| 研究課題/領域番号 |
15F15116
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| 研究機関 | 長崎大学 |
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研究代表者 |
吉田 レイミント 長崎大学, 熱帯医学研究所, 准教授 (90432963)
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| 研究分担者 |
LE MINH NHAT 長崎大学, 熱帯医学研究所, 外国人特別研究員
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| 研究期間 (年度) |
2015-04-24 – 2017-03-31
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| キーワード | RSV / ON1 / severity / Vietnam |
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| 研究実績の概要 |
A total of 1854 ARI cases were enrolled of which 426 (22.98%) were RSV positive. During three years study period, RSV-A and B had been co-circulating. NA1 genotype was the predominant RSV-A genotype before the appearance of ON1 in 2012. We found that the RSV-related ARI hospitalization incidence significantly increased after the emergence of ON1 in Nha Trang. Moreover, multivariate analyses revealed that RSV-A ON1 was associated with clinical severity compared to previously predominant NA1 genotype: risk of Lower Respiratory Tract Infection was 2.26 (95%CI:1.37-3.72) times, and radiologically-confirmed pneumonia was 1.97 (95%CI:1.04-3.74) times greater.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
Our prospective ARI surveillance study was going on well. We could screened for RSV positive samples and genotyped them properly. Currently we are doing preliminary data analysis and will try to report in international conference.
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| 今後の研究の推進方策 |
We will continue virus testing of the pediatric ARI cases enrolled to our study.
Multiplex PCR assays will be conducted to screen for RSV and other respiratory viruses. The RSV positive samples will be genotyped. The association of clinical severity and the genotype will be investigated. We will also investigate the evolution rate, positive and negative selected genetic patterns of RSV viruses and its association with disease severity among hospitalized ARI cases in Vietnam.
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