2003 年度実績報告書

硝子体の病態生理と新しい治療法

研究課題

研究課題/領域番号	14370557
研究機関	名古屋大学
研究代表者	寺崎浩子名古屋大学, 大学院・医学系研究科, 教授 (40207478)
研究分担者	近藤峰生名古屋大学, 医学部附属病院, 講師 (80303642) 中村誠名古屋大学, 大学院・医学系研究科, 講師 (60283438) 三宅養三名古屋大学, 大学院・医学系研究科, 教授 (30166136)
キーワード	加齢黄斑変性 / 網膜色素上皮 / 組織培養 / 網膜内境界膜剥離
研究概要	本年度では,昨年度の硝子体の病態生理に関する研究成果をまとめ、硝子体網膜境界面の形態や硝子体の生化学的検索、硝子体と密接な相互関係を持つ網膜の機能検査などによる評価の結果を報告した(IOVS 2003, 2004, Ophthalmology 2003, 2004)。硝子体網膜境界面の研究の中で、網膜内境界膜に関する研究は従来よりわれわれが行ってきたものであり、本年度には網膜神経線維層に対する影響について光干渉断層計と走査レーザー検眼鏡を用いた研究を行った。さらに加齢黄斑変性を中心とした研究を行った。実際に加齢黄斑変性の症例に網膜色素上皮-脈絡膜を切除し、黄斑部に移動した。本症例について術後1か月から1年間、定期的にOCTによる網膜厚および色素上皮層の観察、走査レーザー検眼鏡による移植部位の網膜感度、蛍光眼底造影、黄斑部局所ERGなどの網膜機能検査を行い近々報告予定である。さらに、数十例の脈絡膜新生血管抜去術を行い、炎症反応の程度により得られた組織の病理学的分類を行った(16年度、眼炎症学会で報告予定)。一方、多数の脈絡膜新生血管抜去により得られた血管膜に付着する網膜色素上皮細胞の培養を組織工学講座の協力を得て行い、培養された細胞が網膜色素上皮の特性を持つことが確認された(報告準備中)。培養された網膜色素上皮は、名古屋大学工学部の協力で磁性微粒子によりシート状になり、細胞移植への道が一歩近づいた(特許出願中)。

研究成果

(28件)

すべてその他

すべて文献書誌 (28件)

[文献書誌] Niwa T., et al.: "Function and morphology of macula before and after removal of an idiopathic epiretinal membrane."Invest Ophthalmol Vis Sci. 44(4). 1652-1656 (2003)
[文献書誌] Sato M., et al.: "Strabological findings following macular translocation surgery with 360-degreeretinotomy."Invest Ophthalmol Vis Sci. 44(5). 1939-1944 (2003)
[文献書誌] Terasaki H., et al.: "Change in focal macular electroretinograms and foveal thickness after vitrectomy fodiabetic macular edema."Invest Ophthalmol Vis Sci. 44(10). 4465-4472 (2003)
[文献書誌] Piao CH., et al.: "Multifocal electroretinograms in X-linked retinoschisis."Invest Ophthalmol Vis Sci. 44(11). 4920-4930 (2003)
[文献書誌] Terasaki H., et al.: "Morphological and angiographic assessment of the macula after macular translocation surgery with 360° retinotomy."Ophthalmology. 110(12). 2403-2408 (2003)
[文献書誌] Nakamura M., et al.: "Retinal and optic disc atrophy associated with a CACNA1F mutation in a Japanese family."Arch Ophthalmol. 121(7). 1028-1033 (2003)
[文献書誌] Ito Y., et al.: "Mapping posterior vitreous detachment by optical coherence tomography in eyes with idiopathic macular hole."Am J Ophthalmol. 135(3). 351-355 (2003)
[文献書誌] Terasaki H., et al.: "Reduced oscillatory of the full-field electroretinogram of eyes with aphakic or pseudophakic cystoid macuar edema."Am J Ophthalmol. 135(4). 477-482 (2003)
[文献書誌] Kondo M., et al.: "Foveal thickness in occult macular dystrophy."Am J Ophthalmol. 135(5). 725-728 (2003)
[文献書誌] Hotta K., et al.: "Macular dystrophy in a Japanese family with fundus albipunctatus."Am J Ophthalmol. 135(6). 917-919 (2003)
[文献書誌] Suzuki T., et al.: "Optical coherence tomography and focal macular electrotinogram in eyes with epiretinal membrane and macular pseudohole."Am J Ophthalmol. 136(1). 62-67 (2003)
[文献書誌] Mori M., et al.: "Foveal shape after idiopathic macular hole surgery with and without internal limiting membran removal."Retina. 23(6). 870-872 (2003)
[文献書誌] Kikuchi K., et al.: "Functional rescue of N-methyl-N-nitrosourea-induced retinopathy by nicotinamde in sprague-dawley rats."Current Eve Res. 26(6). 355-362 (2003)
[文献書誌] Kojima T., et al.: "Vitrectomy for diabetic macular edema : effect of glycemic control(HbA(1c)), renal function (creatinine) and other local factors."Ophthalmic Res. 35(4). 192-198 (2003)
[文献書誌] Shimizu N., et al.: "Refractive errors and factors associated with myopia in an adult Japanese population."Jpn J Ophthalmol. 47(1). 6-12 (2003)
[文献書誌] Nomura H., et al.: "Age-related change in contrast sensitivity among Japanese adults."Jpn J Ophthalmol. 47(3). 299-303 (2003)
[文献書誌] Hiraiwa T., et al.: "Preoperative Electroretinogram and Postoperative Visual Outcome in Patients with Diabetic Vitreous Hemorrhage."Jpn J Ophthalmol. 47(3). 307-311 (2003)
[文献書誌] Terasaki H., et al.: "Late-onest retinal detachment associated with regressed retinopathy."Jpn J Ophthalmol. 47(5). 492-497 (2003)
[文献書誌] Hirai T., et al.: "Stereopsis in idiopathic macular hole with special reference to the size of the hole andits effect on stereoacuity."Binocul Vis Strabismus Q. 18(4). 2242-248 (2003)
[文献書誌] Marmor MF., et al.: "Guidelines for basic multifocal electroretinography (mfERG)."Doc Ophthalmol. 106(2). 105-115 (2003)
[文献書誌] Nakamura M., et al.: "RDH5 gene mutations and electroretinogram in fundus albipunctatus with or without macular dystrophy."Doc Ophthalmol. 107(1). 3-11 (2003)
[文献書誌] Okamoto Y., et al.: "Delayed regeneration of foveal cone photopigments in vogt-koyanagi-harada disease at the convalescent stage."Invest Ophthalmol Vis Sci. 45(1). 318-322 (2004)
[文献書誌] Terasaki H., et al.: "Changes in focal macular ERGs after macular translocation surgery with 360-degrees retinotomy."Invest Ophthalmol Vis Sci. 45(2). 567-573 (2004)
[文献書誌] Ueno S., et al.: "Luminance dependence of neural components that underlies the primate photopic electroretinogram."Invest Ophthalmol Vis Sci. 45(3). 1033-1040 (2004)
[文献書誌] Asami T., et al.: "Ultrastructure of internal limiting membrane removed during plasmin-assisted vitrectomy from eyes with diabetic macular edema."Ophthalmology. 111(2). 231-237 (2004)
[文献書誌] Asano S., et al.: "Monitoring herpesviruses DNA in three cases of acute retinal necrosis by real-time PCR."J Clin Virol. 29(3). 206-209 (2004)
[文献書誌] Kondo M., et al.: "Peripheral cone dystrophy : A variant of cone dystrophy with predominant dysfunction in the peripheral cone system."Ophthalmology. (in press). (2004)
[文献書誌] Asano T., et al.: "High Prevalence of Myopia in Japanese Patients with Multiple Evanescent White Dot Syndrome."Jpn J Ophthalmol. (in press). (2004)

2003 年度 実績報告書

硝子体の病態生理と新しい治療法

研究代表者

寺崎 浩子 名古屋大学, 大学院・医学系研究科, 教授 (40207478)

研究成果

[文献書誌] Niwa T., et al.: "Function and morphology of macula before and after removal of an idiopathic epiretinal membrane."Invest Ophthalmol Vis Sci. 44(4). 1652-1656 (2003)

[文献書誌] Sato M., et al.: "Strabological findings following macular translocation surgery with 360-degreeretinotomy."Invest Ophthalmol Vis Sci. 44(5). 1939-1944 (2003)

[文献書誌] Terasaki H., et al.: "Change in focal macular electroretinograms and foveal thickness after vitrectomy fodiabetic macular edema."Invest Ophthalmol Vis Sci. 44(10). 4465-4472 (2003)

[文献書誌] Piao CH., et al.: "Multifocal electroretinograms in X-linked retinoschisis."Invest Ophthalmol Vis Sci. 44(11). 4920-4930 (2003)

[文献書誌] Terasaki H., et al.: "Morphological and angiographic assessment of the macula after macular translocation surgery with 360° retinotomy."Ophthalmology. 110(12). 2403-2408 (2003)

[文献書誌] Nakamura M., et al.: "Retinal and optic disc atrophy associated with a CACNA1F mutation in a Japanese family."Arch Ophthalmol. 121(7). 1028-1033 (2003)

[文献書誌] Ito Y., et al.: "Mapping posterior vitreous detachment by optical coherence tomography in eyes with idiopathic macular hole."Am J Ophthalmol. 135(3). 351-355 (2003)

[文献書誌] Terasaki H., et al.: "Reduced oscillatory of the full-field electroretinogram of eyes with aphakic or pseudophakic cystoid macuar edema."Am J Ophthalmol. 135(4). 477-482 (2003)

[文献書誌] Kondo M., et al.: "Foveal thickness in occult macular dystrophy."Am J Ophthalmol. 135(5). 725-728 (2003)

[文献書誌] Hotta K., et al.: "Macular dystrophy in a Japanese family with fundus albipunctatus."Am J Ophthalmol. 135(6). 917-919 (2003)

[文献書誌] Suzuki T., et al.: "Optical coherence tomography and focal macular electrotinogram in eyes with epiretinal membrane and macular pseudohole."Am J Ophthalmol. 136(1). 62-67 (2003)

[文献書誌] Mori M., et al.: "Foveal shape after idiopathic macular hole surgery with and without internal limiting membran removal."Retina. 23(6). 870-872 (2003)

[文献書誌] Kikuchi K., et al.: "Functional rescue of N-methyl-N-nitrosourea-induced retinopathy by nicotinamde in sprague-dawley rats."Current Eve Res. 26(6). 355-362 (2003)

[文献書誌] Kojima T., et al.: "Vitrectomy for diabetic macular edema : effect of glycemic control(HbA(1c)), renal function (creatinine) and other local factors."Ophthalmic Res. 35(4). 192-198 (2003)

[文献書誌] Shimizu N., et al.: "Refractive errors and factors associated with myopia in an adult Japanese population."Jpn J Ophthalmol. 47(1). 6-12 (2003)

[文献書誌] Nomura H., et al.: "Age-related change in contrast sensitivity among Japanese adults."Jpn J Ophthalmol. 47(3). 299-303 (2003)

[文献書誌] Hiraiwa T., et al.: "Preoperative Electroretinogram and Postoperative Visual Outcome in Patients with Diabetic Vitreous Hemorrhage."Jpn J Ophthalmol. 47(3). 307-311 (2003)

[文献書誌] Terasaki H., et al.: "Late-onest retinal detachment associated with regressed retinopathy."Jpn J Ophthalmol. 47(5). 492-497 (2003)

[文献書誌] Hirai T., et al.: "Stereopsis in idiopathic macular hole with special reference to the size of the hole andits effect on stereoacuity."Binocul Vis Strabismus Q. 18(4). 2242-248 (2003)

[文献書誌] Marmor MF., et al.: "Guidelines for basic multifocal electroretinography (mfERG)."Doc Ophthalmol. 106(2). 105-115 (2003)

[文献書誌] Nakamura M., et al.: "RDH5 gene mutations and electroretinogram in fundus albipunctatus with or without macular dystrophy."Doc Ophthalmol. 107(1). 3-11 (2003)

[文献書誌] Okamoto Y., et al.: "Delayed regeneration of foveal cone photopigments in vogt-koyanagi-harada disease at the convalescent stage."Invest Ophthalmol Vis Sci. 45(1). 318-322 (2004)

[文献書誌] Terasaki H., et al.: "Changes in focal macular ERGs after macular translocation surgery with 360-degrees retinotomy."Invest Ophthalmol Vis Sci. 45(2). 567-573 (2004)

[文献書誌] Ueno S., et al.: "Luminance dependence of neural components that underlies the primate photopic electroretinogram."Invest Ophthalmol Vis Sci. 45(3). 1033-1040 (2004)

[文献書誌] Asami T., et al.: "Ultrastructure of internal limiting membrane removed during plasmin-assisted vitrectomy from eyes with diabetic macular edema."Ophthalmology. 111(2). 231-237 (2004)

[文献書誌] Asano S., et al.: "Monitoring herpesviruses DNA in three cases of acute retinal necrosis by real-time PCR."J Clin Virol. 29(3). 206-209 (2004)

[文献書誌] Kondo M., et al.: "Peripheral cone dystrophy : A variant of cone dystrophy with predominant dysfunction in the peripheral cone system."Ophthalmology. (in press). (2004)

[文献書誌] Asano T., et al.: "High Prevalence of Myopia in Japanese Patients with Multiple Evanescent White Dot Syndrome."Jpn J Ophthalmol. (in press). (2004)

2003 年度実績報告書

寺崎浩子名古屋大学, 大学院・医学系研究科, 教授 (40207478)