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2015 年度 実施状況報告書

Identifying genetic loci related to the unique phenotypes and immune system of the Negrito populations in Southeast Asia

研究課題

研究課題/領域番号 15K18622
研究機関国立遺伝学研究所

研究代表者

Jinam TimothyA  国立遺伝学研究所, 集団遺伝研究系, 助教 (20648258)

研究期間 (年度) 2015-04-01 – 2017-03-31
キーワードNegrito / Southeast Asia / Population genetics
研究実績の概要

I conducted genome-wide SNP analysis of Negrito groups in Southeast Asia and found some shared genes between various Negrito groups in Malaysia, Philippines and Andaman are linked to common phenotypes seen in these groups.I also found traces of ancient admixture with archaic humans, the Denisovans, in Philippine Negritos but not Malaysian and Andamanese Negritos.
These results have been presented in several local and international meetings, and will be submitted soon for publication.
I have also visited and established contact with possible collaborators in Malaysia for collection of additional DNA samples.

現在までの達成度 (区分)
現在までの達成度 (区分)

2: おおむね順調に進展している

理由

Genome wide SNP analysis of Negrito groups in Southeast Asia has been progressing smoothly and a manuscript has been prepared for submission to a prominent journal.

今後の研究の推進方策

After completing genome-wide SNP analysis, I plan on focusing on targeted sequencing of immune-related loci in several Malaysian groups, including Negritos.
If my research proposal is approved by the collaborators in Malaysia, I plan to visit several sites in Malaysia to collect additional DNA samples.

次年度使用額が生じた理由

Reagents were cheaper than what was initially expected.

次年度使用額の使用計画

Remaining funds will be used to purchase additional reagents.

  • 研究成果

    (8件)

すべて 2015 その他

すべて 国際共同研究 (1件) 雑誌論文 (3件) (うち国際共著 3件、 査読あり 3件、 オープンアクセス 2件) 学会発表 (4件) (うち国際学会 1件、 招待講演 1件)

  • [国際共同研究] Monash University Sunway Campus/University Malaysia Sarawak(Malaysia)

    • 国名
      マレーシア
    • 外国機関名
      Monash University Sunway Campus/University Malaysia Sarawak
  • [雑誌論文] Unique characteristics of the Ainu population in Northern Japan2015

    • 著者名/発表者名
      Jinam TA, Kanzawa-Kiriyama H, Inoue I, Tokunaga K, Omoto K, Saitou N
    • 雑誌名

      Journal of Human Genetics

      巻: 60 ページ: 565-571

    • DOI

      10.1038/jhg.2015.79

    • 査読あり / 国際共著
  • [雑誌論文] Human genetic diversity in the Japanese Archipelago: dual structure and beyond2015

    • 著者名/発表者名
      Jinam TA, Kanzawa-Kiriyama H, Saitou N
    • 雑誌名

      Genes & genetic systems

      巻: 90 ページ: 147-152

    • DOI

      10.1266/ggs.90.147

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Unravelling the genetic history of negritos and indigenous populations of southeast Asia2015

    • 著者名/発表者名
      Aghakhanian F, Yunus Y, Naidu R, Jinam T, Manica A, Hoh BP, Phipps ME
    • 雑誌名

      Genome biology and evolution

      巻: 7 ページ: 1206-1215

    • DOI

      10.1093/gbe/evv065

    • 査読あり / オープンアクセス / 国際共著
  • [学会発表] Population genetic history of Negrito groups in the Philippines2015

    • 著者名/発表者名
      Jinam T
    • 学会等名
      69th Annual Meeting of Anthropological Society of Nippon
    • 発表場所
      Tokyo
    • 年月日
      2015-10-10 – 2015-10-12
  • [学会発表] Tracing human migrations in Southeast Asia using genome-wide Single Nucleotide Polymorphisms2015

    • 著者名/発表者名
      Jinam T
    • 学会等名
      17th Annual Meeting of Society of Evolutionary Studies
    • 発表場所
      Tokyo
    • 年月日
      2015-08-20 – 2015-08-23
  • [学会発表] Human population substructure and population size changes in the Japanese Archipelago2015

    • 著者名/発表者名
      Jinam T
    • 学会等名
      SMBE 2015 Annual Meeting
    • 発表場所
      Vienna, Austria
    • 年月日
      2015-07-12 – 2015-07-16
    • 国際学会
  • [学会発表] Human migration histories in island Southeast Asia from the viewpoint of genetics2015

    • 著者名/発表者名
      Jinam T
    • 学会等名
      15th International Conference of the European Association of Southeast Asian Archaeologists
    • 発表場所
      Paris, France
    • 年月日
      2015-07-06 – 2015-07-10
    • 招待講演

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公開日: 2017-01-06  

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