2000 年度実績報告書

がんの生物学的特性に関する研究の総括

研究課題

研究課題/領域番号	11179101
研究種目	特定領域研究(C)
研究機関	大阪大学
研究代表者	高井義美大阪大学, 医学系研究科, 教授 (60093514)
研究分担者	清木元治東京大学, 医科学研究所, 教授 (10154634) 秋山徹東京大学, 分子細胞生物学研究所, 教授 (70150745) 平井久丸東京大学, 医学部・附属病院, 助教授 (90181130) 谷口維紹東京大学, 医学系研究科, 教授 (50133616) 渋谷正史東京大学, 医科学研究所, 教授 (10107427)
キーワード	がん / 増殖因子 / シグナル伝達 / 分化 / 細胞死 / 細胞周期 / 浸潤・転移 / 細胞外マトリックス
研究概要	本領域は「がん研究の総合的推進に関する研究」の一環として、がんの生物学的研究を担うものである。すなわち、がんの生物学的特性を明らかにすることによって、がんの予防、診断、治療に貢献することを目的とする。本年度の総括班における成果を以下に列記する。 1.がんの生物学的研究の分野において未解決の重要な問題を解明するために、総括班は以下の5項目について研究を計画した。A01:がん細胞の増殖応答の異常の研究、A02:がんの形成過程における細胞の分化と死の研究、A03:がん細胞の制御異常とがん形質の研究、A04:がん細胞の浸潤と転移の研究、A05:組織形成異常とがんとの関連の研究。 2.領域代表者である高井義美をA01の班長とし、以下、A02平井久丸、A03秋山徹、A04清木元治、A05渋谷正史とした。また、本研究分野で顕著な業績を持つ研究者5名(谷口維紹、宮島篤、月田承一郎、西田栄介、広橋説雄)を総括班に加え、主として研究計画実施の方針に対する助言および各研究項目長とともに研究成果の評価にあたることとした。 3.研究を推進するために、重要かつ緊急性のあるテーマと優れた研究者を計画的に支援する目的で、各項目ごとで、総計26の研究計画を設定し、これに担当する研究代表者と分担者の選定と研究内容の評価を行った。また、公募により自由な発想に基づく研究を募集し、この研究内容を評価した。 4.総括班会議および分野長会議を開催しており、上記重要課題につき検討上、方針を決定し領域の円滑な運営を進めた。このように、私共は、本年度の予定をほぼ達成することができた。

研究成果
(20件)

すべてその他

すべて文献書誌 (20件)

[文献書誌] Tachibana,K.: "Two cell adhesion molecules, Nectin and Cadherin interact through their cytoplasmic domain-associated proteins."J.Cell Biol.. 150・5. 1161-1176 (2000)
[文献書誌] Kodama,A.: "Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering."Mol.Biol.Cell. 11・8. 2565-2575 (2000)
[文献書誌] Kurokawa,M.: "The Evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death."EMBO J.. 19・12. 2958-2968 (2000)
[文献書誌] Yamagata,T.: "Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs."EMBO J.. 19・17. 4676-4687 (2000)
[文献書誌] Kawasaki,Y.: "Asef, a Link between the Tumor Suppressor APC and G-protein Signaling."Science. 289・5482. 1194-1197 (2000)
[文献書誌] Tago,K.: "Inhibition of Wnt signaling by ICAT, a Novel β-catenin-interacting Protein."Gense Dev.. 14・14. 1741-1749 (2000)
[文献書誌] Kojima,S.: "Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP."FEBS Lett.. 480・2-3. 142-146 (2000)
[文献書誌] Kim,K.R.: "Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Etsl and invasive growth."Oncogene. 19・14. 1764-1771 (2000)
[文献書誌] Sawano,A.: "Vascular Endothelial Growth Factor Receptor-1. (Flt-1) is a Novel Cell Surface Marker for the Lineage of Monocyte-Macrophages in Humans."Blood. 97・3. 785-791 (2000)
[文献書誌] Maru,Y.: "An oncogenic form of the Flt-1 kinase has a tubulogenic potential in a sinusoidal endothelial cell line."J.Cell Biol.. 79・2. 130-143 (2000)
[文献書誌] Takaoka,A.: "Crosstalk between interferon-γ and-α/β signaling components at caveolar membrane domain."Science. 288・5475. 2357-2360 (2000)
[文献書誌] Takayanagi,H.: "T-cell-mediated regulation of osteocrastogenesis by signalling cross-talk between RANKL and IFN-γ."Nature. 408・6812. 600-605 (2000)
[文献書誌] Ito Y.: "Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and Ras pathways during hepatic development."Hepatology. 32・6. 1370-1376 (2000)
[文献書誌] Kojima N.: "Cell-density-dependent regulation of hepatic development by a gp130-independent pathway."Biochem.Biophys.Res.Commun.. 277・1. 152-158 (2000)
[文献書誌] Tsukita,Sh.: "Pores in the wall : Claudins constitute tight junction strands containing aqueous pares."J.Cell Biol.. 149・1. 13-16 (2000)
[文献書誌] Sitou,M.: "Complex phenotype of mice lacking occludin, a component of tight junction strands."Mol.Cell Biol.. 11・12. 4131-4142 (2000)
[文献書誌] Toyoshima-Morimoto,F.: "Pole-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase."Nature. (in press). (2001)
[文献書誌] Harada,T.: "ERK induces p35, the neuron-specific activator of cdk5 essential for neurite outgrowth, through the induction of Egr1."Nature Cell Biol.. (in press). (2001)
[文献書誌] Ishii,Y.: "Integrin α6β4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer."Gastroenterology. 118・3. 497-506 (2000)
[文献書誌] Genda,T.: "Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells."Laboratory Investigation. 80・3. 387-394 (2000)

2000 年度 実績報告書

がんの生物学的特性に関する研究の総括

研究代表者

高井 義美 大阪大学, 医学系研究科, 教授 (60093514)

研究成果

[文献書誌] Tachibana,K.: "Two cell adhesion molecules, Nectin and Cadherin interact through their cytoplasmic domain-associated proteins."J.Cell Biol.. 150・5. 1161-1176 (2000)

[文献書誌] Kodama,A.: "Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering."Mol.Biol.Cell. 11・8. 2565-2575 (2000)

[文献書誌] Kurokawa,M.: "The Evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death."EMBO J.. 19・12. 2958-2968 (2000)

[文献書誌] Yamagata,T.: "Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs."EMBO J.. 19・17. 4676-4687 (2000)

[文献書誌] Kawasaki,Y.: "Asef, a Link between the Tumor Suppressor APC and G-protein Signaling."Science. 289・5482. 1194-1197 (2000)

[文献書誌] Tago,K.: "Inhibition of Wnt signaling by ICAT, a Novel β-catenin-interacting Protein."Gense Dev.. 14・14. 1741-1749 (2000)

[文献書誌] Kojima,S.: "Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP."FEBS Lett.. 480・2-3. 142-146 (2000)

[文献書誌] Kim,K.R.: "Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Etsl and invasive growth."Oncogene. 19・14. 1764-1771 (2000)

[文献書誌] Sawano,A.: "Vascular Endothelial Growth Factor Receptor-1. (Flt-1) is a Novel Cell Surface Marker for the Lineage of Monocyte-Macrophages in Humans."Blood. 97・3. 785-791 (2000)

[文献書誌] Maru,Y.: "An oncogenic form of the Flt-1 kinase has a tubulogenic potential in a sinusoidal endothelial cell line."J.Cell Biol.. 79・2. 130-143 (2000)

[文献書誌] Takaoka,A.: "Crosstalk between interferon-γ and-α/β signaling components at caveolar membrane domain."Science. 288・5475. 2357-2360 (2000)

[文献書誌] Takayanagi,H.: "T-cell-mediated regulation of osteocrastogenesis by signalling cross-talk between RANKL and IFN-γ."Nature. 408・6812. 600-605 (2000)

[文献書誌] Ito Y.: "Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and Ras pathways during hepatic development."Hepatology. 32・6. 1370-1376 (2000)

[文献書誌] Kojima N.: "Cell-density-dependent regulation of hepatic development by a gp130-independent pathway."Biochem.Biophys.Res.Commun.. 277・1. 152-158 (2000)

[文献書誌] Tsukita,Sh.: "Pores in the wall : Claudins constitute tight junction strands containing aqueous pares."J.Cell Biol.. 149・1. 13-16 (2000)

[文献書誌] Sitou,M.: "Complex phenotype of mice lacking occludin, a component of tight junction strands."Mol.Cell Biol.. 11・12. 4131-4142 (2000)

[文献書誌] Toyoshima-Morimoto,F.: "Pole-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase."Nature. (in press). (2001)

[文献書誌] Harada,T.: "ERK induces p35, the neuron-specific activator of cdk5 essential for neurite outgrowth, through the induction of Egr1."Nature Cell Biol.. (in press). (2001)

[文献書誌] Ishii,Y.: "Integrin α6β4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer."Gastroenterology. 118・3. 497-506 (2000)

[文献書誌] Genda,T.: "Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells."Laboratory Investigation. 80・3. 387-394 (2000)

2000 年度実績報告書

高井義美大阪大学, 医学系研究科, 教授 (60093514)