2002 年度実績報告書

ダイナミック・バイオ統計学:モデル化、解析手法開発とその数理

研究課題

研究課題/領域番号	13308014
研究機関	九州大学
研究代表者	柳川堯九州大学, 大学院・数理学研究院, 教授 (80029488)
研究分担者	吉村功東京理科大学, 工学部, 教授 (30010797) 岸野洋久東京大学, 大学院・農学生命科学研究科, 教授 (00141987) 小西貞則九州大学, 大学院・数理学研究院, 教授 (40090550) 田栗正章千葉大学, 理学部, 教授 (10009607) 大瀧慈広島大学, 原爆放射線影響研究所, 教授 (20110463)
キーワード	観測カオス / 複合汚染リスク評価 / 動径基底関数ネットワーク / 放射線発ガン数理モデル / 薬物動態理論 / インビトロ毒性試験 / QTL解析 / 周辺構造モデル
研究概要	・観測データのカオス性を検証するため、リヤプノフ指数の推定法を開発し,推定量の漸近的一致性を証明した. ・乳児の甲状腺、及び免疫機能に与える,ダイオキシン類,5種類の農薬,及びPCBの,複合的リスクを評価する方法論を開発した。・インビトロ毒性試験において,マウスリンフォーマ試験と細胞形質転換試験におけるデータ解析法を開発した. ・高次元データの分析に有効に機能する動径基底関数ネットワークに基づく識別・判別手法を開発した. ・細胞の遺伝的不安定仮説に基づき,放射線発ガンの数理モデルを開発した.本モデルを使用することにより,発ガンの罹患率に比べて変異発生率が異常に低いことがしめされた. ・ダイオキシン類の血中濃度データに関して,薬物の体内蓄積濃度を体内への取り込み量と排出量で表した薬物動態理論を一般化した混合効果モデルを開発した. ・cDNAマイクロアレイを使った遺伝子発現データの数理モデルの開発を行い,それにもとづく有効なデータの補正方法を提案した(2件の特許出願手続き準備中). ・進化速度確率変動モデルを複数遺伝子モデルに拡張し,遺伝子間の共進化を検出する手法を提案した. ・純系親の作成の困難な他殖性生物の遺伝子マッピングのために,linkage phaseの不確実性を考慮したQTL解析手法とアルゴリズムの開発と実用化を行った. ・進化速度確率変動モデルを、アミノ酸置換を伴わない同義置換およびアミノ酸置換を伴う非同義置換の2変量モデルに拡張し,これらの間の相関構造を測る指標を開発した. ・周辺構造モデルで用いる重みを修正することで,いわゆるSMRをノンパラメトリックに推定できることをしめした.さらに,より一般的な周辺構造モデルと標準化との関係を明らかにした.

研究成果

(39件)

すべてその他

すべて文献書誌 (39件)

[文献書誌] Astuti Tri Erni: "Testing Trend for Count Data with Extra-Poisson Variability"Biometrics. 58. 398-402 (2002)
[文献書誌] Fujii, T.: "Wavelet with a simple thresholding function and its application to EEG time series data"Proceedings of the Chaos and non-linear time series and Related Topics: the Fourth Hakata Symposium. 122-125 (2002)
[文献書誌] Yanagawa, T.: "Testing trend for proportion and count data with extra-valiability"Proceedings of the International Biometric Conference. 60 (2002)
[文献書誌] Koji Yonemoto: "Estimating the Lyapunov exponent from non-linear time series with dynamic noise"Proceedings of the 4th Conference of the IASC, Dec 5-7, 2002, Busan, Korea. 270-273 (2002)
[文献書誌] Yanagawa, T.: "Assessing the joint effects of chlorinated dioxin, some pesticides and polychlorinated byphenyles on thyroid hormone status in Japanese breast fed infants"Environmetrics. (印刷中). (2003)
[文献書誌] Takashi Omori: "A new statistical method for evalution of L5178Yth+/-mammalian cell mutation data using microwell method"Mutation research. 517. 199-208 (2002)
[文献書誌] 寒水孝司: "「臨床試験のための統計的原則」における交互作用の扱い方についての考察"応用統計学. 30. 1-18 (2002)
[文献書誌] Iwao Sonoda: "A prevalidation study for three-dimensional cultured human skin I models as alternatives to skin irritation testing"Alternatives to Animal Testing and Experimentation. 8,Supple 546. 16-26 (2002)
[文献書誌] Hiroshi Nishiyama: "GA composite statistical procedure for evaluating genotoxicity using cell transformation assay data"Environmetrics. (印刷中). (2003)
[文献書誌] Ichikawa, M.: "Asymptotic expansions and bootstrap approximations in factor analysis"Journal of Multivariate Analysis. 81. 47-66 (2002)
[文献書誌] Konishi, S.: "Theory for statistical modeling and information criteria -Functional approach"Sugaku Expositions, American Mathematical Society. 15-1. 89-106 (2002)
[文献書誌] Konishi, S.: "Asymptotic Theory for Information Criteria in Model Selection -Functional Approach"Journal of Statistical Planning and Inference. (印刷中).
[文献書誌] 佐藤健一: "統計グラフライプラリの開発とWebへの応用"統計数理. 49-2(印刷中). (2003)
[文献書誌] Fujikoshi, Y.: "Corrected versions of cross-validation criteria for selecting multivariate regression and growth curve models"Annals of Institute of Statistical Mathematic. (印刷中).
[文献書誌] Otani, K.: "A random effects nonlinear regression model for analysis of environmental contamination data"Environmetrics. (印刷中). (2003)
[文献書誌] Yamaguchi, T.: "Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator"Gene Therapy. (印刷中).
[文献書誌] Yanagihara, H.: "Knots-placement to avoid over fitting in B-spline scedastic smoothing"Communication in Statistics. (印刷中).
[文献書誌] Nakashima, E.: "Estimating the stenosis probabilities in arteriosclerosis obliterans using generalized estimating equations"Statistics in Medicine. (印刷中).
[文献書誌] Shiraishi, K.: "Persistent induction of spmatic reversions of the pink-eyed unstable mutation in F1 mice born to fathers irradiated at the spermatozoa stage"Radiation Research. (印刷中).
[文献書誌] K.Satoh: "Bridging the gap between B-spline and polynomial regression model"Communications in Statistics--Simulation and Computation. (印刷中).
[文献書誌] Seo, T.-K.: "A viral sampling design for testing the molecular clock and for estimating evolutionary rates and divergence times"Bioinformatics. 18. 115-123 (2002)
[文献書誌] Seo, T.-K.: "Estimation of Effective Population Size of HIV-1 within a Host: A Pseudo-maximum likelihood approach"Genetics. (印刷中).
[文献書誌] Thorne, J.L.: "Divergence time and evolutionary rate estimation with multilocus data"Systematic Biology. 51. 689-702 (2002)
[文献書誌] Waddell, P.J.: "Very fast algorithms for evaluating the stability of ML and Bayesian phylogenetic trees"Genome Informatics Series. 13. 82-92 (2002)
[文献書誌] Wiegmann, B.M.: "A revised time-scale for fly evolution: Divergence time estimates without a molecular clock"Systematic Biology. (印刷中).
[文献書誌] Sato T.: "Sample sizes for survival analysis based on the conditional score test for person-time observations"Japanese Journal of Biometrics. 23. 27-35 (2002)
[文献書誌] 佐藤俊哉: "20世紀の臨床試験で統計家はなにをしてきたか21世紀の臨床試験で生物統計家はなにをすべきか"臨床研究・生物統計研究会誌. 22. 61-70 (2002)
[文献書誌] 吉田あつし: "平均分散モデルにおける最適ポートフォリオのリスク推定"ジャフィー・ジャーナル. (印刷中).
[文献書誌] Yoshimichi Ochi: "Adjusting over-dispersion in categorical data analysis with computer intensive methods"Proceedings-Abstracts of the XXIst International Biometric Conference : Special and contributed paper presentations. 90-91 (2002)
[文献書誌] 黒石健太郎: "異機種環境下における分散計算処理と統計計算"大分大学工学部研究報告. 47(印刷中).
[文献書誌] Yoshimichi Ochi: "The Performance of Computer Intensive Methods for Over-dispersed Categorical Data"Journal of the Japanese Society of Computational Statistics. 15-2(印刷中).
[文献書誌] Yoshinori Fujii: "Mantel-Haenszel type estimators for the counter-matched sampling design in nested case-control study"Bulletin of Informatics and Cybernetics. 33. 43-52 (2002)
[文献書誌] Yamaguchi T.: "Proportional Hazards Models with Random Effects to Examine Centre Effects in Multicentre Cancer Clinical Trials"Statistical Methods in Medical Research. 11. 221-236 (2002)
[文献書誌] Ohashi Y.: "Habitual Intake of Lactic Acid Bacteria and Risk Reduction of Bladder Cancer."Urologia Internationalis. 68. 273-280 (2002)
[文献書誌] Sarkar S.: "Bridging Date Between Two Ethnic Populations. A New Application of Matched Case-control Methodology"Drug Information Journal. 36. 349-356 (2002)
[文献書誌] 柳川堯: "環境と健康:リスク評価のデータサイエンス"共立出版. 201 (2002)
[文献書誌] 柳井晴夫他: "多変量解析実例ハンドブック"朝倉書店. 889 (2002)
[文献書誌] 甘利俊一他: "多変量解析の展開隠れた構造と因果を推理する"岩波書店. 223 (2002)
[文献書誌] 田栗正章他: "統計科学のフロンティア:新しい計算手法と統計学"岩波書店(印刷中).

2002 年度 実績報告書

ダイナミック・バイオ統計学:モデル化、解析手法開発とその数理

研究代表者

柳川 堯 九州大学, 大学院・数理学研究院, 教授 (80029488)

研究成果

[文献書誌] Astuti Tri Erni: "Testing Trend for Count Data with Extra-Poisson Variability"Biometrics. 58. 398-402 (2002)

[文献書誌] Fujii, T.: "Wavelet with a simple thresholding function and its application to EEG time series data"Proceedings of the Chaos and non-linear time series and Related Topics: the Fourth Hakata Symposium. 122-125 (2002)

[文献書誌] Yanagawa, T.: "Testing trend for proportion and count data with extra-valiability"Proceedings of the International Biometric Conference. 60 (2002)

[文献書誌] Koji Yonemoto: "Estimating the Lyapunov exponent from non-linear time series with dynamic noise"Proceedings of the 4th Conference of the IASC, Dec 5-7, 2002, Busan, Korea. 270-273 (2002)

[文献書誌] Yanagawa, T.: "Assessing the joint effects of chlorinated dioxin, some pesticides and polychlorinated byphenyles on thyroid hormone status in Japanese breast fed infants"Environmetrics. (印刷中). (2003)

[文献書誌] Takashi Omori: "A new statistical method for evalution of L5178Yth+/-mammalian cell mutation data using microwell method"Mutation research. 517. 199-208 (2002)

[文献書誌] 寒水孝司: "「臨床試験のための統計的原則」における交互作用の扱い方についての考察"応用統計学. 30. 1-18 (2002)

[文献書誌] Iwao Sonoda: "A prevalidation study for three-dimensional cultured human skin I models as alternatives to skin irritation testing"Alternatives to Animal Testing and Experimentation. 8,Supple 546. 16-26 (2002)

[文献書誌] Hiroshi Nishiyama: "GA composite statistical procedure for evaluating genotoxicity using cell transformation assay data"Environmetrics. (印刷中). (2003)

[文献書誌] Ichikawa, M.: "Asymptotic expansions and bootstrap approximations in factor analysis"Journal of Multivariate Analysis. 81. 47-66 (2002)

[文献書誌] Konishi, S.: "Theory for statistical modeling and information criteria -Functional approach"Sugaku Expositions, American Mathematical Society. 15-1. 89-106 (2002)

[文献書誌] Konishi, S.: "Asymptotic Theory for Information Criteria in Model Selection -Functional Approach"Journal of Statistical Planning and Inference. (印刷中).

[文献書誌] 佐藤健一: "統計グラフライプラリの開発とWebへの応用"統計数理. 49-2(印刷中). (2003)

[文献書誌] Fujikoshi, Y.: "Corrected versions of cross-validation criteria for selecting multivariate regression and growth curve models"Annals of Institute of Statistical Mathematic. (印刷中).

[文献書誌] Otani, K.: "A random effects nonlinear regression model for analysis of environmental contamination data"Environmetrics. (印刷中). (2003)

[文献書誌] Yamaguchi, T.: "Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator"Gene Therapy. (印刷中).

[文献書誌] Yanagihara, H.: "Knots-placement to avoid over fitting in B-spline scedastic smoothing"Communication in Statistics. (印刷中).

[文献書誌] Nakashima, E.: "Estimating the stenosis probabilities in arteriosclerosis obliterans using generalized estimating equations"Statistics in Medicine. (印刷中).

[文献書誌] Shiraishi, K.: "Persistent induction of spmatic reversions of the pink-eyed unstable mutation in F1 mice born to fathers irradiated at the spermatozoa stage"Radiation Research. (印刷中).

[文献書誌] K.Satoh: "Bridging the gap between B-spline and polynomial regression model"Communications in Statistics--Simulation and Computation. (印刷中).

[文献書誌] Seo, T.-K.: "A viral sampling design for testing the molecular clock and for estimating evolutionary rates and divergence times"Bioinformatics. 18. 115-123 (2002)

[文献書誌] Seo, T.-K.: "Estimation of Effective Population Size of HIV-1 within a Host: A Pseudo-maximum likelihood approach"Genetics. (印刷中).

[文献書誌] Thorne, J.L.: "Divergence time and evolutionary rate estimation with multilocus data"Systematic Biology. 51. 689-702 (2002)

[文献書誌] Waddell, P.J.: "Very fast algorithms for evaluating the stability of ML and Bayesian phylogenetic trees"Genome Informatics Series. 13. 82-92 (2002)

[文献書誌] Wiegmann, B.M.: "A revised time-scale for fly evolution: Divergence time estimates without a molecular clock"Systematic Biology. (印刷中).

[文献書誌] Sato T.: "Sample sizes for survival analysis based on the conditional score test for person-time observations"Japanese Journal of Biometrics. 23. 27-35 (2002)

[文献書誌] 佐藤俊哉: "20世紀の臨床試験で統計家はなにをしてきたか21世紀の臨床試験で生物統計家はなにをすべきか"臨床研究・生物統計研究会誌. 22. 61-70 (2002)

[文献書誌] 吉田あつし: "平均分散モデルにおける最適ポートフォリオのリスク推定"ジャフィー・ジャーナル. (印刷中).

[文献書誌] Yoshimichi Ochi: "Adjusting over-dispersion in categorical data analysis with computer intensive methods"Proceedings-Abstracts of the XXIst International Biometric Conference : Special and contributed paper presentations. 90-91 (2002)

[文献書誌] 黒石健太郎: "異機種環境下における分散計算処理と統計計算"大分大学工学部研究報告. 47(印刷中).

[文献書誌] Yoshimichi Ochi: "The Performance of Computer Intensive Methods for Over-dispersed Categorical Data"Journal of the Japanese Society of Computational Statistics. 15-2(印刷中).

[文献書誌] Yoshinori Fujii: "Mantel-Haenszel type estimators for the counter-matched sampling design in nested case-control study"Bulletin of Informatics and Cybernetics. 33. 43-52 (2002)

[文献書誌] Yamaguchi T.: "Proportional Hazards Models with Random Effects to Examine Centre Effects in Multicentre Cancer Clinical Trials"Statistical Methods in Medical Research. 11. 221-236 (2002)

[文献書誌] Ohashi Y.: "Habitual Intake of Lactic Acid Bacteria and Risk Reduction of Bladder Cancer."Urologia Internationalis. 68. 273-280 (2002)

[文献書誌] Sarkar S.: "Bridging Date Between Two Ethnic Populations. A New Application of Matched Case-control Methodology"Drug Information Journal. 36. 349-356 (2002)

[文献書誌] 柳川 堯: "環境と健康:リスク評価のデータサイエンス"共立出版. 201 (2002)

[文献書誌] 柳井晴夫 他: "多変量解析実例ハンドブック"朝倉書店. 889 (2002)

[文献書誌] 甘利俊一 他: "多変量解析の展開 隠れた構造と因果を推理する"岩波書店. 223 (2002)

[文献書誌] 田栗正章 他: "統計科学のフロンティア:新しい計算手法と統計学"岩波書店(印刷中).

2002 年度実績報告書

柳川堯九州大学, 大学院・数理学研究院, 教授 (80029488)

[文献書誌] 柳川堯: "環境と健康:リスク評価のデータサイエンス"共立出版. 201 (2002)

[文献書誌] 柳井晴夫他: "多変量解析実例ハンドブック"朝倉書店. 889 (2002)

[文献書誌] 甘利俊一他: "多変量解析の展開隠れた構造と因果を推理する"岩波書店. 223 (2002)

[文献書誌] 田栗正章他: "統計科学のフロンティア:新しい計算手法と統計学"岩波書店(印刷中).