2002 年度実績報告書

細胞周期制御

研究課題

研究課題/領域番号	12060101
研究機関	東京大学
研究代表者	岡山博人東京大学, 大学院・医学系研究科, 教授 (40111950)
研究分担者	鍔田武志東京医科歯科大学, 難治疾患研究所, 教授 (80197756) 東江昭夫東京大学, 大学院・理学系研究科, 教授 (90029249) 岸本健雄東京工業大学, 大学院・生命理工学研究科, 教授 (00124222) 大矢禎一東京大学, 大学院・新領域創成科学研究科, 教授 (20183767) 西田育巧名古屋大学, 大学院・理学研究科, 教授 (50107059)
キーワード	細胞周期制御 / G1 / G2 / 分化 / アポトーシス / 癌
研究概要	当総括班は、特定領域研究「細胞周期制御」の計画・公募班の研究をより効率的に推進するために、組織された。主たる活動は、意見・情報の交換を促進するための国際ワークショップと研究進捗報告全体会議の開催である。平成14年度は、第二班の班長である東工大岸本教授のオーガナイズにより、M-Phase Progressionのタイトルのもとに12月2日から4日まで湘南国際村センターで開催された。演者として、2001年度ノーベル医学生理学賞受賞者の英国Tim Hunt博士を始め欧米から12名、国内から6名の細胞周期の分裂期の研究で国際的にトップクラスの研究者を招聘し、最新の研究成果を発表いただいた。当研究班員を含め全国から若手の研究者を中心に200名以上の参加があり、大変有益な会合であった。一方、特に研究班員のなかでの情報・意見の交換の場として重要な役割を果たしているのが、研究進捗報告全体会議である。10月29-31日の3日間を費やして、東大医学部講義室で行われた。計画・公募研究者を問わず、各自10-15分で約80名の発表が行われ、前年度に引き続き班員からは大変有用な会議との声が多数聞かれた。なお、平成15年度の国際ワークショップは、第三班の班長である東大東江教授の担当で、Proteolysis in Cellular Functionのタイトルのもとに10月中旬開催予定である。

研究成果
(36件)

すべてその他

すべて文献書誌 (36件)

[文献書誌] Tanaka, H. et al.: "The fission Yeast pfh1^+ gene encodes an essential 5' to 3' DNA helicase required for the completion of S-phase"Nucleic Acids Research. 30・22. 4728-4739 (2002)
[文献書誌] Hiroi, N. et al.: "Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation"The EMBO Journal. 21・19. 5235-5244 (2002)
[文献書誌] Jinno, S. et al.: "Cdc6 requires anchorage for its expression"Oncogene. 21. 1777-1784 (2002)
[文献書誌] Chen, Q. et al.: "Overexpression of Cdk6-cyclin D3 highly sensitizes cells to physical and chemical transformation"Oncogene. 22. 992-1001 (2003)
[文献書誌] Uesono, Y. et al.: "Transient inhibition of translation initiation by osmotic stress"J. Biol. Chem.. 277. 13848-13855 (2002)
[文献書誌] Yoshida, S. et al.: "Mitotic exit network controls the localization of Cdc14 to the spindle pole body in Saccharomyces cerevisiae"Curr. Biol.. 12. 944-950 (2002)
[文献書誌] Saeki, Y. et al.: "Ubiquitin-like proteins and Rpn10 play cooperative roles in ubiquitindependent proteolysis"Biochem. Biophys. Res. Commun.. 293. 986-992 (2002)
[文献書誌] Kaida, D., et al.: "Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression"Genes Cells. 7. 543-552 (2002)
[文献書誌] Yoshida, S. et al.: "Budding yeast Cdc5 phosphorylates Net1 and assists Cdc14 release from the nucleolus"Biochem. Biophys. Res. Commun.. 294. 687-691 (2002)
[文献書誌] Asakawa, K. et al.: "A defect in KAP104 alleviates the requirement of the MEN (Mitotic Exit Network) gene function in Saccharomyces cerevisiae"Genetics. 162. 1545-1556 (2002)
[文献書誌] Itoh, K. et al.: "Complex formation with the class IV myosin Myo2p is essential for Ypt11p, a rab-type small GTPase, to facilitate the Myo2p function for mitochondrial distribution in the budding yeast"Mol. Cell. Biol.. 22. 7744-7757 (2002)
[文献書誌] Toh-e, A. et al.: "Genetic charactenization of genes encoding enzymes catalyzing addition of phosphoethanolamine to the glucosylphosphatidylinositol anchor in Saccharomyces cerevisiae"Genes Genet Sys.. 77. 309-322 (2002)
[文献書誌] Saeki, Y. et al.: "Identification of ubiquitin-like protein-binding subunits of the 26S proteasome"Biochem. Biophys. Res. Commun. 296. 813-819 (2002)
[文献書誌] Tone, Y. et al.: "Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae"Genes Dev.. 16. 3142-3157 (2002)
[文献書誌] Mizuno, T. et al.: "Drosophila myosin phosphatase and its role in dorsal closure"Development. 129. 1215-1223 (2002)
[文献書誌] Kwon, E.-J.et al.: "Transcription control of a gene for Drosophila transcription factor, DREF by DRE and cis-elements conserved between Drosophila melanogaster"Gene. (in press). (2003)
[文献書誌] Sekiya, -K.M. et al.: "Dissection of Upstream Regulatory Components of the Rho1p Effector, 1,3-β-Glucan Synthase, in Saccharomyces cerevisiae"Genetics. 162. 663-761 (2002)
[文献書誌] Utsugi, T. et al.: "Movement of yeast 1,3-β-glucan synthase on the surface of the plasma membrane"Gene to Cells. 7. 1-9 (2002)
[文献書誌] Mizutani, R., et al.: "Protein-splicing reaction via a thiazolidine intermediate : crystal structure of the VMA1-derived endonuclease bearing the N-and C-terminal propeptides"J. Mol. Biol.. 316. 919-929 (2002)
[文献書誌] Dijkgraaf, G.J.P. et al.: "Involvement of Saccharomyces cerevisiae Fks1p in β-1,6-glucan biosynthesis"Yeast. 19. 671-690 (2002)
[文献書誌] Nogami, S. et al.: "Karyopherin-mediated Nuclear Import of the Homing Endonuclease, VDE, Is Required for Self-propagation of the Coding Region"Mol. Cell Biol.. 23. 1726-1736 (2002)
[文献書誌] Okuda Y. et al.: "Occurrence, horizonatal transfer and degeneration of VDE intein family in saccharomycete yeasts"Yeast. (in press). (2003)
[文献書誌] Abe, M.et al.: "Lack of GTP-bound Rho1p in Secretory Vesicles of Saccharomyces cerevisiae"J. Cell Biol.. (in press). (2003)
[文献書誌] Ohtani, Sano, F. et al.: "Development of image processing program for yeast cell morphology"J. Bioinfo Comp. Biol.. (in press). (2003)
[文献書誌] Tachibana, M. et al.: "G9a histone methyltransferase plays a dominant role for euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis"Genes and Development. 16. 1779-1791 (2002)
[文献書誌] Xin, Z.et al.: "Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center"J. Biol. Chem.. (in press). (2003)
[文献書誌] Higuchi, T. et al.: "Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease"J. Immunol.. 168. 9-12 (2002)
[文献書誌] Wakabayashi, C. et al.: "A distinct signaling pathway used by the IgG-containing B cell antigen receptor"Science. 298. 2392-2395 (2002)
[文献書誌] Okumura, E. et al.: "Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition"Nature Cell Biol.. 4. 111-116 (2002)
[文献書誌] Iwabuchi, M. et al.: "Coordinated regulation of M phase exit and S phase entry by the Cdc2 activity level in the early embryonic cell cycle"Dev. Biol.. 243. 34-43 (2002)
[文献書誌] Saito, T. et al.: "Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation"J. Neurosci.. 23. 1189-1194 (2003)
[文献書誌] Okano-Uchida, T. et al.: "Distinct regulators for Plk activation in meiotic and early embryonic cycles"EMBO J.. (in press). (2003)
[文献書誌] Higashiyama, H. et al.: "Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced eye degeneration"Cell Death Differ.. 9. 264-273 (2002)
[文献書誌] Hirose, F. et al.: "Drosophila Mi-2 negatively regulates dDREF by inhibiting its DNA binding activity"Mol. Cell. Biol.. 22. 5182-5193 (2002)
[文献書誌] Hwang M.-S.et al.: "The Caudal homeodomain protein activates Drosophila E2F gene expression"Nucleic Acids Res.. 23. 5029-5035 (2002)
[文献書誌] Kwon, E. et al.: "Transcription control of a gene for Drosophila transcription factor, DREF by DRE and cis-elements conserved between Drosophila melanogaster and virilis"Gene. (in press). (2003)

2002 年度 実績報告書

細胞周期制御

研究代表者

岡山 博人 東京大学, 大学院・医学系研究科, 教授 (40111950)

研究成果

[文献書誌] Tanaka, H. et al.: "The fission Yeast pfh1^+ gene encodes an essential 5' to 3' DNA helicase required for the completion of S-phase"Nucleic Acids Research. 30・22. 4728-4739 (2002)

[文献書誌] Hiroi, N. et al.: "Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation"The EMBO Journal. 21・19. 5235-5244 (2002)

[文献書誌] Jinno, S. et al.: "Cdc6 requires anchorage for its expression"Oncogene. 21. 1777-1784 (2002)

[文献書誌] Chen, Q. et al.: "Overexpression of Cdk6-cyclin D3 highly sensitizes cells to physical and chemical transformation"Oncogene. 22. 992-1001 (2003)

[文献書誌] Uesono, Y. et al.: "Transient inhibition of translation initiation by osmotic stress"J. Biol. Chem.. 277. 13848-13855 (2002)

[文献書誌] Yoshida, S. et al.: "Mitotic exit network controls the localization of Cdc14 to the spindle pole body in Saccharomyces cerevisiae"Curr. Biol.. 12. 944-950 (2002)

[文献書誌] Saeki, Y. et al.: "Ubiquitin-like proteins and Rpn10 play cooperative roles in ubiquitindependent proteolysis"Biochem. Biophys. Res. Commun.. 293. 986-992 (2002)

[文献書誌] Kaida, D., et al.: "Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression"Genes Cells. 7. 543-552 (2002)

[文献書誌] Yoshida, S. et al.: "Budding yeast Cdc5 phosphorylates Net1 and assists Cdc14 release from the nucleolus"Biochem. Biophys. Res. Commun.. 294. 687-691 (2002)

[文献書誌] Asakawa, K. et al.: "A defect in KAP104 alleviates the requirement of the MEN (Mitotic Exit Network) gene function in Saccharomyces cerevisiae"Genetics. 162. 1545-1556 (2002)

[文献書誌] Itoh, K. et al.: "Complex formation with the class IV myosin Myo2p is essential for Ypt11p, a rab-type small GTPase, to facilitate the Myo2p function for mitochondrial distribution in the budding yeast"Mol. Cell. Biol.. 22. 7744-7757 (2002)

[文献書誌] Toh-e, A. et al.: "Genetic charactenization of genes encoding enzymes catalyzing addition of phosphoethanolamine to the glucosylphosphatidylinositol anchor in Saccharomyces cerevisiae"Genes Genet Sys.. 77. 309-322 (2002)

[文献書誌] Saeki, Y. et al.: "Identification of ubiquitin-like protein-binding subunits of the 26S proteasome"Biochem. Biophys. Res. Commun. 296. 813-819 (2002)

[文献書誌] Tone, Y. et al.: "Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae"Genes Dev.. 16. 3142-3157 (2002)

[文献書誌] Mizuno, T. et al.: "Drosophila myosin phosphatase and its role in dorsal closure"Development. 129. 1215-1223 (2002)

[文献書誌] Kwon, E.-J.et al.: "Transcription control of a gene for Drosophila transcription factor, DREF by DRE and cis-elements conserved between Drosophila melanogaster"Gene. (in press). (2003)

[文献書誌] Sekiya, -K.M. et al.: "Dissection of Upstream Regulatory Components of the Rho1p Effector, 1,3-β-Glucan Synthase, in Saccharomyces cerevisiae"Genetics. 162. 663-761 (2002)

[文献書誌] Utsugi, T. et al.: "Movement of yeast 1,3-β-glucan synthase on the surface of the plasma membrane"Gene to Cells. 7. 1-9 (2002)

[文献書誌] Mizutani, R., et al.: "Protein-splicing reaction via a thiazolidine intermediate : crystal structure of the VMA1-derived endonuclease bearing the N-and C-terminal propeptides"J. Mol. Biol.. 316. 919-929 (2002)

[文献書誌] Dijkgraaf, G.J.P. et al.: "Involvement of Saccharomyces cerevisiae Fks1p in β-1,6-glucan biosynthesis"Yeast. 19. 671-690 (2002)

[文献書誌] Nogami, S. et al.: "Karyopherin-mediated Nuclear Import of the Homing Endonuclease, VDE, Is Required for Self-propagation of the Coding Region"Mol. Cell Biol.. 23. 1726-1736 (2002)

[文献書誌] Okuda Y. et al.: "Occurrence, horizonatal transfer and degeneration of VDE intein family in saccharomycete yeasts"Yeast. (in press). (2003)

[文献書誌] Abe, M.et al.: "Lack of GTP-bound Rho1p in Secretory Vesicles of Saccharomyces cerevisiae"J. Cell Biol.. (in press). (2003)

[文献書誌] Ohtani, Sano, F. et al.: "Development of image processing program for yeast cell morphology"J. Bioinfo Comp. Biol.. (in press). (2003)

[文献書誌] Tachibana, M. et al.: "G9a histone methyltransferase plays a dominant role for euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis"Genes and Development. 16. 1779-1791 (2002)

[文献書誌] Xin, Z.et al.: "Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center"J. Biol. Chem.. (in press). (2003)

[文献書誌] Higuchi, T. et al.: "Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease"J. Immunol.. 168. 9-12 (2002)

[文献書誌] Wakabayashi, C. et al.: "A distinct signaling pathway used by the IgG-containing B cell antigen receptor"Science. 298. 2392-2395 (2002)

[文献書誌] Okumura, E. et al.: "Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition"Nature Cell Biol.. 4. 111-116 (2002)

[文献書誌] Iwabuchi, M. et al.: "Coordinated regulation of M phase exit and S phase entry by the Cdc2 activity level in the early embryonic cell cycle"Dev. Biol.. 243. 34-43 (2002)

[文献書誌] Saito, T. et al.: "Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation"J. Neurosci.. 23. 1189-1194 (2003)

[文献書誌] Okano-Uchida, T. et al.: "Distinct regulators for Plk activation in meiotic and early embryonic cycles"EMBO J.. (in press). (2003)

[文献書誌] Higashiyama, H. et al.: "Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced eye degeneration"Cell Death Differ.. 9. 264-273 (2002)

[文献書誌] Hirose, F. et al.: "Drosophila Mi-2 negatively regulates dDREF by inhibiting its DNA binding activity"Mol. Cell. Biol.. 22. 5182-5193 (2002)

[文献書誌] Hwang M.-S.et al.: "The Caudal homeodomain protein activates Drosophila E2F gene expression"Nucleic Acids Res.. 23. 5029-5035 (2002)

[文献書誌] Kwon, E. et al.: "Transcription control of a gene for Drosophila transcription factor, DREF by DRE and cis-elements conserved between Drosophila melanogaster and virilis"Gene. (in press). (2003)

2002 年度実績報告書

岡山博人東京大学, 大学院・医学系研究科, 教授 (40111950)