研究実績の概要 |
The ihs mice had significantly higher blood glucose concentrations than control mice throughout during the oral glucose tolerance test, whereas insulin tolerance test showed that ihs mice had normal insulin sensitivity. Thus, the glucose intolerance is thought to be caused by the impairment of insulin secretion, which was the main cause of diabetes in ihs mice. Histological examination of pancreatic islets showed normal islet number and B-cell mass in ihs mice compared with controls. Immunostaining and ultrastructural analysis showed the morphology of pancreas, stain intensities for insulin/glucagon, and the number or size of secretory vesicles was not significantly different between ihs and control mice.
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