| 研究実績の概要 |
Noradrenaline in the lateral amygdala (LA) modulates Hebbian plasticity mechanisms via beta-adrenergic (b-AR) receptors to facilitate formation of auditory fear memories. We have showed that LC activity and activation of LC terminals in LA specifically during aversive experience is required for and facilitates fear memory formation. We have also found that NA release from the LC terminals in LA regulates fear conditioning through actions on b-AR and CRTC1. Fear learning produced a significant increase in CRTC1 nuclear accumulation in LA neurons and expression of dominant negative form of CRTC1 reduced long term fear memory formation, implicating CRTC1 as a potential mechanism for transducing noradrenergic signaling in LA neurons into long term fear memories. We have presented in posters.
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