2002 年度実績報告書

生活習慣病とフィトケミカル(植物微量成分)に関する国際共同研究

研究課題

研究課題/領域番号	13376001
研究機関	東亜大学
研究代表者	奈良安雄東亜大学, 総合学術研究科, 教授 (80116417)
研究分担者	細田公則京都大学, 大学院・人間・環境学研究科, 助手 (40271598) 池田克巳 (財)生産開発科学研究所, 予防栄養医学研究室, 研究員 (80273499) 家森幸男金城学院大学, 生活環境学部, 教授 (80025600) 山形一雄東亜大学, 総合学術研究科, 助教授 (10299323) 堀内孝東亜大学, 総合学術研究科, 教授 (10201758)
キーワード	セサミン / 脳卒中易発症ラット / 疫学調査 / アボリジニ / 食塩
研究概要	ゴマに含まれるセサミンには脳卒中易発症ラット(SHRSP)の血圧上昇を抑制し、脳内の内皮由来一酸化窒素合成酵素の発現を誘導することを既に明らかにした。今回はセサミンがSHRSPの脳卒中発症を抑制するか否かについて検討したところ、0.5%食塩負荷時で明らかな延命効果が認められた。オーストラリアに移民したイタリア人は食習慣の変化に伴って、生活習慣病が増加しているといわれている。今回パイロット研究として、50歳以上のイタリア移民男女26名の血圧測定と問診を行った。収縮期血圧の平均は149+/-3(平均+/-標準誤差)、拡張期血圧の平均は74+/-2であった。先住民族であるアボリジニは長期にわたって乾燥地帯に住んでいたため節約遺伝子を獲得しており、少しの栄養成分を有効に利用することが出来る。現在、この様な人々の食習慣が急激に欧米化するにともなって、生活習慣病が多発している。今回来年度行う予定のフィトケミカルを用いた生活習慣病予防に関する介入試験に向けてのパイロット研究を行った。その結果、35-55歳の男女(男性9、女性15名)の半数が高血圧や糖尿病の治療を受けているかまたは境界域高血圧者であった。さらに、56歳以上では全ての人が何らかの生活習慣病の治療を受けていた。一方、24時間尿を採取した結果、成功者は16名中12名であった。24時間尿中の食塩量は男性(5名)で10.2g+/-0、女性(7名)で8.0g+/-1.3であり、Na/K比はそれぞれ2.2+/-0.3、2.2+/-0.4であった。日本人の1日の平均食塩摂取量が13g前後であることからから考えると彼らの食塩摂取量はそれほど多くないと考えられる。今回の結果から、アボリジニでは生活習慣病の発症が加速しているので、介入試験は若年層を対象にする必要のあることが明らかになった。また、白人とアボリジニとの間に軋櫟があり、介入試験に対する倫理面での許可をどこに求めるかが問題であったが今回の訪問でアボリジニの倫理委員会から疫学調査と介入試験の許可が下りた。

研究成果
(21件)

すべてその他

すべて文献書誌 (21件)

[文献書誌] Mizutan K, Sugimoto K, Okuda T, Katsuya T, Miyata T, Tanabe T, Higaki J, Ogihara T, Yamori Y, Tsujita Y, Tago N, Iwai N: "Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats"Hypertens Res. Jan;25 (1). 135-140 (2002)
[文献書誌] Yamada T, Kadekaru H, Matsumoto S, Inada H, Tanabe M, Moriguchi EH, Moriguchi Y, Ishikawa P, Ishikawa AG, Taira K, Yamori Y: "Related Articles, Books, LinkOut Prevalence of dementia in the older Japanese-Brazilian population"Psychiatry Clin Neurisci. Feb;56(1). 71-75 (2002)
[文献書誌] Njelekela MA, Negishi H, Nara Y, Sato T, Tomohiro M, Kuga S, Noguchi T, Kanda T, Yamori M, Mashalla Y, Liu LJ, Ikeda K, Mtabaji J, Yamori Y: "Obesity and lipid profiles in middle aged men and women in Tanzania. East Afr Med J"East Afr Med J. Feb;79(2). 58-64 (2002)
[文献書誌] Liu L, Ikeda K, Yamori Y: "Inverse relationship between urinary markers of animal protein intake and blood pressure in Chinese results from the WHO Cardiovascular Diseases and Alimentary Comparison(CARDIAC) Study"Int J Epidemiol. Feb;3(1). 227-233 (2002)
[文献書誌] Uesugi T, Fukui Y, Yamori Y: "Beneficial effects of soybean soflavone supplementation on bone metabolism and serum lipids in postmenopausal japanese women : a four-week study"J Am Coll Nutr. Apr;2l(2). 97-102 (2002)
[文献書誌] Michihara A, Sawamura M, Yamori Y, Akasaki K, Tsuji H: "Comparison of subcellular distribution of mevalonate pyrophosphate decarboxylase between stroke-prone spontaneously hypertensive rat and Wistar Kyoto rat"Biol Pharm Bull. Jun;25(6). 734-737 (2002)
[文献書誌] Yamori Y, Liu L, Mu L, Zhao H, Pen Y, Hu Z, Kuga S, Negishi H, Ikeda K: "Diet related factors, educational levels and blood pressure in a Chinese population sample : findings from the Japan-China Cooperative Research Project"Hypertens Res. Jul;25(4). 559-564 (2002)
[文献書誌] Mizutani K, Ikeda K, Tsuda K, Yamori Y: "Inhibitor for advanced glycation end products formation attenuates hypertension and oxidative damage in genetic hypertensive rats"J Hypertens. Aug;20(8). 1607-1614 (2002)
[文献書誌] Kato N, Ikeda K, Nabika T, Morita H, Sugiyama T, Gotoda T, Kurihara H, Kobayashi S, Yazaki Y, Yamori Y: "Evaluation of the atrial natriuretic peptide gene in storke"Atherosclerosis. Aug;163(2). 279-286 (2002)
[文献書誌] Liu L, Ikeda K, Sullivan DH, Ling W, Yamori Y: "Epidemiological evidence of the association between dietary protein intake and blood pressure a meta-analysis of published data"Hypertens Res. Sep;25(5). 689-695 (2002)
[文献書誌] Kuga S, Njelekela M, Noguchi T, Kanda T, Yamori M, Sato T, Miki T, Ikeda K, Nara Y, Mtabaji J: "Prevalence of overweight and hypertension in Tanzania Special emphasis on resting energy expenditure and leptin"Clin Exp Pharmacol Physiol. Oct;29uppl4. S23-S26 (2002)
[文献書誌] Sasaki Y, Noguchi T, Yamamoto E, Giddings JC, Ikeda K, Yamori Y, Yamamoto J: "Effects of Ginkgo biloba extract (EGb 761) on cerebral thrombosis and blood pressure in stroke-prone spontaneously hypertensive rats"Chin Exp Pharmacol Physiol. Nov;29(11). 963-967 (2002)
[文献書誌] Kuga S, Njelekela M, Noguchi T, Kanda T, Yamori M, Sato T, Miki T, Ikeda K, Nara Y, Mtabaji J: "Prevalence of overweight and hypertension in emphasis on resting eliergy expenditure and leptin"Clin Exp Pharmacol Physiol Suppl. Oct;(29). S23-6 (2002)
[文献書誌] Kato N, Kanda T, Sagara M, Bos A, Moriguchi EH, Moriguchi Y, Yamori Y: "Proposition of a feasible protocol to evaluate salt sensitivity in a population-based setting"Hypertens Res. Nov;25(6). 801-809 (2002)
[文献書誌] Yamori Y, Moriguchi EH, Teramoto T, Miura A, Fukui Y, Honda KI, Fukui M, Nara Y, Taira K, Moriguchi Y: "Soybean isoflavones reduce postimenopausal bone resorption in female Japanese immigrants in Brazil: a ten-week study"J Am Coll Nutr. Dec 2l(6). 560-563 (2002)
[文献書誌] Ikeda K, Kitamura A, Machida H, Watanabe M, Negishi H, Hiraoka J, Nakano T: "Effect of Undaria pinnatifida (Wakame)on the development of cerebrovascular diseases in stroke-prone spontaneously hypertensive rats"Chin Exp Pharmacol Physiol. Jan-Feb;3O(1-2). 44-48 (2003)
[文献書誌] Negishi H, Ikeda K, Nara Y, Yamori Y: "Estimation of hydroxyl radicals based on the salicylate trapping method in hippocampus of stroke-prone spontaneously hypertensve rats (SHRSP) during transient ischemia and recircuilation"Adv Exp Med Biol. 510. 313-317 (2003)
[文献書誌] Yamagata K, Tagami M, Takenaga F, Yamori Y, Nara Y, Itoh S: "Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells"Neuroscience. Feb;116(3). 649-656 (2003)
[文献書誌] Kato N, Mashimo T, Nabika T, Cui ZH, Ikeda K, Yamori Y: "Genorne-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony"J Hypertens. Feb;2l(2). 295-303 (2003)
[文献書誌] Michihara A, Sawamura M, Yamori Y, Akasaki K, Tsuji H: "Peroxisome Proliferative Drugs Do not Induce and Increase of Rat Mevabonate Pyrophosphate Decarboxylase"Biol Pharm Bull. Jan26;(1). 93-5 (2003)
[文献書誌] Yamagata K, Tagami M, Torii Y, Takenaga F, Tsumagari S, Itoh S, Yamori Y, Nara Y: "Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes"Glia. Jan15;41 (2). 199-206 (2003)

2002 年度 実績報告書

生活習慣病とフィトケミカル(植物微量成分)に関する国際共同研究

研究代表者

奈良 安雄 東亜大学, 総合学術研究科, 教授 (80116417)

研究成果

[文献書誌] Mizutan K, Sugimoto K, Okuda T, Katsuya T, Miyata T, Tanabe T, Higaki J, Ogihara T, Yamori Y, Tsujita Y, Tago N, Iwai N: "Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats"Hypertens Res. Jan;25 (1). 135-140 (2002)

[文献書誌] Yamada T, Kadekaru H, Matsumoto S, Inada H, Tanabe M, Moriguchi EH, Moriguchi Y, Ishikawa P, Ishikawa AG, Taira K, Yamori Y: "Related Articles, Books, LinkOut Prevalence of dementia in the older Japanese-Brazilian population"Psychiatry Clin Neurisci. Feb;56(1). 71-75 (2002)

[文献書誌] Njelekela MA, Negishi H, Nara Y, Sato T, Tomohiro M, Kuga S, Noguchi T, Kanda T, Yamori M, Mashalla Y, Liu LJ, Ikeda K, Mtabaji J, Yamori Y: "Obesity and lipid profiles in middle aged men and women in Tanzania. East Afr Med J"East Afr Med J. Feb;79(2). 58-64 (2002)

[文献書誌] Liu L, Ikeda K, Yamori Y: "Inverse relationship between urinary markers of animal protein intake and blood pressure in Chinese results from the WHO Cardiovascular Diseases and Alimentary Comparison(CARDIAC) Study"Int J Epidemiol. Feb;3(1). 227-233 (2002)

[文献書誌] Uesugi T, Fukui Y, Yamori Y: "Beneficial effects of soybean soflavone supplementation on bone metabolism and serum lipids in postmenopausal japanese women : a four-week study"J Am Coll Nutr. Apr;2l(2). 97-102 (2002)

[文献書誌] Michihara A, Sawamura M, Yamori Y, Akasaki K, Tsuji H: "Comparison of subcellular distribution of mevalonate pyrophosphate decarboxylase between stroke-prone spontaneously hypertensive rat and Wistar Kyoto rat"Biol Pharm Bull. Jun;25(6). 734-737 (2002)

[文献書誌] Yamori Y, Liu L, Mu L, Zhao H, Pen Y, Hu Z, Kuga S, Negishi H, Ikeda K: "Diet related factors, educational levels and blood pressure in a Chinese population sample : findings from the Japan-China Cooperative Research Project"Hypertens Res. Jul;25(4). 559-564 (2002)

[文献書誌] Mizutani K, Ikeda K, Tsuda K, Yamori Y: "Inhibitor for advanced glycation end products formation attenuates hypertension and oxidative damage in genetic hypertensive rats"J Hypertens. Aug;20(8). 1607-1614 (2002)

[文献書誌] Kato N, Ikeda K, Nabika T, Morita H, Sugiyama T, Gotoda T, Kurihara H, Kobayashi S, Yazaki Y, Yamori Y: "Evaluation of the atrial natriuretic peptide gene in storke"Atherosclerosis. Aug;163(2). 279-286 (2002)

[文献書誌] Liu L, Ikeda K, Sullivan DH, Ling W, Yamori Y: "Epidemiological evidence of the association between dietary protein intake and blood pressure a meta-analysis of published data"Hypertens Res. Sep;25(5). 689-695 (2002)

[文献書誌] Kuga S, Njelekela M, Noguchi T, Kanda T, Yamori M, Sato T, Miki T, Ikeda K, Nara Y, Mtabaji J: "Prevalence of overweight and hypertension in Tanzania Special emphasis on resting energy expenditure and leptin"Clin Exp Pharmacol Physiol. Oct;29uppl4. S23-S26 (2002)

[文献書誌] Sasaki Y, Noguchi T, Yamamoto E, Giddings JC, Ikeda K, Yamori Y, Yamamoto J: "Effects of Ginkgo biloba extract (EGb 761) on cerebral thrombosis and blood pressure in stroke-prone spontaneously hypertensive rats"Chin Exp Pharmacol Physiol. Nov;29(11). 963-967 (2002)

[文献書誌] Kuga S, Njelekela M, Noguchi T, Kanda T, Yamori M, Sato T, Miki T, Ikeda K, Nara Y, Mtabaji J: "Prevalence of overweight and hypertension in emphasis on resting eliergy expenditure and leptin"Clin Exp Pharmacol Physiol Suppl. Oct;(29). S23-6 (2002)

[文献書誌] Kato N, Kanda T, Sagara M, Bos A, Moriguchi EH, Moriguchi Y, Yamori Y: "Proposition of a feasible protocol to evaluate salt sensitivity in a population-based setting"Hypertens Res. Nov;25(6). 801-809 (2002)

[文献書誌] Yamori Y, Moriguchi EH, Teramoto T, Miura A, Fukui Y, Honda KI, Fukui M, Nara Y, Taira K, Moriguchi Y: "Soybean isoflavones reduce postimenopausal bone resorption in female Japanese immigrants in Brazil: a ten-week study"J Am Coll Nutr. Dec 2l(6). 560-563 (2002)

[文献書誌] Ikeda K, Kitamura A, Machida H, Watanabe M, Negishi H, Hiraoka J, Nakano T: "Effect of Undaria pinnatifida (Wakame)on the development of cerebrovascular diseases in stroke-prone spontaneously hypertensive rats"Chin Exp Pharmacol Physiol. Jan-Feb;3O(1-2). 44-48 (2003)

[文献書誌] Negishi H, Ikeda K, Nara Y, Yamori Y: "Estimation of hydroxyl radicals based on the salicylate trapping method in hippocampus of stroke-prone spontaneously hypertensve rats (SHRSP) during transient ischemia and recircuilation"Adv Exp Med Biol. 510. 313-317 (2003)

[文献書誌] Yamagata K, Tagami M, Takenaga F, Yamori Y, Nara Y, Itoh S: "Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells"Neuroscience. Feb;116(3). 649-656 (2003)

[文献書誌] Kato N, Mashimo T, Nabika T, Cui ZH, Ikeda K, Yamori Y: "Genorne-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony"J Hypertens. Feb;2l(2). 295-303 (2003)

[文献書誌] Michihara A, Sawamura M, Yamori Y, Akasaki K, Tsuji H: "Peroxisome Proliferative Drugs Do not Induce and Increase of Rat Mevabonate Pyrophosphate Decarboxylase"Biol Pharm Bull. Jan26;(1). 93-5 (2003)

[文献書誌] Yamagata K, Tagami M, Torii Y, Takenaga F, Tsumagari S, Itoh S, Yamori Y, Nara Y: "Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes"Glia. Jan15;41 (2). 199-206 (2003)

2002 年度実績報告書

奈良安雄東亜大学, 総合学術研究科, 教授 (80116417)