2002 年度実績報告書

新たな成人悪性リンパ腫疾患単位群の確定を目指した臨床病理学的・分子生物学的解析

研究課題

研究課題/領域番号	14570175
研究機関	愛知県がんセンター
研究代表者	中村栄男愛知県がんセンター, 研究所, 研究員 (80180363)
キーワード	Malignant lymphoma / Disease entity / Diffuse large B-cell lymphoma / CD5 / Intravascular pattern / Epstein-Barr virus / Immunodeficiency / Aging
研究概要	新たな成人悪性リンパ腫疾患単位群として、最近急速に関心を集めつつあるCD5陽性びまん性B大細胞リンパ腫(CD5+DLBCLと略)血管内大細胞型B細胞リンパ腫(IVLと略)、および老人性Epstein-Barr virus (EBV)関連リンパ増殖症(Senile EBV+B-LPDと略)に焦点を当て解析を進めた。 CD5+DLBCLについては2002年に疾患単位a distinct subtypeを形成することを報告するとともに、現在、全国主要施設より123症例を集積した。臨床病理学的検討を継続中であり、病理組織学的亜群giant cell-rich variantの存在とその予後的意義を明らかにした。現在、さらにcomparative genomic hybridization (CGH)法による解析を企図しつつある。同様にIVLについても多施設共同研究として100例以上を集積中である。今後、さらに症例の集積と病態解析を続行する予定である。Senile EBV+B-LPDは、2003年1月に世界に先駆けて新たな疾患単位として報告するに至った。病態は、境界病変(oligoclonal proliferation)から腫瘍性(monoclonal proliferation)まで多岐に亘り、加齢そのものに由来する免疫不全を基盤とする可能性が示唆された。現在、複数の主要施設との共同研究として、びまん性大細胞型B細胞リンパ腫2,000例より100数十例が抽出されようとの見通しの上に検討を進めつつある。これにより、同病変の臨床病態、疾患としての特性をより明らかにする予定である。

研究成果

(18件)

すべてその他

すべて文献書誌 (18件)

[文献書誌] Okabe M, et al.: "API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue"Am J Pathol. (in press). (2003)
[文献書誌] Oyama T, et al.: "Senile EBV^+ B-cell lymphoproliferative disorders : a clinicopathologic study of 22 patients"Am J Sung Pathol. 27. 16-26 (2003)
[文献書誌] Kojima M, et al.: "Primary pulmonary low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with prominent hyalinosis : a case report"Pathol Res Pract. 198. 685-688 (2002)
[文献書誌] Kojima M, et al.: "Lymph node infarction associated with infectious mononucleosis"Int J Surg Pathol. 10. 223-226 (2002)
[文献書誌] Kojima M, et al.: "Lymph node lesion in adult onset Still's disease resembling peripheral T-cell lymphoma : a report of three cases"Int J Surg Pathol. 10. 197-202 (2002)
[文献書誌] Kojima M, et al.: "Nodal marginal zone B-cell lymphoma resembling plasmacytoma arising from a plasma cell variant of localized Castlman's disease : a case report"APMIS. 110. 523-527 (2002)
[文献書誌] Yoshino T, et al.: "Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal type natural killer cell lymphoma"Br J Haematol. 118. 482-487 (2002)
[文献書誌] Yago K, et al.: "Primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)-type of the liver in a patient with hepatitis C virus infection"Leuk Lymphoma. 43. 1497-1500 (2002)
[文献書誌] Nakamura N, et al.: "The Distinction between Burkitt Lymphoma and Diffuse Large B-Cell Lymphoma with c-myc Rearrangement"Mod Pathol. 15. 771-776 (2002)
[文献書誌] Kojima M, et al.: "Centroblastic and centroblastic/centrocytic lymphoma associated with a prominent epithelioid granulomatous response a clinicopathologic study of 50 cases"Mod Pathol. 15. 750-758 (2002)
[文献書誌] Igarashi T, et al.: "Factors affecting toxicity, response and progression free survival in relapsed patients with indolent B-cell lymphoma and mantle cell lymphoma treated with rituximab"Ann Oncol. 13. 928-943 (2002)
[文献書誌] Ito M, et al.: "MUM/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)"Jpn J Cancer Res. 93. 685-694 (2002)
[文献書誌] Nakamura T, et al.: "Clinicopathologic comparison between the API2-MALT1 chimeric transcript-positive and -negative gastric low-grade B-cell lymphoma of MALT type"Jpn J Cancer Res. 93. 677-684 (2002)
[文献書誌] Terasawa T, et al.: "Failure to detect EBV DNA in plasma by real-time PCR in a case of EBV-associated posttransplantation lymphoproliferative disorder confined to the CNS"Int J Hematol. 75. 416-420 (2002)
[文献書誌] Niitsu N, et al.: "Simultaneous elevation of the serum concentrations of VEGF and interleukin-6 as independent predictors of prognosis in aggressive non-Hodgkin's lymphoma"Eur J Haematol. 68. 91-100 (2002)
[文献書誌] Kojima M, et al.: "Follicular hyperplasia presenting with a marginal zone pattern in a reactive lymph node lesion"APMIS. 110. 325-331 (2002)
[文献書誌] Inagaki H, et al.: "Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features"Am J Pathol. 160. 1435-1443 (2002)
[文献書誌] Yamaguchi M, et al.: "De novo CD5-positive diffuse large B-cell lymphoma : a clinicopathologic study of 109 patients"Blood. 99. 815-821 (2002)

2002 年度 実績報告書

新たな成人悪性リンパ腫疾患単位群の確定を目指した臨床病理学的・分子生物学的解析

研究代表者

中村 栄男 愛知県がんセンター, 研究所, 研究員 (80180363)

研究成果

[文献書誌] Okabe M, et al.: "API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue"Am J Pathol. (in press). (2003)

[文献書誌] Oyama T, et al.: "Senile EBV^+ B-cell lymphoproliferative disorders : a clinicopathologic study of 22 patients"Am J Sung Pathol. 27. 16-26 (2003)

[文献書誌] Kojima M, et al.: "Primary pulmonary low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type with prominent hyalinosis : a case report"Pathol Res Pract. 198. 685-688 (2002)

[文献書誌] Kojima M, et al.: "Lymph node infarction associated with infectious mononucleosis"Int J Surg Pathol. 10. 223-226 (2002)

[文献書誌] Kojima M, et al.: "Lymph node lesion in adult onset Still's disease resembling peripheral T-cell lymphoma : a report of three cases"Int J Surg Pathol. 10. 197-202 (2002)

[文献書誌] Kojima M, et al.: "Nodal marginal zone B-cell lymphoma resembling plasmacytoma arising from a plasma cell variant of localized Castlman's disease : a case report"APMIS. 110. 523-527 (2002)

[文献書誌] Yoshino T, et al.: "Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal type natural killer cell lymphoma"Br J Haematol. 118. 482-487 (2002)

[文献書誌] Yago K, et al.: "Primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)-type of the liver in a patient with hepatitis C virus infection"Leuk Lymphoma. 43. 1497-1500 (2002)

[文献書誌] Nakamura N, et al.: "The Distinction between Burkitt Lymphoma and Diffuse Large B-Cell Lymphoma with c-myc Rearrangement"Mod Pathol. 15. 771-776 (2002)

[文献書誌] Kojima M, et al.: "Centroblastic and centroblastic/centrocytic lymphoma associated with a prominent epithelioid granulomatous response a clinicopathologic study of 50 cases"Mod Pathol. 15. 750-758 (2002)

[文献書誌] Igarashi T, et al.: "Factors affecting toxicity, response and progression free survival in relapsed patients with indolent B-cell lymphoma and mantle cell lymphoma treated with rituximab"Ann Oncol. 13. 928-943 (2002)

[文献書誌] Ito M, et al.: "MUM/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)"Jpn J Cancer Res. 93. 685-694 (2002)

[文献書誌] Nakamura T, et al.: "Clinicopathologic comparison between the API2-MALT1 chimeric transcript-positive and -negative gastric low-grade B-cell lymphoma of MALT type"Jpn J Cancer Res. 93. 677-684 (2002)

[文献書誌] Terasawa T, et al.: "Failure to detect EBV DNA in plasma by real-time PCR in a case of EBV-associated posttransplantation lymphoproliferative disorder confined to the CNS"Int J Hematol. 75. 416-420 (2002)

[文献書誌] Niitsu N, et al.: "Simultaneous elevation of the serum concentrations of VEGF and interleukin-6 as independent predictors of prognosis in aggressive non-Hodgkin's lymphoma"Eur J Haematol. 68. 91-100 (2002)

[文献書誌] Kojima M, et al.: "Follicular hyperplasia presenting with a marginal zone pattern in a reactive lymph node lesion"APMIS. 110. 325-331 (2002)

[文献書誌] Inagaki H, et al.: "Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features"Am J Pathol. 160. 1435-1443 (2002)

[文献書誌] Yamaguchi M, et al.: "De novo CD5-positive diffuse large B-cell lymphoma : a clinicopathologic study of 109 patients"Blood. 99. 815-821 (2002)

2002 年度実績報告書

中村栄男愛知県がんセンター, 研究所, 研究員 (80180363)