| 研究実績の概要 |
We have completed 3 years of the project with a number of findings for the arsenic affected population in Bangladesh which are potential for the health policy reformulation in Bangladesh. The current study has been mainly conducted in rural Bangladesh which has less focus on health issues. Typical skin lesions of arsenic exposure characterized by keratosis, hyperpigmentation and hypopigmentation have been noted in 72.2% arsenic exposed population in our study. It is evident that arsenic affected population both from cross-sectional and case-control study design are prone to have non-communicable diseases (NCD) namely diabetes, metabolic-syndrome, hypertension. Diabetes, the world greatest epidemic, is highly prevalent in arsenic affected population and is increasing over-time (1998: 4.4% vs. current study 13.2% in 2017) in Bangladesh. In the quartile analysis, more the arsenic concentration of drinking water, greater is the diabetes prevalence in that region. Hypertension prevalence is more than double in arsenic exposed population with skin lesion. In addition, severity and prevalence of the NCD risk factors also depends on the duration of arsenic exposure. The prevalence of obesity in the arsenic exposed population with skin lesion is about 7.2% which is higher in comparison to non-skin lesion population (4.8%). VEGF and its downstream signaling cascade have been intensively investigated revealing VEGF has direct correlation with arsenic exposure and the duration of exposure. In current study, average duration of arsenic exposure having skin lesion is 8.5 years.
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