2002 年度実績報告書

高次複雑系免疫システムの情報伝達制御

研究課題

研究課題/領域番号	11184101
研究機関	大阪大学
研究代表者	平野俊夫大阪大学, 生命機能研究科, 教授 (40136718)
研究分担者	谷口維紹東京大学, 医学系研究科, 教授 (50133616) 笹月健彦国立国際医療センター研究所, 所長 (50014121) 岸本忠三 , 総長 (10093402) 本庶佑京都大学, 医学研究科, 教授 (80090504) 谷口克千葉大学, 医学研究院, 教授 (80110310)
キーワード	免疫応答 / シグナル伝達 / 免疫異常 / ノックアウトマウス / トランスジェニックマウス
研究概要	本特定領域研究では、高次複雑系免疫システムの情報伝達制御機構の解明と、その異常による免疫疾患の発症機構を明らかにするために以下の研究項目を設定している。 A01:抗原非特異的分子による情報伝達制御 A02:抗原認識のシグナル変換機構 A03:免疫システム構築の情報伝達制御本総括班の目的は、1)上記の研究項目それぞれの年次ごとの研究評価を行い、計画立案に対する助言や計画に従って成果が蓄積されているか否かを厳密にチェックする、2)各々の研究項目の研究者が密な連携をもって、相補的に、また相互活性化しながら、研究を推進するように、公開シンポジウムの開催、研究資材の交換、共通な研究支援体制を確立する、3)情報公開を積極的に推進するなど、時機をえた柔軟な活動を行うことである。平成14年度は、7月9日に第一回総括班会議を、平成15年2月20日に第二回総括班会議を開催し、本特定領域研究の研究評価並びに研究計画に対する検討を行った。第一回班会議においては、平成14年度の方針を決めた。第二回班会議においては、本特定領域研究の研究評価をおこない、おおむね順調に計画が遂行されていることが確認された。ニュースレターNo.6(平成14年6月)、No.7(平成15年1月)を発刊した。情報の公開を促進する目的でホームページを開設し、内容の更新を随時行った。さらに、平成15年2月に、理学研究所・免疫アレルギー総合科学センターとの共同で、国際シンポジウムを開催した。海外から23名、特定領域研究班員を中心に、国内から24名の講演者によるシンポジウムを行った。海外からの40名を含めて、合計434名の参加のもとに、2月20日〜23日の4日間、熱心な発表、討論、情報交換を行った。このシンポジウム期間中に、本特定領域研究によっておこなわれた研究成果が、海外の研究成果と比較して、勝るとも劣らないことが確認できた。又、今後の免疫学研究の方向性が確認できた。

研究成果
(29件)

すべてその他

すべて文献書誌 (29件)

[文献書誌] Atsumi, T., T.Hirano, et al.: "A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp13O causes autoimmune arthritis"J. Exp Med.. 196. 979-990 (2002)
[文献書誌] Nishida, K., T.Hirano, et al.: "Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling"Blood. 99. 1866-1869 (2002)
[文献書誌] Hirano, T.: "Revival of the autoantibody model in rheumatoid arthritis"Nature Immunology. 3. 342-344 (2002)
[文献書誌] Azeredo da Silveira, S., T., Saito, et al.: "Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody"J. Exp. Med. 195. 665-672 (2002)
[文献書誌] Ioan-Facsinay, A., T.Saito, et al.: "Fcγ RI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses and protection from bacterial infection"Immunity. 16. 391-402 (2002)
[文献書誌] Yokosuka, T., T.Saito, et al.: "Predominant role of T cell receptor α chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system"J. Exp. Med.. 195. 991-1001 (2002)
[文献書誌] Redegeld, F.A., T.Saito, et al.: "Immunoglobulin free light chains elicit immediate hypersensitivity-like responses"Nat. Med. 8. 694-701 (2002)
[文献書誌] Wang, Y-H., T.Saito, et al.: "Differential surrogate light chain expression governs B cell differentiation"Blood. 99. 2459-2467 (2002)
[文献書誌] Kudo, S., H.Karasuyama, et al.: "Long-term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE"J. Immunol.. 170. 775-780 (2003)
[文献書誌] Saijo, K., H.Karasuyama, et al.: "Essential role of Src-family protein tyrosine kinases in NF-kB activation during B cell development"Nature Immunol.. 4. 274-279 (2003)
[文献書誌] Nakagawa R., T.Kishimoto, et al.: "SOCS-1 participates in negative regulation of LPS responses"IMMUNITY. 17. 677-687 (2002)
[文献書誌] Seki Y, T.Kishimoto, et al.: "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation"Proceedings of the national academy of sciences of the united states of america. 99. 13003-13008 (2002)
[文献書誌] Morishima Y, T.Sasazuki, et al.: "The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donor"BLOOD. 99. 4200-4206 (2002)
[文献書誌] Marsh SGE, T.Sasazuki, et al.: "Nomenclature for factors of the HLA system"EUROPEAN JOURNAL OF IMMUNOGENETICS. 29. 463-516 (2002)
[文献書誌] Gonzalez-Aseguinolaza G, T.Tanigushi, et al.: "Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines"J. Exp. Med.. 195. 617-624 (2002)
[文献書誌] Higuchi M, T.Tanigushi, et al.: "Immune tolerance to combined organ and bone marrow transplants after fractionated lymphoid irradiation involves regulatory NK T cells and clonal"JOURNAL OF IMMUNOLOGY. 169. 5564-5570 (2002)
[文献書誌] Fagarasan S, T.Honjo, et al.: "Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora"SCIENCE. 298. 1424-1427 (2002)
[文献書誌] Yoshikawa K, T.Honjo, et al.: "AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts"SCIENCE. 296. 2033-2036 (2002)
[文献書誌] Okazaki IM, T.Honjo, et al.: "The AID enzyme induces class switch recombination in fibroblasts"NATURE. 416. 340-345 (2002)
[文献書誌] Nagaoka H, T.Honjo, et al.: "Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin S mu region : Implication of AID involvement in a common step of class switch recombination and somatic hypermutation"JOURNAL OF EXPERIMENTAL MEDICINE. 195. 529-534 (2002)
[文献書誌] Honjo T, et al.: "Molecular mechanism of class switch recombination : Linkage with somatic hypermutation"ANNUAL REVIEW OF IMMUNOLOGY. 20. 165-196 (2002)
[文献書誌] Takayanagi H, T.Taniguchi, et al.: "RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta"NATURE. 416. 744-749 (2002)
[文献書誌] Taniguchi T, Takaoka A: "The interferon-alpha/beta system in antiviral responses : a multimodal machinery of gene regulation by the IRF family of transcription factors"CURRENT OPINION IN IMMUNOLOGY. 14. 111-116 (2002)
[文献書誌] Nishimura EK, S.Nishikawa, et al.: "Dominant role of the niche in melanocyte stem-cell fate determination"NATURE. 416. 854-860 (2002)
[文献書誌] Miyashita H, S.Nishikawa, et al.: "A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis"BLOOD. 99. 3241-3249 (2002)
[文献書誌] Hanafusa H, E.Nishida, et al.: "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway"NATURE CELL BIOLOGY. 4. 850-858 (2002)
[文献書誌] Akashi M, E.Nishida, et al.: "Control of intracellular dynamics of mammalian period proteins by casein kinase epsilon (CKI epsilon) and CKI delta in cultured cells"MOLECULAR AND CELLULAR BIOLOGY. 22. 1693-1703 (2002)
[文献書誌] Yoshida Y, T.Yamamoto, et al.: "Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling"DEVELOPMENTAL BIOLOGY. 247. 73 (2002)
[文献書誌] Yasuda T, T.Yamamoto, et al.: "Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma 2 in B cells"JOURNAL OF EXPERIMENTAL MEDICINE. 196. 51-63 (2002)

2002 年度 実績報告書

高次複雑系免疫システムの情報伝達制御

研究代表者

平野 俊夫 大阪大学, 生命機能研究科, 教授 (40136718)

研究成果

[文献書誌] Atsumi, T., T.Hirano, et al.: "A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp13O causes autoimmune arthritis"J. Exp Med.. 196. 979-990 (2002)

[文献書誌] Nishida, K., T.Hirano, et al.: "Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling"Blood. 99. 1866-1869 (2002)

[文献書誌] Hirano, T.: "Revival of the autoantibody model in rheumatoid arthritis"Nature Immunology. 3. 342-344 (2002)

[文献書誌] Azeredo da Silveira, S., T., Saito, et al.: "Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody"J. Exp. Med. 195. 665-672 (2002)

[文献書誌] Ioan-Facsinay, A., T.Saito, et al.: "Fcγ RI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses and protection from bacterial infection"Immunity. 16. 391-402 (2002)

[文献書誌] Yokosuka, T., T.Saito, et al.: "Predominant role of T cell receptor α chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system"J. Exp. Med.. 195. 991-1001 (2002)

[文献書誌] Redegeld, F.A., T.Saito, et al.: "Immunoglobulin free light chains elicit immediate hypersensitivity-like responses"Nat. Med. 8. 694-701 (2002)

[文献書誌] Wang, Y-H., T.Saito, et al.: "Differential surrogate light chain expression governs B cell differentiation"Blood. 99. 2459-2467 (2002)

[文献書誌] Kudo, S., H.Karasuyama, et al.: "Long-term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE"J. Immunol.. 170. 775-780 (2003)

[文献書誌] Saijo, K., H.Karasuyama, et al.: "Essential role of Src-family protein tyrosine kinases in NF-kB activation during B cell development"Nature Immunol.. 4. 274-279 (2003)

[文献書誌] Nakagawa R., T.Kishimoto, et al.: "SOCS-1 participates in negative regulation of LPS responses"IMMUNITY. 17. 677-687 (2002)

[文献書誌] Seki Y, T.Kishimoto, et al.: "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation"Proceedings of the national academy of sciences of the united states of america. 99. 13003-13008 (2002)

[文献書誌] Morishima Y, T.Sasazuki, et al.: "The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donor"BLOOD. 99. 4200-4206 (2002)

[文献書誌] Marsh SGE, T.Sasazuki, et al.: "Nomenclature for factors of the HLA system"EUROPEAN JOURNAL OF IMMUNOGENETICS. 29. 463-516 (2002)

[文献書誌] Gonzalez-Aseguinolaza G, T.Tanigushi, et al.: "Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines"J. Exp. Med.. 195. 617-624 (2002)

[文献書誌] Higuchi M, T.Tanigushi, et al.: "Immune tolerance to combined organ and bone marrow transplants after fractionated lymphoid irradiation involves regulatory NK T cells and clonal"JOURNAL OF IMMUNOLOGY. 169. 5564-5570 (2002)

[文献書誌] Fagarasan S, T.Honjo, et al.: "Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora"SCIENCE. 298. 1424-1427 (2002)

[文献書誌] Yoshikawa K, T.Honjo, et al.: "AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts"SCIENCE. 296. 2033-2036 (2002)

[文献書誌] Okazaki IM, T.Honjo, et al.: "The AID enzyme induces class switch recombination in fibroblasts"NATURE. 416. 340-345 (2002)

[文献書誌] Nagaoka H, T.Honjo, et al.: "Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin S mu region : Implication of AID involvement in a common step of class switch recombination and somatic hypermutation"JOURNAL OF EXPERIMENTAL MEDICINE. 195. 529-534 (2002)

[文献書誌] Honjo T, et al.: "Molecular mechanism of class switch recombination : Linkage with somatic hypermutation"ANNUAL REVIEW OF IMMUNOLOGY. 20. 165-196 (2002)

[文献書誌] Takayanagi H, T.Taniguchi, et al.: "RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta"NATURE. 416. 744-749 (2002)

[文献書誌] Taniguchi T, Takaoka A: "The interferon-alpha/beta system in antiviral responses : a multimodal machinery of gene regulation by the IRF family of transcription factors"CURRENT OPINION IN IMMUNOLOGY. 14. 111-116 (2002)

[文献書誌] Nishimura EK, S.Nishikawa, et al.: "Dominant role of the niche in melanocyte stem-cell fate determination"NATURE. 416. 854-860 (2002)

[文献書誌] Miyashita H, S.Nishikawa, et al.: "A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis"BLOOD. 99. 3241-3249 (2002)

[文献書誌] Hanafusa H, E.Nishida, et al.: "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway"NATURE CELL BIOLOGY. 4. 850-858 (2002)

[文献書誌] Akashi M, E.Nishida, et al.: "Control of intracellular dynamics of mammalian period proteins by casein kinase epsilon (CKI epsilon) and CKI delta in cultured cells"MOLECULAR AND CELLULAR BIOLOGY. 22. 1693-1703 (2002)

[文献書誌] Yoshida Y, T.Yamamoto, et al.: "Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling"DEVELOPMENTAL BIOLOGY. 247. 73 (2002)

[文献書誌] Yasuda T, T.Yamamoto, et al.: "Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma 2 in B cells"JOURNAL OF EXPERIMENTAL MEDICINE. 196. 51-63 (2002)

2002 年度実績報告書

平野俊夫大阪大学, 生命機能研究科, 教授 (40136718)