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2015 年度 実施状況報告書

Role of a novel DNA demethylation enzyme in cellular memory

研究課題

研究課題/領域番号 15K18558
研究機関筑波大学

研究代表者

ブザス ダイアナ・ミハエラ  筑波大学, 生命環境系, 准教授 (00616229)

研究期間 (年度) 2015-04-01 – 2018-03-31
キーワードEpigenetics
研究実績の概要

The central protein under investigation for this project in plants, is highly conserved from yeast to human. Recent studies in other organisms have identified new protein interactors - also conserved in plants- and mechanisms. To significantly advance the project, such orthologues proteins were integrated in the existing research plan and are investigated in the context of parent of origin memory, which remains unique for any organism.

現在までの達成度 (区分)
現在までの達成度 (区分)

3: やや遅れている

理由

My employment changed from postdoc to PI. After a pause in my laboratory experiments of over half a year,the establishment of my own laboratory is underway.

今後の研究の推進方策

The initial plan was to investigate the role of DRE2 outside reproductive phase, in vegetative cells where the understanding of the biochemical function could be facilitated eventually. Using the new developments mentioned above together with results from a parallel project, more direct approaches can now be used to address the mechanism of parent of origin memory for DRE2. Should these prove unsuccessful in the near future, I will revert to original plan.

次年度使用額が生じた理由

Since my laboratory did not function for a proportion of the time, only a promotion of funding was spend.

次年度使用額の使用計画

I plan to use the funds carried over in the next year to perform the planned research.

  • 研究成果

    (3件)

すべて 2016 2015

すべて 雑誌論文 (1件) (うち査読あり 1件、 オープンアクセス 1件) 学会発表 (2件) (うち招待講演 1件)

  • [雑誌論文] From the laboratory to the field: assaying histone methylation at FLOWERING LOCUS C in naturally growing Arabidopsis halleri.2016

    • 著者名/発表者名
      Nishio H, Buzas DM, Nagano AJ, Suzuki Y, Sugano S, Ito M, Morinaga SI, Kudoh H.
    • 雑誌名

      Genes and Genetics Systems

      巻: in press ページ: in press

    • 査読あり / オープンアクセス
  • [学会発表] Epigenetic role for the conserved Fe-S cluster biogenesis protein atDRE2 in Arabidopsis thaliana2015

    • 著者名/発表者名
      Diana Buzas
    • 学会等名
      Epigenetic Dynamics: Roles in Development, Inheritance and responses to Environment
    • 発表場所
      Bentley Univestity, Waltham MA US
    • 年月日
      2015-08-02 – 2015-08-07
  • [学会発表] Requirements for Iron-Sulfur clusters cofactors in DNA demethylation2015

    • 著者名/発表者名
      Diana Buzas
    • 学会等名
      A consortium of plant epigeneticsts in Japan- first meeting
    • 発表場所
      NIG Mishima, Shizuoka, Japan
    • 年月日
      2015-07-29 – 2015-07-30
    • 招待講演

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公開日: 2017-01-06  

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