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2018 年度 実績報告書

ジルコニアインプラントへの新規ハイドロキシアパタイト成膜法

研究課題

研究課題/領域番号 15K11167
研究機関長崎大学

研究代表者

バラネザハド アリレザ  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (00608870)

研究分担者 渡邊 郁哉  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (00274671)
白石 孝信  長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (10150468) [辞退]
尾立 哲郎  長崎大学, 病院(歯学系), 講師 (70513167)
研究期間 (年度) 2015-04-01 – 2019-03-31
キーワードZirconia / Zinc phosphate
研究実績の概要

The purpose of this study was preparation of a thin zinc phosphate and calcium phosphate coating on the zirconia to be used as a dental implant materials. For that purpose zirconia plates were placed in an acidic zinc phosphatizing solution for hydrothermal treatment. The coating layer was made by hydrothermal treatment in an acidic zinc phosphate solution at 250°C for 30 min to 12 h. SEM images confirmed that the zinc phosphate coating layer was successfully prepared by hydrothermal treatment in an acidic zinc phosphate solution and fully covered the surface at 250°C for 6 hours or longer. Calcium acetate solution was used to form calcium phosphate coating layer on the zinc phosphate layer for 6 hours hydrothermal treatment. The coating layer morphology changed and calcium and phosphate were detected by EDS after calcium treatment. The adhesive strength between zirconia substrate and zinc phosphate coating layer prepared at 250°C for 6 was measured around 60.25±2.57 MPa. In vitro cell study indicated that cell morphology and cell proliferation results for zinc phosphate and calcium treated layer were much better than those for non-coated zirconia substrates. We therefore concluded that the zinc phosphate and calcium phosphate coating might be useful for biomedical applications. Based on the XRD pattern the crystalline coating structure indexed as zinc phosphate (hopeite). The characterizations and cell study results approved the satisfying conclusion for the presented coating method on the zirconia substrates.

  • 研究成果

    (2件)

すべて 2018

すべて 雑誌論文 (2件) (うち国際共著 2件、 査読あり 2件、 オープンアクセス 1件)

  • [雑誌論文] Influences of Surface Finishes on Properties of Biological Zinc Phosphate Conversion Coating on Titanium2018

    • 著者名/発表者名
      Shi Xingling、Zhu Haiming、Valanezhad Alireza、Xu Lingli、Xu Lin、Qian Qian
    • 雑誌名

      physica status solidi (a)

      巻: 215 ページ: 1800143~1800143

    • DOI

      10.1002/pssa.201800143

    • 査読あり / 国際共著
  • [雑誌論文] Alginate Microcapsules as Nutrient Suppliers: An In Vitro Study2018

    • 著者名/発表者名
      Khoshzaban A, Keyhanvar P, Delrish E, Najafi F, Keshel S H, Watanabe I, Valanezhad A, Kashi T J
    • 雑誌名

      Cell Journal

      巻: 20 ページ: 25-30

    • DOI

      10.22074/cellj.2018.4508

    • 査読あり / オープンアクセス / 国際共著

URL: 

公開日: 2019-12-27  

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