2001 年度実績報告書

低線量・低線量率放射線による細胞応答の発現機構

研究課題

研究課題/領域番号	12358010
研究機関	奈良県立医科大学
研究代表者	大西武雄奈良県立医科大学, 医学部, 教授 (60094554)
研究分担者	小松賢志広島大学, 原医研, 教授 (80124577) 丹羽太貫京都大学, 放生研, 教授 (80093293) 内海博司京都大学, 原子炉, 教授 (20025646) 渡辺正巳長崎大学, 薬学部, 教授 (20111768) 法村俊之産業医科大学, 医学部, 教授 (20039530)
キーワード	低線量・低線量率放射線 / p53 / 情報伝達 / 適応 / アポトーシス / 細胞周期 / 突然変異誘発 / 遺伝的不安定性
研究概要	(1)センサー(受容;何が放射線を受容しているのか) ・低線量及び低線量率放射線照射においては、誘導型NO合成酵素の蓄積誘導は変異型p53細胞にしか認められなかったが、野生型p53細胞においても低線量率放射線照射後の急照射により誘導型NO合成酵素の蓄積が誘導されることを明らかにした。(NOラジカルの関与:福井医大・松本) ・NBS1蛋白は放射線により発生したDNA二重鎖切断を相同組換えにより修復するだけでなく、DNA損傷の認識によるシグナル伝達で細胞周期制御にも関与していることを明らかにした。(NBS1による低線量放射線損傷細胞の認識機能:広大・小松) (2)情報伝達(応答) ・あらかじめの低線量・低線量率放射線により、後の放射線によるアポトーシスの誘導が抑えられる現象がDNA-PK欠損マウスではみられないことを明らかにした。(情報伝達誘導機構:奈良医大・大西) ・低線量照射でリン酸化されたERK1/2はp90RSKのリン酸化、ヒストンH3のアセチル化を引き起こしクロマチンの構造変化が誘導され遺伝子転写活性を増強するが、10cGy以上の線量ではp53のリン酸化が優先して起きるためにこれらの反応が抑制されることを明らかにした。(遺伝子転写活性促進効果:長崎大・渡辺) (3)適応を含む機能発現・遅延型の放射線誘発アポトーシスには、細胞周期制御因子とcaspase非依存型の細胞死実行因子が関与していることを明らかにした。(細胞周期チェックポイント遺伝子の機能:広大・鈴木) ・低線量率照射は分割照射回復の極限状態ではないことと非相同組換末端結合修復が重要であることを明らかにした。(DNA2重鎖切断修復の役割:京大・内海) ・低線量放射線照射したマウスTCR遺伝子突然変異の経時変化がp53遺伝子依存性であることを明らかにした。(アポトーシス:産業医大・法村) ・突然変異検出のためlacZ遺伝子を導入されたMutaマウスを用い、低線量多数回照射による肝臓と脾臓での突然変異特性を明らかにした。(突然変異誘発機構:東北大・小野) ・受精卵でp53依存性S期チェックポイントを見つけた。照射精子次世代マウスでpink-eyed unstable遺伝子の体細胞突然変異頻度が上昇していた。(遺伝的不安定性の誘導:京大・丹羽)

研究成果

(59件)

すべてその他

すべて文献書誌 (59件)

[文献書誌] Takahashi, A., et al.: "Radiation-induced apoptosis in scid mouse spleen after low dose-rate irradiation"Int. J. Radiat. Biol.. (in press). (2002)
[文献書誌] Harima, Y., et al.: "Human papilloma virus (HPV) DNA associated with prognosis of cervical cancer after radiotherapy"Int. J. Radiat. Oncol. Biol. Phys.. (in press). (2002)
[文献書誌] Harima, Y., et al.: "Mutation of the PTEN gene in advanced cervical cancer correlated with tumor progression and poor outcome after radiotherapy"Int. J. Oncol.. 18. 493-497 (2001)
[文献書誌] Ohnishi, T., et al.: "Alkylating agent (MNU)-induced mutation in space environment"Adv. Space Res.. 28. 563-568 (2001)
[文献書誌] Takahashi, A., et al.: "The effects of microgravity on induced-mutation in Escherichia ccli and Saccharomyces cerevisiae"Adv. Space Res.. 28. 555-561 (2001)
[文献書誌] Takahashi, A., et al.: "Differentiation of Dictyostelium discoideum vegetative cells into spores during space flight"Adv. Space Res.. 28. 549-553 (2001)
[文献書誌] Takahashi, A., et al.: "p53-dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET."Int. J. Radiat. Biol.. 77. 1043-1051 (2001)
[文献書誌] Takahashi, A., et al.: "Radiation response of apoptosis in C57BL/6N mouse spleen after wholebody irradiation"Int. J. Radiat. Biol.. 77. 939-946 (2001)
[文献書誌] Harima, Y., et al.: "Chromosome 6p21.2, 18q21.2 and human papilloma virus (HPV) DNA can predict prognosis of cervical cancer after radiotherapy"Int. J. Cancer. 96. 286-296 (2001)
[文献書誌] Ohnishi, T., et al.: "Tumor suppressor p53 response is blunted by pre-irradiation at a low-dose-rate radiation"Physica Medica. 17,Suppl.1. 215-216 (2001)
[文献書誌] Harima, Y., et al.: "Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women"Int. J. Mol. Medicine. 7. 261-264 (2001)
[文献書誌] 高橋, 大西: "宇宙放射線の生物影響研究におけるセントリフュージの重要性"宇宙生物科学. 15. 167-171 (2001)
[文献書誌] 高橋, 大西: "重粒子線と温熱との併用療法の基礎的研究"INNERVISION. 16. 67 (2001)
[文献書誌] Ohnishi, K., T.Ohnishi: "Heat-induced p53-dependent signal transduction and its role in hyperthermic cancer therapy"Int. J. Hyperthermia. 17. 415-427 (2001)
[文献書誌] Kirita, T., et al.: "New strategy for cancer therapy based on a predictive indicator"Human Cell. 14. 1-6 (2001)
[文献書誌] 桐田, 他: "p53遺伝子型からみたglioblastomaの新しい治療法"脳の科学. 23. 397-403 (2001)
[文献書誌] 高橋, 大西: "宇宙放射線生物学"宇宙生物科学. 15. 40-46 (2001)
[文献書誌] 高橋, 他: "無菌的混合法-宇宙実験成果を生活に活かす"Foods Food Integredients J. Jpn.. 191. 28-38 (2001)
[文献書誌] Saito, Y., et al.: "Genetic loci controlling susceptibility to r-ray-induced thymic lymphoma"Oncogene. 20. 5243-5247 (2001)
[文献書誌] Matsuki, A., et al.: "Allelic loss mapping and physical delineation of a region harboring a thymic lymphoma suppressor gene on mouse chromosome 16"Biochem. Biophys. Rex. Commun.. 282. 16-20 (2001)
[文献書誌] Niwa, 0, R.Kominami: "Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in Fl mice born to irradiated spermatozoa"Proc. Natl. Acad. Sci USA. 98. 1705-1710 (2001)
[文献書誌] Okazaki, R., et al.: "Effects of 4.7T static magnetic field on fetal development in ICR mice"J. Radiat. Res.. 42. 273-283 (2001)
[文献書誌] Kato, F., et al.: "Threshold effect for teratogenic risk of radiation depends on dose-rate and P53-denendent apoptosis"Int. J. Radiat. Biol.. 77. 13-19 (2001)
[文献書誌] 法村, 加藤: "奇形の発生を防ぐp53遺伝子:ノックアウトマウスを用いたp53依存性監視機構の解析"アニテックス. 13. 191-196 (2001)
[文献書誌] 高橋, 大西: "あらかじめの低線量率放射線被曝による放射線誘導アポトーシスの軽減"放射線生物研究. 36. 401-412 (2001)
[文献書誌] Utsumi, H., et al.: "Requirement for repair of DNA double-strand breaks by homologous recombination in split-dose recovery"Radiat. Res.. 155. 680-686 (2001)
[文献書誌] Yasuda, Y., et al.: "Inhibition of erythropoiethin signalling destroys xenografts of ovarian and uterine cancers in nude mice"Br. J Cancer. 84. 836-843 (2001)
[文献書誌] 内海: "DNA二本鎖切断修復と放射線効果"蛋白質・核酸・酵素. 46. 1089-1096 (2001)
[文献書誌] Shimura, T., et al.: "p53 dependent S phase damage checkpoint and pronuclear crosstalk in mouse zygotes with X-irradiated sperm"Mol. Cell Biol.. (in press). (2002)
[文献書誌] Ohtaki, M., 0 Niwa: "A mathematical model for radiation carcinogenesis with induction of genomic instability and cell death"Radiat. Res.. 56. 672-677 (2001)
[文献書誌] Kashino, G., et al.: "Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced"BBRC. 289. 111-115 (2002)
[文献書誌] Miyakoda, M., et al.: "Activation of ATM by heat shock and phosphorylation of p53"Oncogene. (in press). (2002)
[文献書誌] Nakahata, K., et al.: "Heat shock induces centrosomal dysfunction, and causes non-apoptotic catastrophe in human tumor cells"Int. J Hyperthermia. (in press). (2002)
[文献書誌] Kumagai, J., et al.: "Analysis of the protective effects of gallic acid against long-lived radicals produced in r-ray irradiated cells and against hemolysis produced by chemical radicals in blood cells"Comparison of Both Methods. Free Radical Res.. (in press). (2002)
[文献書誌] Kumagai, J., et al.: "Scavenging of long-lived radicals by(-)-epigallocatechin-3-O-gallate and simultaneous suppression of mutation in irradiated mammalian cells"Radiat. Phys. Chem.. (in press). (2002)
[文献書誌] Suzuki, K., et al.: "Extremely low-dose ionizing radiation causes activation of MAP kinase pathway and enhances proliferation of normal human diploid cells"Cancer Res.. 61. 5396-5401 (2001)
[文献書誌] Yanase, H., et al.: "Possible involvement of ERK 1/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes"Pigment Cell Res.. 14. 103-109 (2001)
[文献書誌] Kodama, S., et al.: "Culture condition dependent senescence like growth arrest and immortaliz4ion in rodent embryo cells"Radiat. Res.. 155. 254-262 (2001)
[文献書誌] Suzuki, K., et al.: "Radiation-induced senescence-like growth arrest requires p53 function, but not telomere shortening"Radiat. Res.. 155. 248-253 (2001)
[文献書誌] Komura, J., et al.: "Mapping psoralen cross-links at the nucleotide level in mammalian cells : suppression of cross-linking at transcripti6n factor-or nucleosome-binding sites"Biochemistry. 40. 4096-4105 (2001)
[文献書誌] Horiguchi, M., et al.: "Molecular nature of ultraviolet B light-induced deletions in the murine epidermis"Cancer Res.. 61. 3913-3918 (2001)
[文献書誌] Nakamura, S., et al.: "Characteristics of mutations generated through digestion with restriction enzyme and ligation in plasmid DNA"Environ. Mol. Mutagenesis. 38. 46-54 (2001)
[文献書誌] Ikehata, H., et al.: "Thermolysin improves mutation analysis in skin epidermis from ultraviolet light-irradiated MutaTM mouse"Environ. Mol. Mutagenesis. 38. 55-58 (2001)
[文献書誌] Sasai, K., et al.: "Suppression of postmitochondrial signaling and delayed response to UV-induced nuclear apoptosis in HeLa cells"Jap. J. Cancer Res.. (in press). (2002)
[文献書誌] Ishizaki, K., et al.: "Genetic changes induced in human cells in space shuttle experiment (STS-95)"Aviation Space Environ. Med.. 72. 794-798 (2001)
[文献書誌] 鈴木, 他: "放射線誘発アポトーシスにおける細胞種依存的な形質変化とcaspaseの活性化"広島医学. (in press). (2002)
[文献書誌] Matsumoto, H., et al.: "Intercellular signaling mediated by nitric oxide in human glioblastoma cells"Methods Enzymol. (in press). (2002)
[文献書誌] Jin, Z.H., et al.: "Effects of, combined treatment with 40 degree C hyperthermia and bleomycin on the accumulation of heat shock protein in murine L cells"Int. J. Oncol.. 20. 137-142 (2002)
[文献書誌] Ohtsubo, T., et al.: "Enhancement of cell killing by induction of apoptosis after treatment with mild hyperthermia at 42 degrees C and cisplatin"Radiat. Res.. 156. 103-109 (2001)
[文献書誌] Hayashi, S., et al.: "Modification of thermosensitivity and chemosensitivity induced by combined treatments with hyperthermia and adriamycin"Int. J. Mol. Med.. 8. 417-422 (2001)
[文献書誌] Ohtsubo, T., et al.: "Acidic environment modifies heat-or radiation-induced apoptosis in human maxillary cancer cells"Int J Radiat. Oncol. Biol. Phys.. 49. 1391-1398 (2001)
[文献書誌] Matsumoto, H., et al.: "Induction of radioresistance by a nitric oxide-mediated bystander effect"Radiat. Res.. 155. 387-396 (2001)
[文献書誌] Tauchi, H., et al.: "The FHA domain of NBS1 is essential for nuclear foci formation after irradiation, but not essential for hMRE11/hRAD5O/NBS1 complex DNA repair activity"J. Biol. Chem.. 276. 12-15 (2001)
[文献書誌] Buscemi, G., et al.: "Chk2 activation dependence on NBS1 after DNA damage"Mol. Cell. Biol.. 21. 5214-5222 (2001)
[文献書誌] 大西, 他: "集学的癌治療の研究と臨床(p53遺伝子を先行指標とする放射線・温熱治療のための基礎的研究)"篠原出版(in press). (2002)
[文献書誌] 大西, 他: "癌放射線療法2000(癌関連遺伝子からみたアポトーシス)"篠原出版(in press). (2002)
[文献書誌] 大西: "宇宙放射線生物学"株式会社アイプリコム. 63 (2001)
[文献書誌] Norimura, T., et al.: "International Symposium on Radiation and Homeostasis(Essential role of p53 gene in apoptotic tissue repair for radiation-induced teratogenic injury)"Elsevier Science(in press). (2002)
[文献書誌] Kobayashi, K., et al.: "Establishment of Fe-filtered neutron beam facility and measurement of the filtered neurons"American society for testing and materials. 7 (2001)

2001 年度 実績報告書

低線量・低線量率放射線による細胞応答の発現機構

研究代表者

大西 武雄 奈良県立医科大学, 医学部, 教授 (60094554)

研究成果

[文献書誌] Takahashi, A., et al.: "Radiation-induced apoptosis in scid mouse spleen after low dose-rate irradiation"Int. J. Radiat. Biol.. (in press). (2002)

[文献書誌] Harima, Y., et al.: "Human papilloma virus (HPV) DNA associated with prognosis of cervical cancer after radiotherapy"Int. J. Radiat. Oncol. Biol. Phys.. (in press). (2002)

[文献書誌] Harima, Y., et al.: "Mutation of the PTEN gene in advanced cervical cancer correlated with tumor progression and poor outcome after radiotherapy"Int. J. Oncol.. 18. 493-497 (2001)

[文献書誌] Ohnishi, T., et al.: "Alkylating agent (MNU)-induced mutation in space environment"Adv. Space Res.. 28. 563-568 (2001)

[文献書誌] Takahashi, A., et al.: "The effects of microgravity on induced-mutation in Escherichia ccli and Saccharomyces cerevisiae"Adv. Space Res.. 28. 555-561 (2001)

[文献書誌] Takahashi, A., et al.: "Differentiation of Dictyostelium discoideum vegetative cells into spores during space flight"Adv. Space Res.. 28. 549-553 (2001)

[文献書誌] Takahashi, A., et al.: "p53-dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET."Int. J. Radiat. Biol.. 77. 1043-1051 (2001)

[文献書誌] Takahashi, A., et al.: "Radiation response of apoptosis in C57BL/6N mouse spleen after wholebody irradiation"Int. J. Radiat. Biol.. 77. 939-946 (2001)

[文献書誌] Harima, Y., et al.: "Chromosome 6p21.2, 18q21.2 and human papilloma virus (HPV) DNA can predict prognosis of cervical cancer after radiotherapy"Int. J. Cancer. 96. 286-296 (2001)

[文献書誌] Ohnishi, T., et al.: "Tumor suppressor p53 response is blunted by pre-irradiation at a low-dose-rate radiation"Physica Medica. 17,Suppl.1. 215-216 (2001)

[文献書誌] Harima, Y., et al.: "Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women"Int. J. Mol. Medicine. 7. 261-264 (2001)

[文献書誌] 高橋, 大西: "宇宙放射線の生物影響研究におけるセントリフュージの重要性"宇宙生物科学. 15. 167-171 (2001)

[文献書誌] 高橋, 大西: "重粒子線と温熱との併用療法の基礎的研究"INNERVISION. 16. 67 (2001)

[文献書誌] Ohnishi, K., T.Ohnishi: "Heat-induced p53-dependent signal transduction and its role in hyperthermic cancer therapy"Int. J. Hyperthermia. 17. 415-427 (2001)

[文献書誌] Kirita, T., et al.: "New strategy for cancer therapy based on a predictive indicator"Human Cell. 14. 1-6 (2001)

[文献書誌] 桐田, 他: "p53遺伝子型からみたglioblastomaの新しい治療法"脳の科学. 23. 397-403 (2001)

[文献書誌] 高橋, 大西: "宇宙放射線生物学"宇宙生物科学. 15. 40-46 (2001)

[文献書誌] 高橋, 他: "無菌的混合法-宇宙実験成果を生活に活かす"Foods Food Integredients J. Jpn.. 191. 28-38 (2001)

[文献書誌] Saito, Y., et al.: "Genetic loci controlling susceptibility to r-ray-induced thymic lymphoma"Oncogene. 20. 5243-5247 (2001)

[文献書誌] Matsuki, A., et al.: "Allelic loss mapping and physical delineation of a region harboring a thymic lymphoma suppressor gene on mouse chromosome 16"Biochem. Biophys. Rex. Commun.. 282. 16-20 (2001)

[文献書誌] Niwa, 0, R.Kominami: "Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in Fl mice born to irradiated spermatozoa"Proc. Natl. Acad. Sci USA. 98. 1705-1710 (2001)

[文献書誌] Okazaki, R., et al.: "Effects of 4.7T static magnetic field on fetal development in ICR mice"J. Radiat. Res.. 42. 273-283 (2001)

[文献書誌] Kato, F., et al.: "Threshold effect for teratogenic risk of radiation depends on dose-rate and P53-denendent apoptosis"Int. J. Radiat. Biol.. 77. 13-19 (2001)

[文献書誌] 法村, 加藤: "奇形の発生を防ぐp53遺伝子:ノックアウトマウスを用いたp53依存性監視機構の解析"アニテックス. 13. 191-196 (2001)

[文献書誌] 高橋, 大西: "あらかじめの低線量率放射線被曝による放射線誘導アポトーシスの軽減"放射線生物研究. 36. 401-412 (2001)

[文献書誌] Utsumi, H., et al.: "Requirement for repair of DNA double-strand breaks by homologous recombination in split-dose recovery"Radiat. Res.. 155. 680-686 (2001)

[文献書誌] Yasuda, Y., et al.: "Inhibition of erythropoiethin signalling destroys xenografts of ovarian and uterine cancers in nude mice"Br. J Cancer. 84. 836-843 (2001)

[文献書誌] 内海: "DNA二本鎖切断修復と放射線効果"蛋白質・核酸・酵素. 46. 1089-1096 (2001)

[文献書誌] Shimura, T., et al.: "p53 dependent S phase damage checkpoint and pronuclear crosstalk in mouse zygotes with X-irradiated sperm"Mol. Cell Biol.. (in press). (2002)

[文献書誌] Ohtaki, M., 0 Niwa: "A mathematical model for radiation carcinogenesis with induction of genomic instability and cell death"Radiat. Res.. 56. 672-677 (2001)

[文献書誌] Kashino, G., et al.: "Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced"BBRC. 289. 111-115 (2002)

[文献書誌] Miyakoda, M., et al.: "Activation of ATM by heat shock and phosphorylation of p53"Oncogene. (in press). (2002)

[文献書誌] Nakahata, K., et al.: "Heat shock induces centrosomal dysfunction, and causes non-apoptotic catastrophe in human tumor cells"Int. J Hyperthermia. (in press). (2002)

[文献書誌] Kumagai, J., et al.: "Analysis of the protective effects of gallic acid against long-lived radicals produced in r-ray irradiated cells and against hemolysis produced by chemical radicals in blood cells"Comparison of Both Methods. Free Radical Res.. (in press). (2002)

[文献書誌] Kumagai, J., et al.: "Scavenging of long-lived radicals by(-)-epigallocatechin-3-O-gallate and simultaneous suppression of mutation in irradiated mammalian cells"Radiat. Phys. Chem.. (in press). (2002)

[文献書誌] Suzuki, K., et al.: "Extremely low-dose ionizing radiation causes activation of MAP kinase pathway and enhances proliferation of normal human diploid cells"Cancer Res.. 61. 5396-5401 (2001)

[文献書誌] Yanase, H., et al.: "Possible involvement of ERK 1/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes"Pigment Cell Res.. 14. 103-109 (2001)

[文献書誌] Kodama, S., et al.: "Culture condition dependent senescence like growth arrest and immortaliz4ion in rodent embryo cells"Radiat. Res.. 155. 254-262 (2001)

[文献書誌] Suzuki, K., et al.: "Radiation-induced senescence-like growth arrest requires p53 function, but not telomere shortening"Radiat. Res.. 155. 248-253 (2001)

[文献書誌] Komura, J., et al.: "Mapping psoralen cross-links at the nucleotide level in mammalian cells : suppression of cross-linking at transcripti6n factor-or nucleosome-binding sites"Biochemistry. 40. 4096-4105 (2001)

[文献書誌] Horiguchi, M., et al.: "Molecular nature of ultraviolet B light-induced deletions in the murine epidermis"Cancer Res.. 61. 3913-3918 (2001)

[文献書誌] Nakamura, S., et al.: "Characteristics of mutations generated through digestion with restriction enzyme and ligation in plasmid DNA"Environ. Mol. Mutagenesis. 38. 46-54 (2001)

[文献書誌] Ikehata, H., et al.: "Thermolysin improves mutation analysis in skin epidermis from ultraviolet light-irradiated MutaTM mouse"Environ. Mol. Mutagenesis. 38. 55-58 (2001)

[文献書誌] Sasai, K., et al.: "Suppression of postmitochondrial signaling and delayed response to UV-induced nuclear apoptosis in HeLa cells"Jap. J. Cancer Res.. (in press). (2002)

[文献書誌] Ishizaki, K., et al.: "Genetic changes induced in human cells in space shuttle experiment (STS-95)"Aviation Space Environ. Med.. 72. 794-798 (2001)

[文献書誌] 鈴木, 他: "放射線誘発アポトーシスにおける細胞種依存的な形質変化とcaspaseの活性化"広島医学. (in press). (2002)

[文献書誌] Matsumoto, H., et al.: "Intercellular signaling mediated by nitric oxide in human glioblastoma cells"Methods Enzymol. (in press). (2002)

[文献書誌] Jin, Z.H., et al.: "Effects of, combined treatment with 40 degree C hyperthermia and bleomycin on the accumulation of heat shock protein in murine L cells"Int. J. Oncol.. 20. 137-142 (2002)

[文献書誌] Ohtsubo, T., et al.: "Enhancement of cell killing by induction of apoptosis after treatment with mild hyperthermia at 42 degrees C and cisplatin"Radiat. Res.. 156. 103-109 (2001)

[文献書誌] Hayashi, S., et al.: "Modification of thermosensitivity and chemosensitivity induced by combined treatments with hyperthermia and adriamycin"Int. J. Mol. Med.. 8. 417-422 (2001)

[文献書誌] Ohtsubo, T., et al.: "Acidic environment modifies heat-or radiation-induced apoptosis in human maxillary cancer cells"Int J Radiat. Oncol. Biol. Phys.. 49. 1391-1398 (2001)

[文献書誌] Matsumoto, H., et al.: "Induction of radioresistance by a nitric oxide-mediated bystander effect"Radiat. Res.. 155. 387-396 (2001)

[文献書誌] Tauchi, H., et al.: "The FHA domain of NBS1 is essential for nuclear foci formation after irradiation, but not essential for hMRE11/hRAD5O/NBS1 complex DNA repair activity"J. Biol. Chem.. 276. 12-15 (2001)

[文献書誌] Buscemi, G., et al.: "Chk2 activation dependence on NBS1 after DNA damage"Mol. Cell. Biol.. 21. 5214-5222 (2001)

[文献書誌] 大西, 他: "集学的癌治療の研究と臨床(p53遺伝子を先行指標とする放射線・温熱治療のための基礎的研究)"篠原出版(in press). (2002)

[文献書誌] 大西, 他: "癌放射線療法2000(癌関連遺伝子からみたアポトーシス)"篠原出版(in press). (2002)

[文献書誌] 大西: "宇宙放射線生物学"株式会社アイプリコム. 63 (2001)

[文献書誌] Norimura, T., et al.: "International Symposium on Radiation and Homeostasis(Essential role of p53 gene in apoptotic tissue repair for radiation-induced teratogenic injury)"Elsevier Science(in press). (2002)

[文献書誌] Kobayashi, K., et al.: "Establishment of Fe-filtered neutron beam facility and measurement of the filtered neurons"American society for testing and materials. 7 (2001)

2001 年度実績報告書

大西武雄奈良県立医科大学, 医学部, 教授 (60094554)