2002 年度実績報告書

エキノコックス症免疫診断法(国際標準診断、早期診断、治癒判定法)の実用化

研究課題

研究課題/領域番号	12557024
研究機関	旭川医科大学
研究代表者	伊藤亮旭川医科大学, 医学部, 教授 (70054020)
研究分担者	山崎浩旭川医科大学, 医学部, 助教授 (00138207) 中谷和宏旭川医科大学, 医学部, 助教授 (70109388) 高後裕旭川医科大学, 医学部, 教授 (10133183) 中尾稔旭川医科大学, 医学部, 助手 (70155670) 藤本佳範旭川医科大学, 医学部, 講師 (90292127)
キーワード	エキノコックス症 / 多包虫症 / 単包虫症 / 有鉤嚢虫症 / 遺伝子組み換え診断抗原 / 血清学的鑑別診断 / ミトコンドリアDNA / 遺伝子多型
研究概要	本研究における主要研究テーマは、現在地球規模で流行が深刻化しているエキノコックス症(多包虫症、単包虫症)に関する信頼性の高い免疫診断法(国際標準診断、早期診断、治癒判定法)の開発と実用化である。 (1)現在、国際的に最も信頼性が高いと評価されている多包虫症特異診断抗原Em18を遺伝子組み換え抗原(RecEm18)として作成し、その過程でEm18の生化学的特性の解析がなされた。世界各国で別個に検索されてきた診断抗原の中でEm18のB cell epitope活性が最も高いことが判明した(Sako et al. 2002. J Clin Microbiol 40,2760-2765)。(2)フランスとのブラインドテストによる共同研究から、RecEm18を用いる血清診断法はフランスにおける多包虫症と単包虫症を100%鑑別できることが判明した(Ito et al. 2002. J Clin Microbiol 40,4161-4165)。現在、フランス、スイスにおいて認定された300例以上の多包虫症例の血清学的確認要請を受けている。(3)単包虫症の血清診断法についても遺伝子組み換えAntigen Bを作製した(Mamuti et al. 2002. Clin Diag Lab Immunol 9,573-576;Mamuti et al. in prep.)。(4)血清診断上、最も交差反応が高い致死的寄生虫疾患、有鉤嚢虫症に関する遺伝子組み換え抗原を作製した(Sako et al. 2000. J Clin Microbiol 38,4439-4444)。血清診断上鑑別を要する多包虫症、単包虫症、有鉤嚢虫症すべてに関する遺伝子組み換え抗原作製に成功し、国際的な評価を得た。現在、合成ペプチド抗原作製を試みている。(5)北海道を中心に、主治医から直接相談を受けた多包虫症疑診例において、Em18抗原を用いる血清検査で多包虫症と他の疾患を術前に100%鑑別し、術前確定血清診断法を確立した。国内での現行の血清検査が確定検査として機能していないことから、Em18を用いる血清検査の導入が望まれる。(6)ミトコンドリアDNA解析により、遺伝子診断法の開発が可能になった。遺伝子解析、遺伝子診断研究も含め、これらの研究成果は現在印刷中を含め国際誌に原著論文総説29編、国際会議録14編、著書5篇として発表した。和文総説、報告書も22編発表した。

研究成果

(62件)

すべてその他

すべて文献書誌 (62件)

[文献書誌] Ito, A.: "Perspective on control options for Echinococcus multilocularis"Parasitology. 127(in press). (2003)
[文献書誌] Ito, A.: "Review : Echinococcosis and cysticercosis in Asia : evaluation of the modern technology for epidemiological study"Southeast Asian Journal of Tropical Medicine and Public Health. 34(in press). (2003)
[文献書誌] Yamasaki, H.: "Cysticercosis/taeniosis : recent advances in serological and molecular diagnoses"Southeast Asian Journal of Tropical Medicine and Public Health. 34(in press). (2003)
[文献書誌] Ito, A.: "Multiple genotypes of Taenia solium-ramifications for control"Acta Tropica. (in press). (2003)
[文献書誌] Nakao, M.: "The abbreviated stop codon U found in the mitochondrial genome of the tapeworm Taenia solium"Journal of Parasitology. (in press). (2003)
[文献書誌] Ito, A.: "Control of echinococcosis and cysticercosis : a public health challenge to international cooperation in China"Acta Tropica. (in press). (2003)
[文献書誌] Ito, A.: "Detection and control of zoonotic cestode infections : immunodiagnostic and molecular approaches"Trends in Parasitology. (in press). (2003)
[文献書誌] Ito, A.: "Development of Em18-immunoblot and Em18-ELISA for special diagnosis of alveolar echinococcosis"Acta Tropica. 85. 173-182 (2003)
[文献書誌] Ito, A.: "Recent advances in basic and applied science for the control of taeniasis/cysticercosis"Southeast Asian Journal of Tropical Medicine and Public Health. 33(in press). (2002)
[文献書誌] Ito, A.: "Collaboration for the control of cysticercosis/echinococcosis in Vietnam"Southeast Asian Journal of Tropical Medicine and Public Health. 33(in press). (2002)
[文献書誌] Margono, S.S.: "Taenia solium taeniasis/cysticercosis in Papua, Indonesia in 2001 : detection of human worm carriers"Journal of Helminthology. 77. 39-42 (2003)
[文献書誌] Sato, M.O.: "Evaluation of tongue inspection and serology for diagnosis of Taenia solium cysticercosis in swine : usefulness of ELISA using purified glycoproteins and recombinant antigen"Veterinary Parasitology. 111. 309-322 (2003)
[文献書誌] Ito, A.: "Dogs as alternative intermediate hosts of Taenia solium in Papua(Irian Jaya), Indonesia confirmed by highly specific ELISA and immunoblot using native and recombinant antigens and mitochondrial DNA analysis"Journal of Helminthology. 76. 311-314 (2002)
[文献書誌] Ito, A.: "Evaluation of an enzyme-linked immunosorbent assay(ELISA) with affinity-purified Em18 and ELSIA with recombinant Em18 for differential diagnosis of alveolar echinococcosis : results of a blind test"Journal of Clinical Microbiology. 40. 4161-4165 (2002)
[文献書誌] Ito, A.: "Human Taenia in NOD-scid mice : how can we use such an animal model?"Proceedings of the 10^<th> International Congress of Parasitology. 179-183 (2002)
[文献書誌] Ito, A: "Taeniasis/cysticercosis in Papua(Irian Jaya), Indonesia"Proceedings of the 10^<th> International Congress of Parasitology. 207-211 (2002)
[文献書誌] Yamasaki, H.: "DNA differential diagnosis of human taeniid cestodes using restriction fragment length polymorphism and base excision sequence scanning T-base system"Proceedings of the 10^<th> International Congress of Parasitology. 189-203 (2002)
[文献書誌] Sato, M.O.: "Comparison of traditional tongue examination and serology for diagnosis of swine cysticercosis : usefulness of ELISA using native and recombinant antigens"Proceedings of the 10^<th> International Congress of Parasitology. 195-199 (2002)
[文献書誌] Nakao, M.: "The complete mitochondrial DNA sequence of the cestode Echinococcus multilocularis (Cyclophyllidea : taeniidae)"Mitochondrion. 1. 497-509 (2002)
[文献書誌] Yamasaki, H.: "DNA differential diagnosis of human taeniid cestodes by base excision sequence scanning thymine-base reader analysis with mitochondrial genes"Journal of Clinical Microbiology. 40. 3818-3821 (2002)
[文献書誌] Ito, A.: "Serologic and molecular diagnosis of zoonotic larval cesode infections"Parasitology International. 51. 221-235 (2002)
[文献書誌] Margono, S.S.: "Multiple cysticercus nodules in skin and brain in a Balinese woman : a case report"Medical Journal of Indonesia. 11. 169-173 (2002)
[文献書誌] Sako, Y.: "Alveolar echinococcosis : characterization of diagnostic antien Em18 and serological evaluation of recombinant Em 18"Journal of Clinical Microbiology. 40. 2760-2765 (2002)
[文献書誌] Yamasaki, H.: "Characterization and expression of the Fasciola gigantica cathepsin L gene"International Journal for Parasitology. 32. 1031-1042 (2002)
[文献書誌] Nakao, M.: "A phylogenetic hypothesis for the distribution of two genotypes of the pig tapeworm Taenia solium worldwide"Parasitology. 124. 657-662 (2002)
[文献書誌] Manuti, W.: "Usefulness of hydatid cyst fluid of Echinococcus granulosus developed in mice with secondary infection for serodiagnosis of cystic echinococcosis in humans"Clinical and Diagnostic Laboratory Immunology. 9. 573-576 (2002)
[文献書誌] Ito, A.: "Cry wolf!"Trends in Parasitology. 18. 47-48 (2002)
[文献書誌] Ito, A.: "Comparison of the antigenicity of protoscoleces and microvesicles of Echinococcus multilocularis prepared from rats"Journal of Helminthology. 75. 355-358 (2001)
[文献書誌] Subahar, R.: "Taenia solium infection in Irian Jaya(West Papua), Indonesia : a pilot serological survey of human and porcine cysticercosis in Jayawijaya District"Transactions of the Royal Society of Tropical Medicine and Hygiene. 95. 388-390 (2001)
[文献書誌] Jiang, L.: "Immunodiagnostic differentiation of alveolar and cystic echinococcosis using ELISA test with 18-kDa antigen extracted from Echinococcus protoscoleces"Transactions of the Royal Society of Tropical Medicine and Hygiene. 95. 285-288 (2001)
[文献書誌] Wang, Q.: "Investigation of risk factors for development of human hydatidosis among households raising livestock in Tibetan areas of western Sichuan province"Chinese Journal of Parasitology and Parasitic Diseases. 19. 93-96 (2001)
[文献書誌] Margono, S.S.: "The problem of taeniasis and cysticercosis in Irian Jaya, Indonesia"Medical Journal of Indonesia. 10. 110-114 (2001)
[文献書誌] Margono, S.S.: "Cysticercosis in Indonesia : epidemiological aspects"Southeast Asian Journal of Tropical Medicine and Public Health. 32. 79-84 (2001)
[文献書誌] Ito, A.: "NOD-scid mouse as an experimental animal model for cysticercosis"Southeast Asian Journal of Tropical Medicine and Public Health. 32. 85-89 (2001)
[文献書誌] Okamoto, M.: "Molecular variation of Taenia solium in the world"Southeast Asian Journal of Tropical Medicine and Public Health. 32. 90-93 (2001)
[文献書誌] Sako, Y.: "Recent advances in serodiagnosis for cysticercosis"Southeast Asian Journal of Tropical Medicine and Public Health. 32. 98-104 (2001)
[文献書誌] Ito, A.: "Differential serodiagnosis of cystic and alveolar echinococcosis using native and recombinant antigens in Japan"Southeast Asian Journal of Tropical Medicine and Public Health. 32. 111-115 (2001)
[文献書誌] Ito, A.: "Neurocysticercosis and echinococcosis in Asia : Recent advances in the establishment of highly reliable differential serodiagnosis for international collaboration"Southeast Asian Journal of Tropical Medicine and Public Health. 31. 16-20 (2000)
[文献書誌] Nakao, M.: "Mitochondrial genetic code in cestodes"Molecular and Biochemical Parasitology. 111. 415-424 (2000)
[文献書誌] Sako, Y.: "Molecular characterization and diagnostic value of Taenia solium low-molecular-weight antigen genes"Journal of Clinical Microbiology. 38. 4439-4444 (2000)
[文献書誌] Craig, P.S.: "An epidemiological and ecological study of human alveolar echinococcosis transmission in south Gansu, China"Acta Tropica. 77. 167-177 (2000)
[文献書誌] Wandra, T.: "Resurgence of cases of epileptic seizures and burns associated with cysticercosis in Assologaima, Jayawijaya, Irian Jaya, Indonesia, 1991-95"Transactions of the Royal Society of Tropical Medicine and Hygiene. 94. 46-50 (2000)
[文献書誌] 伊藤亮: "特集人畜共通感染症肺エキノコックス症"呼吸. 22. 56-60 (2003)
[文献書誌] 伊藤亮: "特集テーマ:今日常診療で注目すべき原虫症、寄生虫症エキノコックス症"JIM. 13(in press). (2002)
[文献書誌] 畠山優一: "肝単包虫症の1切除例"手術. 56. 819-823 (2002)
[文献書誌] 伊藤亮: "技術講座単包虫症、多包虫症の免疫学的診断"Medical Technology. 30. 97-103 (2002)
[文献書誌] 伊藤亮: "寄生虫学講座におけるエキノコックス症、有鉤嚢虫症、ライム病についての研究総括"旭川医科大学研究フォーラム. 2(2). 14-21 (2001)
[文献書誌] 伊藤亮: "新興・再興寄生虫症(有鉤嚢虫腫御、エキノコックス症)の世界における現状 10,59-66"臨床環境医学. 10. 59-66 (2001)
[文献書誌] 伊藤亮: "エキノコックス症の疫学と血清診断"Current Concepts in Infectious Disease. 20. 18-19 (2001)
[文献書誌] 伊藤亮: "執筆者からの返事"北海道医学雑誌. 76. 367-368 (2001)
[文献書誌] 伊藤亮: "旭川医科大学におけるエキノコックス症研究の現状と日本におけるエキノコックス症の問題点"北海道医学雑誌. 76. 3-8 (2001)
[文献書誌] 伊藤亮: "新興・再興寄生虫病としてのエキノコックス症、有鉤嚢虫症"岐阜県医師会医学雑誌. 14. 35-46 (2001)
[文献書誌] 伊藤亮: "エキノコックス症を取り巻く諸問題"旭川医科大学研究フォーラム. 2(1). 13-19 (2001)
[文献書誌] 伊藤亮: "エキノコックス症(多包虫症)血清診断の問題点"Infection Control. 10. 44-46 (2001)
[文献書誌] 伊藤亮: "エキノコックス症-世界・日本での現状、診断・治療・予防-"北海道プライマリケア研究会会報. 19. 31-41 (2001)
[文献書誌] Ito, A.: "In : Progress of Medical Parasitology in Japan. Chapter III. Session 6. Immunology in cestode infections (2) Immunity to the larval cestodes"Meguro Parasitology Museum, Tokyo(in press). (2003)
[文献書誌] Ito, A.: "Taenia solium Cysticercosis. Chapter 5. Mitochondrial DNA of Taenia solium : from basic to applied science"CABI Press, Oxson, UK. 47-55 (2002)
[文献書誌] Singh, G.: "Taenia solium Cysticercosis. Chapter 12. Taenia solium taeniasis and cysticercosis in Asia"CABI Press, Oxson, UK. 111-127 (2002)
[文献書誌] Ito, A.: "Cestode Zoonoses : Echinococcosis and Cysticercosis-An Emergent and Global problem. Neurocysticercosis in Asia : serology/seroepidemiology in humans and pigs"IOS Press, Amsterdam. 25-31 (2002)
[文献書誌] Ito, A.: "Cestode Zoonoses : Echinococcosis and Cysticercosis-An Emergent and Global problem. Differential serodiagnosis for alveolar echinococcosis by Em18-immunoblot and Em18-ELISA in Japan and China"IOS Press, Amsterdam. 147-155 (2002)
[文献書誌] 皆川知紀: "北海道感染症対策マニュアル"北海道保健福祉部保健予防課. 242 (2001)
[文献書誌] 伊藤亮: "シンプル微生物学(改訂第3版)"南江堂. 343-354 (2000)

2002 年度 実績報告書

エキノコックス症免疫診断法(国際標準診断、早期診断、治癒判定法)の実用化

研究代表者

伊藤 亮 旭川医科大学, 医学部, 教授 (70054020)

研究成果

[文献書誌] Ito, A.: "Perspective on control options for Echinococcus multilocularis"Parasitology. 127(in press). (2003)

[文献書誌] Ito, A.: "Review : Echinococcosis and cysticercosis in Asia : evaluation of the modern technology for epidemiological study"Southeast Asian Journal of Tropical Medicine and Public Health. 34(in press). (2003)

[文献書誌] Yamasaki, H.: "Cysticercosis/taeniosis : recent advances in serological and molecular diagnoses"Southeast Asian Journal of Tropical Medicine and Public Health. 34(in press). (2003)

[文献書誌] Ito, A.: "Multiple genotypes of Taenia solium-ramifications for control"Acta Tropica. (in press). (2003)

[文献書誌] Nakao, M.: "The abbreviated stop codon U found in the mitochondrial genome of the tapeworm Taenia solium"Journal of Parasitology. (in press). (2003)

[文献書誌] Ito, A.: "Control of echinococcosis and cysticercosis : a public health challenge to international cooperation in China"Acta Tropica. (in press). (2003)

[文献書誌] Ito, A.: "Detection and control of zoonotic cestode infections : immunodiagnostic and molecular approaches"Trends in Parasitology. (in press). (2003)

[文献書誌] Ito, A.: "Development of Em18-immunoblot and Em18-ELISA for special diagnosis of alveolar echinococcosis"Acta Tropica. 85. 173-182 (2003)

[文献書誌] Ito, A.: "Recent advances in basic and applied science for the control of taeniasis/cysticercosis"Southeast Asian Journal of Tropical Medicine and Public Health. 33(in press). (2002)

[文献書誌] Ito, A.: "Collaboration for the control of cysticercosis/echinococcosis in Vietnam"Southeast Asian Journal of Tropical Medicine and Public Health. 33(in press). (2002)

[文献書誌] Margono, S.S.: "Taenia solium taeniasis/cysticercosis in Papua, Indonesia in 2001 : detection of human worm carriers"Journal of Helminthology. 77. 39-42 (2003)

[文献書誌] Sato, M.O.: "Evaluation of tongue inspection and serology for diagnosis of Taenia solium cysticercosis in swine : usefulness of ELISA using purified glycoproteins and recombinant antigen"Veterinary Parasitology. 111. 309-322 (2003)

[文献書誌] Ito, A.: "Dogs as alternative intermediate hosts of Taenia solium in Papua(Irian Jaya), Indonesia confirmed by highly specific ELISA and immunoblot using native and recombinant antigens and mitochondrial DNA analysis"Journal of Helminthology. 76. 311-314 (2002)

[文献書誌] Ito, A.: "Evaluation of an enzyme-linked immunosorbent assay(ELISA) with affinity-purified Em18 and ELSIA with recombinant Em18 for differential diagnosis of alveolar echinococcosis : results of a blind test"Journal of Clinical Microbiology. 40. 4161-4165 (2002)

[文献書誌] Ito, A.: "Human Taenia in NOD-scid mice : how can we use such an animal model?"Proceedings of the 10^<th> International Congress of Parasitology. 179-183 (2002)

[文献書誌] Ito, A: "Taeniasis/cysticercosis in Papua(Irian Jaya), Indonesia"Proceedings of the 10^<th> International Congress of Parasitology. 207-211 (2002)

[文献書誌] Yamasaki, H.: "DNA differential diagnosis of human taeniid cestodes using restriction fragment length polymorphism and base excision sequence scanning T-base system"Proceedings of the 10^<th> International Congress of Parasitology. 189-203 (2002)

[文献書誌] Sato, M.O.: "Comparison of traditional tongue examination and serology for diagnosis of swine cysticercosis : usefulness of ELISA using native and recombinant antigens"Proceedings of the 10^<th> International Congress of Parasitology. 195-199 (2002)

[文献書誌] Nakao, M.: "The complete mitochondrial DNA sequence of the cestode Echinococcus multilocularis (Cyclophyllidea : taeniidae)"Mitochondrion. 1. 497-509 (2002)

[文献書誌] Yamasaki, H.: "DNA differential diagnosis of human taeniid cestodes by base excision sequence scanning thymine-base reader analysis with mitochondrial genes"Journal of Clinical Microbiology. 40. 3818-3821 (2002)

[文献書誌] Ito, A.: "Serologic and molecular diagnosis of zoonotic larval cesode infections"Parasitology International. 51. 221-235 (2002)

[文献書誌] Margono, S.S.: "Multiple cysticercus nodules in skin and brain in a Balinese woman : a case report"Medical Journal of Indonesia. 11. 169-173 (2002)

[文献書誌] Sako, Y.: "Alveolar echinococcosis : characterization of diagnostic antien Em18 and serological evaluation of recombinant Em 18"Journal of Clinical Microbiology. 40. 2760-2765 (2002)

[文献書誌] Yamasaki, H.: "Characterization and expression of the Fasciola gigantica cathepsin L gene"International Journal for Parasitology. 32. 1031-1042 (2002)

[文献書誌] Nakao, M.: "A phylogenetic hypothesis for the distribution of two genotypes of the pig tapeworm Taenia solium worldwide"Parasitology. 124. 657-662 (2002)

[文献書誌] Manuti, W.: "Usefulness of hydatid cyst fluid of Echinococcus granulosus developed in mice with secondary infection for serodiagnosis of cystic echinococcosis in humans"Clinical and Diagnostic Laboratory Immunology. 9. 573-576 (2002)

[文献書誌] Ito, A.: "Cry wolf!"Trends in Parasitology. 18. 47-48 (2002)

[文献書誌] Ito, A.: "Comparison of the antigenicity of protoscoleces and microvesicles of Echinococcus multilocularis prepared from rats"Journal of Helminthology. 75. 355-358 (2001)

[文献書誌] Subahar, R.: "Taenia solium infection in Irian Jaya(West Papua), Indonesia : a pilot serological survey of human and porcine cysticercosis in Jayawijaya District"Transactions of the Royal Society of Tropical Medicine and Hygiene. 95. 388-390 (2001)

[文献書誌] Jiang, L.: "Immunodiagnostic differentiation of alveolar and cystic echinococcosis using ELISA test with 18-kDa antigen extracted from Echinococcus protoscoleces"Transactions of the Royal Society of Tropical Medicine and Hygiene. 95. 285-288 (2001)

[文献書誌] Wang, Q.: "Investigation of risk factors for development of human hydatidosis among households raising livestock in Tibetan areas of western Sichuan province"Chinese Journal of Parasitology and Parasitic Diseases. 19. 93-96 (2001)

[文献書誌] Margono, S.S.: "The problem of taeniasis and cysticercosis in Irian Jaya, Indonesia"Medical Journal of Indonesia. 10. 110-114 (2001)

[文献書誌] Margono, S.S.: "Cysticercosis in Indonesia : epidemiological aspects"Southeast Asian Journal of Tropical Medicine and Public Health. 32. 79-84 (2001)

[文献書誌] Ito, A.: "NOD-scid mouse as an experimental animal model for cysticercosis"Southeast Asian Journal of Tropical Medicine and Public Health. 32. 85-89 (2001)

[文献書誌] Okamoto, M.: "Molecular variation of Taenia solium in the world"Southeast Asian Journal of Tropical Medicine and Public Health. 32. 90-93 (2001)

[文献書誌] Sako, Y.: "Recent advances in serodiagnosis for cysticercosis"Southeast Asian Journal of Tropical Medicine and Public Health. 32. 98-104 (2001)

[文献書誌] Ito, A.: "Differential serodiagnosis of cystic and alveolar echinococcosis using native and recombinant antigens in Japan"Southeast Asian Journal of Tropical Medicine and Public Health. 32. 111-115 (2001)

[文献書誌] Ito, A.: "Neurocysticercosis and echinococcosis in Asia : Recent advances in the establishment of highly reliable differential serodiagnosis for international collaboration"Southeast Asian Journal of Tropical Medicine and Public Health. 31. 16-20 (2000)

[文献書誌] Nakao, M.: "Mitochondrial genetic code in cestodes"Molecular and Biochemical Parasitology. 111. 415-424 (2000)

[文献書誌] Sako, Y.: "Molecular characterization and diagnostic value of Taenia solium low-molecular-weight antigen genes"Journal of Clinical Microbiology. 38. 4439-4444 (2000)

[文献書誌] Craig, P.S.: "An epidemiological and ecological study of human alveolar echinococcosis transmission in south Gansu, China"Acta Tropica. 77. 167-177 (2000)

[文献書誌] Wandra, T.: "Resurgence of cases of epileptic seizures and burns associated with cysticercosis in Assologaima, Jayawijaya, Irian Jaya, Indonesia, 1991-95"Transactions of the Royal Society of Tropical Medicine and Hygiene. 94. 46-50 (2000)

[文献書誌] 伊藤 亮: "特集 人畜共通感染症 肺エキノコックス症"呼吸. 22. 56-60 (2003)

[文献書誌] 伊藤 亮: "特集テーマ:今日常診療で注目すべき原虫症、寄生虫症 エキノコックス症"JIM. 13(in press). (2002)

[文献書誌] 畠山優一: "肝単包虫症の1切除例"手術. 56. 819-823 (2002)

[文献書誌] 伊藤 亮: "技術講座 単包虫症、多包虫症の免疫学的診断"Medical Technology. 30. 97-103 (2002)

[文献書誌] 伊藤 亮: "寄生虫学講座におけるエキノコックス症、有鉤嚢虫症、ライム病についての研究総括"旭川医科大学研究フォーラム. 2(2). 14-21 (2001)

[文献書誌] 伊藤 亮: "新興・再興寄生虫症(有鉤嚢虫腫御、エキノコックス症)の世界における現状 10,59-66"臨床環境医学. 10. 59-66 (2001)

[文献書誌] 伊藤 亮: "エキノコックス症の疫学と血清診断"Current Concepts in Infectious Disease. 20. 18-19 (2001)

[文献書誌] 伊藤 亮: "執筆者からの返事"北海道医学雑誌. 76. 367-368 (2001)

[文献書誌] 伊藤 亮: "旭川医科大学におけるエキノコックス症研究の現状と日本におけるエキノコックス症の問題点"北海道医学雑誌. 76. 3-8 (2001)

[文献書誌] 伊藤 亮: "新興・再興寄生虫病としてのエキノコックス症、有鉤嚢虫症"岐阜県医師会医学雑誌. 14. 35-46 (2001)

[文献書誌] 伊藤 亮: "エキノコックス症を取り巻く諸問題"旭川医科大学研究フォーラム. 2(1). 13-19 (2001)

[文献書誌] 伊藤 亮: "エキノコックス症(多包虫症)血清診断の問題点"Infection Control. 10. 44-46 (2001)

[文献書誌] 伊藤 亮: "エキノコックス症-世界・日本での現状、診断・治療・予防-"北海道プライマリケア研究会会報. 19. 31-41 (2001)

[文献書誌] Ito, A.: "In : Progress of Medical Parasitology in Japan. Chapter III. Session 6. Immunology in cestode infections (2) Immunity to the larval cestodes"Meguro Parasitology Museum, Tokyo(in press). (2003)

[文献書誌] Ito, A.: "Taenia solium Cysticercosis. Chapter 5. Mitochondrial DNA of Taenia solium : from basic to applied science"CABI Press, Oxson, UK. 47-55 (2002)

[文献書誌] Singh, G.: "Taenia solium Cysticercosis. Chapter 12. Taenia solium taeniasis and cysticercosis in Asia"CABI Press, Oxson, UK. 111-127 (2002)

[文献書誌] Ito, A.: "Cestode Zoonoses : Echinococcosis and Cysticercosis-An Emergent and Global problem. Neurocysticercosis in Asia : serology/seroepidemiology in humans and pigs"IOS Press, Amsterdam. 25-31 (2002)

[文献書誌] Ito, A.: "Cestode Zoonoses : Echinococcosis and Cysticercosis-An Emergent and Global problem. Differential serodiagnosis for alveolar echinococcosis by Em18-immunoblot and Em18-ELISA in Japan and China"IOS Press, Amsterdam. 147-155 (2002)

[文献書誌] 皆川知紀: "北海道感染症対策マニュアル"北海道保健福祉部保健予防課. 242 (2001)

[文献書誌] 伊藤 亮: "シンプル微生物学(改訂第3版)"南江堂. 343-354 (2000)

2002 年度実績報告書

伊藤亮旭川医科大学, 医学部, 教授 (70054020)

[文献書誌] 伊藤亮: "特集人畜共通感染症肺エキノコックス症"呼吸. 22. 56-60 (2003)

[文献書誌] 伊藤亮: "特集テーマ:今日常診療で注目すべき原虫症、寄生虫症エキノコックス症"JIM. 13(in press). (2002)

[文献書誌] 伊藤亮: "技術講座単包虫症、多包虫症の免疫学的診断"Medical Technology. 30. 97-103 (2002)

[文献書誌] 伊藤亮: "寄生虫学講座におけるエキノコックス症、有鉤嚢虫症、ライム病についての研究総括"旭川医科大学研究フォーラム. 2(2). 14-21 (2001)

[文献書誌] 伊藤亮: "新興・再興寄生虫症(有鉤嚢虫腫御、エキノコックス症)の世界における現状 10,59-66"臨床環境医学. 10. 59-66 (2001)

[文献書誌] 伊藤亮: "エキノコックス症の疫学と血清診断"Current Concepts in Infectious Disease. 20. 18-19 (2001)

[文献書誌] 伊藤亮: "執筆者からの返事"北海道医学雑誌. 76. 367-368 (2001)

[文献書誌] 伊藤亮: "旭川医科大学におけるエキノコックス症研究の現状と日本におけるエキノコックス症の問題点"北海道医学雑誌. 76. 3-8 (2001)

[文献書誌] 伊藤亮: "新興・再興寄生虫病としてのエキノコックス症、有鉤嚢虫症"岐阜県医師会医学雑誌. 14. 35-46 (2001)

[文献書誌] 伊藤亮: "エキノコックス症を取り巻く諸問題"旭川医科大学研究フォーラム. 2(1). 13-19 (2001)

[文献書誌] 伊藤亮: "エキノコックス症(多包虫症)血清診断の問題点"Infection Control. 10. 44-46 (2001)

[文献書誌] 伊藤亮: "エキノコックス症-世界・日本での現状、診断・治療・予防-"北海道プライマリケア研究会会報. 19. 31-41 (2001)

[文献書誌] 伊藤亮: "シンプル微生物学(改訂第3版)"南江堂. 343-354 (2000)