2001 年度実績報告書

獲得性生体情報の構築・応答ならびにその異常と病態の研究

研究課題

研究課題/領域番号	12CE2006
研究機関	京都大学
研究代表者	本庶佑京都大学, 医学研究科, 教授 (80090504)
研究分担者	北徹京都大学, 医学研究科, 教授 (60161460) 湊長博京都大学, 生命科学研究科, 教授 (40137716) 中西重忠京都大学, 生命科学研究科, 教授 (20089105)
キーワード	クラススイッチ / 体細胞突然変異 / AID / PD-1 / PD-L / IMCT法 / パーキンソン / グルタミン酸受容体 / 立体構造
研究概要	本庶は、クラススイッチ組換えの分子機構として、以下のことを明らかにした。 (1)クラススイッチ組換えがs領域の転写の量に比例して頻度が上昇すること。(2)クラススイッチ組換えの切断がニックによる両端が不揃いの端々を形成すること。(3)クラススイッチの産物として放出される環状DNA上で転写が起こり、これがクラススイッチが起こったことを示す優れたマーカーであること。(4)クラススイッチ組換えにおけるAIDの役割は、切断に関与すること。(5)これまで謎であった腸管のIgA産生が腸管粘膜固有層でスイッチが起こること。(6)AIDは、クラススイッチ組換えと体細胞突然変異の両者において共通のしくみを取ること。中西は、神経ネットワーク伝達の制御、並びに受容体シグナル伝達系の機構に関し多くの新しい事実を明らかにしたが、中でも(1)イムノトキシン標的細胞破壊法を用い、側座核アセチルコリンがドーパミンに拮抗してコカインによる神経可塑性ひいてはコカイン中毒を制御していること、又網膜starburstアマクリン細胞が視覚情報の方向選択性と眼振運動を決定していること。(2)代謝型グルタミン酸受容体mGluR1,5に結合する新規蛋白質tamalinを同定しGTP交換促進因子と複合体を形成し、mGluR1,5の細胞膜分布を促進すること、mGluR1,5のアダプター蛋白homerlaがNMDA受容体/Ca2+/MAPキナーゼ情報伝達系を介してmRNAレベルで誘導されることを明らかにした。湊は、(1)ヒトgdT細胞のgdT細胞レセプター(TCR)による細菌由来非ペプチド抗原の認識がCDR3領域のJg1.2ゲノム配列によってコードされる特定のモチーフによっていること、同モチーフはヒトにのみ存在すること、さらにgdT細胞がガン細胞に結合した非ペプチド抗原を選択的に認識し強い抗ガン活性を示すことを明らかにし、ヒトgdT細胞の認識と機能、とくに感染と腫瘍における交叉免疫における新局面を開いた。(2)低分子G蛋白Rap1がインテグリンの主たる活性化因子であり、これによりT細胞と抗原提示細胞との免疫シナプス形成およびそこでのT細胞の活性化様式を支配する必須の因子であることを明らかにし、さらにRap1制御因子SPA-1の遺伝子破壊マウスの解析から、Rap1の異常な活性化により免疫アナージーと免疫記憶応答の喪失にいたることを個体レベルで証明した。北は、ヒト動脈硬化病変において酸化LDL受容体SR-PSOXは主にマクロファージに、LOX-1は平滑筋に多く発現されること、LOX-1を介した酸化LDLの取り込みが平滑筋のアポトーシスを誘導することを示した。また、LOX-1は細菌やフィブロネクチンをも接着することをみいだした。血栓形成の引き金は血小板活性化にあるが、新たに確立した形質膜透過型の血小板を用いて穎粒放出制御因子としてRab4とPKCαを、凝集制御因子としてRh6を同定した。凝集には、さらに何らかの細胞質因子が必要であった。動脈硬化硬化病変への単球の集積を制御するケモカインMCP-1を介した細胞接着と遊走の分子機構を明らかにした。MCP-1による細胞接着はERKの活性化に依存したβ1インテグリンの活性化に、遊走はP38とRhoの活性化によるものであった。これらの独立したシグナル伝達を介した細胞接着と遊走がおきることが単球の集積に重要との結論に達した。

研究成果

(64件)

すべてその他

すべて文献書誌 (64件)

[文献書誌] Tanigaki, K.: "Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate"Neuron. 29. 45-55 (2001)
[文献書誌] Latchman, Y.: "PD-L2, a novel B7 homologue, is a second ligand for PD-1 and inhibits Tcell activation"Nature Immunol.. 2. 261-268 (2001)
[文献書誌] Nishimura, H.: "Autoimmune dilated cardiomyopathy in PD-i receptor deficient mice"Science. 291. 319-322 (2001)
[文献書誌] Tani, S.: "The amino-and carboxy-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription"Nucleic Acids Res.. 29. 1373-1380 (2001)
[文献書誌] Muramatsu, M.: "Complex layers of genetic alteration in generation of antibody diversity"Trends in Immunol.. 22. 66-68 (2001)
[文献書誌] Tashiro, J.: "Palindromic but not G-rich sequences are targets of class switch recombination"Int. Immunol.. 13. 495-505 (2001)
[文献書誌] Okazaki, T.: "The regulation ofPD-1/PD-L1 pathway and autommune diseases"Activating and Inhibitory Immunoglobulin-like Receptors. 211-214 (2001)
[文献書誌] Agata, Y.: "Histone acetylation determines the developmentally regulated accessibility for TCRγ gene recombination"J.Exp.Med.. 193. 873-879 (2001)
[文献書誌] Nishimura, H.: "PD-1:an inhibitory immunoreceptor involved in peripheral tolerance"Trend Immunol.. 22. 265-268 (2001)
[文献書誌] Ikegawa, M.: "Elevated plasma stromal cell-derived factor 1 protein level in the progression of HIV type 1 infection/AIDS"Aids Res Hum Retroviruses. 17. 587-595 (2001)
[文献書誌] Kinoshita, K.: "Linking class-switch recombination with somatic hypermutation"Nature Reviews MCB. 2. 493-503 (2001)
[文献書誌] Lee, H.: "Induction of germline transcription in the human T cell receptor γ locus by STAT5"J. Immunol.. 167. 320-326 (2001)
[文献書誌] Ye, S-K.: "Differential roles of cytokine receptors in the developmentof epidermal γδ T cells^1"J. Immunol.. 167. 1929-1934 (2001)
[文献書誌] Mizutani, T.: "Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members"Proc. Nati. Acad. Sci. USA. 98. 9026-9031 (2001)
[文献書誌] Lee, C-G.: "Quantitative regulation of class switch Yoshida M recombination by S region transcription"J.Exp. Med.. 194. 365-373 (2001)
[文献書誌] Durandy, A.: "Human genetic defects in class-switch recombination (hyper-IgM syndromes)"Curr.Opin.Immunol.. 13. 543-548 (2001)
[文献書誌] Kobuke, K.: "ESDN, a Novel neuropiin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is upregulated after vascular injury"J. Biol. Chem.. 276. 34105-34114 (2001)
[文献書誌] Fagarasan, S.: "In situ class switching and differentiation to IgA-producing cells in the gut lamina propria"Nature. 413. 639-643 (2001)
[文献書誌] Kinoshita, K.: "A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs"Proc. Natl. Acad. Sci. USA. 98. 12620-12623 (2001)
[文献書誌] Okazaki, T.: "PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine"Proc. Natl. Acad. Sci. USA. 98. 13866-13871 (2001)
[文献書誌] Chen, X.: "Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class switch recombination"Proc. Natl. Acad. Sci. USA. 98. 13860-13865 (2001)
[文献書誌] Ye, S-K.: "The IL-7 receptor controls the accessibility of the TCRγ locus by stat5 and histone acetylation"Immunity. 15. 813-823 (2001)
[文献書誌] Petersen, S.: "AID is required to initiate Nbs 1/γ-H2AX focus formation and mutations at sites of class switching"Nature. 414. 660-665 (2001)
[文献書誌] Higuchi, T.: "Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease 1"J. Immunol. 168. 9-12 (2002)
[文献書誌] Shinohara, M.: "Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice"Proc. Nati. Acad. Sci. USA. 99. 1383-1388 (2002)
[文献書誌] Honjo, T.: "Molecular mechanism of class switch recombination: linkage with somatic hypermutation"Ann. Rev. Immunol.. 20. 165-196 (2002)
[文献書誌] Nagaoka, H.: "MD-directed hypermutation in the immunoglobulin Sμ region: Implication to AID involvement in a common step of class switch recombination and somatic hypermutation"J. Exp. Med.. 195. 529-534 (2002)
[文献書誌] Nakamura, T.: "Fibulin-5/DANCE is essential for elastogenesis in vivo"Nature. 415. 171-175 (2002)
[文献書誌] Okazaki, I.: "AID induces class switch recombination in fibroblasts"Nature (DOI 10.1038/nature 727). (in press). (2002)
[文献書誌] Fagarasan, S.: "Experimental models of autoimmune hemolytic anemia"The Molecular Pathology of Autoimmmune Diseases, Second edition, Gordon and Breach/Harwood. (in press). (2002)
[文献書誌] Krnoshita, K.: "Switch region"Encyclopedia of Melecular Medicine. (in press). (2002)
[文献書誌] Bross, L.: "DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation"J.Exp.Med.. (in press). (2002)
[文献書誌] Taniguchi, Y.: "Notch receptor cleavage is dependent on but not directly executed by presenilins"Proc. Nati. Acad. Sci. USA. (in press). (2002)
[文献書誌] Han, H.: "Inducible gene knockout of transcription factor RBP-J reveals its essential role in T versus B lineage decision"Int. Immunol.. (in press). (2002)
[文献書誌] Yoshida, K.: "A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement"Neuron. 30. 771-780 (2001)
[文献書誌] Sato, M.: "NMDA receptor stimulation and brain-derived neurotrophic factor upregulate Homer 1a mRNA via the mitogen-activated protein kinase cascade in cultured cerebellar granule cells"J. Neurosci.. 21. 3797-3805 (2001)
[文献書誌] Shinohara Y.: "Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrengement in heterologous mGluRl-expressing CHO cells via calcium/calmodulin signalin"J. Neurochem.. 78. 365-373 (2001)
[文献書誌] Hikida, T.: "Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens"Proc. Nati. Acad. Sci. USA. 98. 13351-13354 (2001)
[文献書誌] Dev, K. K.: "Regulation of mglu(7) receptors by proteins that interact with the intracellular C-terminus"Trends Pharmacological Sciences. 22(7). 355-361 (2001)
[文献書誌] Kitano, J.: "Tamalin, a PDZ domain-containing protein links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins"J.Neurosci.. (in press). (2002)
[文献書誌] John J. R.: "Experience-dependent plasticity without long-term depression by means of type 2 metabotropic glutamate receptors in developing visual cortex"Proc. Natl. Acad. Sci. USA. (in press). (2002)
[文献書誌] Suga.K.: "CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation"FEBS Letters. 489. 249-253 (2001)
[文献書誌] Nishimura, H.: "Autoimmune dilated cardiomyopathy in PD-1 reptor deficient mice"Science. 291. 319-322 (2001)
[文献書誌] Miyagawa, F.: "Essential requirement of antigen presentation by monocyte-lineage cells for the activation of primary human gd T cells by aminobisphosphonate antigen"J.Immunol. 166. 166. 5508-5514 (2001)
[文献書誌] Kawakami, T.: "NEDD8 recruits E2-ubiquitin to SCE E3 ligase"EMBO J.. 20. 4003-4012 (2001)
[文献書誌] Kato, Y.: "Targeting of tumor cells for human gamma delta T cells by nonpeptide antigens"J. Immunol. 167. 5092-5098 (2001)
[文献書誌] Miyagawa, F.: "Essential contribution of germilne-encoded residues in Jg1.2 segment to the recognition of nonpeptide antigens by human gd T cells"J. Immunol. 167. 6773-6779 (2001)
[文献書誌] Okuda H: "The Von Hippel-Lindau (VHL) tumor suppressor protein mediates ubiquitination of activated atypical protein krnase C"J Biol Chem.. 276. 43611-4361 (2001)
[文献書誌] Katagiri, K.: "Rap 1 functions as a key regulator of T cell and APC interactions and modulates T cell-responses"Mol. Cell. Biol.. 22. 1001-1015 (2002)
[文献書誌] Suganuma M: "Helicobacter pylon membrane protein 1: a new carcinogenic factor of Helicobacter pylori"Cancer Res.. 61. 6356-6359 (2001)
[文献書誌] Yoshida M: "CD4 T cells monospecific to ovalbumin produced by Eschelichia coil can induce colitis upon transfer to BALB/c and SCID mice"Int. Immunology. 13. 1561-1570 (2001)
[文献書誌] Watanabe T: "Oral administration of an antigen at a high dose generates tolerogenicCD4+CD25+ T cells expressing CD95 ligand in the liver"J. Immunol:. 168. 2188-2199 (2001)
[文献書誌] Hayashida K: "Lectin-like oxidized LDL receptor-i (LOX-1) supports adhesion of mononuclearleukocytes and a monocyte-like cell line THP-1 cells under static and flow conditions"FEBS Lett.. 511. 170-174 (2001)
[文献書誌] Hashimoto K: "Roles of glutamate receptor delta 2 subunit (GluRdelta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse ostnatal cerebellar development"J. Neurosci.. 21. 9701-9712 (2001)
[文献書誌] Onoe H: "Cortical networks recruited for time perception: A monkey positron emission tomography (PET) study"Neuroimage. 13. 37-45 (2001)
[文献書誌] Nishioka H: "Small GTPase Rho regulates thrombin-induced platelet aggregation. Biochem"Biophys. Res. Commun. 280. 970-975 (2001)
[文献書誌] Sano H: "Functional blockade of platelet-derived growth factor receptor-b but not ofreceptor-a prevents vascular smooth muscle cell accumulation in the fibrouscap lesions in apoliporotein E-deficient mice"Circulation. 103. 2955-2960 (2001)
[文献書誌] Nishioka H: "Small GTPase Rho regulates thrombin-induced platelet aggregation. Biochem"Biophys. Res. Commun. 280. 970-975 (2001)
[文献書誌] Onoe H: "Cortical networks recruited for time perception: A monkey positron emission tomography (PET) study"Neurolmage. 13. 37-45 (2001)
[文献書誌] Hashimoto K: "Roles of glutamate receptor delta 2 subunit (GluRdelta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse eliminationdurin postnatal cerebellar develop meat"J. Neurosci.. 21. 9701-9712 (2001)
[文献書誌] Hayashida K.: "Lectin-like oxidized LDL receptor-i (LOX-1) supports adhesion of mononuclear leukocytes and a monocyte-like cell line THP-1 cells under static and flow conditions"FEBS Lett.. 511. 170-174 (2001)
[文献書誌] Watanabe T: "Oral administration of an antigen at a high dose generates tolerogenicCD4+CD25+ T cells expressing CD95 ligand in the liver"J. Immunol.. 168. 2188-2199 (2001)
[文献書誌] Yoshida M: "CD4 T cells monospecific to ovalbumin produced by Eschelichia coli can induce colitis upon transfer to BALB/c and SCID mice"Int. Immunology. 13. 1561-1570 (2001)
[文献書誌] Suganuma M: "Helicobacter pylori membrane protein 1: a new carcinogernc factor of Helicobacter pylori"Cancer Res.. 61. 6356-6359 (2001)

2001 年度 実績報告書

獲得性生体情報の構築・応答ならびにその異常と病態の研究

研究代表者

本庶 佑 京都大学, 医学研究科, 教授 (80090504)

研究成果

[文献書誌] Tanigaki, K.: "Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate"Neuron. 29. 45-55 (2001)

[文献書誌] Latchman, Y.: "PD-L2, a novel B7 homologue, is a second ligand for PD-1 and inhibits Tcell activation"Nature Immunol.. 2. 261-268 (2001)

[文献書誌] Nishimura, H.: "Autoimmune dilated cardiomyopathy in PD-i receptor deficient mice"Science. 291. 319-322 (2001)

[文献書誌] Tani, S.: "The amino-and carboxy-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription"Nucleic Acids Res.. 29. 1373-1380 (2001)

[文献書誌] Muramatsu, M.: "Complex layers of genetic alteration in generation of antibody diversity"Trends in Immunol.. 22. 66-68 (2001)

[文献書誌] Tashiro, J.: "Palindromic but not G-rich sequences are targets of class switch recombination"Int. Immunol.. 13. 495-505 (2001)

[文献書誌] Okazaki, T.: "The regulation ofPD-1/PD-L1 pathway and autommune diseases"Activating and Inhibitory Immunoglobulin-like Receptors. 211-214 (2001)

[文献書誌] Agata, Y.: "Histone acetylation determines the developmentally regulated accessibility for TCRγ gene recombination"J.Exp.Med.. 193. 873-879 (2001)

[文献書誌] Nishimura, H.: "PD-1:an inhibitory immunoreceptor involved in peripheral tolerance"Trend Immunol.. 22. 265-268 (2001)

[文献書誌] Ikegawa, M.: "Elevated plasma stromal cell-derived factor 1 protein level in the progression of HIV type 1 infection/AIDS"Aids Res Hum Retroviruses. 17. 587-595 (2001)

[文献書誌] Kinoshita, K.: "Linking class-switch recombination with somatic hypermutation"Nature Reviews MCB. 2. 493-503 (2001)

[文献書誌] Lee, H.: "Induction of germline transcription in the human T cell receptor γ locus by STAT5"J. Immunol.. 167. 320-326 (2001)

[文献書誌] Ye, S-K.: "Differential roles of cytokine receptors in the developmentof epidermal γδ T cells^1"J. Immunol.. 167. 1929-1934 (2001)

[文献書誌] Mizutani, T.: "Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members"Proc. Nati. Acad. Sci. USA. 98. 9026-9031 (2001)

[文献書誌] Lee, C-G.: "Quantitative regulation of class switch Yoshida M recombination by S region transcription"J.Exp. Med.. 194. 365-373 (2001)

[文献書誌] Durandy, A.: "Human genetic defects in class-switch recombination (hyper-IgM syndromes)"Curr.Opin.Immunol.. 13. 543-548 (2001)

[文献書誌] Kobuke, K.: "ESDN, a Novel neuropiin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is upregulated after vascular injury"J. Biol. Chem.. 276. 34105-34114 (2001)

[文献書誌] Fagarasan, S.: "In situ class switching and differentiation to IgA-producing cells in the gut lamina propria"Nature. 413. 639-643 (2001)

[文献書誌] Kinoshita, K.: "A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs"Proc. Natl. Acad. Sci. USA. 98. 12620-12623 (2001)

[文献書誌] Okazaki, T.: "PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine"Proc. Natl. Acad. Sci. USA. 98. 13866-13871 (2001)

[文献書誌] Chen, X.: "Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class switch recombination"Proc. Natl. Acad. Sci. USA. 98. 13860-13865 (2001)

[文献書誌] Ye, S-K.: "The IL-7 receptor controls the accessibility of the TCRγ locus by stat5 and histone acetylation"Immunity. 15. 813-823 (2001)

[文献書誌] Petersen, S.: "AID is required to initiate Nbs 1/γ-H2AX focus formation and mutations at sites of class switching"Nature. 414. 660-665 (2001)

[文献書誌] Higuchi, T.: "Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease 1"J. Immunol. 168. 9-12 (2002)

[文献書誌] Shinohara, M.: "Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice"Proc. Nati. Acad. Sci. USA. 99. 1383-1388 (2002)

[文献書誌] Honjo, T.: "Molecular mechanism of class switch recombination: linkage with somatic hypermutation"Ann. Rev. Immunol.. 20. 165-196 (2002)

[文献書誌] Nagaoka, H.: "MD-directed hypermutation in the immunoglobulin Sμ region: Implication to AID involvement in a common step of class switch recombination and somatic hypermutation"J. Exp. Med.. 195. 529-534 (2002)

[文献書誌] Nakamura, T.: "Fibulin-5/DANCE is essential for elastogenesis in vivo"Nature. 415. 171-175 (2002)

[文献書誌] Okazaki, I.: "AID induces class switch recombination in fibroblasts"Nature (DOI 10.1038/nature 727). (in press). (2002)

[文献書誌] Fagarasan, S.: "Experimental models of autoimmune hemolytic anemia"The Molecular Pathology of Autoimmmune Diseases, Second edition, Gordon and Breach/Harwood. (in press). (2002)

[文献書誌] Krnoshita, K.: "Switch region"Encyclopedia of Melecular Medicine. (in press). (2002)

[文献書誌] Bross, L.: "DNA double-strand breaks: Prior to but not sufficient in targeting hypermutation"J.Exp.Med.. (in press). (2002)

[文献書誌] Taniguchi, Y.: "Notch receptor cleavage is dependent on but not directly executed by presenilins"Proc. Nati. Acad. Sci. USA. (in press). (2002)

[文献書誌] Han, H.: "Inducible gene knockout of transcription factor RBP-J reveals its essential role in T versus B lineage decision"Int. Immunol.. (in press). (2002)

[文献書誌] Yoshida, K.: "A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement"Neuron. 30. 771-780 (2001)

[文献書誌] Sato, M.: "NMDA receptor stimulation and brain-derived neurotrophic factor upregulate Homer 1a mRNA via the mitogen-activated protein kinase cascade in cultured cerebellar granule cells"J. Neurosci.. 21. 3797-3805 (2001)

[文献書誌] Shinohara Y.: "Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrengement in heterologous mGluRl-expressing CHO cells via calcium/calmodulin signalin"J. Neurochem.. 78. 365-373 (2001)

[文献書誌] Hikida, T.: "Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens"Proc. Nati. Acad. Sci. USA. 98. 13351-13354 (2001)

[文献書誌] Dev, K. K.: "Regulation of mglu(7) receptors by proteins that interact with the intracellular C-terminus"Trends Pharmacological Sciences. 22(7). 355-361 (2001)

[文献書誌] Kitano, J.: "Tamalin, a PDZ domain-containing protein links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins"J.Neurosci.. (in press). (2002)

[文献書誌] John J. R.: "Experience-dependent plasticity without long-term depression by means of type 2 metabotropic glutamate receptors in developing visual cortex"Proc. Natl. Acad. Sci. USA. (in press). (2002)

[文献書誌] Suga.K.: "CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation"FEBS Letters. 489. 249-253 (2001)

[文献書誌] Nishimura, H.: "Autoimmune dilated cardiomyopathy in PD-1 reptor deficient mice"Science. 291. 319-322 (2001)

[文献書誌] Miyagawa, F.: "Essential requirement of antigen presentation by monocyte-lineage cells for the activation of primary human gd T cells by aminobisphosphonate antigen"J.Immunol. 166. 166. 5508-5514 (2001)

[文献書誌] Kawakami, T.: "NEDD8 recruits E2-ubiquitin to SCE E3 ligase"EMBO J.. 20. 4003-4012 (2001)

[文献書誌] Kato, Y.: "Targeting of tumor cells for human gamma delta T cells by nonpeptide antigens"J. Immunol. 167. 5092-5098 (2001)

[文献書誌] Miyagawa, F.: "Essential contribution of germilne-encoded residues in Jg1.2 segment to the recognition of nonpeptide antigens by human gd T cells"J. Immunol. 167. 6773-6779 (2001)

[文献書誌] Okuda H: "The Von Hippel-Lindau (VHL) tumor suppressor protein mediates ubiquitination of activated atypical protein krnase C"J Biol Chem.. 276. 43611-4361 (2001)

[文献書誌] Katagiri, K.: "Rap 1 functions as a key regulator of T cell and APC interactions and modulates T cell-responses"Mol. Cell. Biol.. 22. 1001-1015 (2002)

[文献書誌] Suganuma M: "Helicobacter pylon membrane protein 1: a new carcinogenic factor of Helicobacter pylori"Cancer Res.. 61. 6356-6359 (2001)

[文献書誌] Yoshida M: "CD4 T cells monospecific to ovalbumin produced by Eschelichia coil can induce colitis upon transfer to BALB/c and SCID mice"Int. Immunology. 13. 1561-1570 (2001)

[文献書誌] Watanabe T: "Oral administration of an antigen at a high dose generates tolerogenicCD4+CD25+ T cells expressing CD95 ligand in the liver"J. Immunol:. 168. 2188-2199 (2001)

[文献書誌] Hayashida K: "Lectin-like oxidized LDL receptor-i (LOX-1) supports adhesion of mononuclearleukocytes and a monocyte-like cell line THP-1 cells under static and flow conditions"FEBS Lett.. 511. 170-174 (2001)

[文献書誌] Hashimoto K: "Roles of glutamate receptor delta 2 subunit (GluRdelta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse ostnatal cerebellar development"J. Neurosci.. 21. 9701-9712 (2001)

[文献書誌] Onoe H: "Cortical networks recruited for time perception: A monkey positron emission tomography (PET) study"Neuroimage. 13. 37-45 (2001)

[文献書誌] Nishioka H: "Small GTPase Rho regulates thrombin-induced platelet aggregation. Biochem"Biophys. Res. Commun. 280. 970-975 (2001)

[文献書誌] Sano H: "Functional blockade of platelet-derived growth factor receptor-b but not ofreceptor-a prevents vascular smooth muscle cell accumulation in the fibrouscap lesions in apoliporotein E-deficient mice"Circulation. 103. 2955-2960 (2001)

[文献書誌] Nishioka H: "Small GTPase Rho regulates thrombin-induced platelet aggregation. Biochem"Biophys. Res. Commun. 280. 970-975 (2001)

[文献書誌] Onoe H: "Cortical networks recruited for time perception: A monkey positron emission tomography (PET) study"Neurolmage. 13. 37-45 (2001)

[文献書誌] Hashimoto K: "Roles of glutamate receptor delta 2 subunit (GluRdelta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse eliminationdurin postnatal cerebellar develop meat"J. Neurosci.. 21. 9701-9712 (2001)

[文献書誌] Hayashida K.: "Lectin-like oxidized LDL receptor-i (LOX-1) supports adhesion of mononuclear leukocytes and a monocyte-like cell line THP-1 cells under static and flow conditions"FEBS Lett.. 511. 170-174 (2001)

[文献書誌] Watanabe T: "Oral administration of an antigen at a high dose generates tolerogenicCD4+CD25+ T cells expressing CD95 ligand in the liver"J. Immunol.. 168. 2188-2199 (2001)

[文献書誌] Yoshida M: "CD4 T cells monospecific to ovalbumin produced by Eschelichia coli can induce colitis upon transfer to BALB/c and SCID mice"Int. Immunology. 13. 1561-1570 (2001)

[文献書誌] Suganuma M: "Helicobacter pylori membrane protein 1: a new carcinogernc factor of Helicobacter pylori"Cancer Res.. 61. 6356-6359 (2001)

2001 年度実績報告書

本庶佑京都大学, 医学研究科, 教授 (80090504)