| 研究実績の概要 |
23人の精神病ハイリスク群、18人の初発精神病群、16人の健常対照群に対して、言語流暢性課題中の局所脳活動をNIRSで、局所脳体積をMRIで測定した。ハイリスク群と初発精神病群で、左側三角部の脳活動低下を認め、かつ初発精神病群では脳活動低下と体積減少に有意な相関を認めた。同部位が統合失調症などの精神病発症の病態解明に置いて重要な部位であると考えられる。
The relationship between cortical activity measured using functional near-infrared spectroscopy (fNIRS) during a verbal fluency task, and GMV in the Broca's area assessed using a manual tracing in magnetic resonance imaging (MRI), which considers individual structural variation, was examined for 57 subjects (23 UHR/18 FES/16 controls). The UHR and FES group showed significantly reduced brain activity compared to control group in the left pars triangularis (PT) (P=.036, .003, respectively). Furthermore in the FES group, the reduced brain activity significantly positively correlated with the volume in the left PT (B=0.29, P=.027). The significant relationship between neural activity and GMV in the left PT may reflect a specific pathophysiology related to the onset of schizophrenia.
|
