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2016 年度 実績報告書

体内環境下における最先端人工関節材料のビーリングスの分光学的・力学的評価

研究課題

研究課題/領域番号 14F04783
研究機関京都工芸繊維大学

研究代表者

PEZZOTTI G.  京都工芸繊維大学, 材料化学系, 教授 (70262962)

研究分担者 MRIN ELIA  京都工芸繊維大学, 材料化学系, 外国人特別研究員
研究期間 (年度) 2014-04-25 – 2017-03-31
キーワードtribology / biomaterials / ceramics / prosthetic implants / osteointegration / lubrication / metal staining / silicon nitride
研究実績の概要

This research project provided a further insight on the durability of various ceramic biomaterials applied in orthopaedic prosthetic implants both in-vitro and in-vivo. Simulated wear testing and retrieved materials analysis clearly showed that most commonly applied ceramic biomaterials (monolithic alumina, zirconia and zirconia toughened alumina) degrade in-vivo at a rhythm which is significantly higher when compared to conventional laboratory simulations. It was also shown that metal staining caused by dislocation of the implant, leads to an even faster degradation. The presence of lubrication limits the severity of the tribological contact reducing the friction coefficient but might promote the transformation of tetragonal zirconia into monoclinic, reducing the mechanical properties of the implant. The concept of bioinert biomaterials has then been questioned: even oxides, which are extremely stable from a chemical point of view, have a clear and unexpected interaction with the human body environment. Taking into account these results, silicon nitride has been introduced as an alternative biomaterial. Studies conducted in-vitro clearly showed that Si3N4 positively interact with the human body environment and can thus be successfully used for different applications, from promotion of bone growth and osteointegration (e.g.: in spinal implants or bone fillers) to wear resistance (e.g.: in femoral heads for hip implants). The additional anti-bacterial effect granted by Si3N4 has never been observed before for other conventional ceramic material used in orthopaedics.

現在までの達成度 (段落)

28年度が最終年度であるため、記入しない。

今後の研究の推進方策

28年度が最終年度であるため、記入しない。

  • 研究成果

    (13件)

すべて 2017 2016

すべて 雑誌論文 (13件) (うち国際共著 13件、 査読あり 13件、 オープンアクセス 1件)

  • [雑誌論文] Raman spectroscopic investigation on the molecular structure of apatite and collagen in osteoporotic cortical bone2017

    • 著者名/発表者名
      G. Pezzotti, A. Rondinella, E. Marin, W. Zhu, N.N. Aldini, G. Ulian, G. Valdre
    • 雑誌名

      Journal of Mechanical Behavior of Biomedical Materials

      巻: 65 ページ: 264-273

    • DOI

      10.1016/j.jmbbm.2016.08.030

    • 査読あり / 国際共著
  • [雑誌論文] Wear and surface degradation of commercial ZTA femoral heads under boundary lubrication conditions2017

    • 著者名/発表者名
      E. Marin, A. Rondinella, W. Zhu, B.J. McEntire, B.S. Bal, G. Pezzotti
    • 雑誌名

      Journal of the Mechanical Behavior of Biomedical Materials

      巻: 65 ページ: 616-626

    • DOI

      10.1016/j.jmbbm.2016.09.038

    • 査読あり / 国際共著
  • [雑誌論文] Reconciling in vivo and in vitro kinetics of the polymorphic transformation in zirconia-toughened alumina for hip joints: III. Molecular scale mechanisms2017

    • 著者名/発表者名
      G. Pezzotti, B.S. Bal, M. Zanocco, E. Marin, N. Sugano, B.J. McEntire, W. Zhu
    • 雑誌名

      Materials Science and Engineering: C

      巻: 71 ページ: 552-557

    • DOI

      10.1016/j.msec.2016.11.007

    • 査読あり / 国際共著
  • [雑誌論文] Reconciling in vivo and in vitro kinetics of the polymorphic transformation in zirconia-toughened alumina for hip joints: II. Theory2017

    • 著者名/発表者名
      G. Pezzotti, W. Zhu, M. Zanocco, E. Marin, N. Sugano, B.J. McEntire, B.S. Bal
    • 雑誌名

      Materials Science and Engineering: C

      巻: 71 ページ: 446-451

    • DOI

      10.1016/j.msec.2016.10.031

    • 査読あり / 国際共著
  • [雑誌論文] In situ monitoring of osteosarcoma cells on surface-modulated silicon nitride and titanium biomaterials2017

    • 著者名/発表者名
      B.J. McEntire, G. Pezzotti, R. Bock, W. Zhu, E. Marin, T. Adachi, B.S. Bal
    • 雑誌名

      Bone Joint J.

      巻: 99 (3) ページ: 47-47

    • 査読あり / 国際共著
  • [雑誌論文] Transition metal ions accelerate polymorphic phase transformation in zirconia-toughened alumina artificial hip joints: an in vitro study2017

    • 著者名/発表者名
      B.J. McEntire, W. Zhu, G. Pezzotti, E. Marin, N. Sugano, B.S. Bal
    • 雑誌名

      Bone Joint J

      巻: 99 (3) ページ: 25-25

    • 査読あり / 国際共著
  • [雑誌論文] Vibrational monitor of early demineralization in tooth enamel after in vitro exposure to phosphoridic liquid2017

    • 著者名/発表者名
      G. Pezzotti, T. Adachi, I. Gasparutti, G. Vincini, W. Zhu, M. Boffelli, A. Rondinella, E. Marin, H. Ichioka, T. Yamamoto, Y. Marunaka, N. Kanamura
    • 雑誌名

      Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

      巻: 1732017 ページ: 19-33

    • DOI

      Vibrational monitor of early demineralization in tooth enamel after in vitro exposure to phosphoridic liquid

    • 査読あり / 国際共著
  • [雑誌論文] In toto microscopic scanning of ZTA femoral head retrievals using CAD-assisted confocal Raman spectroscopy2017

    • 著者名/発表者名
      A. Rondinella, S. Affatato, E. Marin, W. Zhu, B.J. McEntire, B.S. Bal, T. Tatewa, K. Yamamaoto, G. Valdre, G. Pezzotti
    • 雑誌名

      Materials & Design

      巻: 116 ページ: 631-637

    • DOI

      10.1016/j.matdes.2016.12.064

    • 査読あり / 国際共著
  • [雑誌論文] Tensor-resolved Raman spectroscopic analysis of wear-induced residual stress fields in long-term alumina hip-joint retrievals2017

    • 著者名/発表者名
      W. Zhu, E. Marin, N. Sugano, G. Pezzotti
    • 雑誌名

      Journal of the Mechanical Behavior of Biomedical Materials

      巻: 66 ページ: 201-210

    • DOI

      10.1016/j.jmbbm.2016.11.016

    • 査読あり / 国際共著
  • [雑誌論文] Reconciling in vivo and in vitro kinetics of the polymorphic transformation in zirconia-toughened alumina for hip joints: I. Phenomenology2017

    • 著者名/発表者名
      B.S. Bal, W. Zhu, M. Zanocco, E. Marin, N. Sugano, B.J.McEntire, G. Pezzotti
    • 雑誌名

      Materials Science and Engineering: C

      巻: 72 ページ: 252-258

    • DOI

      10.1016/j.msec.2016.11.059

    • 査読あり / 国際共著
  • [雑誌論文] Bioactive silicon nitride: A new therapeutic material for osteoarthropathy2017

    • 著者名/発表者名
      G. Pezzotti, E. Marin, T. Adachi, A. Rondinella, F. Boschetto, W. Zhu, N. Sugano, R. Bock, B.J. McEntire, S.B. Bal
    • 雑誌名

      Scientific Reports

      巻: 7 ページ: 44848 1-11

    • DOI

      10.1038/srep44848

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] In Situ Spectroscopic Screening of Osteosarcoma Living Cells on Stoichiometry-Modulated Silicon Nitride Bioceramic Surfaces2016

    • 著者名/発表者名
      G. Pezzotti, B.J. McEntire, R. Bock, W. Zhu, F. Boschetto, A. Rondinella, E. Marin, Y. Marunaka, T. Adachi, T. Yamamoto, N. Kanamura, B.S. Bal
    • 雑誌名

      ACS Biomaterials Science & Engineering

      巻: 2(7) ページ: 1121-1134

    • DOI

      10.1021/acsbiomaterials.6b00126

    • 査読あり / 国際共著
  • [雑誌論文] Effect of etching on the composition and structure of anodic spark deposition films on titanium2016

    • 著者名/発表者名
      E. Marin, M.V. Diamanti, M. Boffelli, M. Sendoh, M.P. Pedeferri, A. Mazinani, M. Moscatelli, B. Del Curto, W. Zhu, G. Pezzotti, R. Chiesa
    • 雑誌名

      Materials & Design

      巻: 108 ページ: 77-85

    • DOI

      10.1016/j.matdes.2016.06.088

    • 査読あり / 国際共著

URL: 

公開日: 2018-01-16  

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