| 研究課題/領域番号 |
16H05181
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| 研究機関 | 大阪大学 |
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研究代表者 |
Coban Cevayir 大阪大学, 免疫学フロンティア研究センター, 教授 (00397712)
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| 研究期間 (年度) |
2016-04-01 – 2019-03-31
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| キーワード | Bone homeostasis / Malaria / Chronic infection |
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| 研究実績の概要 |
As we proposed, in order to address how malaria infection effects bone tissue, we have set up in vivo and in vitro studies by using various mouse malaria models. For the comprehensive analysis of bone tissue, we have used microCT for bone analyses. We have set up in vitro cell cultures which enable bone marrow hematopoietic stem cells to differentiate into osteoclast and calvarial osteoblast generation during malaria infection. Our aim has been to evaluate whether the formation of osteoclast and osteoblast is impaired during malaria infection or not.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
Our initial plan to set up experimental conditions have progressed more than we expected. Therefore, our hypothesis on the effect of malaria on bone have been smoothly moving forward.
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| 今後の研究の推進方策 |
In the second year of the project, in addition to acute effect of malaria infection on bone, we will elucidate the underlying mechanism of chronic effects of malaria on bone. Furthermore, we aim to elucidate signaling molecules in bone homeostasis affected during malaria infection. We will address signaling molecules important for bone remodeling such as in osteoclasts and/or osteoblasts.
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