造血系の制御機構の解析とゲノム異常の網羅的探索による造血器腫瘍発症機構の解明

2009 年度 研究成果報告書

• 研究課題/領域番号: 17013022
• 研究種目: 特定領域研究
• 配分区分: 補助金
• 審査区分: 生物系
• 研究機関: 東京大学
• 研究代表者: 小川 誠司 東京大学, 医学部附属病院, 特任准教授 (60292900)
• 研究期間 (年度): 2008 – 2009

研究概要

造血器腫瘍は造血系の様々な構成要素の細胞が正常の制御を逸脱することによって生ずる腫瘍性疾患と考えられる。実際、これまでに造血器腫瘍の原因として同定された遺伝子変異の多くが、正常造血において重要な役割を担う遺伝子に生ずる異常であることが知られている。本研究では2000検体を越える多数の造血器腫瘍について高密度SNPアレイによる網羅的なゲノム解析を通じて造血器腫瘍の原因となる遺伝子異常を明らかにすることにより、造血器腫瘍の病態解明を図るとともに造血系の制御機構を明らかにすることを目的として行われた。研究の結果、骨髄系腫瘍におけるc-CBL遺伝子の活性化変異、B細胞悪性リンパ腫におけるA20遺伝子の不活化変異を含む多数の遺伝子変異・ゲノム異常が同定され、これらの変異が腫瘍化に及ぼす効果の詳細が明らかにされた。これらの知見は、造血器腫瘍の病態の理解と正常造血の制御機構の解明に資するとともに、造血器腫瘍の新規治療診断技術の開発に有用であると考えられる。

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• [備考]
  • URL: http://www.genome.umin.jp/