| 研究実績の概要 |
This year, we characterized the ihs mice more. The ihs mice exhibited several distinctive diabetes-related characteristics: (1) diabetes was observed in male but not female mice; (2) there were no differences in insulin content between the ihs and control mice; (3) impaired insulin secretion was elicited by glucose, potassium chloride and sulfonylureas; (4) they exhibited a normal glycemic response to exogenous insulin; and (5) the mice were not obese. The ihs mouse provides a novel murine model of congenital diabetes that exhibits insulin secretion failure. This model allows not only an analysis of the progression of diabetes, but also the identification of unknown genes involved in insulin secretion.
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