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2015 年度 実施状況報告書

Toward the World's First Tumor-Following Radiation Therapy Technique: Development of High-Accuracy Tumor Tracking System

研究課題

研究課題/領域番号 15K20852
研究機関東北大学

研究代表者

張 暁勇  東北大学, 工学(系)研究科(研究院), 助教 (90722752)

研究期間 (年度) 2015-04-01 – 2017-03-31
キーワードRadiation therapy / Radiographic imaging / Tumor tracking
研究実績の概要

The purpose of this research is to develop a radiographic image tracking system to track respiration-induced tumor motion in real-time for adaptive tumor following radiation therapy. The tracking system will be able to provide conformable tumor motion information and allows the treatment device to accurately deliver high-dose conformable radiation to the moving target during the treatment.
The research achievements in the FY2015 are summarized as follows. (1) Three phantom and six clinical image data sets including 4-D CT, kilo-voltage (kV) images, and megavoltage (MV) images have been acquired at Hirosaki university hospital. (2) A kernel-based algorithm has been developed for tracking tumor position in kV images. The tracking algorithm has been evaluated using the phantom and clinical kV image sequences. Experimental results demonstrated that the proposed method was capable of accurately locating the tumor position in low contrast kV images and being robust against the image deformation. (3) A level set method-based algorithm has been developed for tracking tumor boundary in MV images. The algorithm has also been evaluated using three data sets including digital phantom image, phantom MV images, and clinical MV images. Experimental results demonstrated that the proposed algorithm was able to track the tumor boundary in MV images and has a potential for tumor following radiotherapy application.

現在までの達成度 (区分)
現在までの達成度 (区分)

2: おおむね順調に進展している

理由

In the FY2015, the research has been conducted steadily, and the progress has been made smoothly according to the research plan. A paper about tracking the tumor boundary in MV images has been published by a prime international journal (Medical Physics). Several related researches on the tumor tracking in kV and MV images have also been published and presented orally in domestic and international conferences.

今後の研究の推進方策

According to the research plan, the main research work in FY2016 will be focused on the following four tasks.
(1) Phantom and clinical data acquisition. In order to evaluate the performance of our tracking system, phantom and clinical radiographic images data acquisition will be continued at Tohoku university hospital and Hirosaki university hospital.
(2) Implementation of real-time tracking system. A real-time tracking system will be implemented tentatively based on a GPGPU computational platform.
(3) System evaluation and improvement. Experiments on phantom and clinical images will be conducted for system evaluation. On the base of experimental results, the current tracking algorithms will be further improved for clinical application.
(4) Related papers will be submitted to prime international journal or conferences.

  • 研究成果

    (10件)

すべて 2015

すべて 雑誌論文 (2件) (うち査読あり 2件) 学会発表 (8件) (うち国際学会 3件)

  • [雑誌論文] Tracking Tumor Boundary in MV-EPID Images Without Implanted Markers: A Feasibility Study2015

    • 著者名/発表者名
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Yoshihiro Takai, Yuichiro Narita, Makoto Yoshizawa
    • 雑誌名

      Medical Physics

      巻: 42 ページ: 2510-2523

    • DOI

      10.1118/1.4918578

    • 査読あり
  • [雑誌論文] Is Mammographic Breast Density a Risk Factor for Breast Cancer in Japanese Women?2015

    • 著者名/発表者名
      Xiaoyong Zhang, Norimasa Chikushima, Atsutoshi Watanabe, Yuji Ohashi, Nao Hasegawa, Kei Ichijii, Atsushi Tamura, Makoto Osanai, Noriyasu Homma,
    • 雑誌名

      Bulletin of School of Health Sciences Tohoku University

      巻: 24 ページ: 45-51

    • 査読あり
  • [学会発表] 呼吸性移動時系列の最大リャプノフ指数推定に基づく予測可能性の検討2015

    • 著者名/発表者名
      市地慶, 本間経康, 張曉勇, 武田賢, 髙井良尋 , 杉田典大, 吉澤誠
    • 学会等名
      2015計測自動制御学会システム・情報部門学術講演会
    • 発表場所
      函館アリーナ(北海道・函館市)
    • 年月日
      2015-11-18 – 2015-11-20
  • [学会発表] Tumor Motion Tracking Using kV/MV X-Ray Fluoroscopy for Adaptive Radiation Therapy2015

    • 著者名/発表者名
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Norihiro Sugita, Yoshihiro Takai, Makoto Yoshizawa
    • 学会等名
      2015計測自動制御学会システム・情報部門学術講演会
    • 発表場所
      函館アリーナ(北海道・函館市)
    • 年月日
      2015-11-18 – 2015-11-20
  • [学会発表] Tumor Motion Tracking Using kV/MV X-Ray Fluoroscopy for Adaptive Radiation Therapy2015

    • 著者名/発表者名
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Makoto Abe, Norihiro Sugita, Ivo Bukovsky, Yoshihiro Takai, Makoto Yoshizawa
    • 学会等名
      2015 International Workshop on Computational Intelligence for Multimedia Understanding
    • 発表場所
      Prague (Czech Republic)
    • 年月日
      2015-10-29 – 2015-10-30
    • 国際学会
  • [学会発表] A Real-Time Feature-Based Markerless Tumor Tracking Method Using X-Ray Image Sequence for Radiotherapy2015

    • 著者名/発表者名
      Yusuke Yoshida, Kei Ichiji, Xiaoyong Zhang, Noriyasu Homma, Yoshihiro Takai, Makoto Yoshizawa
    • 学会等名
      2015 International Workshop on Computational Intelligence for Multimedia Understanding
    • 発表場所
      Prague (Czech Republic)
    • 年月日
      2015-10-29 – 2015-10-30
    • 国際学会
  • [学会発表] A Real-Time Homography-Based Algorithm for Markerless Deformable Lung Tumor Motion Tracking Using kV X-Ray Fluoroscopy2015

    • 著者名/発表者名
      Xiaoyong Zhang, Noriyasu Homma, Kei Ichiji, Norihiro Sugita, Yoshihiro Takai, Makoto Yoshizawa
    • 学会等名
      第25回インテリジェント・システム・シンポジウム
    • 発表場所
      東北大学(宮城県・仙台市)
    • 年月日
      2015-09-24 – 2015-09-25
  • [学会発表] 赤外線深度センサを用いた体表面同時多点の呼吸誘導システムに関する研究2015

    • 著者名/発表者名
      塚田拓也,市地慶,張曉勇,本間経康,髙井良尋,吉澤誠
    • 学会等名
      第25回インテリジェント・システム・シンポジウム
    • 発表場所
      東北大学(宮城県・仙台市)
    • 年月日
      2015-09-24 – 2015-09-25
  • [学会発表] A Real-Time Homography-Based Algorithm for Markerless Deformable Lung Tumor Motion Tracking Using kV X-Ray Fluoroscopy2015

    • 著者名/発表者名
      Xiaoyong Zhang, Noriyasu Homma, Yuichiro Narita, Yoshihiro Takai, Kei Ichiji, Makoto Abe, Norihiro Sugita, Makoto Yoshizawa
    • 学会等名
      2015 American Association of Physicists in Medicine 57th Annual Meeting
    • 発表場所
      Anaheim (USA)
    • 年月日
      2015-07-12 – 2015-07-16
    • 国際学会
  • [学会発表] 乳房 X 線画像診断支援のための多層自己組織化マップによる自動特徴分類の試み2015

    • 著者名/発表者名
      長谷川奈保,本間経康,張暁勇,市地慶,小山内実,阿部誠,杉田典大,吉澤誠
    • 学会等名
      計測自動制御学会第7回コンピューテーショナル・インテリジェンス研究会
    • 発表場所
      東北大学(宮城県・仙台市)
    • 年月日
      2015-05-29 – 2015-05-30

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公開日: 2017-01-06  

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