2001 年度実績報告書

心不全モデル動物における薬物治療と脂肪酸代謝

研究課題

研究課題/領域番号	13670750
研究機関	新潟薬科大学
研究代表者	渡辺賢一新潟薬科大学, 薬学部・臨床薬理学, 教授 (70175090)
研究分担者	馬梅蕾新潟薬科大学, 薬学部・臨床薬理学, 助手 (20333536)
キーワード	心不全 / アンジオテンシン変換酵素阻害薬 / ベータ遮断薬 / 心筋炎 / 免疫異常 / 遺伝子導入 / 拡張型心筋症 / CD36欠損症
研究概要	ミオシン注射による自己免疫性心筋炎のモデルラットにインターロイキン10(IL-10)を遺伝子導入し、死亡率と心筋炎の改善がみられた(Circulation.2001;104:1098-1100.に報告)。この心筋炎後の拡張型心筋症様モデルラットにアンジオテンシン変換酵素阻害薬のキナプリルを投与後、心機能の改善・線維化の抑制・各種遺伝子発現の変化が見られた(J Cardiobascul Pharmacol.2001;38:S51-S54.)。一方、ベータ遮断薬のビソプロロールの投与では、心機能改善が見られなかったが生存率が上がり抗不整脈作用によるものと思われた。(J Cardiobascul Pharmacol.2001;38:S55-S58.)。ヒトCD36欠損症では心筋脂肪酸代謝のイメージング剤であるBMIPPが心筋に集積せず、遺伝子異常が見られた(Exp Hematology.29;2001:1194-4200.,J Med Geneticus.2002.in press)。

研究成果

(10件)

すべてその他

すべて文献書誌 (10件)

[文献書誌] Watanabe K et al.: "Effects of carvedilol on cardiac function and cardiac adrenergic neuronal damage in rats with dilated cardiomyopathy"J Nucl Med. (in press). (2002)
[文献書誌] Wen Juan, Watanabe K et al.: "Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myocarditis"Mol Cell Biochem.. (in press). (2002)
[文献書誌] Hanawa H, Watanabe K et al.: "Identification of cryptic splice site, exon skipping and novel point mutations in type I CD36 deficiency"J Med Genetics. (in press). (2002)
[文献書誌] Kato K, Watanabe K et al.: "Effects of pimobendan on adverse cardiac events and physical activities in patients with mild to moderate chronic heart failure"Circ J.. 66. 149-157 (2002)
[文献書誌] Watanabe K et al.: "Protection against autoimmune myocarditis by gene transfer of interleukin-10 by electroporation"Circulation. 104. 1098-1100 (2001)
[文献書誌] Watanabe K et al.: "Bisoprolol improves survival in rats with heart failure"J Cardiovascul Pharmacol. 38. S55-S58 (2001)
[文献書誌] Fuse K, Watanabe K et al.: "Enhanced expression and production of monocyte chemoattractant protein-1 in myocarditis"Clin Exp Immunol.. 124. 346-352 (2001)
[文献書誌] Ma M, Watanabe K et al.: "Inhibition of progression of heart failure and expression of TGF-β1 mRNA in rats with heart failure by the ACE inhibitor quinapril"J Cardiovascul Pharmacol. 38. S51-S54 (2001)
[文献書誌] Toba K, Watanabe K et al.: "Erythroid involvement in CD36 deficiency"Exp Hematology. 29. 1194-1200 (2001)
[文献書誌] Kodama M, Watanabe K et al.: "Mechanical alternans in patients with chronic heart failure"J Cardiac Failure. 7. 138-145 (2001)

2001 年度 実績報告書

心不全モデル動物における薬物治療と脂肪酸代謝

研究代表者

渡辺 賢一 新潟薬科大学, 薬学部・臨床薬理学, 教授 (70175090)

研究成果

[文献書誌] Watanabe K et al.: "Effects of carvedilol on cardiac function and cardiac adrenergic neuronal damage in rats with dilated cardiomyopathy"J Nucl Med. (in press). (2002)

[文献書誌] Wen Juan, Watanabe K et al.: "Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myocarditis"Mol Cell Biochem.. (in press). (2002)

[文献書誌] Hanawa H, Watanabe K et al.: "Identification of cryptic splice site, exon skipping and novel point mutations in type I CD36 deficiency"J Med Genetics. (in press). (2002)

[文献書誌] Kato K, Watanabe K et al.: "Effects of pimobendan on adverse cardiac events and physical activities in patients with mild to moderate chronic heart failure"Circ J.. 66. 149-157 (2002)

[文献書誌] Watanabe K et al.: "Protection against autoimmune myocarditis by gene transfer of interleukin-10 by electroporation"Circulation. 104. 1098-1100 (2001)

[文献書誌] Watanabe K et al.: "Bisoprolol improves survival in rats with heart failure"J Cardiovascul Pharmacol. 38. S55-S58 (2001)

[文献書誌] Fuse K, Watanabe K et al.: "Enhanced expression and production of monocyte chemoattractant protein-1 in myocarditis"Clin Exp Immunol.. 124. 346-352 (2001)

[文献書誌] Ma M, Watanabe K et al.: "Inhibition of progression of heart failure and expression of TGF-β1 mRNA in rats with heart failure by the ACE inhibitor quinapril"J Cardiovascul Pharmacol. 38. S51-S54 (2001)

[文献書誌] Toba K, Watanabe K et al.: "Erythroid involvement in CD36 deficiency"Exp Hematology. 29. 1194-1200 (2001)

[文献書誌] Kodama M, Watanabe K et al.: "Mechanical alternans in patients with chronic heart failure"J Cardiac Failure. 7. 138-145 (2001)

2001 年度実績報告書

渡辺賢一新潟薬科大学, 薬学部・臨床薬理学, 教授 (70175090)