2003 年度実績報告書

骨髄細胞移植による肝組織再構築に関する研究

研究課題

研究課題/領域番号	13307037
研究機関	日本大学
研究代表者	高山忠利日本大学, 医学部, 教授 (30280944)
研究分担者	成瀬勝俊東京大学, 医学部附属病院, 助手 (50291323) 三木健司東京大学, 医学部附属病院, 助手 (10242059) 幕内雅敏東京大学, 医学部附属病院, 教授 (60114641) 渡邉善広日本大学, 医学部, 講師 (20240533) 加藤高明日本大学, 医学部, 講師 (40233788)
キーワード	骨髄幹細胞 / 分化誘導 / Acetoaminofluorene / ケモカイン / Gene Chip
研究概要	平成14年度までの間に、In vitroおよびIn vivoにおいて骨髄細胞が内胚葉系の細胞からさらに肝細胞へ分化するメカニズムについて研究してきた。Acetoaminofluorene(AAF)投与後、70%部分肝切除を行った(AAF/Phx群)マウスの骨髄細胞中にAFPやHNF3、HNF4などの内胚葉に特異的な遺伝子の発現がコントロールの100倍前後まで増加することを見出したが、平成15年度には、このような遺伝子変化が骨髄中のどのような性質を持った細胞に発現しているかを検討した。AAF/PHx群のマウス骨髄細胞をFACSを用いて様々な分画に分離し、それぞれの分画中のmRNAをRT-PCRにて増幅し、AFPmRNAの発現している分画を調べた。FACSによる解析によって、AFP産生細胞は、1 in^- CD34^+ c-kit^+ Sca-1^+ CD49f^+ CD45^+の造血幹細胞の分画に存在することが明らかになった。さらに、AAF/PHx群においてPHx群よりも特異的に骨髄細胞の分化が誘導されるメカニズムを明らかにするために、AAF/PHx群とPHx群の肝臓の遺伝子発現プロファイルの差を、Affymetrix Gene Chipにて解析した。AAF/PHx 2日目にPHxに比べて5.7倍(log ratio>2.5)以上に発現している遺伝子が28個同定された。そのうち半数以上の遺伝子が、TNF_あるいはIL6によって誘導される、ケモカインや、acute phase proteinであった。近年、炎症性ケモカインが肝の再生を促進する働きがあることが報告されており、ケモカインは、マクロファージやモノサイトといった炎症性細胞のみならず生体内のさまざまな細胞に対する多岐にわたる作用が明らかになってきた。本研究において同定されたケモカインは肝再生のみならず、骨髄細胞を肝細胞に分化させる働きがあると推測され、肝不全治療の有力な候補になりうると考えられる。最後に、それぞれのケモカインの作用をブロックするアンタゴニストの投与やステロイドによるケモカインの抑制により骨髄の遺伝子変化に影響があるかどうかを調べている。

研究成果
(89件)

すべてその他

すべて文献書誌 (89件)

[文献書誌] Takayama T: "Preoperative portal vein embolization : is it useful?"Journal of Hepatobiliary Pancreat Surg. 11・1. 17-20 (2004)
[文献書誌] Takayama T: "Adjuvant therapy for hepatocellular carcinoma : is there an effective modality?"Cancer Reviews : Asia-Pacific. 1・2. 237-244 (2003)
[文献書誌] Makuuchi M: "Both parietal lobes are involved in drawing : a functional MRI study and implications for constructional apraxia"Brain Res Cogn Brain Res. 16・3. 338-347 (2003)
[文献書誌] Makuuchi M: "Living-donor liver transplantation using the left liver, with special reference to vein reconstruction"Transplantation. 15・75. S23-S24 (2003)
[文献書誌] Makuuchi M: "The surgical approach to HCC : our progress and results in Japan"Liver Transpl. 10・2. S46-S52 (2004)
[文献書誌] Makuuchi M: "IHPBA concordant classification of primary liver cancer : working group report"J Hepatobiliary Pancreat Surg. 10・1. 26-30 (2003)
[文献書誌] Yamazaki S: "Sera from liver failure patients and a demethylating agent stimulate transdifferentiation of murine bone marrow cells into hepatocytes in coculture with nonparenchymal liver cells"J Hepatol. 39・1. 17-23 (2003)
[文献書誌] Naruse K: "Development of a new extracorporeal whole-liver perfusion system"J Artif Organs. 6・3. 211-217 (2003)
[文献書誌] Naruse K: "Xenogeneic direct hemoperfusion using whole swine liver for liver failure in dogs"J Surg Res. 111・2. 229-235 (2003)
[文献書誌] Torzilli G: "Contrast-enhanced intraoperative ultrasonography in surgery for hepatocellular carcinoma in cirrhosis"Liver Transpl. 10・2. S34-S38 (2004)
[文献書誌] Torzilli G: "Indication and contraindication for hepatic resection for liver tumors without fine-needle biopsy : validation and extension of an Eastern approach in a Western community hospital"Liver Transpl. 10・2. S30-S33 (2004)
[文献書誌] Inoue K: "Clinical significance of early hepatocellular carcinoma"Liver Transpl. 10・2. S16-S19 (2004)
[文献書誌] Torzilli G: "Differences and similarities in the approach to hepatocellular carcinoma between Eastern and Western institutions"Liver Transpl. 10・2. S1-S2 (2004)
[文献書誌] Takayasu K: "Neovasculature of benign thrombus of the inferior vena cava demonstrated by computed tomography during hepatic arteriography, mimicking a small hepatocellular carcinoma"Japanese Journal of Clinical Oncology. 33・1. 44-46 (2003)
[文献書誌] Kishi Y: "Hepatic arterial anatomy for right liver procurement from living donors"Liver Transpl. 10・1. 129-133 (2004)
[文献書誌] Hata S: "Volume regeneration after right liver donation"Liver Transpl. 10・1. 65-70 (2004)
[文献書誌] Ikai I: "Report of the 15th follow-up survey of primary liver cancer"Hepatol Res. 28・1. 21-29 (2004)
[文献書誌] Sakamot Y: "Bloodless liver resection using the monopolar floating ball plus ligasure diathermy : preliminary results of 16 liver resections"World J Surg. 28・2. 166-172 (2004)
[文献書誌] Kokudo N: "Clinical application of TcGSA"Nucl Med Biol. 30・8. 845-849 (2003)
[文献書誌] Sugawara Y: "Duct-to-duct biliary reconstruction for living donor liver transplantation : experience of 92 cases"Transplant Proc. 35・8. 2981-2982 (2003)
[文献書誌] Noritomi T: "Refractory acute refection in a living related liver transplantation"Hepato-gastroenterology. 50・54. 2192-2193 (2003)
[文献書誌] Torzilli G: "Ultrasound-guided finger compression in liver subsegmentectomy for hepatocellular carcinoma"Surg Endosc. 18・1. 136-139 (2004)
[文献書誌] Natori T: "Nicotine enhances neovascularization and promotes tumor growth"Mol Cells. 16・2. 143-146 (2003)
[文献書誌] Arita J: "Liver resection in patients with Gilbert's syndrome"Surgery. 134・5. 835-837 (2003)
[文献書誌] Imamura H: "One thousand fifty-six hepatectomies without mortality in 8 years"Arch Surg. 138・11. 1198-1206 (2003)
[文献書誌] Sugawara Y: "Living donor liver transplantation for hepatitis B cirrhosis"Liver Transpl. 9・11. 1181-1184 (2003)
[文献書誌] Minagawa M: "Surgical treatment of colorectal liver metastasis"Nippon Geka Gakkai Zasshi. 104・10. 721-729 (2003)
[文献書誌] Minagawa M: "Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma"Ann Surg. 238・5. 703-710 (2003)
[文献書誌] Ijichi H: ""Duodenal intussusception" due to adenoma of the papilla of Vater"Hepato-gastroenterology. 50・53. 1399-1402 (2003)
[文献書誌] Guo L: "Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation"Transpl Immunol. 12・1. 41-48 (2003)
[文献書誌] Sugawara Y: "Arterial anatomy unsuitable for a right liver donation"Liver Transpl. 9・10. 1116-1117 (2003)
[文献書誌] Sugawara Y: "Positive T lymphocytotoxic cross-match in living donor liver transplantation"Liver Transpl. 9・10. 1062-1066 (2003)
[文献書誌] Seyama Y: "Anatomical segmentectomy of the pancreas head : can this procedure be curtively applied for intraductal papillary mucinous tumors?"Pancreas. 27・3. 270-272 (2003)
[文献書誌] Sano K: "Overexpression of retinoic acid receptor alpha in hepatocellular carcinoma"Clin Cancer Res. 9・10. 3679-3683 (2003)
[文献書誌] Akamatsu N: "Effects of middle hepatic vein reconstruction on right liver graft regeneration"Transplantation. 76・5. 832-837 (2003)
[文献書誌] Kokudo N: "Sling suspension of the liver in donor operation : a gradual taperepositioning technique"Transplantation. 76・5. 803-807 (2003)
[文献書誌] Matsui Y: "Identification of gene expression profile in tolerizing murine cardiac allograft by costimulatory blockade"Physiol Genomics. 15・3. 199-208 (2003)
[文献書誌] Saiura A: "Little evidence for cell fusion between recipient and donor-derived cells"J Surg Res. 113・2. 222-227 (2003)
[文献書誌] Umeshika K: "Operative morbidity of living liver donors in Japan"Lancet. 362・9358. 687-690 (2003)
[文献書誌] Sakamoto Y: "Segmental resection of the third portion of the duodenum for a gastrointestinal stromal tumor : a case report"Jpn J Clin Oncol. 33・7. 364-366 (2003)
[文献書誌] Guo L: "AdCTLA-4Ig combined with donor splenocytes, bone marrow cells and anti-ICOS antibody treatment induce tolerance in a rat heart transplantation model"Transpl Int. 17・1. 15-21 (2003)
[文献書誌] Sugawara Y: "Living-donor liver transplantation in adults : Tokyo University experience"J Hepatobiliary Pancreat Surg. 10・1. 1-4 (2003)
[文献書誌] Yano Y: "Combined hepatocellular and cholangiocarcinoma : a clinicopathologic study of 26 resected cases"Jpn J Clin Oncol. 33・6. 283-287 (2003)
[文献書誌] Guo Q: "An in vitro evaluation of radiation effects of different fractionated regimens by absolute cell count beads"Oncol Rep. 10・5. 1405-1410 (2003)
[文献書誌] Hasegawa K: "Effect of apolipoprotein E polymorphism on bile lipid composition and the formation of cholesterol gallstone"Am J Gastroenterol. 98・7. 1605-1609 (2003)
[文献書誌] Yamashita H: "Smallest Todani's type II choledochal cyst"Dig Liver Dis. 35・7. 498-502 (2003)
[文献書誌] Sugawara Y: "Risk factors for acute rejection in living donor liver transplantation"Clin Transplant. 17・4. 347-352 (2003)
[文献書誌] Kokubo N: "Strategies for surgical treatment of gallbladder carcinoma based on information available before resection"Arch Surg. 138・7. 741-750 (2003)
[文献書誌] Aoki T: "EBAG9/RCAS1 expression in hepatocellular carcinoma : correlation with tumour dedifferentiation and proliferation"Eur J Cancer. 39・11. 1552-1561 (2003)
[文献書誌] Kobayashi T: "The role of preoperative phenylalanine breath test in hepatectomy"Hepato-gastroenterology. 50・52. 1124-1127 (2003)
[文献書誌] Seyama Y: "Long-term outcome of extended hemihepatectomy for hilar bile duct cancer with no mortality and high survival rate"Ann Surg. 8・1. 73-83 (2003)
[文献書誌] Maruyama T: "Anti-HBs antibodies produced after liver transplantation : from the donor or the recipient?"Hepatology. 38・1. 271-272 (2003)
[文献書誌] Kogure K: "Long-term survival after hepatectomy for large metastatic breast cancer : a case report"Hepato-gastroenterology. 50・51. 827-829 (2003)
[文献書誌] Aoki T: "Follicular cholangitis : another cause of benign biliary stricture"Hepato-gastroenterology. 50・51. 639-642 (2003)
[文献書誌] Seyama Y: "Intraoperative direct pancreatography using ultrasound-guided puncture for accessory duct sphincteroplasty in a patient with pancreas divisum"Pancreas. 27・1. 98-100 (2003)
[文献書誌] Sugawara Y: "Left liver grafts for patients with MELD score of less than 15"Transplant Proc. 35・4. 1433-1434 (2003)
[文献書誌] Guo L: "Prolongation of liver xenograft survival by adenovirus vector-mediated CTLA-4Ig gene transfer"Transpl Immunol. 11・2. 155-162 (2003)
[文献書誌] Katayama A: "Autopsy findings in patients after curative esophagectomy for esophageal carcinoma"J Am Coll Surg. 196・6. 866-873 (2003)
[文献書誌] Sakamoto Y: "Surgical resection of liver metastases of gastric cancer : an analysis of a 17-year experience with 22 patients"Surgery. 133・5. 507-511 (2003)
[文献書誌] Chiappa A: "Effects of the Free Radical Scavenger Dimethyl Sulphoxide on Experimental Normothermic Ischaemia of the Liver"Dig Surg. 20・3. 238-245 (2003)
[文献書誌] Hasegawa K: "Extended right hepatectomy and total gastrectomy with double Roux-en-Y reconstruction for hilar bile duct and gastric carcinomas"Hepato-gastroenterology. 50・50. 374-376 (2003)
[文献書誌] Torzilli G: "Intraoperative ultrasonography in liver cancer"Surg Oncol Clin N Am. 12・1. 91-103 (2003)
[文献書誌] Hasegawa K: "Endovascular stenting for celiac axis stenosis before pancreaticoduodenectomy"Surgery. 133・4. 440-442 (2003)
[文献書誌] Takikawa H: "An advanced strategy of enhanced specific gene expression for hepatocellular carcinoma"Int J Oncol. 22・5. 1051-1056 (2003)
[文献書誌] Tang W: "Des-gamma-carboxy prothrombin in cancer and non-cancer liver tissue of patients with hepatocellular carcinoma"Int J Oncol. 22・5. 969-975 (2003)
[文献書誌] Abe H: "CT findings of cystic duct carcinoma two years before obstructive jaundice"Hepato-gastroenterology. 50・49. 24-26 (2003)
[文献書誌] Torzilli G: "Tricks for ultrasound-guided resection of colorectal liver metastases"Hepato-gastroenterology. 50・49. 1-3 (2003)
[文献書誌] Sugawara Y: "Outflow reconstruction in extended right liver grafts from living donors"Liver Transpl. 9・3. 306-309 (2003)
[文献書誌] Fukunishi I: "Pain in liver donors"Psychosomatics. 44・2. 172-173 (2003)
[文献書誌] Tang W: "Association of histochemical expression of Maackia amurensis leukoagglutinin-positive glycoconjugates with behaviour of human gastric cancer"Histopathology. 42・3. 239-245 (2003)
[文献書誌] Sugawara Y: "MELD score for selection of patients to receive a left liver graft"Transplantation. 75・4. 573-574 (2003)
[文献書誌] Aoki T: "Bile duct of Luschka connecting with the cystohepatic duct : the importance of cholangiography during surgery"AJR Am J Roentgenol. 180・3. 694-696 (2003)
[文献書誌] Kitamura T: "Severe hemolytic anemia related to production of cold agglutinins following living donor liver transplantation : a case report"Transplant Proc. 35・1. 399-400 (2003)
[文献書誌] Fukunishi I: "Alexithymia characteristics before and after living donor transplantation"Transplant Proc. 35・1. 296 (2003)
[文献書誌] Fukunishi I: "Paradoxical psychiatric syndrome and DSM-IV psychiatric disorders in recipients after living donor transplantation"Transplant Proc. 35・1. 294 (2003)
[文献書誌] Fan ST: "Right anterior sector drainage in right-lobe live-donor liver transplantation"Transplantation. 75・3. S25-S27 (2003)
[文献書誌] Sugawara Y: "Small-for-size graft problems in adult-to-adult living-donor liver transplantation"Transplantation. 75・3. S20-S22 (2003)
[文献書誌] Chen CL: "Living-donor liver transplantation:12 years of experience in Asia"Transplantation. 75・3. S6-S11 (2003)
[文献書誌] Midorikawa Y: "Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling"Int J Cancer. 103・4. 455-465 (2003)
[文献書誌] Masuda H: "Distinct gene expression of osteopontin in patients with ulcerative colitis"Journal of Surgical Research. 111・1. 85-90 (2003)
[文献書誌] Eguch T: "Mortality for gastric cancer in elderly patients"Journal of Surgical Oncology. 84・3. 132-136 (2003)
[文献書誌] Aramaki O: "Induction of operational tolerance and generation of regulatory cells after intratracheal delivery of alloantigen combined with nondepleting anti-CD4 monoclonal antibody"Transplantation. 76・6. 1305-1314 (2003)
[文献書誌] Eguch T: "Docetaxel plus 5-fluorouracil for terminal gastric cancer patients with peritoneal dissemination"Hepato-Gastroenterology. 50・53. 1735-1738 (2003)
[文献書誌] Sugawara Y: "Vein reconstruction in modified right liver graft for living donor liver transplantation"Ann Surg. 237・2. 180-185 (2003)
[文献書誌] Imamura H: "Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy"J Hepatol. 38・2. 200-207 (2003)
[文献書誌] Koyama K: "Psychiatric symptoms after hepatic resection"Psychosomatics. 44・1. 86-87 (2003)
[文献書誌] Seyama Y: "The pH modulator chloroquine blocks trypsinogen activation peptide generation in cerulein-induced pancreatitis"Pancreas. 26・1. 15-17 (2003)
[文献書誌] Cescon M: "Thrombectomy of portal vein thrombosis in living donor liver transplantation"Abdom Imaging. 28・1. 60-61 (2003)
[文献書誌] Kaneko J: "Successful conservative therapy for portal vein thrombosis after living donor liver transplantation"Abdom Imaging. 28・1. 58-59 (2003)

2003 年度 実績報告書

骨髄細胞移植による肝組織再構築に関する研究

研究代表者

高山 忠利 日本大学, 医学部, 教授 (30280944)

研究成果

[文献書誌] Takayama T: "Preoperative portal vein embolization : is it useful?"Journal of Hepatobiliary Pancreat Surg. 11・1. 17-20 (2004)

[文献書誌] Takayama T: "Adjuvant therapy for hepatocellular carcinoma : is there an effective modality?"Cancer Reviews : Asia-Pacific. 1・2. 237-244 (2003)

[文献書誌] Makuuchi M: "Both parietal lobes are involved in drawing : a functional MRI study and implications for constructional apraxia"Brain Res Cogn Brain Res. 16・3. 338-347 (2003)

[文献書誌] Makuuchi M: "Living-donor liver transplantation using the left liver, with special reference to vein reconstruction"Transplantation. 15・75. S23-S24 (2003)

[文献書誌] Makuuchi M: "The surgical approach to HCC : our progress and results in Japan"Liver Transpl. 10・2. S46-S52 (2004)

[文献書誌] Makuuchi M: "IHPBA concordant classification of primary liver cancer : working group report"J Hepatobiliary Pancreat Surg. 10・1. 26-30 (2003)

[文献書誌] Yamazaki S: "Sera from liver failure patients and a demethylating agent stimulate transdifferentiation of murine bone marrow cells into hepatocytes in coculture with nonparenchymal liver cells"J Hepatol. 39・1. 17-23 (2003)

[文献書誌] Naruse K: "Development of a new extracorporeal whole-liver perfusion system"J Artif Organs. 6・3. 211-217 (2003)

[文献書誌] Naruse K: "Xenogeneic direct hemoperfusion using whole swine liver for liver failure in dogs"J Surg Res. 111・2. 229-235 (2003)

[文献書誌] Torzilli G: "Contrast-enhanced intraoperative ultrasonography in surgery for hepatocellular carcinoma in cirrhosis"Liver Transpl. 10・2. S34-S38 (2004)

[文献書誌] Torzilli G: "Indication and contraindication for hepatic resection for liver tumors without fine-needle biopsy : validation and extension of an Eastern approach in a Western community hospital"Liver Transpl. 10・2. S30-S33 (2004)

[文献書誌] Inoue K: "Clinical significance of early hepatocellular carcinoma"Liver Transpl. 10・2. S16-S19 (2004)

[文献書誌] Torzilli G: "Differences and similarities in the approach to hepatocellular carcinoma between Eastern and Western institutions"Liver Transpl. 10・2. S1-S2 (2004)

[文献書誌] Takayasu K: "Neovasculature of benign thrombus of the inferior vena cava demonstrated by computed tomography during hepatic arteriography, mimicking a small hepatocellular carcinoma"Japanese Journal of Clinical Oncology. 33・1. 44-46 (2003)

[文献書誌] Kishi Y: "Hepatic arterial anatomy for right liver procurement from living donors"Liver Transpl. 10・1. 129-133 (2004)

[文献書誌] Hata S: "Volume regeneration after right liver donation"Liver Transpl. 10・1. 65-70 (2004)

[文献書誌] Ikai I: "Report of the 15th follow-up survey of primary liver cancer"Hepatol Res. 28・1. 21-29 (2004)

[文献書誌] Sakamot Y: "Bloodless liver resection using the monopolar floating ball plus ligasure diathermy : preliminary results of 16 liver resections"World J Surg. 28・2. 166-172 (2004)

[文献書誌] Kokudo N: "Clinical application of TcGSA"Nucl Med Biol. 30・8. 845-849 (2003)

[文献書誌] Sugawara Y: "Duct-to-duct biliary reconstruction for living donor liver transplantation : experience of 92 cases"Transplant Proc. 35・8. 2981-2982 (2003)

[文献書誌] Noritomi T: "Refractory acute refection in a living related liver transplantation"Hepato-gastroenterology. 50・54. 2192-2193 (2003)

[文献書誌] Torzilli G: "Ultrasound-guided finger compression in liver subsegmentectomy for hepatocellular carcinoma"Surg Endosc. 18・1. 136-139 (2004)

[文献書誌] Natori T: "Nicotine enhances neovascularization and promotes tumor growth"Mol Cells. 16・2. 143-146 (2003)

[文献書誌] Arita J: "Liver resection in patients with Gilbert's syndrome"Surgery. 134・5. 835-837 (2003)

[文献書誌] Imamura H: "One thousand fifty-six hepatectomies without mortality in 8 years"Arch Surg. 138・11. 1198-1206 (2003)

[文献書誌] Sugawara Y: "Living donor liver transplantation for hepatitis B cirrhosis"Liver Transpl. 9・11. 1181-1184 (2003)

[文献書誌] Minagawa M: "Surgical treatment of colorectal liver metastasis"Nippon Geka Gakkai Zasshi. 104・10. 721-729 (2003)

[文献書誌] Minagawa M: "Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma"Ann Surg. 238・5. 703-710 (2003)

[文献書誌] Ijichi H: ""Duodenal intussusception" due to adenoma of the papilla of Vater"Hepato-gastroenterology. 50・53. 1399-1402 (2003)

[文献書誌] Guo L: "Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation"Transpl Immunol. 12・1. 41-48 (2003)

[文献書誌] Sugawara Y: "Arterial anatomy unsuitable for a right liver donation"Liver Transpl. 9・10. 1116-1117 (2003)

[文献書誌] Sugawara Y: "Positive T lymphocytotoxic cross-match in living donor liver transplantation"Liver Transpl. 9・10. 1062-1066 (2003)

[文献書誌] Seyama Y: "Anatomical segmentectomy of the pancreas head : can this procedure be curtively applied for intraductal papillary mucinous tumors?"Pancreas. 27・3. 270-272 (2003)

[文献書誌] Sano K: "Overexpression of retinoic acid receptor alpha in hepatocellular carcinoma"Clin Cancer Res. 9・10. 3679-3683 (2003)

[文献書誌] Akamatsu N: "Effects of middle hepatic vein reconstruction on right liver graft regeneration"Transplantation. 76・5. 832-837 (2003)

[文献書誌] Kokudo N: "Sling suspension of the liver in donor operation : a gradual taperepositioning technique"Transplantation. 76・5. 803-807 (2003)

[文献書誌] Matsui Y: "Identification of gene expression profile in tolerizing murine cardiac allograft by costimulatory blockade"Physiol Genomics. 15・3. 199-208 (2003)

[文献書誌] Saiura A: "Little evidence for cell fusion between recipient and donor-derived cells"J Surg Res. 113・2. 222-227 (2003)

[文献書誌] Umeshika K: "Operative morbidity of living liver donors in Japan"Lancet. 362・9358. 687-690 (2003)

[文献書誌] Sakamoto Y: "Segmental resection of the third portion of the duodenum for a gastrointestinal stromal tumor : a case report"Jpn J Clin Oncol. 33・7. 364-366 (2003)

[文献書誌] Guo L: "AdCTLA-4Ig combined with donor splenocytes, bone marrow cells and anti-ICOS antibody treatment induce tolerance in a rat heart transplantation model"Transpl Int. 17・1. 15-21 (2003)

[文献書誌] Sugawara Y: "Living-donor liver transplantation in adults : Tokyo University experience"J Hepatobiliary Pancreat Surg. 10・1. 1-4 (2003)

[文献書誌] Yano Y: "Combined hepatocellular and cholangiocarcinoma : a clinicopathologic study of 26 resected cases"Jpn J Clin Oncol. 33・6. 283-287 (2003)

[文献書誌] Guo Q: "An in vitro evaluation of radiation effects of different fractionated regimens by absolute cell count beads"Oncol Rep. 10・5. 1405-1410 (2003)

[文献書誌] Hasegawa K: "Effect of apolipoprotein E polymorphism on bile lipid composition and the formation of cholesterol gallstone"Am J Gastroenterol. 98・7. 1605-1609 (2003)

[文献書誌] Yamashita H: "Smallest Todani's type II choledochal cyst"Dig Liver Dis. 35・7. 498-502 (2003)

[文献書誌] Sugawara Y: "Risk factors for acute rejection in living donor liver transplantation"Clin Transplant. 17・4. 347-352 (2003)

[文献書誌] Kokubo N: "Strategies for surgical treatment of gallbladder carcinoma based on information available before resection"Arch Surg. 138・7. 741-750 (2003)

[文献書誌] Aoki T: "EBAG9/RCAS1 expression in hepatocellular carcinoma : correlation with tumour dedifferentiation and proliferation"Eur J Cancer. 39・11. 1552-1561 (2003)

[文献書誌] Kobayashi T: "The role of preoperative phenylalanine breath test in hepatectomy"Hepato-gastroenterology. 50・52. 1124-1127 (2003)

[文献書誌] Seyama Y: "Long-term outcome of extended hemihepatectomy for hilar bile duct cancer with no mortality and high survival rate"Ann Surg. 8・1. 73-83 (2003)

[文献書誌] Maruyama T: "Anti-HBs antibodies produced after liver transplantation : from the donor or the recipient?"Hepatology. 38・1. 271-272 (2003)

[文献書誌] Kogure K: "Long-term survival after hepatectomy for large metastatic breast cancer : a case report"Hepato-gastroenterology. 50・51. 827-829 (2003)

[文献書誌] Aoki T: "Follicular cholangitis : another cause of benign biliary stricture"Hepato-gastroenterology. 50・51. 639-642 (2003)

[文献書誌] Seyama Y: "Intraoperative direct pancreatography using ultrasound-guided puncture for accessory duct sphincteroplasty in a patient with pancreas divisum"Pancreas. 27・1. 98-100 (2003)

[文献書誌] Sugawara Y: "Left liver grafts for patients with MELD score of less than 15"Transplant Proc. 35・4. 1433-1434 (2003)

[文献書誌] Guo L: "Prolongation of liver xenograft survival by adenovirus vector-mediated CTLA-4Ig gene transfer"Transpl Immunol. 11・2. 155-162 (2003)

[文献書誌] Katayama A: "Autopsy findings in patients after curative esophagectomy for esophageal carcinoma"J Am Coll Surg. 196・6. 866-873 (2003)

[文献書誌] Sakamoto Y: "Surgical resection of liver metastases of gastric cancer : an analysis of a 17-year experience with 22 patients"Surgery. 133・5. 507-511 (2003)

[文献書誌] Chiappa A: "Effects of the Free Radical Scavenger Dimethyl Sulphoxide on Experimental Normothermic Ischaemia of the Liver"Dig Surg. 20・3. 238-245 (2003)

[文献書誌] Hasegawa K: "Extended right hepatectomy and total gastrectomy with double Roux-en-Y reconstruction for hilar bile duct and gastric carcinomas"Hepato-gastroenterology. 50・50. 374-376 (2003)

[文献書誌] Torzilli G: "Intraoperative ultrasonography in liver cancer"Surg Oncol Clin N Am. 12・1. 91-103 (2003)

[文献書誌] Hasegawa K: "Endovascular stenting for celiac axis stenosis before pancreaticoduodenectomy"Surgery. 133・4. 440-442 (2003)

[文献書誌] Takikawa H: "An advanced strategy of enhanced specific gene expression for hepatocellular carcinoma"Int J Oncol. 22・5. 1051-1056 (2003)

[文献書誌] Tang W: "Des-gamma-carboxy prothrombin in cancer and non-cancer liver tissue of patients with hepatocellular carcinoma"Int J Oncol. 22・5. 969-975 (2003)

[文献書誌] Abe H: "CT findings of cystic duct carcinoma two years before obstructive jaundice"Hepato-gastroenterology. 50・49. 24-26 (2003)

[文献書誌] Torzilli G: "Tricks for ultrasound-guided resection of colorectal liver metastases"Hepato-gastroenterology. 50・49. 1-3 (2003)

[文献書誌] Sugawara Y: "Outflow reconstruction in extended right liver grafts from living donors"Liver Transpl. 9・3. 306-309 (2003)

[文献書誌] Fukunishi I: "Pain in liver donors"Psychosomatics. 44・2. 172-173 (2003)

[文献書誌] Tang W: "Association of histochemical expression of Maackia amurensis leukoagglutinin-positive glycoconjugates with behaviour of human gastric cancer"Histopathology. 42・3. 239-245 (2003)

[文献書誌] Sugawara Y: "MELD score for selection of patients to receive a left liver graft"Transplantation. 75・4. 573-574 (2003)

[文献書誌] Aoki T: "Bile duct of Luschka connecting with the cystohepatic duct : the importance of cholangiography during surgery"AJR Am J Roentgenol. 180・3. 694-696 (2003)

[文献書誌] Kitamura T: "Severe hemolytic anemia related to production of cold agglutinins following living donor liver transplantation : a case report"Transplant Proc. 35・1. 399-400 (2003)

[文献書誌] Fukunishi I: "Alexithymia characteristics before and after living donor transplantation"Transplant Proc. 35・1. 296 (2003)

[文献書誌] Fukunishi I: "Paradoxical psychiatric syndrome and DSM-IV psychiatric disorders in recipients after living donor transplantation"Transplant Proc. 35・1. 294 (2003)

2003 年度実績報告書

高山忠利日本大学, 医学部, 教授 (30280944)