研究実績の概要 |
In this study, we developed an redox injectable hydrogel (NO-RIG), which generates nitric oxide (NO) and scavenges reactive oxygen species (ROS), for cardiovascular disease. In our experiment, we successfully prepared and analyzed NO-RIG and other control injectable gels. We also performed myocardial infarction (MI) model mice and confirmed the therapeutic effects of NO-RIG on this model as compared to other control gel. We could also confirmed the disintegration of gel in vitro and retention of gel in vivo after intracardial injection. Using echocardiogram, cardiac functions were evaluated after MI and injection of gels. We foundt that NO-RIG showed significant therapeutic efficacy in MI. Interestingly, we could investigate the angiogenesis and the generation of NO in vivo mice.
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現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
This work is very interesting with high originality. We try our effort to investigate the therapeutic effect and mechanism underlying. Because we used very high level of animal model such as myocardial infarction models mice or angiogenesis model in vivo, which are not easy to perform properly. Fortunately, we collaborated experts who has long experience on these animal models. And our research teams are always supported by university and collaborators
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