| 研究実績の概要 |
Our purpose is to develop a dynamic adaptive brachytherapy system for real-time visualization of four-dimensional in vivo locations of an applicator, 192Ir source, tumor, OAR, and dose distributions for intracavitary brachytherapy using a pixel-based portable radiation camera. For that purpose, at first, dosimetric impacts of heterogeneous materials on dose distributions for cervical cancer intracavitary brachytherapy have been investigated using Monte Carlo simulation. Second, we has designed the a pixel-based portable radiation camera using Monte Carlo simulations based on the Particle and Heavy Ion Transport (PHITS) code System, and an automated system for dynamic estimation of seed locations for cervical intracavitary brachytherapy.
The results of this research have been published in 2 international conference (American Association of Physics in Medicine; International Conference on Medical Physics) and 2 domestic conferences, in which the research could receive encouraging and constructive comments. In addition, the research has received the Best Oral Presentation Award of the 9th Vietnamese - Japanese Student’s Scientific Exchange Meeting (VJSE-2016). Furthermore, the research has been published in a journal in the field of radiation research (Journal of Radiation Research) in collaboration with researchers from Kagoshima University Hospital, Kagoshima, Japan.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Our purpose is to develop a dynamic adaptive brachytherapy system for real-time visualization of four-dimensional in vivo locations of an applicator, 192Ir source, tumor, OAR, and dose distributions for intracavitary brachytherapy using a pixel-based portable radiation camera. For that purpose, at first, dosimetric impacts of heterogeneous materials on dose distributions for cervical cancer intracavitary brachytherapy have been investigated using Monte Carlo simulation. To evaluate the impacts of heterogeneous materials on dose distributions, the comparisons of water phantoms and patient physical maps, which were constructed by converting CT values in planning CT images, were performed on Monte Carlo-based dose distributions by using 3D gamma analysis. Second, we has designed the a pixel-based portable radiation camera using Monte Carlo simulations based on the Particle and Heavy Ion Transport (PHITS) code System, and an automated system for dynamic estimation of seed locations for cervical intracavitary brachytherapy. As a proof-of-concept study, a patient physical map based on planning CT image was employed in this study. 192Ir seed and gamma camera were positioned in the patient physical map.
The results of this research have been published in 2 international and 2 domestic conferences. In addition, the research has received the Best Oral Presentation Award of the VJSE-2016. Furthermore, the research has been published in Journal of Radiation Research in collaboration with researchers from Kagoshima University Hospital.
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| 今後の研究の推進方策 |
We will improve the automated system for dynamic estimation of seed locations based on a pixel-based portable radiation camera using Monte Carlo simulations based on the Particle and Heavy Ion Transport code System.
Next an automated recognition approach for the applicator, source, tumor, and OAR will be developed for the treatment of cervical cancer in intracavitary brachytherapy.
In addition, an estimation approach for planning computerized tomography images as well as magnetic resonance images during the treatment time using a 2D/3D image registration will be developed.
Finally, 4D dose distribution during the treatment time will be estimated.
The results will be presented in the international and domestic conferences and submitted to international journal.
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