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This research has shown for the first time that paracrine signals from the stroma that are known to associated with cancer progression have the ability to regulate androgen metabolism in epithelial tissue in estrogen negative breast cancers. This is an important finding for a number of reasons. Biologically it adds to the growing body of evidence that suggests stromal tissue play a large part in the sustenance of breast cancer. This understanding is essential to further our understanding of biology underlying breast cancer. Clinically it is important as androgen directed therapy is currently being proposed and studied as a potential new therapeutic approach in breast cancer and this research demonstrates additional therapeutic targets in modulating the local androgenic environment as well as a potential mechanism for therapeutic resistance to androgen directed therapy.
The novelty of this project has been underlined by its acceptance for presentation at a number of international scientific conferences. It is currently under consideration for publication.
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