et al.: "Abnormal premovement gating of somatosensory input in writer's cramp"Brain. (in press). (2000)

1999 年度実績報告書

池田昭夫京都大学, 医学研究科, 助手 (90212761)