2001 年度実績報告書

高機能ステント工学の開発:要素材料・要素技術とデバイス化

研究課題

研究課題/領域番号	12358017
研究機関	九州大学
研究代表者	松田武久九州大学, 大学院・医学研究院, 教授 (60142189)
研究分担者	藤井康雄九州大学, 大学院・医学研究院, 助手 (90336032) 下川宏明九州大学, 大学院・医学研究院, 助教授 (00235681) 居石克夫九州大学, 大学院・医学研究院, 教授 (70108710) 中山泰秀国立循環器病センター研究所, 生体工学部, 室長(研究職) (50250262) 梅津光夫早稲田大学, 機械工学, 教授 (90132927)
キーワード	ステント / エキシマ・レーザ / 光加工
研究概要	・電鋳法と光加工技術を組み合わせて金をステンレス棒に析出させてステントを作製した。・通電量、析出膜厚、パターンおよ焼きなまし温度・時間を変えて、市販と同等の力学的強度を有するステントが作製できた。・ウサギ動脈に移植し高い開存性を得た。・コーティング材料として光反応性ゼラチンを分子設計し、これにヘパリンを用いることによって抗血栓性を付与した。・ドラッグ・モデルとしてローダミン・アルブミンを用いると、経時的に血管内腔から外側へ薬が拡散した。・LacZ遺伝子導入したアデノウィルスをゲルに封入し、in vitroおよびin vivoで徐放・発現を確認した。・現在、J.Biomedical Materials Researchに投稿受理されている

研究成果

(12件)

すべてその他

すべて文献書誌 (12件)

[文献書誌] Shinya Kato, Joji Ando, Takehisa Matsuda: "mRNA expression on shape-engineered endothelial cells : Adhesion molecules ICAM-1 and VCAM-1"J Biomed Mater res. 54. 366-372 (2001)
[文献書誌] Satoru Kidoaki, Yasuhide Nakayama, Takehisa Matsuda: "Measurement of the Interaction Forces between proteins and Iniferer-Based Graft-Polymerized Surfaces with an Atomic Force Microscope in Aqueous Media"Langmuir. 17(4). 1080-1087 (2001)
[文献書誌] T.Ikeda, K.Nakayama, K.Sakagami, H.Iwahashi, K.Sugimoto, T.Matsuda: "Emulsification Tendency of Silicone-Phenylsilicone Copolymer"JPN J Ophthalmol. 45. 53-59 (2001)
[文献書誌] S.Kidoaki, S.Ohya, Y.Nakayama, T.Matsuda: "Thermoresponsive Structural Change of a Poly(N-isopropylacrylamide) Graft Layer Measured with an Atomic Force Microscope"Lanamuir. 17(8). 2402-2407 (2001)
[文献書誌] H.Sonoda, K.Takamizawa, Y.Nakayama, H.Yasui, T.Matsuda: "Small-Diameter Compliant Arterial Graft Prosthesis : Design Concept of Coaxial Double Tubular Graft and its Fabrication"J Biomed Mater Res. 55. 266-276 (2001)
[文献書誌] Y.Nakayama, K.Ji-Youn, S.Nishi, H.Ueno, T.Matsuda: "Development of high-performance stent : gelatinous photogel-coated stent that permits drug delivery and gene transfer"J Biomed Mater Res. 57. 559-566 (2001)
[文献書誌] Shoji Ohya, Yasuhide Nakayama, Takehisa Matsuda: "Thermoresponsive Artificiall Extracellular Matrix for Tissue Engineering : Hyaluronic Acid Bioconjugated with Poly (N-isopropylacrylamide) Grafts"Biomacromolecules. 2. 856-863 (2001)
[文献書誌] W.G.Brodbeck, M.S.Shive, E.Colton, Y.Nakayama, T.Matsuda, J.M.Anderson: "Influence of biomaterial surface chemistry on the apoptosis of adherent cells"J Biomed Mater Res. 55. 661-668 (2001)
[文献書誌] M.Kikuchi, H.Takita, Y.Nakayama, T.Matsuda, Y.Kuboki: "Laser perforated Collagen Membrane : Pore size-Dependent Bone Induction as a New BMP Carrier"J. of Hard Tissue Biology. 10(1). 55-65 (2001)
[文献書誌] Takehisa Matsuda, Tomoko Magoshi: "Terminally Alkylated Heparin. 1. Antithrombogenic Surface Modifier"Biomacromolecules. 2(4). 1169-1177 (2001)
[文献書誌] M.Gohda, T.Magoshi, S.Kato, T.Noguchi, S.Yasuda, H.Nonogi, T.Matsuda: "Terminally Alkylated Heparin. 2. Potent Antiproliferative Agent for Vascular Smooth Muscle Cells"Biomacromolecules. 2(4). 1178-1183 (2001)
[文献書誌] Shoji Ohya, Yasuhide Nakayama, Takehisa Matsuda: "Material design for an artificial extracellular matrix : cell entrapment in poly(N-isopropylacrylamide) (PNIPAM)-grafted gelatin hydrogel"J Artif Organs. 4. 308-314 (2001)

2001 年度 実績報告書

高機能ステント工学の開発:要素材料・要素技術とデバイス化

研究代表者

松田 武久 九州大学, 大学院・医学研究院, 教授 (60142189)

研究成果

[文献書誌] Shinya Kato, Joji Ando, Takehisa Matsuda: "mRNA expression on shape-engineered endothelial cells : Adhesion molecules ICAM-1 and VCAM-1"J Biomed Mater res. 54. 366-372 (2001)

[文献書誌] Satoru Kidoaki, Yasuhide Nakayama, Takehisa Matsuda: "Measurement of the Interaction Forces between proteins and Iniferer-Based Graft-Polymerized Surfaces with an Atomic Force Microscope in Aqueous Media"Langmuir. 17(4). 1080-1087 (2001)

[文献書誌] T.Ikeda, K.Nakayama, K.Sakagami, H.Iwahashi, K.Sugimoto, T.Matsuda: "Emulsification Tendency of Silicone-Phenylsilicone Copolymer"JPN J Ophthalmol. 45. 53-59 (2001)

[文献書誌] S.Kidoaki, S.Ohya, Y.Nakayama, T.Matsuda: "Thermoresponsive Structural Change of a Poly(N-isopropylacrylamide) Graft Layer Measured with an Atomic Force Microscope"Lanamuir. 17(8). 2402-2407 (2001)

[文献書誌] H.Sonoda, K.Takamizawa, Y.Nakayama, H.Yasui, T.Matsuda: "Small-Diameter Compliant Arterial Graft Prosthesis : Design Concept of Coaxial Double Tubular Graft and its Fabrication"J Biomed Mater Res. 55. 266-276 (2001)

[文献書誌] Y.Nakayama, K.Ji-Youn, S.Nishi, H.Ueno, T.Matsuda: "Development of high-performance stent : gelatinous photogel-coated stent that permits drug delivery and gene transfer"J Biomed Mater Res. 57. 559-566 (2001)

[文献書誌] Shoji Ohya, Yasuhide Nakayama, Takehisa Matsuda: "Thermoresponsive Artificiall Extracellular Matrix for Tissue Engineering : Hyaluronic Acid Bioconjugated with Poly (N-isopropylacrylamide) Grafts"Biomacromolecules. 2. 856-863 (2001)

[文献書誌] W.G.Brodbeck, M.S.Shive, E.Colton, Y.Nakayama, T.Matsuda, J.M.Anderson: "Influence of biomaterial surface chemistry on the apoptosis of adherent cells"J Biomed Mater Res. 55. 661-668 (2001)

[文献書誌] M.Kikuchi, H.Takita, Y.Nakayama, T.Matsuda, Y.Kuboki: "Laser perforated Collagen Membrane : Pore size-Dependent Bone Induction as a New BMP Carrier"J. of Hard Tissue Biology. 10(1). 55-65 (2001)

[文献書誌] Takehisa Matsuda, Tomoko Magoshi: "Terminally Alkylated Heparin. 1. Antithrombogenic Surface Modifier"Biomacromolecules. 2(4). 1169-1177 (2001)

[文献書誌] M.Gohda, T.Magoshi, S.Kato, T.Noguchi, S.Yasuda, H.Nonogi, T.Matsuda: "Terminally Alkylated Heparin. 2. Potent Antiproliferative Agent for Vascular Smooth Muscle Cells"Biomacromolecules. 2(4). 1178-1183 (2001)

[文献書誌] Shoji Ohya, Yasuhide Nakayama, Takehisa Matsuda: "Material design for an artificial extracellular matrix : cell entrapment in poly(N-isopropylacrylamide) (PNIPAM)-grafted gelatin hydrogel"J Artif Organs. 4. 308-314 (2001)

2001 年度実績報告書

松田武久九州大学, 大学院・医学研究院, 教授 (60142189)