| 研究課題/領域番号 |
16J09442
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| 研究機関 | 東京大学 |
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研究代表者 |
KHAIRULINA KATERYNA 東京大学, 大学院工学系研究科(工学部), 特別研究員(DC2)
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| 研究期間 (年度) |
2016-04-22 – 2018-03-31
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| キーワード | polymer gel / dynamics / electrophoresis |
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| 研究実績の概要 |
I have developed new polymer gel with precise control over the mechanical properties and charge amount. This is first system that that allow for exact evaluation of the contribution of electro-osmosis into the transport of both charged and neutral particles. Our gel system is important for the biomedical applications to understand the role of electro-osmotic flow in native biological tissue, but in precisely controlled environment. Contribution of charge of native tissue, especially of brain tissue, is still not fully understood, as it contributes to both transport phenomena and also to charge transfer. Our polymer gel can be used as a surrogate for understanding the transport properties of native tissues.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
I have been working on studying the dynamics of solutes in polymer networks and achieved considerable results. Now we understand the basic mechanism of mobility of both short and semi-flexible polyelectrolytes in polymer gels with homogenous networks and in that with tuned amount of defects. In addition, i fabricated new type of polymer gels with precise control over the charge density and mechanical properties independently. Using this gel, we can predict the value and direction of electro-osmotic flow, and this is the first report on this topic to the best of our knowledge. Now i am concentrating on the understanding of mobility and diffusion of small molecules in composite polymer gel, which incorporate graphene oxide as a filler for the potential applications in separation science and drug delivery
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| 今後の研究の推進方策 |
Polymer gels are basis for the future biomedical applications, being used as fillers for tissue regeneration, support media for cells or drug delivery. Development of new systems with controlled properties for the drug delivery is extremely important. One of the current approaches is use of micelles to incorporate hydrophilic or hydrophobic drug for sustained release in vivo. However, the fabrication of micelles is laborious process, which requires long and expensive polymer synthesis facility. One of the ways to ease the delivery process is incorporation of drug into the polymer gel with further injection into the installation site. I am currently working on new composite polymer gel, which contain biocompatible PEG matrix and graphene oxide for controlled release of small molecules.
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