2002 年度実績報告書

ヒトの感覚運動機能連関に関する非侵襲的研究

研究課題

研究課題/領域番号	12210012
研究機関	京都大学
研究代表者	柴崎浩京都大学, 医学研究科, 教授 (30037444)
研究分担者	池田昭夫京都大学, 医学研究科, 講師 (90212761) 長峯隆京都大学, 医学研究科, 助教授 (10231490) 福山秀直京都大学, 医学研究科, 教授 (90181297) 美馬達哉京都大学, 医学研究科, 助手 (20324618)
キーワード	磁気共鳴画像法 / 脳磁図 / 遅延反応課題 / 経頭蓋的磁気刺激
研究概要	本研究は、正常者および神経疾患患者を対象として、各種の感覚情報を処理して随意運動の発現に至るまでの機構(感覚運動機能連関)を、それぞれ異なった特徴を有する各種非侵襲的検索法を統合的に用いることによって、解明するものである。ヒトの感覚運動連関における運動前野(PM)の役割難治性てんかん患者に二連発刺激反応時間測定課題(刺激間間隔2秒)を課して、皮質電位を記録することにより、ventro-rostral PMが短潜時で刺激の受容に関連して活動し、続いてdorsal PM、そしてcaudal PMから一次運動野(M1)に向かって活動が移行することを明らかにした。また、運動閾値下の強さの反復磁気刺激をventral PMに与えると、刺激終了後もM1の興奮性を抑制することを見い出した。ジストニー患者における感覚運動皮質機能連関の異常 fMRIにより、ジストニーでは運動皮質の抑制機構に異常があることを明らかにした。低頻度反復磁気刺激による脳機能解明大脳皮質を低頻度電気刺激(約1Hz)することで刺激終了後にも持続する一過性の局所の脳機能抑制を引き起こすことができることが報告され、神経科学領域での新しい非侵襲的機能検索法として注目されている(virtual lesion study)。この手法を応用して、ヒト一次感覚運動野を低頻度磁気刺激することで一過性の触覚閾値の上昇が生じることを発見した。また、ヒト運動前野(PM)への低頻度磁気刺激の直後には脳波ム筋電図コヒーレンスが減少していることを発見した。これは大脳と筋活動間の機能的カップリングが、PM刺激によって一時的に抑制されたことを示唆する。

研究成果
(24件)

すべてその他

すべて文献書誌 (24件)

[文献書誌] Kanda M. et al.: "Cortical potentials related to assessment of pain intensity with visual analogue scale (VAS)"Clin Neurophysiol. 113. 1013-1024 (2002)
[文献書誌] Sawamoto N. et al.: "Cognitive slowing in Parkinson's disease : a behavioral evaluation independent of motor slowing J Neurosci"J Neurosci. 15. 5198-5203 (2002)
[文献書誌] Yamamoto J, et al.: "Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy"Epiolepsia. 43. 491-495 (2002)
[文献書誌] Shibasaki H: "Physiology of negative myoclonus"Adv Neurol. 89. 101-113 (2002)
[文献書誌] Oga T, et al.: "Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp : an fMRI study"Brain. 125. 895-903 (2002)
[文献書誌] Nakamura K, et al.: "Modulation of the visual word retrieval system in writing : a functional MRI study on the Japanese orthographies"J Cogn Neurosci. 14. 104-115 (2002)
[文献書誌] Satow T, et al.: "Partial epilepsy manifesting atonic seizure : report of two case"Epilepsia. 43. 1425-1431 (2002)
[文献書誌] Fujiwara N. et al.: "Second somatosensory area (SII) plays a significant role in selective somatosensory attention"Cognitive Brain Research. 14. 389-397 (2002)
[文献書誌] Yoshida K. et al.: "Factors influencing the therapeutic effect of muscle afferent block for oromandibular dystonia and dyskinesia : implications for their distinct pathophysiology"Int J Oral Maxillofac Surg. 31. 499-505 (2002)
[文献書誌] Ikeda A. et al.: "Cortical motor mapping in epilepsy patients : information from subdural electrodes in presurgical evaluation"Epilepsia. 43. 56-60 (2002)
[文献書誌] Oyanagi C. et al.: "Comparison of striatal dopamine D2 receptors in Parkinson's disease and progressive supranuclear palsy patients using [123l] iodobenzofuran single-photon emission computed tomography"J Neuroimaging. 12. 316-324 (2002)
[文献書誌] Hanakawa T. et al.: "The role of rostral Brodmann area 6 in mental-operation tasks : an integrative neuroimaging approach"Cereb Cortex. 12. 1157-1170 (2002)
[文献書誌] Hayashi T. et al.: "Neuronal nitric oxide has a role as a perfusion regulator and a synaptic modulator in cerebellum but not in neocortex during somatosensory stimulation--an animal PET study"Neurosci Res. 44. 155-165 (2002)
[文献書誌] Ikeda A. et al.: ""Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates : a document of subdural mapping"J Neurol Sci. 15. 43-52 (2002)
[文献書誌] Takeshita K et al.: "Maturational change of parallel auditory processing in school-aged children revealed by simultaneous recording of magnetic and electric cortical resronses"Clin Neurophysiol. 113. 1470-1484 (2002)
[文献書誌] Yamamoto J et al.: "Seizures arising from the inferior parietal lobule can show ictal semiology of the second sensory seizure (SII seizure)"J Neurol Neurosurg Psychiatry. 74. 367-369 (2002)
[文献書誌] Satow, T. et al.: "Nausea as a complication of low-frequency repetitive transcranial magnetic stimulation of the posterior fossa"Clin Neurophysiol. 113. 1441-1443 (2002)
[文献書誌] Kanda M, et al.: "Cortical potentials related to assessment of pain intensity with visual analogue scale (VAS)"Clin Neurophysiol. 113. 1013-1024 (2002)
[文献書誌] Usui K et al.: "Conversion of semantic information into phonological representation : a function in left posterior basal temporal area"Brain. 126. 632-641 (2003)
[文献書誌] Yoshida K et al.: "Movement-related cortical potentials before jaw excursions in oromandibular dystonia"Mov Disord. 18. 94-100 (2003)
[文献書誌] Satow T, et al.: "Short-lasting impairment of tactile perception after low-frequency rTMS of the sensorimotor cortex"Neurology. 60. 1045-1047 (2003)
[文献書誌] Hanakawa T. et al.: "Functional properties of brain areas associated with motor execution and imagery"J Neurophysiol. 89. 989-1002 (2003)
[文献書誌] Kanda M. et al.: "Transcranial magnetic stimulation (TMS) of the sensorimotor cortex and medial frontal cortex modifies human pain perception"Clin Neurophysiol. (In press).
[文献書誌] Ikeda A et al.: "Motor inhibition by human supplementary motor area proper"Clin Neurophysiol. (In press).

2002 年度 実績報告書

ヒトの感覚運動機能連関に関する非侵襲的研究

研究代表者

柴崎 浩 京都大学, 医学研究科, 教授 (30037444)

研究成果

[文献書誌] Kanda M. et al.: "Cortical potentials related to assessment of pain intensity with visual analogue scale (VAS)"Clin Neurophysiol. 113. 1013-1024 (2002)

[文献書誌] Sawamoto N. et al.: "Cognitive slowing in Parkinson's disease : a behavioral evaluation independent of motor slowing J Neurosci"J Neurosci. 15. 5198-5203 (2002)

[文献書誌] Yamamoto J, et al.: "Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy"Epiolepsia. 43. 491-495 (2002)

[文献書誌] Shibasaki H: "Physiology of negative myoclonus"Adv Neurol. 89. 101-113 (2002)

[文献書誌] Oga T, et al.: "Abnormal cortical mechanisms of voluntary muscle relaxation in patients with writer's cramp : an fMRI study"Brain. 125. 895-903 (2002)

[文献書誌] Nakamura K, et al.: "Modulation of the visual word retrieval system in writing : a functional MRI study on the Japanese orthographies"J Cogn Neurosci. 14. 104-115 (2002)

[文献書誌] Satow T, et al.: "Partial epilepsy manifesting atonic seizure : report of two case"Epilepsia. 43. 1425-1431 (2002)

[文献書誌] Fujiwara N. et al.: "Second somatosensory area (SII) plays a significant role in selective somatosensory attention"Cognitive Brain Research. 14. 389-397 (2002)

[文献書誌] Yoshida K. et al.: "Factors influencing the therapeutic effect of muscle afferent block for oromandibular dystonia and dyskinesia : implications for their distinct pathophysiology"Int J Oral Maxillofac Surg. 31. 499-505 (2002)

[文献書誌] Ikeda A. et al.: "Cortical motor mapping in epilepsy patients : information from subdural electrodes in presurgical evaluation"Epilepsia. 43. 56-60 (2002)

[文献書誌] Oyanagi C. et al.: "Comparison of striatal dopamine D2 receptors in Parkinson's disease and progressive supranuclear palsy patients using [123l] iodobenzofuran single-photon emission computed tomography"J Neuroimaging. 12. 316-324 (2002)

[文献書誌] Hanakawa T. et al.: "The role of rostral Brodmann area 6 in mental-operation tasks : an integrative neuroimaging approach"Cereb Cortex. 12. 1157-1170 (2002)

[文献書誌] Hayashi T. et al.: "Neuronal nitric oxide has a role as a perfusion regulator and a synaptic modulator in cerebellum but not in neocortex during somatosensory stimulation--an animal PET study"Neurosci Res. 44. 155-165 (2002)

[文献書誌] Ikeda A. et al.: ""Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates : a document of subdural mapping"J Neurol Sci. 15. 43-52 (2002)

[文献書誌] Takeshita K et al.: "Maturational change of parallel auditory processing in school-aged children revealed by simultaneous recording of magnetic and electric cortical resronses"Clin Neurophysiol. 113. 1470-1484 (2002)

[文献書誌] Yamamoto J et al.: "Seizures arising from the inferior parietal lobule can show ictal semiology of the second sensory seizure (SII seizure)"J Neurol Neurosurg Psychiatry. 74. 367-369 (2002)

[文献書誌] Satow, T. et al.: "Nausea as a complication of low-frequency repetitive transcranial magnetic stimulation of the posterior fossa"Clin Neurophysiol. 113. 1441-1443 (2002)

[文献書誌] Kanda M, et al.: "Cortical potentials related to assessment of pain intensity with visual analogue scale (VAS)"Clin Neurophysiol. 113. 1013-1024 (2002)

[文献書誌] Usui K et al.: "Conversion of semantic information into phonological representation : a function in left posterior basal temporal area"Brain. 126. 632-641 (2003)

[文献書誌] Yoshida K et al.: "Movement-related cortical potentials before jaw excursions in oromandibular dystonia"Mov Disord. 18. 94-100 (2003)

[文献書誌] Satow T, et al.: "Short-lasting impairment of tactile perception after low-frequency rTMS of the sensorimotor cortex"Neurology. 60. 1045-1047 (2003)

[文献書誌] Hanakawa T. et al.: "Functional properties of brain areas associated with motor execution and imagery"J Neurophysiol. 89. 989-1002 (2003)

[文献書誌] Kanda M. et al.: "Transcranial magnetic stimulation (TMS) of the sensorimotor cortex and medial frontal cortex modifies human pain perception"Clin Neurophysiol. (In press).

[文献書誌] Ikeda A et al.: "Motor inhibition by human supplementary motor area proper"Clin Neurophysiol. (In press).

2002 年度実績報告書

柴崎浩京都大学, 医学研究科, 教授 (30037444)