| 研究実績の概要 |
Malaria has deadly complications; however, chronic complications caused by malaria are largely neglected. Our study targeting bone during malaria infection has suggested that malaria infection causes bone loss which involves several inflammatory pathways involving osteoblasts, osteoclasts and MyD88 in response to Plasmodium products. In FY2018, we focused on the contribution of specific cells to MyD88-dependent bone loss. We generated cell type specific MyD88 deficient mice. We have made additional progress on the underlying mechanisms of malaria-induced bone loss.In our recent report, we also evaluated the possibility that the continuous malaria co-infection with EBV reactivation may also influence T cell maturation and differentiation for an increased risk of cancer.
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