2002 年度実績報告書

ヒトがんの環境・宿主要因に関する疫学的研究

研究課題

研究課題/領域番号	11181101
研究機関	愛知県がんセンター
研究代表者	田島和雄愛知県がんセンター, 疫学・予防部, 部長 (30150212)
研究分担者	今井浩三札幌医科大学, 医学部, 教授 (60117603) 中地敬放射線影響研究所, 放射線生物・分子疫学部, 部長 (00142117) 古野純典九州大学, 大学院・医学系研究院, 教授 (70128015) 鶴尾隆東京大学, 分子細胞生物学研究所, 教授 (00012667) 玉腰暁子名古屋大学, 大学院・医学系研究科, 助教授 (90236737)
キーワード	民族疫学 / 分析疫学 / 分子疫学 / 臨床疫学 / 分子疫学コーホート / 危険・防御要因 / 予防
研究概要	今年度から領域内の研究課題を4つの分野、1)国際比較による民族疫学研究、2)発がん・予防に関する分析疫学研究、3)発がんリスクの個体差を解明する分子疫学研究、4)進展・予後に関する臨床疫学研究、に再編成して機能的な研究推進を図ってきた。さらに、総括班のもとに三つの委員会、1)大規模コーホート研究運営委員会、2)分子疫学生体材料利用委員会、3)ATL研究推進委員会、を設置して各分野間で共有できる研究資料や生体材料の効率的運用を図ってきた。本領域の重要な研究課題の一つである大規模コーホート研究においては、昨年度までに肺がんと胃がんの危険・防御要因の解析を終了したので、平成14〜15年度は大腸がんと肝臓がんを対象とした血清疫学的解析、特に大腸がんでは各種脂肪酸成分量を、肝臓がんでは関連ウイルスの抗原・抗体価を検索し、それぞれ生活習慣との関連性において危険・防御要因を解析中である。また、分子疫学生体材料利用委員会は10万人以上を対象とした全国規模の分子疫学コーホートの設立を計画し、国民の研究への理解と協力の推進、倫理的対応、標準化した生活習慣質問票の作成、生体試料の保管・利用方法など重要課題について検討してきた。さらに、ATL研究推進委員会では本邦における過去20年間の疫学的、基礎的、臨床的研究成果を再評価し、新しい研究手法を駆使して新しく挑戦できる包括的な研究課題について検討してきた。一方、領域内では総括報告会を開催し、全分野の計画研究(22課題)や公募研究(27課題)の成果に関する相互情報交換、および各研究の問題点や研究協力の可能性などについて建設的討議を行ってきた。同時に、ヒト集団のがん予防を目指した疫学・予防研究の成果を広く国民に伝達していくため、平成12〜13年度に引き続き一般公開シンポジウムを広島市と東京都で開催し、HPにおいても公開してきた。

研究成果
(38件)

すべてその他

すべて文献書誌 (38件)

[文献書誌] Hishida, A.: "Population based case-control study of HER2 genetic polymorphism and breast cancer risk"J. Natl. Cancer Inst.. 94. 1807 (2002)
[文献書誌] Hirose, K.: "Impact of established risk factors for breast cancer in nulligravid Japanese women"Breast Cancer. 10. 45-53 (2003)
[文献書誌] Teramukai, S.: "Anthropometric and behavioral correlates of insulin-like growth factor I and insulin-like growth factor binding protein 3 in middle-aged Japanese men"Am. J. Epidemiol.. 156(4). 344-348 (2002)
[文献書誌] Nakachi, K.: "Can teatime increase one's lifetime"Ageing Res. Reviews. 44. 1-10 (2003)
[文献書誌] Kikuchi, T.: "Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors"Oncogene. 21. 2741-2749 (2002)
[文献書誌] Sato, S.: "Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3"J. Biol. Chem.. 277. 39360-39367 (2002)
[文献書誌] Tsunoda, T.: "A novel mechanism of nuclear factor kB activation through the binding between inhibitor of nuclear factor -kBa and the processed NH2-terminal region of Mig-6"Cancer Res.. 62(20). 5668-5671 (2002)
[文献書誌] Hiratsuka, S.: "MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung specific metastasis"Cancer Cell. 2. 289-300 (2002)
[文献書誌] Endo, H.: "Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4"J. Biol. Chem.. 277. 26396-26402 (2002)
[文献書誌] Tatemichi, M.: "Ethnic difference in serology of Helicobactor pylori CagA between Japanese and non-Japanese Brazilians for non-cardia gastric cancer"Cancer Science. 94. 64-69 (2003)
[文献書誌] Cheng, J.L.: "Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors"Cancer Lett.. (in press).
[文献書誌] Fujino, Y.: "A prospective study of blood transfusion history and Liver cancer in a high-endemic area of Japan"Transfusion Med.. 12. 297-302 (2002)
[文献書誌] Fujino, Y.: "A prospective study of educational background and stomach cancer in Japan"Preventive Med.. 35. 121-127 (2002)
[文献書誌] Hoshiyama, Y.: "A prospective study of stomach cancer death in relation to green tea consumption in Japan"Br. J. Cancer. 87. 309-313 (2002)
[文献書誌] Iso, H.: "Perceived mental stress and mortality from cardiovascular disease among Japanese men and women : Japan collaborative cohort study for evaluation of cancer risk sponsored by Monbusho(JACC Study)"Circulation. 106. 1229-1236 (2002)
[文献書誌] Ito, Y.: "Mortality form cancer or all causes and SOD activity level and Zn/Cu ratio in peripheral blood : population based follow-up study"J. Epidemiol.. 12. 14-21 (2002)
[文献書誌] Ito, Y.: "Serum antioxidants and subsequent mortality rates of all causes or cancer among rural Japanese inhabitants"Internal J. Vit. Nutr. Res.. 72. 237-250 (2002)
[文献書誌] Iwai, N.: "Relationship between coffee and green tea consumption and all-cause mortality in a cohort of a rural Japanese population"J. Epidemiol.. 12. 191-198 (2002)
[文献書誌] Lin, Y.: "A prospective cohort study of cigarette smoking and pancreatic cancer in Japan"Cancer Causes Control. 13. 249-254 (2002)
[文献書誌] Lin, Y.: "Risk of pancreatic cancer in relation to alcohol drinking, coffee consumption and medical history : findings from the Japan Collaborative Study for evaluation of cancer risk"Int. J. Cancer. 99. 742-746 (2002)
[文献書誌] Ngoan, L.: "Dietary factors and stomach cancer mortality"Br. J. Cancer. 87. 37-42 (2002)
[文献書誌] Wakai, K.: "Serum insulin-like growth factors, insulin-like growth factor binding protein-3, and risk of lung cancer death : a case-control study nested in the Japan Collaborative Cohort (JACC) Study"Jpn. J. Cancer Res.. 93. 1279-1286 (2002)
[文献書誌] Yatsuya, H.: "Family history and the risk of stomach cancer death in Japan : differences by age and gender"Int. J. Cancer. 97. 688-694 (2002)
[文献書誌] Zhu, S.K.: "Short-and long-term reliability of information on previous illness and family history as compared with that on smoking and drinking habits in questionnaire surveys"J. Epidemiol.. 12. 120-125 (2002)
[文献書誌] Suzuki, K.: "The relationship between smoking habits and serum levels of 8-OhdG, oxidized LDL antibodies, Mn-SOD and carotenoids in rural Japanese residents"J. Epidemiol.. 13. 29-37 (2003)
[文献書誌] Zembutsu, H.: "Genome-wide cDNA microarray screening to correlate gene expression profiles with sensitivity of 85 human cancer xenografts to anticancer drugs"Cancer Res.. 62. 518-527 (2002)
[文献書誌] Ogata, M.: "Successful bone marrow transplantation from an unrelated donor in a patient with adult T cell leukemia"Bone Marrow Transplantation. 30. 699-701 (2002)
[文献書誌] Kunitomi, A.: "OX40 signaling renders adult T-cell leukemia cells resistant to fas-induced poptosis"Int. J. Hematol.. 76. 260-266 (2002)
[文献書誌] Yamaguchi, M.: "De novo CD5+ positive diffuse large B-cell lymphoma : a clinicopathologic study of 109 patients"Blood. 99. 815-821 (2002)
[文献書誌] Yamaguchi, K.: "Human T lymphotropic virus type-1 and adult T-cell leukemia in Japan"Int. J. Hematol.. 76(2). 240-245 (2002)
[文献書誌] Nosaka, K.: "Mechanism of hypercalcemia in adult T-cell leukemia : Overexpression of RANK ligand on adult T-cell leukemia"Blood. 99. 634-640 (2002)
[文献書誌] Ego, T.: "The interaction of HTLV-1 tax with HDAC1 negatively regulates the viral gene expression"Oncogene. 21. 7241-7246 (2002)
[文献書誌] Koiwa, T.: "5-LTR-selective CpG methylation of latent HTLV-1 provirus in vitro and in vivo"J. Virol.. 76. 9389-9397 (2002)
[文献書誌] Hasegawa, A.: "Expansion of human T-cell leukemia virus type I (HTLV-I) reservoir in orally infected rates : Inverse correlation with HTLV-I-specific cellular immune response"J. Virol.. (in press).
[文献書誌] Ando, M.: "Atrributable and absolute risk of lung cancer death by smoking status ; Findings from the Japan Collaborative Cohort (JACC) Study"Int. J. Cancer. (in press).
[文献書誌] Ito, Y.: "Serum carotenoids and mortality from lung cancer : a case-control study nested in the Japan Collaborative Cohort (JACC) Study"Cancer Science. (in press).
[文献書誌] Kaneko, S.: "Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females"Cancer Causes Control. (in press).
[文献書誌] Hino, S.: "Primary prevention of adult T cell leukemia (ATL) in Nagasaki, Japan by refraining from breast-feeding"Gann Monogr.. (in press).

2002 年度 実績報告書

ヒトがんの環境・宿主要因に関する疫学的研究

研究代表者

田島 和雄 愛知県がんセンター, 疫学・予防部, 部長 (30150212)

研究成果

[文献書誌] Hishida, A.: "Population based case-control study of HER2 genetic polymorphism and breast cancer risk"J. Natl. Cancer Inst.. 94. 1807 (2002)

[文献書誌] Hirose, K.: "Impact of established risk factors for breast cancer in nulligravid Japanese women"Breast Cancer. 10. 45-53 (2003)

[文献書誌] Teramukai, S.: "Anthropometric and behavioral correlates of insulin-like growth factor I and insulin-like growth factor binding protein 3 in middle-aged Japanese men"Am. J. Epidemiol.. 156(4). 344-348 (2002)

[文献書誌] Nakachi, K.: "Can teatime increase one's lifetime"Ageing Res. Reviews. 44. 1-10 (2003)

[文献書誌] Kikuchi, T.: "Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors"Oncogene. 21. 2741-2749 (2002)

[文献書誌] Sato, S.: "Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3"J. Biol. Chem.. 277. 39360-39367 (2002)

[文献書誌] Tsunoda, T.: "A novel mechanism of nuclear factor kB activation through the binding between inhibitor of nuclear factor -kBa and the processed NH2-terminal region of Mig-6"Cancer Res.. 62(20). 5668-5671 (2002)

[文献書誌] Hiratsuka, S.: "MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung specific metastasis"Cancer Cell. 2. 289-300 (2002)

[文献書誌] Endo, H.: "Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4"J. Biol. Chem.. 277. 26396-26402 (2002)

[文献書誌] Tatemichi, M.: "Ethnic difference in serology of Helicobactor pylori CagA between Japanese and non-Japanese Brazilians for non-cardia gastric cancer"Cancer Science. 94. 64-69 (2003)

[文献書誌] Cheng, J.L.: "Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors"Cancer Lett.. (in press).

[文献書誌] Fujino, Y.: "A prospective study of blood transfusion history and Liver cancer in a high-endemic area of Japan"Transfusion Med.. 12. 297-302 (2002)

[文献書誌] Fujino, Y.: "A prospective study of educational background and stomach cancer in Japan"Preventive Med.. 35. 121-127 (2002)

[文献書誌] Hoshiyama, Y.: "A prospective study of stomach cancer death in relation to green tea consumption in Japan"Br. J. Cancer. 87. 309-313 (2002)

[文献書誌] Iso, H.: "Perceived mental stress and mortality from cardiovascular disease among Japanese men and women : Japan collaborative cohort study for evaluation of cancer risk sponsored by Monbusho(JACC Study)"Circulation. 106. 1229-1236 (2002)

[文献書誌] Ito, Y.: "Mortality form cancer or all causes and SOD activity level and Zn/Cu ratio in peripheral blood : population based follow-up study"J. Epidemiol.. 12. 14-21 (2002)

[文献書誌] Ito, Y.: "Serum antioxidants and subsequent mortality rates of all causes or cancer among rural Japanese inhabitants"Internal J. Vit. Nutr. Res.. 72. 237-250 (2002)

[文献書誌] Iwai, N.: "Relationship between coffee and green tea consumption and all-cause mortality in a cohort of a rural Japanese population"J. Epidemiol.. 12. 191-198 (2002)

[文献書誌] Lin, Y.: "A prospective cohort study of cigarette smoking and pancreatic cancer in Japan"Cancer Causes Control. 13. 249-254 (2002)

[文献書誌] Lin, Y.: "Risk of pancreatic cancer in relation to alcohol drinking, coffee consumption and medical history : findings from the Japan Collaborative Study for evaluation of cancer risk"Int. J. Cancer. 99. 742-746 (2002)

[文献書誌] Ngoan, L.: "Dietary factors and stomach cancer mortality"Br. J. Cancer. 87. 37-42 (2002)

[文献書誌] Wakai, K.: "Serum insulin-like growth factors, insulin-like growth factor binding protein-3, and risk of lung cancer death : a case-control study nested in the Japan Collaborative Cohort (JACC) Study"Jpn. J. Cancer Res.. 93. 1279-1286 (2002)

[文献書誌] Yatsuya, H.: "Family history and the risk of stomach cancer death in Japan : differences by age and gender"Int. J. Cancer. 97. 688-694 (2002)

[文献書誌] Zhu, S.K.: "Short-and long-term reliability of information on previous illness and family history as compared with that on smoking and drinking habits in questionnaire surveys"J. Epidemiol.. 12. 120-125 (2002)

[文献書誌] Suzuki, K.: "The relationship between smoking habits and serum levels of 8-OhdG, oxidized LDL antibodies, Mn-SOD and carotenoids in rural Japanese residents"J. Epidemiol.. 13. 29-37 (2003)

[文献書誌] Zembutsu, H.: "Genome-wide cDNA microarray screening to correlate gene expression profiles with sensitivity of 85 human cancer xenografts to anticancer drugs"Cancer Res.. 62. 518-527 (2002)

[文献書誌] Ogata, M.: "Successful bone marrow transplantation from an unrelated donor in a patient with adult T cell leukemia"Bone Marrow Transplantation. 30. 699-701 (2002)

[文献書誌] Kunitomi, A.: "OX40 signaling renders adult T-cell leukemia cells resistant to fas-induced poptosis"Int. J. Hematol.. 76. 260-266 (2002)

[文献書誌] Yamaguchi, M.: "De novo CD5+ positive diffuse large B-cell lymphoma : a clinicopathologic study of 109 patients"Blood. 99. 815-821 (2002)

[文献書誌] Yamaguchi, K.: "Human T lymphotropic virus type-1 and adult T-cell leukemia in Japan"Int. J. Hematol.. 76(2). 240-245 (2002)

[文献書誌] Nosaka, K.: "Mechanism of hypercalcemia in adult T-cell leukemia : Overexpression of RANK ligand on adult T-cell leukemia"Blood. 99. 634-640 (2002)

[文献書誌] Ego, T.: "The interaction of HTLV-1 tax with HDAC1 negatively regulates the viral gene expression"Oncogene. 21. 7241-7246 (2002)

[文献書誌] Koiwa, T.: "5-LTR-selective CpG methylation of latent HTLV-1 provirus in vitro and in vivo"J. Virol.. 76. 9389-9397 (2002)

[文献書誌] Hasegawa, A.: "Expansion of human T-cell leukemia virus type I (HTLV-I) reservoir in orally infected rates : Inverse correlation with HTLV-I-specific cellular immune response"J. Virol.. (in press).

[文献書誌] Ando, M.: "Atrributable and absolute risk of lung cancer death by smoking status ; Findings from the Japan Collaborative Cohort (JACC) Study"Int. J. Cancer. (in press).

[文献書誌] Ito, Y.: "Serum carotenoids and mortality from lung cancer : a case-control study nested in the Japan Collaborative Cohort (JACC) Study"Cancer Science. (in press).

[文献書誌] Kaneko, S.: "Menstrual and reproductive factors and the mortality risk of gastric cancer in Japanese menopausal females"Cancer Causes Control. (in press).

[文献書誌] Hino, S.: "Primary prevention of adult T cell leukemia (ATL) in Nagasaki, Japan by refraining from breast-feeding"Gann Monogr.. (in press).

2002 年度実績報告書

田島和雄愛知県がんセンター, 疫学・予防部, 部長 (30150212)