研究課題
Incomplete recovery from malaria infection causes chronic illness, and little is known of the potential outcomes of this chronicity. As we proposed bone health might be affected from chronicity of malaria infection. To address how malaria infection effects bone tissue, we set up in vivo and in vitro studies by using various mouse malaria models. We found that malaria causes bone loss and growth retardation as a result of chronic bone inflammation induced by Plasmodium products. Acute malaria infection severely suppresses bone homeostasis, but sustained accumulation of Plasmodium products in the bone marrow niche induces MyD88 dependent inflammatory responses in osteoclast and osteoblast precursors.
2: おおむね順調に進展している
We have smoothly set up the experimental conditions in mice models and progressed more than we expected.
We have finalized the investigation of acute as well as chronic effects of malaria infection on bone. In the third year of the project, we will address signaling molecules important for bone remodeling such as in osteoclasts and/or osteoblasts. We will search possible signal effecting RANK-RANKL and MyD88 interaction.
http://malimm.ifrec.osaka-u.ac.jp/index.html
すべて 2018 2017
すべて 雑誌論文 (4件) (うち国際共著 4件、 査読あり 4件、 オープンアクセス 3件) 学会発表 (5件) (うち国際学会 1件、 招待講演 5件)
Nature Reviews Immunology
巻: 18(4) ページ: 266-278
10.1038/nri.2017.138.
International Immunology
巻: 30 ページ: 121
10.1093/intimm/dxx076.
Proc Natl Acad Sci U S A.
巻: 114 ページ: 6400
10.1073/pnas.1705551114
Science Immunology
巻: 2 ページ: 2
10.1126/sciimmunol.aam8093
