心血管疾患リスクおよび死亡率の関連因子としての精神ストレス

2016 年度 実績報告書

• 研究課題/領域番号: 15J05980
• 研究機関: 東京大学
• 研究代表者: SVENSSON THOMAS 東京大学, 医学系研究科, 特別研究員(DC2)
• 研究期間 (年度): 2015-04-24 – 2017-03-31
• キーワード: Coping / Stress / Cardiovascular disease / Cancer / Epidemiology / Cohort / Incidence / Mortality

研究実績の概要

My research over the past two years has progressed in accordance with the initial timeline defined in my grant application.
The first goal was to investigate the association between stress coping strategies and disease. This has been accomplished and resulted in two publications of which one was considered Editors’Choice. The results of the second article were highlighted by NHK News.
The second goal was to investigate if genetic susceptibility to coronary heart disease modified the effect of stress on cardiovascular disease. The results of this study were presented at the prestigious ESC Congress in Rome, and the manuscript has been accepted for publication in PLOS ONE.
I have also managed additional publications outside the current grant proposal (for details, please see below).

現在までの達成度 (段落)

28年度が最終年度であるため、記入しない。

今後の研究の推進方策

28年度が最終年度であるため、記入しない。

研究成果

• [国際共同研究] Lund University(Sweden)
  • 国名: スウェーデン
  • 外国機関名: Lund University
• [雑誌論文] Psychological stress and risk of incident atrial fibrillation in men and women with known atrial fibrillation genetic risk scores (2017)
  • 著者名/発表者名: Svensson T, Kitlinski M, Engstrom G, Melander O.
  • 雑誌名: Scientific Reports 巻: 7 ページ: -
  • DOI: 10.1038/srep42613
  • 査読あり / オープンアクセス / 国際共著 / 謝辞記載あり
• [雑誌論文] A genetic risk score for CAD, psychological stress, and their interaction as predictors of CAD, fatal MI, non-fatal MI and cardiovascular death (2017)
  • 著者名/発表者名: Svensson T, Kitlinski M, Engstrom G, Melander O.
  • 雑誌名: PLOS ONE 巻: - ページ: -
  • 査読あり / オープンアクセス / 国際共著 / 謝辞記載あり
• [雑誌論文] Coping strategies and risk of cardiovascular disease incidence and mortality: the Japan Public Health Center-based prospective Study (2016)
  • 著者名/発表者名: Svensson T, Inoue M, Sawada N, Yamagishi K, Charvat H, Saito I, Kokubo Y, Iso H, Kawamura N, Shibuya K, Mimura M, Tsugane S.
  • 雑誌名: European Heart Journal 巻: 37 ページ: 890-899
  • DOI: 10.1093/eurheartj/ehv724
  • 査読あり / 国際共著 / 謝辞記載あり
• [雑誌論文] Coping strategies and cancer incidence and mortality: The Japan Public Health Center-based prospective study (2016)
  • 著者名/発表者名: Svensson T, Inoue M, Sawada N, Charvat H, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Kawamura N, Shibuya K, Mimura M, Tsugane S.
  • 雑誌名: Cancer Epidemiology 巻: 40 ページ: 126-133
  • DOI: 10.1016/j.canep.2015.12.003
  • 査読あり / 国際共著 / 謝辞記載あり
• [雑誌論文] Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study (2016)
  • 著者名/発表者名: Svensson T, Yamaji T, Budhathoki S, Hidaka A, Iwasaki M, Sawada N, Inoue M, Sasazuki S, Shimazu T, Tsugane S
  • 雑誌名: Scientific Reports 巻: 6 ページ: -
  • DOI: 10.1038/srep36607
  • 査読あり / オープンアクセス / 国際共著 / 謝辞記載あり
• [学会発表] Coping strategies and cancer incidence and mortality: The Japan Public Health Center-based prospective study (2016)
  • 著者名/発表者名: Thomas Svensson
  • 学会等名: International Congress of Behavioural Medicine
  • 発表場所: Melbourne,Australia
  • 年月日: 2016-12-08
  • 国際学会
• [学会発表] Genetic Risk Score, individual genetic variants and psychological stress as predictors of CAD, fatal MI and cardiovascular death (2016)
  • 著者名/発表者名: Thomas Svensson
  • 学会等名: European Society of Cardiology Congress
  • 発表場所: Rome,Italy
  • 年月日: 2016-08-29
  • 国際学会
• [備考] Department of Clinical Sciences
  • URL: http://www.med.lu.se/english/klinvetmalmo/about_the_department